Institutions In Spain Research Articles

Perception of translation competence among master’s degree graduates in translation and interpreting: a quantitative study

ABSTRACT In a global context increasingly prone to e-learning formats at all levels of education, especially in and after the context of the COVID-19 pandemic, the acquisition of skills in distance learning programmes should not differ from the ones in onsite learning programmes. The main objective of this study is to analyse the perception that master’s in translation and interpreting (TIS) graduates have of the competences acquired during their studies offered by higher education institutions in Spain. This will be done by means of a questionnaire that uses a 4-point Likert scale to collect evaluations of different issues related to the translation skills of 256 graduates. Our results indicate that the mode of study (face-to-face or distance) does not influence graduates’ perceptions. Finally, we conclude that the graduates’ perception is positive.

First consensus document of waiting list prioritization for liver transplantation by the Spanish Society of Liver Transplantation (SETH).

Spain is worldwide leader in deceased donation rates per million habitants and count on a strong network of twenty-five liver transplant institutions. Although the access to liver transplantation is higher than in other countries, approximately 10% of patients qualifying for liver transplantation in Spain will die in the waiting list or would be excluded due to clinical deterioration. A robust waiting list prioritization system is paramount to grant the sickest patients with the first positions in the waiting list for an earlier access to transplant. In addition, the allocation policy may not create or perpetuate inequities, particularly in a public and universal healthcare system. Hitherto, Spain lacks a unique national allocation system for elective liver transplantation. Most institutions establish their own rules for liver allocation and only two autonomous regions, namely Andalucía and Cataluña, share part of their waiting list within their territory to provide regional priority to patients requiring more urgent transplantation. This heterogeneity is further aggravated by the recently described sex-based disparities for accessing liver transplantation in Spain, and by the expansion of liver transplant indications, mainly for oncological indications, in absence of clear guidance on the optimal prioritization policy. The present document contains the recommendations from the first consensus of waiting list prioritization for liver transplantation issued by the Spanish Society of Liver Transplantation (SETH). The document was supported by all liver transplant institutions in Spain and by the Organización Nacional de Trasplantes (ONT). Its implementation will allow to homogenize practices and to improve equity and outcomes among patients with end-stage liver disease.

A study of social media use for scientific communication and dissemination among Spanish education researchers

This work focuses on understanding how researchers in Spain perceive the importance of social media in scientific communication and dissemination and deepening their understanding of the influential underlying factors. From the initial identification of 5,314 researchers affiliated with higher education institutions in Spain, who published in journals indexed in Scopus and Web of Sciences from 2016 to 2020, 487 were surveyed, and 20 were interviewed. The results show how despite the potential of non-academic social media for the social dissemination of scientific knowledge, use remains low among the researchers surveyed in this study. Also, data allow us to recognize how the time of use of social media and the perception of the training needed influence the perception of the usefulness of social media by Spanish researchers on education. Use that does not seem to be oriented toward dialogue and citizen participation. Higher education institutions should improve the communication and scientific dissemination led by researchers through training and the design of dissemination policies that guarantee an active and general use of them (not only academics but also generalists like Facebook or Youtube) to transfer scientific knowledge to society better.

Managing employee self-esteem in higher education: impact on individuals, organizations and society

PurposeOrganizations increasingly promote the health and well-being of their employees. There is a growing need for organizations to develop a long-term humanistic approach towards their workforce. This study aims to examine how self-esteem influences the organization, the employee and society within the context of higher education institutions.Design/methodology/approachThe research has been carried out among the teaching and research staff of a higher education institution in Spain. For this, a structured questionnaire was used. Data analysis was conducted using 272 valid questionnaires. A linear regression analysis was used to examine the relationship between self-esteem and the variables of the model.FindingsWe identified a positive correlation between self-esteem and productivity, job satisfaction and altruism, where significant differences were observed according to gender, age, seniority and professional category of the teaching staff. The results revealed that teachers with high self-esteem are more productive, satisfied and participate in more altruistic activities than their counterparts with low self-esteem.Originality/valueThis study reveals the importance that worker self-esteem has on their behavior in the work environment and in society as a whole, to improve the overall results of the organization. We identified self-esteem as an attribute that improves productivity, job satisfaction and altruism, that can be used to reduce job turnover intention and improve job retention levels, positively affecting the organization. We also contribute to the achievement of some Sustainable Development Goals. This study offers a theoretical contribution by extending the application of social learning theory to the context of self-esteem within higher education institutions.

