In-line Filter Research Articles

In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients

BackgroundThe potential harmful effects of particle-contaminated infusions for critically ill adult patients are yet unclear. So far, only significant improved outcome in critically ill children and new-borns was demonstrated when using in-line filters, but for adult patients, evidence is still missing.MethodsThis single-centre, retrospective controlled cohort study assessed the effect of in-line filtration of intravenous fluids with finer 0.2 or 1.2 μm vs 5.0 μm filters in critically ill adult patients. From a total of n = 3215 adult patients, n = 3012 patients were selected by propensity score matching (adjusting for sex, age, and surgery group) and assigned to either a fine filter cohort (with 0.2/1.2 μm filters, n = 1506, time period from February 2013 to January 2014) or a control filter cohort (with 5.0 μm filters, n = 1506, time period from April 2014 to March 2015). The cohorts were compared regarding the occurrence of severe vasoplegia, organ dysfunctions (lung, kidney, and brain), inflammation, in-hospital complications (myocardial infarction, ischemic stroke, pneumonia, and sepsis), in-hospital mortality, and length of ICU and hospital stay.ResultsComparing fine filter vs control filter cohort, respiratory dysfunction (Horowitz index 206 (119–290) vs 191 (104.75–280); P = 0.04), pneumonia (11.4% vs 14.4%; P = 0.02), sepsis (9.6% vs 12.2%; P = 0.03), interleukin-6 (471.5 (258.8–1062.8) ng/l vs 540.5 (284.5–1147.5) ng/l; P = 0.01), and length of ICU (1.2 (0.6–4.9) vs 1.7 (0.8–6.9) days; P < 0.01) and hospital stay (14.0 (9.2–22.2) vs 14.8 (10.0–26.8) days; P = 0.01) were reduced. Rate of severe vasoplegia (21.0% vs 19.6%; P > 0.20) and acute kidney injury (11.8% vs 13.7%; P = 0.11) was not significantly different between the cohorts.ConclusionsIn-line filtration with finer 0.2 and 1.2 μm filters may be associated with less organ dysfunction and less inflammation in critically ill adult patients.Trial registrationThe study was registered at ClinicalTrials.gov (number: NCT02281604).

Field demonstration of a microwave black powder detection device in gas transmission pipelines

Black Powder (BP) poses a serious threat to the integrity and operation of natural gas transmission networks worldwide. While BP corrective and preventive remedies have been proposed in the past, real-time detection and quantification of BP in natural gas flows using a viable technology is yet to be addressed. Real-time monitoring of BP is imperative not only to ensure on-spec supply of sales gas, but also to facilitate maintenance decisions and assess the efficacy of in-line filters. In this paper, an industrial-grade BP detection device (BPDD) capable of measuring the total suspended solids (TSS) in real-time is demonstrated. The proposed device is based on measurements of microwave signals transmitted through a pipe section as solids traverse in the gas flow using a custom-made transceiver and in-situ probes. The BPDD is extensively tested on sales gas pipelines in field conditions, whereby high sensitivity is verified. Concentration measurements of the BPDD is benchmarked against a TSS analysis conducted as part of isokinetic sampling of the gas flow. The reported measurement error using the BPDD is less than 7%. Hence, the proposed device is deemed a valuable asset to flow assurance in the oil & gas industry.

Transcatheter aspiration of large pacemaker and implantable cardioverter-defibrillator lead vegetations facilitating safe transvenous lead extraction.

