Innovative Planning Research Articles

Exploring the Efficacy of Novel Therapeutic Strategies for Periodontitis: A Literature Review.

Periodontitis, a prevalent oral condition, is facing difficulties in therapeutic approaches, sometimes leading to failure. This literature review was conducted to investigate the diversity of other therapeutic approaches and their potential contributions to the successful management of the disease. This research scrutinized the alterations in microbial diversity and imbalances in crucial microbial species, which contribute significantly to the pathogenesis of periodontitis. Within the limitations of this study, we highlight the importance of understanding the treatment plan's role in periodontitis disease, opening the way for further research and innovative treatment plans to mitigate the impact of periodontitis on oral health. This will aid both healthcare professionals and patients in preventing and effectively treating periodontitis, ultimately improving oral health outcomes and overall systemic health and well-being.

The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU-ARROW): A study protocol for a single-blind, multi-site, randomized controlled trial.

The Finnish Geriatric Intervention Study (FINGER) led to the global dementia risk reduction initiative: World-Wide FINGERS (WW-FINGERS). As part of WW-FINGERS, the Australian AU-ARROW study mirrors aspects of FINGER, as well as US-POINTER. AU-ARROW is a randomized, single-blind, multisite, 2-year clinical trial (n = 600; aged 55-79). The multimodal lifestyle intervention group will engage in aerobic exercise, resistance training and stretching, dietary advice to encourage MIND diet adherence, BrainHQ cognitive training, and medical monitoring and health education. The Health Education and Coaching group will receive occasional health education sessions. The primary outcome measure is the change in a global composite cognitive score. Extra value will emanate from blood biomarker analysis, positron emission tomography (PET) imaging, brain magnetic resonance imaging (MRI), and retinal biomarker tests. The finalized AU-ARROW protocol is expected to allow development of an evidence-based innovative treatment plan to reduce cognitive decline and dementia risk, and effective transfer of research outcomes into Australian health policy. Study protocol for a single-blind, randomized controlled trial, the AU-ARROW Study.The AU-ARROW Study is a member of the World-Wide FINGERS (WW-FINGERS) initiative.AU-ARROW's primary outcome measure is change in a global composite cognitive score.Extra significance from amyloid PET imaging, brain MRI, and retinal biomarker tests.Leading to development of an innovative treatment plan to reduce cognitive decline.

Smart city planning focused on the US cities in need of policing innovations and public health safety technologies and strategies

The issue of firearm-related injuries, deaths and crime in the United States is of particular relevance. Every year, about 32,000 lives are lost as a result of firearm-related incidents, including self-inflicted injuries. Other 74,000 people suffer non-fatal gunshot wounds. Addressing this multi-faceted problem is possible through a comprehensive and integrated approach that encompasses public health initiatives, law enforcement efforts, and security measures. In the context of solving this problem, the concepts of “community-oriented policing”, “problem-oriented policing”, “broken windows theory”, “smart city social sustainability initiative” (multi-system improvement and meeting the needs of marginalised residents), “feedback methodology”, etc. are thoroughly considered. The author proposes the strategic deployment of mini-police stations in areas with a high crime rate as proper centres of police visibility and a deterrent to criminals. To realise this task, it is necessary to integrate the latest approaches to Smart Urban Development with innovative urban planning technologies that would increase the influence of law enforcement agencies in the process of protecting public health and safety in cities. In particular, the article proposes the following for implementation: identifying crime hotspots by means of advanced geographic information systems, applying machine learning algorithms to predict future crime trends, using advanced real-time surveillance technologies and firearms detection systems, applying geospatial analysis to optimise patrol routes, dynamically adjusting patrol routes depending on real-time data analytics, deploying mobile command centres. As a result, law enforcement agencies can effectively communicate to potential criminals that their actions will not go unnoticed. They may achieve significant success in improving the overall quality of life of residents in such areas. Also, they will create safer communities, and reduce the number of incidents involving the use of firearms.

