A large-signal linearization method for operational transconductance amplifiers (OTA) using a combination of cross-coupled quadratic cell and a novel non-linear current injection technique is presented in this paper. Post-layout simulations show that for 180 nm CMOS process with a 1.8 V power supply, total harmonic distortion (THD) at 1.5 V peak-to-peak and 5 kHz input is less than −46 dB. Also, the dynamic range (DR) at given THD is 68 dB with power consumption of 0.64 mW. To verify the performance, the proposed OTA is used to design a new configurable filter in high-frequency range using N-path filter methodology. Universal Butterworth Gm-C active filters are embedded in the proposed 4-path filter, which makes it possible to change the type and order of the filter by means of four digital bits. The center frequency of the proposed 4-path filter can be tuned from 100 MHz to 3.5 GHz. The final filter is designed to achieve a voltage gain of 0 dB, in-band input third-order intercept point (IIP3) of +2.5 dBm and a total NF of 2.6 dB. Post-layout simulation results of the first-order filter show a THD of −44 dB with a 5 kHz input tone and 614 mV peak-to-peak swing.