Treatment of patients with systemic cardiac implantable electronic device (CIED) infection with large lead vegetations is challenging and associated with relevant morbidity and mortality. To avoid complications from open surgical extraction, a novel approach with percutaneous aspiration of large vegetations prior to transvenous lead extraction was instituted. The results of this treatment concept were retrospectively analysed in this multicentre study. One hundred and one patients [mean age 68.2 ± 13.1 (30-92) years] were treated in four centres for endovascular CIED infection with large lead vegetations. Mean lead vegetation size was 30.7 ± 13.5 mm. Two hundred and forty-seven leads were targeted for extraction (170 pacemaker leads, 77 implantable cardioverter-defibrillator leads). Mean lead implant duration was 81.7 (1-254) months. The transcatheter aspiration system with a specialized long venous drainage cannula and a funnel-shaped tip was based on a veno-venous extracorporeal circuit with an in-line filter. The aspiration of vegetations showed complete procedural success in 94.0% (n = 95), partial success in 5.0% (n = 5). Three major complications (3.0%) were encountered. Complete procedural success (per lead) of the subsequently performed transvenous lead extraction procedure was 99.2% (n = 245). Thirty-day mortality was 3.0% (n = 3). Five patients (5.0%) died in the further course on Days 51, 54, 68, 134, and 182 post-procedure (septic complications: n = 4; heart failure: n = 1). The percutaneous aspiration procedure is highly effective and is associated with a low complication profile. The aspiration of vegetations immediately prior and during the lead extraction procedure may avoid septic embolization into the pulmonary circulation. This may potentially lead to a long-term survival benefit.

Bound States in the Continuum in Fiber Bragg Gratings

Optical fibers typically confine light through total internal reflection or through photonic bandgaps. Here we show that light can be perfectly guided in optical fibers through a different mechanism based on bound states in the continuum (BICs). In fibers with periodic Bragg gratings, we predict bona fide BICs in pure-polarization modes, as well as quasi-BICs in hybrid-polarization modes. These guided modes exist robustly without the need for fine structural tuning, and they persist even with the very small grating index contrasts that are available in conventional fiber Bragg gratings. The suppression of radiation loss arises from the coupling between a weakly-radiating mode and a strongly-radiating one. This finding opens the possibility of guiding light with BICs in optical fibers and their applications in distributed fiber sensors, in-line fiber filters, and high-power fiber lasers.

The Use of 0.2 Micron Filter for All Intravenous Fluids in Sheikh Khalifa Medical City Paediatric Intensive Care Unit Practice Change Project

The Aim of this paper is to determine if the use of inline filter (0.2 Micron filter) is an evidence based practice, wither it has any positive impact on Decreasing CLABSI (Central Line Associated Blood-Stream Infection), Removing Large Particles or Air from line thus at the end prevent phlebitis and air embolism. This paper is benchmarking similar institutions practice, reviewing hospital’s policy requirements in this matter, reviewing literatures related to this practice and providing a clue about the annual coast of the use of this filter in Sheikh Khalifa Medical City –Abu Dhabi PICU.

P3136Percutaneous aspiration procedure as an adjunct to transvenous lead extraction procedures in patients with large lead vegetations

Abstract Background Patients with systemic CIED (Cardiac implantable electronic device) infection with large lead vegetations are a clinical challenge and carry a high operative risk. In three lead extraction centers a treatment strategy with minimal-invasive percutaneous aspiration of vegetations and subsequent transvenous lead extraction was established. The results of this concept were evaluated with regard to safety and efficacy in this retrospective multi-center study. Methods Between June 2015 and December 2018 we performed combined percutaneous aspiration procedures and transvenous lead extractions in 107 patients with 262 targeted leads (179 pacemaker leads, 83 ICD leads) for extraction. Mean lead vegetation size in preoperative echocardiography was 30.6±13.3 mm. Mean lead implant duration were 82.8 (1–254) months. The aspiration system is based on a veno-venous extracorporeal circuit with an in-line filter and a specialized venous drainage cannula. Results Complete procedural success of the percutaneous aspiration procedure was 94.4% (n=101), partial success was achieved in 4.7% (n=5). Three complications (2.8%) related to the aspiration procedure were encountered. In the concomitantly performed transvenous lead extraction procedures complete procedural success per targeted lead was 99.2% (n=260). 30 day mortality was 2.8% (n=3). Conclusion The minimal-invasive percutaneous aspiration procedure proved to be safe and effective. It facilitated the subsequent transvenous lead extraction procedure, avoids septic embolization into the pulmonary circulation and abolished the need for open surgical extraction in this high-risk patient group.