Regulatory Implications of the Supervision and Management of Liquidity Risk: An Analysis of Recent Developments in Spanish Financial Institutions

The aim of this paper is to analyze the evolution of bank liquidity regulations, considering the global regulatory framework applicable to financial institutions, from the beginning of the banking and liquidity crisis in 2007–2008 to the present. The new liquidity requirements under Basel III regulations are defined. An analysis is made of the recent evolution of credit institutions in Spain from different banking prisms to determine how the new banking regulation and supervision, following the start of supervisory powers by the European Central Bank at the end of 2014, has affected them. The methodology applied has been firstly the literature review, followed by a compilation and analysis of the financial and statistical evidence available on the main Spanish financial institutions, from the European Central Bank and the Bank of Spain, as well as information published by other agencies and the financial institutions themselves. It concludes with a reflection and analysis of the outlook for the sector once the most recent impacts, derived from COVID-19, and the supply crisis with the rise in global inflation and the increase in interest rates have been overcome. It can be stated that credit institutions in Spain have significantly improved their liquidity position over the last 15 years.

Prognostic factors in young women with epithelial ovarian cancer: the Young Ovarian Cancer-Care (YOC-Care) study

ObjectiveTo determine oncological outcomes and to identify prognostic factors in women aged <45 years with epithelial ovarian cancer.MethodsA multicenter retrospective study was performed of patients treated for epithelial ovarian cancer...

P11.76.A SPECTRUM OF TP53 SOMATIC MUTATIONS IN A PROSPECTIVE STUDY OF PATIENTS WITH GLIOMA

Abstract BACKGROUND TP53 mutations occur frequently in gliomas, being most common in IDH-wild-type (WT) glioblastomas (GB) and in IDH-mutant (MUT) oligodendrogliomas (OD). Our aim was to describe the mutation spectrum of TP53 somatic mutations in patients (pts) with glioma. MATERIAL AND METHODS This was a prospective multicenter study of patients with glioma diagnosed at four different institutions in Spain. Next-generation sequencing (NGS) of formalin-fixed paraffin-embedded (FFPE) or fresh tumor samples were used for sequencing the TP53 gene in an Illumina Miseq instrument (Illumina, Inc.). Only TP53 pathogenic mutations were considered as valid and are reported here. RESULTS Between February 2017 and March 2020, 61 glioma patients (pts) were enrolled among which 17 different pathogenic mutations in TP53 were detected. Mutant allele frequency (MAF) was &amp;gt; 4% in all cases. TP53 pathogenic mutations occurred at the following loci: L145P, R158H, R175H, H193R, G199V, R202C, R213X, H214R, Y234C, R248Q, I255S, E271Vfs*36, R273C, P278T, G278T, G279E, R280K. Additional clinical characteristics and survival results will be presented at the meeting. CONCLUSION TP53 occur frequently in glioma but widely distributed across the whole exome. The contribution of each specific pathogenic TP53 mutation in gliomas should be further studied.

Can public food procurement drive agroecological transitions? Pathways and barriers to sustainable food procurement in higher education institutions in Spain

ABSTRACT Public procurement can help drive a transition to a more sustainable food system based on local agroecological production. In countries with large public education systems, school and university canteen services can play a significant role by virtue of their enormous centralized purchasing power. In this study, we investigate the potential and feasibility of implementing an enduring transformation to a sustainable food procurement model in public higher education institutions based on agroecological principles for the case of Spain. To address our research questions, we employed participatory workshops and a questionnaire survey (1,058 respondents) to analyze perceptions and priorities around sustainable food practices on campus of the university community across three Spanish public universities. Workshop participants proposed and prioritized interventions aimed at improving the sustainability of on-campus food services. Some recommendations for action for policy makers are detailed in the Discussion section, as key actors in this process. Pathways toward a future transition to more sustainable practices included the importance of food services to the university community, the high level of understanding of food system impacts and demand for change from consumers on university campuses, the universities’ commitment to the UN Sustainable Development Goals and the potential of university networks as a powerful agent of social change and social innovation.