The Sustainable Micro-Landscape Urban Building Gardens: Case of Factory 4376, Sama Beirut and Tamlis–Tarik Jdideh

This paper tackles the sustainable micro-landscape urban building gardens, and aims to explore innovative planning and green design approaches, thus finding solutions to the depletion of green spaces in Beirut. This study is conducted on three buildings located within Beirut city, each having a different architectural typology. The first is Factory 4376 located in Sin EL Fil, the second is Sama Beirut located in Achrafieh, and the third Al Tamlis – Tarik Jdideh. Each building is either residential, commercial or both; and each is surrounded by different socio-economic neighborhoods. This study adopts a comparative methodology; it relies on detailed analysis of maps and aerial photographs, obtained from one of the local municipalities, as well as interviews with residents in the investigated areas, surveys, pictures, and similar case studies. Three solutions were suggested for the locations stated above:  First solution: the implantation of a metallic structure on an old building that forms an extension to preexisting balconies.  Second solution: the integration of the green sliding balconies on buildings with glass façades.  Third solution: the integration of prefabricated modules to buildings with no balconies. The paper concludes that green technologies, if integrated in the context of sustainability, can make a great difference, even if space is limited; hence overcoming the risk of losing greenery.

Development of Nurse-led Self-Management Education Instruments for Type 2 Diabetes Mellitus Patients

Purpose: The purpose of this study is to develop and outline the Nurse-Led Diabetes Mellitus Self-Management Education (Nu-DiMENTION) program, aimed at improving knowledge and behavior change among type 2 diabetes mellitus (DM) patients. Given the challenges faced by these patients in managing their disease effectively, including risks of complications such as diabetic foot ulcers, retinopathy, and ketoacidosis, there is a pressing need for tailored self-management education programs. The study seeks to address this need by creating a web-based nurse-led educational intervention that has demonstrated efficacy in increasing patient knowledge and promoting positive behavior change. Methods: The research adopts a research and development (R&D) approach to outline the development process of Nu-DiMENTION. Drawing upon theory, existing research evidence, international guidelines, and qualitative data from target users, the study identifies determinants of self-management and defines the content to be included in the program. The development process involves multiple stages, including evaluating existing educational instruments, conducting focus groups with relevant stakeholders (e.g., healthcare professionals and type 2 DM patients), and assessing item validity through expert evaluation. Results and discussion: The initial evaluation of 19 diabetes mellitus educational instruments revealed inadequacies in terms of goals, targets, content, methods, media, time, and evaluation. Subsequent focus groups involving healthcare professionals and type 2 DM patients provided valuable insights into strategic issues and innovation plans for the Nu-DiMENTION program. The assessment of item validity conducted by diabetes mellitus education experts confirmed the validity and reliability of the developed instruments, with a Cronbach's alpha value of 0.834 indicating good internal consistency. Implications of the research: The development of Nu-DiMENTION holds significant implications for improving the self-management capabilities of type 2 DM patients and reducing the risk of diabetes-related complications. By providing accessible, web-based nurse-led education, the program has the potential to empower patients with the knowledge and skills necessary to effectively manage their condition. Moreover, the rigorous development process, including expert validation, ensures the quality and reliability of the program, enhancing its suitability for implementation in clinical settings. Originality/value: This study contributes to the literature by outlining the development process and subject matter of Nu-DiMENTION, a novel web-based nurse-led self-management education program for type 2 DM patients. By synthesizing theory, existing evidence, and stakeholder insights, the program offers a comprehensive approach to addressing the educational needs of this patient population. Furthermore, the emphasis on item validity assessment ensures the program's reliability and effectiveness, adding to its value as a practical intervention for improving diabetes self-management. Overall, Nu-DiMENTION represents an innovative and valuable contribution to diabetes care and patient education.