Realization of Multiple Transmission Zeroes for Bandpass Filters With Simple Inline Topology

The realization method of multiple transmission zeroes (TZs) for second-order bandpass filters (BPFs) is presented in this brief. A modified filter topology with mixed couplings is investigated at first. With the cancelation effect of electric and dominant magnetic couplings, two close-to-passband TZs can be easily realized for a second-order inline filter. Furthermore, the dual-function feature of loaded quarter-wavelength ( $\lambda $ /4) resonators is analyzed. Besides of filtering response, $\lambda $ /4 resonators can be used to realize two more TZs in the stopband. At last, multiple open stubs are loaded asymmetrically at feeding lines, each of which can generate one TZ independently. Due to the asymmetric loading, the extra circuit area of bandstop structures is reduced by half. For demonstration, a wideband BPF using $\lambda $ /4 resonators and four asymmetric open stubs is designed, fabricated, and measured. The stopband suppression can be improved to 10.2 GHz without sacrificing in-band properties or enlarging circuit size. Good agreement can be observed between the measured and simulated results of the proposed BPF.

Dual-wavelength fiber Bragg grating laser with independently controllable output polarization

By incorporating an inline filter based on a polarization-diversified loop structure composed of two fiber Bragg gratings (FBGs) with different resonant wavelengths and three quarter-wave plates (QWPs), we propose a dual-wavelength FBG laser that can independently control the output polarization of dual-lasing lines oscillating at two Bragg resonances. At a special combination of the orientation angles of the QWPs, the inline filter can be arranged so that its transmittance depends on input polarization, and it can also select the output polarization states of reflection spectra of two FBGs independently according to its input polarization. For example, their reflection spectra chosen by the inline filter can be linear horizontally polarized at one Bragg wavelength and linear vertically polarized at the other Bragg wavelength, and vice versa. Moreover, linear horizontally or vertically polarized reflection spectra at both Bragg resonances can also be realized. By controlling the QWPs and a cavity polarizer used as an input polarizer of the filter, switching operation among four possible output polarization sets (i.e., two kinds of orthogonal output polarization sets and two kinds of parallel ones at two Bragg resonances) could be implemented in the proposed fiber laser with the measured polarization extinction ratio of each lasing line more than 20.0 dB.

Successful management of catastrophic peripheral vascular hemorrhage using massive autotransfusion and damage control surgery in a dog

To describe a case of massive transfusion using unwashed, non-anticoagulated, nonsterile autologous blood in a dog with catastrophic hemorrhage from a peripheral vessel during orthopedic surgery. A damage control surgical strategy was also employed. A 6-year-old, 48kg neutered male Labrador Retriever experienced massive hemorrhage after transection of a large blood vessel while undergoing femoral head and neck osteotomy. Blood was collected from clean, but not sterile, suction canisters and clots were skimmed off. The blood was then transfused back to the dog using a standard in-line blood filter. Approximately 58% of the dog's blood volume was autotransfused in less than 2 hours, thereby meeting the criteria for massive transfusion. Surgery was aborted after hemostasis was achieved by ligation of the vessel and packing of the surgical site. Two units of fresh frozen plasma were administered postoperatively due to the development of a coagulopathy. Hemoglobinuria developed but resolved within 18 hours. Three days later, completion of the surgical procedure was performed without incident. The dog was discharged 4 days after the initial surgery. Marked swelling of the affected limb developed, but resolved after the sixth day. No other significant complications developed. In this case report, the authors describe the successful management of catastrophic hemorrhage with autotransfusion performed in the absence of sterile collection, cell washing, or anticoagulation. Although not ideal, autotransfusion under these conditions can be lifesaving in situations of massive hemorrhage. This case also highlighted the employment of a damage control surgical strategy.

