The article analyzes the processes of transformation of the economy of Ukraine in the direction of building a postindustrial society. The real situation in the scientific and innovative sphere was analyzed and the place of Ukraine in the global innovation space was determined. On the basis of the analysis of the innovativeness of the domestic economy, a range of problems was identified, namely: the presence of an ineffective and weak mechanism for the introduction of innovations in the sphere of economic activity and further commercialization, an insufficient level of financing, the outflow of qualified personnel, a high degree of riskiness, and others. According to the results of the analysis, it was found that the share of innovative products in the volume of industrial products sold in Ukraine is less than 3% and is currently the smallest among European countries. The export of innovative products is about half of the realization of innovative products, which causes a decrease in the competitiveness of Ukraine on world markets, in particular high-tech ones, and leads to the consolidation of Ukraine’s status as a raw material and lowtech country. Extremely small amounts of funding for innovations and in fact the absence of budgetary funding for the scientific sphere indicate an unjustified slowdown in the process of post-industrialization of the Ukrainian economy. It has been proven that the creation of favorable conditions for the development and improvement of the efficiency of scientific and innovative activities is a priority task of the state innovation policy, because the influence of scientific, technical and innovative spheres on the development and growth of the economic system is of crucial importance in the process of building a post-industrial economy in Ukraine. The measures to overcome the main obstacles on the way to “post-industrialization” of the domestic economy are substantiated. The article notes the need to develop science-intensive, resource-saving and information technologies; strengthening the role and importance of the human factor along with increasing costs for training highly qualified workers; expanding the scale of use of information and communication technologies, forming new stereotypes of thinking and models of economic behavior of individuals and forming a unique information culture.