Research and Practice on the Reform of Practical Training for Field Engineers in Mold Design and Manufacturing Majors in Higher Vocational Education

This article aims to study and explore the reform issues of practical training for on-site engineers majoring in mold design and manufacturing in vocational colleges. By analyzing the relevant background and needs, an innovative practical training plan is proposed, and the effectiveness of this plan in practical application is explored. This practical training program has positive significance in improving students practical operation ability, meeting enterprise needs, and promoting industry university cooperation. This study provides certain reference value for the practical training of on-site engineers in the field of mold design and manufacturing in vocational colleges.

Opportunities and Challenges Associated with the Uptake of Residential Clean Fuel Usage.

Almost 3 billion people worldwide use solid fuel for cooking and heating. This review examines (i) household energy practices and infrastructures and their influence on fuel usage in different contexts; (ii) barriers in adoption of household clean energy technologies and uses in diverse settings and population groups and (iii) potential air pollution exposure reduction in homes through using processed fuel. Population health burden from solid fuel combustion-derived particulate air pollution has been estimated in several low- and middle-income countries. However, such studies have not been carried out in high income countries (e.g., UK). Irrespective of the region, fuel prices are the most dominant factor influencing the choice of fuel. Laboratory studies suggest processed fuel - pellets and briquettes - reduce particulate matter emissions by 70-80% and can be a promising alternative. Adoption of clean fuels for domestic energy needs facilitates progress towards five of the UN Sustainable Development Goals (SDGs). There is evidence that a variety of factors, including cost savings, encourage and hinder such uptake. These factors include price fluctuations, expenses, and the usage of clean fuels. Due to their distinct development scenarios, more expansive policy frameworks, and political economies of energy, these determinants are localized in character and differ significantly amongst economies. Therefore, in order to create innovative plans for the adoption of clean fuel use, strategies centred on local settings must be developed while keeping broad socio-technical and socio-economic issues in mind. Solid fuel processing - pelletization and briquetting - have the potential to reach Liquefied Petroleum Gas (LPG)-like emissions, and could be a potential strategy to mitigate exposure to household air pollution.

Transforming Integrated Care Through Co-production: A Systematic Review Using Meta-ethnography.

There is a requirement for health and care systems and services to work on an equitable basis with people who use and provide integrated care. In response, co-production has become essential in the design and transformation of services. Globally, an array of approaches have been implemented to achieve this. This unique review explores multi-context and multi-method examples of co-production in integrated care using an exceptional combination of methods. To review and synthesise evidence that examines how co-production with service users, unpaid carers and members of staff can affect the design and transformation of integrated care services. Systematic review using meta-ethnography with input from a patient and public involvement (PPI) co-production advisory group. Meta-ethnography can generate theories by interpreting patterns between studies set in different contexts. Nine academic and four grey literature databases were searched for publications between 2012-2022. Data were extracted, analysed, translated and interpreted using the seven phases of meta-ethnography and PPI. A total of 2,097 studies were identified. 10 met the inclusion criteria. Studies demonstrated a variety of integrated care provisions for diverse populations. Co-production was most successful through person-centred design, innovative planning, and collaboration. Key impacts on service transformation were structural changes, accessibility, and acceptability of service delivery. The methods applied organically drew out new interpretations, namely a novel cyclic framework for application within integrated care. Effective co-production requires a process with a well-defined focus. Implementing co-delivery, with peer support, facilitates service user involvement to be embedded at a higher level on the 'ladder of co-production'. An additional step on the ladder is proposed; a cyclic co-delivery framework. This innovative and operational development has potential to enable better-sustained person-centred integrated care services.

Supply Chain Leadership in a Developing Economy for Sustainable Innovation and Competitiveness: The Case of Johannesburg Stock Exchange-Listed Companies