Development of an automated on-line purification HPLC single cell-ICP-MS approach for fast diatom analysis

The most challenging part in performing a single cell ICP-MS (sc-ICP-MS) approach is the sample preparation, in particular the reduction of the ionic background. This step is, in many cases, time-consuming and required for each sample separately. Furthermore, sc-ICP-MS measurements are mostly carried out “manually”, given the fact that present systems are not allowing for an automated change of samples. Thus, within this work, we developed an approach based on a HPLC system coupled on-line with sc-ICP-MS via a set of switching valves as well as an in-line filter for automated cell washing. This set-up enables the ionic background removal as well as analysis of single cells completely automated without any manual sample pretreatment. Our approach was applied for the analysis of the single celled diatom species Cyclotella meneghiniana, a marine diatom species, on the basis of 24Mg and facilitates testing in 11 min per sample, requiring only around 10,000 cells in a volume of 10 μL and approx. 10 mL of a 5% MeOH/95% deionized water (v/v) mixture. Even at extremely saline culturing media concentrations (up to 1000 mg L−1 magnesium) our on-line approach worked sufficiently allowing for distinction of ionic and particulate fractions. Furthermore, a set of diatom samples was analyzed completely automated without the need for changing samples manually. So, utilizing this approach enables analyzing a high quantity of samples in a short time and therefore in future the investigation of ecotoxicological effects is simplified for example in terms of metal accumulation by taking biovariability into account.

Serial hyphenation of dried spot, reversed phase liquid chromatography, hydrophilic interaction liquid chromatography, and tandem mass spectrometry towards direct chemical profiling of herbal medicine-derived liquid matrices, an application in Cistanche sinensis

Inspired by dried blood spots (DBS), “dried spots of herbal medicines” (DSHM) concept was proposed here. In response to this superior sampling means, a new platform integrating dried spot, serially coupled reversed phase liquid chromatography and hydrophilic interaction liquid chromatography (RPLC-HILIC), and tandem mass spectrometry (MS/MS), was configured for directly, comprehensively chemical profiling of HM-derived liquid matrices. As an important original source of Cistanches Herba (Chinese name: Roucongrong) that is a well-known tonic HM, Cistanche sinensis (Csi) was employed to illustrate and validate the applicability. Dried spots (I.D. 3.0 mm) were prepared by loading 2 μL aliquots of Csi extract onto filter paper. Each dried spot was packed into an in-line filter holder (I.D. 3.0 mm × 4.0 mm) and then inserted behind the auto-sampler of a well-defined instrumentation named RPLC-HILIC–MS/MS. Hybrid ion trap-time of flight MS and hybrid triple quadrupole-linear ion trap MS were deployed in combination for the in-depth MS/MS data acquisition of diverse chemical families, such as phenylethanoid glycosides, lignans, iridoids, amino acids, and so forth. To assist chemical profiling, an in-house chemical library was built by collecting as much prior knowledge as possible. A total of 88 components were detected and tentatively annotated in Csi by matching their multi-stage MS spectra with those of authentic standards and literature data. Collectively, DSHM carried all merits of DBS, and the integrative dried spot-RPLC-HILIC-MS/MS platform was a promising analytical tool for direct chemical analysis and rapid quality evaluation of HMs, in particular those traditional Chinese medicine injections.