Teaching sustainability in higher education by integrating mathematical concepts

Purpose This paper aims to identify the current situation of higher education institutions in Spain regarding the introduction of the Sustainable Development Goals in the classroom, and what is the role of mathematics in this task. Design/methodology/approach A review is made of how the concept of sustainability has evolved in higher education, its gradual introduction in the University and the way in which this subject is approached in the field of mathematics. Findings The study concludes that higher education has a key role to play in designing strategies that lead to the global sustainability of the planet. This implies major changes in degree curricula, assessment, competences and teacher training. Cross-disciplinarity and interdisciplinarity between different subjects within the same degree is a strategy for students to analyse the Sustainable Development Goals using mathematical techniques. Social implications The University as an institution must train socially responsible professionals who are aware of the importance of promoting a sustainable world. Changes should be made to introduce values in the classroom that promote and encourage sustainability. Training should be seen as a continuous process that leads to the preparation of professionals committed to society and nature and who develop strategies aimed at improving the planet through values. Originality/value Through practical activities, the Sustainable Development objectives can be analysed from several subjects of the same degree, emphasising the interdisciplinary and transversal nature that should be the central axis of higher education. Each subject can develop a strategy for change in favour of sustainability that will be reinforced and increased by working together on the proposed teaching practice. In this way, the contents of the different subjects are not isolated, but rather the student can see how there is an interrelationship between them and with real life.

A critical view on the current use of daptomycin in Spain: The daptomise study

BackgroundThe Study on the Clinical Use of DAPTOMycin in Spain (DAPTOMISE Study) is a national surveillance program of daptomycin use. The objectives of this study are to evaluate the current variability in daptomycin consumption across the different hospitals and the adequacy of therapy, specially focused on underdosing. MethodsAll adult and pediatric patients who received, at least, one dose of daptomycin in a single week in 98 institutions in Spain were included. The adequacy of daptomycin use was evaluated with respect to the indication, dosage, adjustments after microbiology results, switching to an oral agent and length of treatment. ResultsA total of 615 patients received daptomycin during the study week. The prevalence use was 2.3 patients / 100,000 inhabitants per week, 12.4 patients / 1000 admissions and 9.2 Days of Therapy (DOT) / 1000 hospital stays. These rates varied between hospitals: from 0 to 13.9 patients / 100,000 inhabitants, from 0 to 76.1 patients / 1000 admissions and from 0 to 49.4 DOT / 1000 hospital stays. The most frequent infections were bacteremia (31.6 %) and skin and soft tissue infections (17.9 %). Microbiological results were available in only 65.4 % of infections. The most frequent microorganisms were Staphylococcus aureus (192 isolates, of which 87 were resistant to methicillin) and coagulase-negative staphylococci (124 isolates). A total of 136 prescriptions (22.1 %) were underdosed. Dosages < 8 mg/kg were used for 35.6 % of endovascular infections and for 26.2 % of osteoarticular infections. Overall, 57.2 % of prescriptions were not optimal in, at least, one item. Clinical cure rate was 76.1% and mortality attributable to the infection 8.1%. ConclusionThis is the first registry that identifies the prevalence of use of daptomycin in Spain and shows a high variability in the consumption between the different hospitals. Daptomycin underdosing was present in more than 20 % of cases.

Performance of cultural heritage institutions: A regional perspective

Most studies on performance evaluation in the cultural sector are based on the efficiency assessment of a network of institutions. Nevertheless, very few works take territorial divisions as the case study. Under this approach, we design a spatial production function which merges several cultural resources in order to optimize the impact of a regional system of cultural institutions in terms of cultural production and use of services provided. The aim of this paper is therefore to evaluate the efficiency of cultural heritage institutions in Spain from a regional perspective. We take regional networks of museums and libraries as emblematic case studies over a long period, from 2002 to 2020. We first apply a dynamic-network DEA model to measure efficiency, which allows the production function to be divided into stages and time intervals, considering inter-reliant inputs between production phases and time lapses. We also apply truncated regression models to study the effect of external variables on regional cultural efficiency, especially those related to socioeconomic conditions in regions, the scope of the cultural and tourist sector, and institutional indicators. Results show that regional cultural efficiency depends on the level of training and on the demographic structure rather than on economic wealth. Differences are also found between the goals of cultural production and cultural consumption (visitor impact). These findings might prove useful for policy implications regarding resource allocation vis-à-vis defining and accomplishing cultural purposes at a regional scale, and also for revealing causes of inefficiency with a view to improving quality in institutions –which ultimately drives economic development.