The supply chain leadership (SCL) concept has gradually gained traction among various stakeholders such as legislators and specialists because of its dependable practices for companies in sustainable innovation and competitiveness across developing economies. The effective implementation of SCL strategic actions in a company can initiate sustainable innovation and competitiveness at each level of the company. Statistical data collection was performed for 46 of the top 100 Johannesburg Stock Exchange (JSE)-listed companies through an online Survey Monkey questionnaire. The primary purpose of this study was to identify the SCL strategic actions that are undertaken by companies in a developing economy regarding sustainable innovation and competitiveness. The findings significantly reveal empirical insights for companies to include and leverage in SCL strategic actions that influence sustainable innovation and competitiveness in an emerging economy. The findings show that firms operating within developing economies must adopt, and recognize the importance of, sustainable innovation and competitiveness in their practices for the betterment of the goods and services provided to the market. A major contribution is offered to the literature for the assistance and planning of sustainable innovation and competitive practice in developing economies in a global environment. This study further offers a robust recognition of, and information about, the characteristics and strategies that commonly lead to SCL being prioritised by the top 100 JSE-listed companies.

Efficient Path Planning Based on Dynamic Bridging Rapidly Exploring Random Tree

In the domain of mobile robotic navigation, the real-time generation of low-cost, executable reference trajectories is crucial. This paper propounds an innovative path planning strategy, termed Dynamic Bridging Rapidly Exploring Random Tree (DBR-RRT), which endeavors to enable safe and expedited path navigation. Initially, a heuristic discrimination method is engaged in the path search phase, whereby the issue of sluggish search velocity is tackled by evaluating whether sampled points reside at “bridging locations” within a free space, and by assessing the spatial–geometric relationships between proximate obstacles and auxiliary points. Subsequently, by leveraging extended speed, additional sampling points are generated in the vicinity of existing points to augment the search’s efficacy. Ultimately, the path is optimized and pruned by synthesizing the local curvature of the sampling points and the proximity to obstacles, assigning varied priorities to nodes, thus ensuring that the path’s quality and smoothness is upheld.

Three-dimensional printed models can reduce costs and surgical time for complex proximal humeral fractures: preoperative planning, patient satisfaction, and improved resident skills

BackgroundProximal humeral fractures (PHFs) are still controversial with regards to treatment and are difficult to classify. The study’s objective is to show that preoperative planning performed while handling a three-dimensional (3D) printed anatomical model of the fracture can ensure a better understanding of trauma for both surgeons and patients.Materials and methodsTwenty patients (group A, cases) with complex PHF were evaluated preoperatively by reproducing life-size, full-touch 3D anatomical models. Intraoperative blood loss, radiographic controls, duration of surgery, and clinical outcomes of patients in group A were compared with 20 patients (group B, controls) who underwent standard preoperative evaluation. Additionally, senior surgeons and residents, as well as group A patients, answered a questionnaire to evaluate innovative preoperative planning and patient compliance. Cost analysis was evaluated.ResultsIntraoperative radiography controls and length of operation were significantly shorter in group A. There were no differences in clinical outcomes or blood loss. Patients claim a better understanding of the trauma suffered and the proposed treatment. Surgeons assert that the planning of the definitive operation with 3D models has had a good impact. The development of this tool has been well received by the residents. The surgery was reduced in length by 15%, resulting in savings of about EUR 400 for each intervention.ConclusionsFewer intraoperative radiography checks, shorter surgeries, and better patient compliance reduce radiation exposure for patients and healthcare staff, enhance surgical outcomes while reducing expenses, and lower the risk of medicolegal claims.Level of evidenceLevel I, prospective randomized case–control study.

Comparison of two 3D scanning software to identify facial features: a prospective instrument to predict difficult airway

BackgroundClinical airway assessment has limited predictive ability to anticipate difficult airway. Three-dimensional (3D) technologies have emerged in medicine as valuable tools in different settings including innovation and surgical planning. Three-dimensional facial scanning could add value to clinical measurements and two-dimensional models to assess the airway. However, commonly used high-fidelity scans are expensive. This study aims to compare the accuracy of the measurements made by the Scandy Pro app as a cost-effective alternative to high-fidelity scans made by the Artec Space Spider. We also aim to evaluate the interobserver variability for the measurements performed with Scandy Pro.Materials and methodsWe conducted a cross-sectional, comparison study on 10 healthy volunteers. Four observers measured 720 distances and 400 using both Scandy Pro and Artec Space Spider facial scans. Wilcoxon test was used for group–group comparison.ResultsComparison of both instruments showed no difference in angle or distance measurements. The percentage error (measurement difference between the two devices) exhibited by one of the observers was significantly different compared with the other three observers; however, the magnitude of this individual deviation did not affect the overall percentage error. The overall error for Scandy Pro was 5.5% (3.9% and 6.7% for angles and distances, respectively).ConclusionThree-dimensional facial scanning with Scandy Pro is an accurate tool that can be a cost-effective alternative to high-fidelity scans produced by the Artec Space Spider.

