The rapid development of science and technology has created new condition for the teaching methods of higher English education, which has greatly enriched the English teaching resources and has promoted the renovation of English teaching methods. As a second to none common language in the world, English has always been playing an important role in international communication, and has been valued highly in the educational circles. Compared with previous English teaching, modern college English teaching has the characteristics of convenient and efficient and is easily to be accepted by students. Considering the diversity and comprehensiveness of college English, it is necessary to divide it into such secondary subjects as vocabulary, grammar and reading, in order to help students to develop learning interest in English in daily life, and to achieve the purpose of reducing students’ burden. This paper discusses the current application situation and problems of multimedia teaching in college English vocabulary teaching and the countermeasures with emphasis, hoping to provide beneficial views for the research and practice of innovative classroom teaching methods.