Bibliometric Analysis of the Digitalized Economy: A Systematic Review

The digital economy has gained excellent research attention in both practices and academia. Various organizations in the world are using digital technology. Recently, there has been much interest in topics like the Blockchain, sharing economy, and others, leading to apparent changes in several fields. At the same time, interest in the digital business economy is expanding. The bibliometrics analysis on the subject is a great way to address and discuss the possibilities and risks of the digital revolution. This study retrieved 10258 articles from the web of sciences database between 2015 and 2022. The analysis's findings revealed that since 2015, publications have significantly increased in several disciplines, including management, business, economics, library and information science, business economics, and others. In addition, research institutions in Spain, the USA, and the UK have excelled in the field of the digital economy. The authors used the VOS viewers software to examine what occurred and generate a keyword map showing the connection between the topic and the cooccurrence network generated by keyword data. As a result, researchers, funding organizations, policymakers, and business professionals interested in developing the digital economy can use this paper as a resource.

Nurse prescription start-up in a Spanish health organization: Nurses' preparedness and 6-month results

IntroductionNurse prescribing is well consolidated in many countries. In Spain, recent legislation has allowed nurse to prescribe under specific conditions, but the implementation process is complex. ObjectivesFirst, to describe nurses' knowledge and expectations of nurse prescribing in a health institution in Spain. Second, to report the nurses' prescriptions in a pilot group at 6 months. MethodsA descriptive, online survey design was used to identify nurses' knowledge and expectations of prescribing. The results were compared according to the nurses' professional position and training. We analyzed the number and type of prescriptions issued in the first 6 months. ResultsTraining needs (overall score = 4.2/5) and lack of knowledge of the law (4.25/5) were scored lower by nurses with postgraduate training. Subjective assessment of preparedness among nurses was high (>4/5), and the highest-scoring expected impact was improvement in patients' experience (4.25/5). Years of nursing experience were negatively correlated with preparedness and the expectation of an increase in patient management errors. A total of 212 prescriptions were issued (2 drugs and 200 health devices). ConclusionsNurses perceived good preparedness but also the need for more training in medicines and prescribing law. Expectations of prescribing were favourable. Most prescriptions were for health devices.

Effect of diabetes on shock wave therapy for the treatment of erectile dysfunction

Objectives To evaluate the effect of diabetes in patients with erectile dysfunction treated with focal shock wave therapy in a specialized center in Spain. Methods The clinical data of men with erectile dysfunction treated during 2018-2019 in a specialized institution in Spain, who received 1 cycle of shock waves, were extracted. Patients with other sexual dysfunctions or incomplete data were excluded for analysis. The change in the score of the IIEF-15 questionnaire in diabetics versus non-diabetics was compared, adjusting for confounding variables using linear regression models. Results 409 patients met selection criteria and were included in this study. 53.5% were treated in Barcelona and 18% in Madrid, the average age was 55.5 years (+/- 12.5), 16.9% were diabetic and 80.4% had some other cardiovascular risk factor. The time with erectile dysfunction ranged between 1 and 36 months, and the baseline IIEF-5 score was 12.5 (+/- 6.2). At the end of therapy, the mean change in this score was lower in diabetics compared to non-diabetics (4.6 vs 1.9, p-value 0.006), which was independent of other confounding variables (p-value 0.029). Conclusions Diabetes decreases the effectiveness of focal shock wave therapy in Spanish men with vasculogenic ED, this condition should be treated to obtain better results. Conflicts of Interest The authors are employees of Boston Medical Group. This is a private institution to treat men's sexual dysfunctions. To evaluate the effect of diabetes in patients with erectile dysfunction treated with focal shock wave therapy in a specialized center in Spain. The clinical data of men with erectile dysfunction treated during 2018-2019 in a specialized institution in Spain, who received 1 cycle of shock waves, were extracted. Patients with other sexual dysfunctions or incomplete data were excluded for analysis. The change in the score of the IIEF-15 questionnaire in diabetics versus non-diabetics was compared, adjusting for confounding variables using linear regression models. 409 patients met selection criteria and were included in this study. 53.5% were treated in Barcelona and 18% in Madrid, the average age was 55.5 years (+/- 12.5), 16.9% were diabetic and 80.4% had some other cardiovascular risk factor. The time with erectile dysfunction ranged between 1 and 36 months, and the baseline IIEF-5 score was 12.5 (+/- 6.2). At the end of therapy, the mean change in this score was lower in diabetics compared to non-diabetics (4.6 vs 1.9, p-value 0.006), which was independent of other confounding variables (p-value 0.029). Diabetes decreases the effectiveness of focal shock wave therapy in Spanish men with vasculogenic ED, this condition should be treated to obtain better results.