A Novel Framework for Thermoradiotherapy Treatment Planning

Thermoradiotherapy combines radiation therapy with hyperthermia to increase therapeutic effectiveness. Currently, both modalities are optimized separately and in state-of-the-art research the enhanced therapeutic effect is evaluated using equivalent radiation dose in 2-Gy fractions (EQD2). This study proposes a novel thermoradiotherapy treatment planning framework with voxelwise EQD2 radiation therapy optimizing including thermal radiosensitization and direct thermal cytotoxicity. To demonstrate proof-of-concept of the planning framework, 3 strategies consisting of 20 radiation therapy fractions were planned for 4 prostate cancer cases with substantially different temperature distributions: (1) Conventional radiation therapy plan of 60 Gy combined with 4 hyperthermia sessions (RT60 + HT), (2) standalone uniform dose escalation to 68 Gy without hyperthermia (RT68), and (3) uniform target EQD2 that maximizes the tumor control probability (TCP) accounting for voxelwise thermal effects of 4 hyperthermia sessions without increasing normal tissue doses (RTHT + HT). Assessment included dose, EQD2, TCP, and rectal normal tissue complication probability (NTCP), alongside robustness analyses for TCP and NTCP against parameter uncertainties. The estimated TCP of around 76% for RT60 without hyperthermia was increased to an average of 85.9% (range, 81.3%-90.5%) for RT60 + HT, 92.5% (92.4%-92.5%) for RT68, and 94.4% (91.7%-96.6%) for RTHT + HT. The corresponding averaged rectal NTCPs were 8.7% (7.9%-10.0%), 14.9% (13.8%-17.1%), and 8.4% (7.5%-9.7%), respectively. RT68 and RTHT + HT exhibited slightly enhanced TCP robustness against parameter uncertainties compared with RT60 + HT, and RT68 presented higher and less robust rectal NTCP values compared with the other planning strategies. This study introduces an innovative thermoradiotherapy planning approach, integrating thermal effects into EQD2-based radiation therapy optimization. Results demonstrate an ability to achieve enhanced and uniform target EQD2 and TCP across various temperature distributions without elevating normal tissue EQD2 or NTCP compared with conventional methods. Although promising for improving clinical outcomes, realizable enhancements depend on accurate tumor- and tissue-specific data and precise quantification of hyperthermic effects, which are seamlessly integrable in the planning framework as they emerge.

Plan for innovation and educational technologies: a bibliographic analysis of the connected education innovation program

The use of digital technologies in education is clearly expanding, a fact observed in the government's concern to create public policies in this area. This present have aims to report on the Connected Innovation Program. As a methodology, a bibliographical review was chosen, which is a way to collect documentary data about the program under study. The bibliographic survey was carried out in the Ministry of Education database and on the program's website. Considering the emerging context of society marked by the passage of a pandemic, the need to implement digital resources as well as empower teachers to fully use the tools, the public authorities are concerned about bringing possibilities for advancement in education supported by technological development. Today's traditional ways of teaching no longer have meaning for a generation plugged into social networks, specialists in entertainment games, followers of influential personalities on the internet. The Connected Innovation Program arises from this reality and seeks to support teachers and students in the saga of innovative teaching and meaningful learning.

Flagellar pH homeostasis mediated by Na+/H+ exchangers regulates human sperm functions through coupling with CatSper and KSper activation.

