As a critical component of wearable electronic devices, flexible strain sensors have made significant contributions in the fields of smart healthcare, motion monitoring and communication, garnering escalating research interests. However, the pursuit of ideal materials synergizing high sensitivity with facile and cost-effective manufacturing methodologies remains a persistent challenge, significantly hindering the full realization of the potential of flexible strain sensors. Herein, an innovative hybrid conductive network architecture constituted by multi-walled carbon nanotubes and laser-induced graphene (MWCNTs/LIG) has been explored via a facile, cost-effective, controllable, and environmentally friendly laser direct writing (LDW) technique. Subsequently, the resultant MWCNTs/LIG composite with a cross-linked microstructure has been harnessed for the fabrication of a high-performance strain sensor. Notably, the proposed sensor exhibits remarkable sensitivity with a gauge factor (GF) reaching 192, rapid response and recovery times of 27/20 ms, and favorable durability exceeding 2300 cycles. Furthermore, the developed sensor demonstrates the capability to accurately capture full-range motions in real-time, as well as the ability to transmit information as a portable communication device. This promising discovery offers a new insight for the flourishing development of high-performance flexible strain sensors in the realm of wearable sensing.