Characteristics of university teaching in institutions in Spain, Mexico and Venezuela

The complexity of university teaching requires the development of studies that allow contrasting the experiences of teachers in different settings, so this work compares the characteristics of the training of students in three universities, one in Spain, one in Mexico and one in Venezuela. A non-experimental design research was carried out with a descriptive level using the Questionnaire “Indicators of Teaching Excellence at the University of Granada”. The results demonstrate the importance attributed in teaching to the following features: knowledge of the subject, planning, communication, didactics, evaluation, and reflection as mechanisms for permanent innovation. The relevance of evaluation and motivation were found as coincident elements in the three institutions, that demonstrates a shared vision of context-independent teaching. To conclude, the centrality of the ethical dimension stands out, the vision of this activity as a quality service prevails in which improvisation must be avoided and an innovative action must be deployed and also permanent communication and fair evaluation. La complejidad de la enseñanza universitaria requiere el desarrollo de estudios que permitan contrastar las experiencias de los profesores en diferentes escenarios, por lo que en este trabajo se comparan las características de la formación de estudiantes en tres universidades, una en España, una en México y una en Venezuela. Se realizó una investigación de diseño no experimental con un nivel descriptivo utilizando el Cuestionario “Indicadores de Excelencia Docente en la Universidad de Granada”. Los resultados demuestran la importancia que se atribuye en la docencia a los siguientes rasgos: conocimiento de la materia, planificación, comunicación, didáctica, evaluación, y reflexión como mecanismos para la innovación permanente. Se encontraron como elementos coincidentes en las tres instituciones la relevancia de la evaluación y la motivación, cuestión que demuestra una visión compartida de la enseñanza independiente del contexto. Para concluir destaca la centralidad de la dimensión ética, prevalece la visión de esta actividad como un servicio de calidad en el que se debe evitar la improvisación y desplegar una acción innovadora, mantener la comunicación permanente y evaluar de forma justa.

Designing advisory councils to do what? Analysing the most common participatory institution in Spain

ABSTRACT Advisory councils (ACs) are one of the most common participatory institutions, aimed to provide authorities with a forum to consult the organized groups at a given territorial or sectoral level. Although they constitute permanent spaces for civic participation, they remain overlooked. This work systematically analyses ACs from a large-N perspective that goes beyond the best-cases approach. The article initially reflects on the role and expected benefits of ACs, identifying three important design choices: organizational structure, objectives, and accountability channels. Then, the article maps 2,013 ACs in Spain and develops a descriptive analysis relying on an original database obtained from the study of official regulations and web pages of 70 ACs. Our first goal is to describe ACs. Secondly, a good picture of these councils sets the foundation for discussing their performance in terms of inclusiveness, impact in policy-making and democratic control. Combining different statistical techniques the article shows that: (1) ACs present diverse design features; (2) these characteristics enable the generation of typologies of ACs; and (3) having the explicit goal of influencing public policies positively correlates with being an empowered council. These findings connect with the broader debate on participatory governance.

“Worth More Than Life Itself”: Military Honour and the Birth of Its Courts in Spain (1810–1870)

ABSTRACT This article deals with military honour in nineteenth-century Spain, after first examining how the meaning of this term evolved from the revolutionary Napoleonic wars onwards. This highly important moral value was learnt from the moment someone joined the army, and even before then, through education and common public military demonstrations. It related to individual behaviour, while also maintaining a high collective and corporative aspect, and it varied depending on gender or class and on the identity of the social group. It was part of the political thought of most relevant Spanish generals, and consequently it influenced the political dynamics of Spain. The Court of Honour, an institution in Spain that was not regulated until 1811, controlled honour compliance. The last section of this article focuses on how and why these institutions were born and explains their early legislative evolution. Spanish political and military development are inevitably bound together to the extent that an understanding of the nature of honour and its effects on the army and civilian ethics provides us with a deep socio-political and ethical analysis of the country during the nineteenth century.