Whether and how do Na+/H+ exchangers (NHEs) regulate the physiological functions of human sperm? NHE-mediated flagellar intracellular pH (pHi) homeostasis facilitates the activation of the pH-sensitive, sperm-specific Ca2+ channel (CatSper) and the sperm-specific K+ channel (KSper), which subsequently modulate sperm motility, hyperactivation, flagellar tyrosine phosphorylation, and the progesterone (P4)-induced acrosome reaction. Sperm pHi alkalization is an essential prerequisite for the acquisition of sperm-fertilizing capacity. Different sperm functions are strictly controlled by particular pHi regulatory mechanisms. NHEs are suggested to modulate sperm H+ efflux. This was a laboratory study that used samples from >50 sperm donors over a period of 1 year. To evaluate NHE action on human sperm function, 5-(N,N-dimethyl)-amiloride (DMA), a highly selective inhibitor of NHEs, was utilized. All experiments were repeated at least five times using different individual sperm samples or cells. By utilizing the pH fluorescent indicator pHrodo Red-AM, we detected alterations in single-cell pHi value in human sperm. The currents of CatSper and KSper in human sperm were recorded by the whole-cell patch-clamp technique. Changes in population and single-cell Ca2+ concentrations ([Ca2+]i) of human sperm loaded with Fluo 4-AM were measured. Membrane potential (Vm) and population pHi were quantitatively examined by a multimode plate reader after sperm were loaded with 3,3'-dipropylthiadicarbocyanine iodide and 2',7'-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein, acetoxymethyl ester, respectively. Sperm motility parameters were assessed by a computer-assisted semen analysis system. Tyrosine phosphorylation was determined by immunofluorescence, and sperm acrosome reaction was evaluated by Pisum sativum agglutinin-FITC staining. DMA-induced NHEs inhibition severely acidified the human sperm flagellar pHi from 7.20 ± 0.04 to 6.38 ± 0.12 (mean ± SEM), while the effect of DMA on acrosomal pHi was less obvious (from 5.90 ± 0.13 to 5.57 ± 0.12, mean ± SEM). The whole-cell patch-clamp recordings revealed that NHE inhibition remarkably suppressed alkalization-induced activation of CatSper and KSper. As a consequence, impairment of [Ca2+]i homeostasis and Vm maintenance were detected in the presence of DMA. During the capacitation process, pre-treatment with DMA for 2 h potently decreased sperm pHi, which in turn decreased sperm motility and kinetic parameters. Sperm capacitation-associated functions, including hyperactivation, tyrosine phosphorylation, and P4-induced acrosome reaction, were also compromised by NHE inhibition. N/A. This was an in vitro study. Caution should be taken when extrapolating these results to in vivo applications. This study revealed that NHEs are important physiological regulators for human CatSper and KSper, which are indispensable for human sperm fertility, suggesting that malfunction of NHEs could be an underlying mechanism for the pathogenesis of male infertility. This work was supported by the National Natural Science Foundation of China (32271167 and 81871202 to X.Z.), Jiangsu Innovation and Entrepreneurship Talent Plan (JSSCRC20211543 to X.Z.), the Social Development Project of Jiangsu Province (No. BE2022765 to X.Z.), the Society and livelihood Project of Nantong City (No. MS22022087 to X.Z.), and the Natural Science Foundation of Jiangsu Province (BK20220608 to H.K.). The authors have no competing interests to declare.

Both protein and non-protein components in extracellular vesicles of human seminal plasma improve human sperm function via CatSper-mediated calcium signaling.

