The formation of inorganic precipitates at the cathode is the most persistent problem in direct seawater electrolysis (DSWE) for hydrogen production. To address this issue, we demonstrate the combination of lyocell-based carbon cloth (CC, as a conductive substrate) and bipolar membrane (BPM)-based DSWE. The entire process, from fabricating lyocell-based CC to coating FeNiCo catalysts, is conducted to ensure stable adhesion between the CC surface and electrocatalysts, thereby enhancing charge transfer. The hydrogen evolution reaction activity of FeNiCo@lyocell-based CC in 1.0 M NaOH shows the overpotential of 152 mV at 10 mA/cm2, which is much lower than that (342 mV) of bare lyocell-based CC. When the FeNiCo@lyocell-based CC is used as a cathode in the BPM-DSWE, the growth rate of inorganic precipitates formed at the cathode is significantly reduced. As a result, the rate of increase in cathodic potential over 100 h at 100 mA/cm2 is approximately 6 %, which is more than four times smaller than that of Pt-coated Ti foam. The woven structure of the lyocell-based CC provides small holes densely distributed at regular intervals and empty spaces between carbon fibers arranged in the same direction. The unique structure is expected to help the protons generated from the BPM escape directly into bulk seawater. In this process, free protons can play a role in reducing the high pH formed at the interfaces of each fiber, slowing down the growth rate of inorganic deposits. If the empty space ratio of the porous structure and the three-dimensional connectivity are optimized for BPM-DSWE, lyocell-based CC is expected to be a promising conductive substrate that can suppress the formation of inorganic deposits even at higher current densities.