Reconnecting the Cinchona (Rubiaceae) collections of the “Real Expedición Botánica al Virreinato del Perú” (1777-1816)

During the “Real Expedición Botánica al Virreinato del Perú”, 1777-1816, Hipólito Ruiz López (1754-1816), José Antonio Pavón Jiménez (1754-1840), Juan José Tafalla Navascués (1755-1811) and Juan Agustín Manzanilla (fl. 1793-1816) collected economically important specimens of anti-malarial cinchona bark (Cinchona spp.). In the 230 years since, these specimens have been dispersed across institutions in Spain, Britain, Germany and Italy. Two major sub-collections of these are found at the Real Jardín Botánico, Madrid, Spain (n = 243), and the Royal Botanic Gardens, Kew, UK (n = 188). The Kew collection arrived in Britain through Pavón and other Spanish botanists selling part of the collections. This study traces the history, trajectory and relationship of the collections between the two institutes.

Online teaching and gender bias

I study the impact of online instruction on teaching evaluations at a higher education institution in Spain. Using a difference-in-differences approach, I show that in the semester when teaching moved online, female lecturers were evaluated more poorly than in previous semesters. The performance of male lecturers was not impacted by the new teaching environment, according to student opinion. I rule out several mechanisms: for example, poorer adaptation to online teaching by female lecturers, less experience in taught courses or student sorting. Additional results indicate that among the female lecturers, those who were younger and who did not have a permanent contract were those impacted most negatively. The bias was driven by male students and by low achievers (who were going to fail the course), and was particularly pronounced in Social Sciences. If the online environment keeps gaining in importance in higher education, the gender gap in teaching evaluations that I document is likely to have important direct and indirect effects on the career progression of women.

Time-of-day infusion of immunotherapy in metastatic urothelial cancer (mUC): Should it be considered to improve survival outcomes?

e16541 Background: Immune-checkpoint inhibitors (ICIs) are key in the current management of mUC pts. Recent data in melanoma revealed a link in between the circadian rhythm of the immune-system and expected activity with ICIs (Quian et al, Lancet Oncol 2021). In preclinical models naïve CD4 and CD8 T cells in blood have shown to approach nadir levels around 4 P.M., and therefore, to lower adaptative immune responses after that time. We aimed to correlate the activity of single agent ICIs for the systemic treatment of mUC pts depending on the time of administration. Methods: This is a multicenter and retrospective study performed in 3 academic institutions in Spain and 1 in Italy of patients with mUC who initiated treatment with anti-PD1 or anti-PDL1 as 1st or subsequent line. ICIs were administered and managed according to product labelling. Time cut-off as adaptive immune-modulation for ICIs administration was considered after 4:30 PM. We divided pts into those who received at least 20% of their infusions after 4:30 PM and those who received fewer than 20% after that time. Other data such as patient characteristics and adverse-events related to the treatment were also collected. We carried out a survival analysis by a Cox regression model. Results: From 2016, 92 pts were treated with single agent ICIs for mUC. Most of the pts (n = 62; 67.4%) received less than 20% of the doses after 4:30 PM, while a lower proportion (n = 26; 28.3%) received at least 20% of the doses after that time. Median follow-up time of immunotherapy was 8.6 months. 35 (38.0%) and 57 (62.0%) pts received ICIs as 1st and subsequent lines of treatment respectively. There were no differences in the proportion of pts in 1st vs subsequent lines and time of administration, nor other well prognostic baseline factors like PD-L1 expression, or Bajorin or Bellmunt’s scoring. A significant benefit in both PFS (11.38 vs 3.58 months; HR 2.66: 95%CI 1.53-4.63; p = 0.001) and in OS (14.04 vs 6.80 months; HR 2.62: 95%CI 1.48-4.63: p = 0.001) benefited to pts who received less than 20% of the doses after 4:30 PM. Response rate also favored (59.3% vs 16.0%) the earlier administration of the treatments. Neither corticosteroids concomitant use nor immune-related toxicity appeared to impact on these outcomes. Conclusions: Time of the day administration of ICIs may influence the efficacy of ICIs in mUC pts. Although the small size of the sample and the short median follow-up is something to be considered, this data are promising and consistent with the previous studies. Prospective confirmation is needed.