What is the significance and mechanism of human seminal plasma extracellular vesicles (EVs) in regulating human sperm functions? EV increases the intracellular Ca2+ concentrations [Ca2+]i via extracellular Ca2+ influx by activating CatSper channels, and subsequently modulate human sperm motility, especially hyperactivated motility, which is attributed to both protein and non-protein components in EV. EVs are functional regulators of human sperm function, and EV cargoes from normal and asthenozoospermic seminal plasma are different. Pre-fusion of EV with sperm in the acidic and non-physiological sucrose buffer solution could elevate [Ca2+]i in human sperm. CatSper, a principle Ca2+ channel in human sperm, is responsible for the [Ca2+]i regulation when sperm respond to diverse extracellular stimuli. However, the role of CatSper in EV-evoked calcium signaling and its potential physiological significance remain unclear. EV isolated from the seminal plasma of normal and asthenozoospermic semen were utilized to investigate the mechanism by which EV regulates calcium signal in human sperm, including the involvement of CatSper and the responsible cargoes in EV. In addition, the clinical application potential of EV and EV protein-derived peptides were also evaluated. This is a laboratory study that went on for more than 5 years and involved more than 200 separate experiments. Semen donors were recruited in accordance with the Institutional Ethics Committee on human subjects of the Affiliated Hospital of Nantong University and Jiangxi Maternal and Child Health Hospital. The Flow NanoAnalyzer, western blotting, and transmission electron microscope were used to systematically characterize seminal plasma EV. Sperm [Ca2+]i responses were examined by fluorimetric measurement. The whole-cell patch-clamp technique was performed to record CatSper currents. Sperm motility parameters were assessed by computer-assisted sperm analysis. Sperm hyperactivation was also evaluated by examining their penetration ability in viscous methylcellulose media. Protein and non-protein components in EV were analyzed by liquid chromatography-mass spectrum. The levels of prostaglandins, reactive oxygen species, malonaldehyde, and DNA integrity were detected by commercial kits. EV increased [Ca2+]i via an extracellular Ca2+ influx, which could be suppressed by a CatSper inhibitor. Also, EV potentiated CatSper currents in human sperm. Furthermore, the EV-in [Ca2+]i increase and CatSper currents were absent in a CatSper-deficient sperm, confirming the crucial role of CatSper in EV induced Ca2+ signaling in human sperm. Both proteins and non-protein components of EV contributed to the increase of [Ca2+]i, which were important for the effects of EV on human sperm. Consequently, EV and its cargos promoted sperm hyperactivated motility. In addition, seminal plasma EV protein-derived peptides, such as NAT1-derived peptide (N-P) and THBS-1-derived peptide (T-P), could activate the sperm calcium signal and enhance sperm function. Interestingly, EV derived from asthenozoospermic semen caused a lower increase of [Ca2+]i than that isolated from normal seminal plasma (N-EV), and N-EV significantly improved sperm motility and function in both asthenozoospermic samples and frozen-thawed sperm. N/A. This was an in vitro study and caution must be taken when extrapolating the physiological relevance to in vivo regulation of sperm. Our findings demonstrate that the CatSper-mediated-Ca2+ signaling is involved in EV-modulated sperm function under near physiological conditions, and EV and their derivates are a novel CatSper and sperm function regulators with potential for clinical application. They may be developed to improve sperm motility resulting from low [Ca2+]i response and/or freezing and thawing. This research was supported by the National Natural Science Foundation of China (32271167), the Social Development Project of Jiangsu Province (BE2022765), the Nantong Social and People's Livelihood Science and Technology Plan (MS22022087), the Basic Science Research Program of Nantong (JC22022086), and the Jiangsu Innovation and Entrepreneurship Talent Plan (JSSCRC2021543). The authors declare no conflict of interest.

Enhancing Public Space Accessibility and Inclusivity in Residential Neighbourhoods: A Methodological Framework and Pilot Application

The paper adds to the debate on urban transformation, which plays a significant role in improving quality of urban life and liveability of public spaces, as also stated in UN Sustainable Development Goal No. 11. The research aims to test a methodology for identifying an abacus of urban regeneration interventions to enhance attractive and critical nodes through accessibility and inclusivity. The quality of the system of connections between polarities, the promotion of active mobility, zero soil consumption and the renaturalisation of urban spaces are fundamental criteria to define urban regeneration solutions. The proposed approach develops on two levels: a GIS-based spatial analysis of urban data and a participatory process. The innovative planning process is tested on the San Leonardo neighbourhood in the Municipality of Parma, Italy, which allows us to verify the potentials and limitations of the procedure, identifying future work perspectives. Moreover, the application allows us to check the replicability in other urban contexts, possibly envisaging other applications to more case studies. Our results consist of the identification of the vocations and the critical aspects of nodes and axes to regenerate urban space in medium-sized and large cities’ suburbs.

Fundamental principles of planning innovative activities at the enterprise

This article defines and establishes the essence of the concept of "innovation activity" and also identifies the stages of the innovation process, which are four in total. The types of planning and peculiarities of their application to innovation activities are considered. It is determined that the types of plans differ in terms of objectives, subject matter, level, content and planning period. According to the target orientation, there are strategic, current and operational planning of innovations. Strategic planning as an element of strategic management is to define the mission of the organization at each stage of its life cycle, to form a system of goals and a strategy for behavior in the innovation markets. The author summarizes that the main condition for the formation of the innovation market is the volume of investments in both scientific and scientific and technical activities. Given the 3-5-year duration of the innovation process, long-term and medium-term investments play a key role, providing financing for innovations throughout their entire life cycle It is determined that innovation activity is aimed at the practical use of scientific, scientific and technical results and intellectual potential in order to obtain new or radically improved products, production technology and satisfaction of effective consumer demand for high-quality goods and services, and improvement of social services.

Technological innovations in mitigating winter health challenges in New York City, USA

This review paper examines the role of technological innovations in mitigating winter health challenges in New York City (NYC). The primary objective is to analyze how emerging technologies are integrated into public health strategies to address the unique health risks posed by the winter season in one of the world's most populous urban environments. The methodology involves a comprehensive literature review focusing on recent advancements in technology within the context of public health and urban planning. Key sources include peer-reviewed articles, case studies, and reports on smart city initiatives, climate change impacts, and the implementation of health technologies in NYC. Key findings reveal that the integration of smart city technologies, such as advanced data analytics, IoT devices, and AI-driven solutions, has significantly improved healthcare delivery and emergency response during winter. However, challenges in implementation, particularly in under-resourced settings, highlight the need for tailored, context-driven technological solutions. The impact of climate change on winter health dynamics underscores the importance of innovative urban planning and public health strategies. The potential of emerging technologies, including nanotechnology for air purification and spatial analysis of health data, offers promising avenues for improving public health in urban settings during winter. The review suggests that technological innovations play a crucial role in enhancing the capacity of NYC to manage winter health risks. It recommends increased investment in smart city technologies, support for under-resourced healthcare settings, and the development of climate change adaptation strategies. The evolution of healthcare in winter contexts is increasingly being shaped by these technological advancements, paving the way for a more resilient and sustainable approach to public health in urban environments.

Discovering ME: An innovative planning tool for students with significant disabilities

BACKGROUND: The Individuals with Disabilities Act (IDEA) requires transition plans for students with disabilities to be based on high-quality, age-appropriate transition assessments. However, educators struggle to garner reliable assessment results for students with significant disabilities, because so few assessments are designed or validated for students with these barriers. OBJECTIVE: The purpose of this practice brief is to share details on the process, called Discovering ME, which provides an effective transition assessment and planning tool that is critical to increasing students’ employment outcomes, especially for those who face the most significant barriers to employment. METHODS: Sixty-one students across rural, urban, and suburban school districts participated in Discovering ME. Data were collected across five years, including demographic information and examples of students’ top career cluster areas for future employment. In addition, a statewide survey was conducted with educators participating in Discovering ME on the effectiveness of this early career planning process. RESULTS: The Discovering ME process provides career-related opportunities for students with significant barriers in the home, school, and community in a variety of career clusters based on their expressed interests. Educators report that the focus of this process on students and their interests helped to create positive experiences for them by creating opportunities for success. CONCLUSION: The Discovering ME process provides students with disabilities with authentic, coordinated career awareness and development activities and the building of self-determination, work readiness, and community integration skills.