Predictive Equations for Butterhead Lettuce (Lactuca Sativa, cv. Flandria) Root Surface Area Grown in Aquaponic Conditions

Aquaponic systems are becoming more prevalent and have led to accurate mass and energy balance models that allow nutrient utilization to be maximized and plant and fish systems to be coupled or complimentary. Such models still do not address the potential of using the plant side as both the primary nitrification system and as a sink for the nitrate being produced from the fish system. However, using the plants as the nitrification system for the fish waste requires a better understanding and quantification of the nitrification capacity of the plant system. A series of experiments were conducted using butterhead lettuce (Lactuca sativa, cv. Flandria) in deep water culture rafts. Plants were grown under two growing conditions and were evaluated based upon harvestable weight. Treatment 1 (H5) consisted of a standard hydroponic nutrient solution maintained at pH 5.8, while treatment 2 (A7) consisted of an aquaponic waste solution maintained at pH 7.0. The aquaponic conditions were created from a fish rearing system using koi (Cyprinus carpio) that was continuously recirculated between the designated plant tubs and the fish tank with an in-line bead filter to capture and mineralize fish solids. The total root surface area was not significantly different between treatments, but the ratio of root surface area to root fresh weight was different, suggesting that aquaponic roots are finer than hydroponic roots. Predictive equations were developed to correlate root surface area to shoot or root fresh weight, which can be used to design the nitrification component for a recirculating aquaculture system (RAS), as part of an integrated aquaponic system.

Compact Folded Bandpass Filter in Empty Substrate Integrated Coaxial Line at $S$ -Band

This letter presents a novel compact folded bandpass filter in empty substrate integrated coaxial line (ESICL) technology. To obtain these compact filters, the inverters are modified to provide a 180° bend when inserted in an ESICL. As a result, the proposed filter has a more compact topology based on parallel resonators. A sixth-order Chebyshev bandpass filter operating at 3 GHz has been designed, manufactured, and measured to experimentally validate this new folded configuration. The length of the novel compact filter has been reduced by 82.2% with respect to an equivalent in-line filter, obtaining very similar results in terms of electrical response.

High Flow-Rate Sample Loading in Large Volume Whole Water Organic Trace Analysis Using Positive Pressure and Finely Ground Sand as a SPE-Column In-Line Filter.

By using an innovative, positive pressure sample loading technique in combination with an in-line filter of finely ground sand the bottleneck of solid phase extraction (SPE) can be reduced. Recently published work by us has shown the proof of concept of the technique. In this work, emphasis is put on the SPE flow rate and method validation for 26 compounds of emerging environmental concern, mainly from the 1st and 2nd EU Watch List, with various physicochemical properties. The mean absolute recoveries in % and relative standard deviations (RSD) in % for the investigated compounds from spiked pure water samples at the three investigated flow rates of 10, 20, and 40 mL/min were 63.2% (3.2%), 66.9% (3.3%), and 69.0% (4.0%), respectively. All three flow rates produced highly repeatable results, and this allowed a flow rate increase of up to 40 mL/min for a 200 mg, 6 mL, reversed phase SPE cartridge without compromising the recoveries. This figure is more than four times the maximum flow rate recommended by manufacturers. It was indicated that some compounds, especially pronounced for the investigated macrolide molecules, might suffer when long contact times with the sample glass bottle occurs. A reduced contact time somewhat decreases this complication. A very good repeatability also held true for experiments on both spiked matrix-rich pond water (high and low concentrations) and recipient waters (river and wastewater) applying 40 mL/min. This work has shown that, for a large number of compounds of widely differing physicochemical properties, there is a generous flow rate window from 10 to 40 mL/min where sample loading can be conducted. A sample volume of 0.5 L, which at the recommended maximum flow rate speed of 10 mL/min, would previously take 50 min, can now be processed in 12 min using a flow rate of 40 mL/min. This saves 38 min per processed sample. This low-cost technology allows the sample to be transferred to the SPE-column, closer to the sample location and by the person taking the sample. This further means that only the sample cartridge would need to be sent to the laboratory, instead of the whole water sample, like today’s procedure.

Effect of leukoreduction and pathogen reduction on the hemostatic function of whole blood.

There is renewed interest in the use of whole blood (WB) for resuscitation of patients in hemorrhagic shock. Leukoreduction with platelet-sparing filters and pathogen reduction may be used to improve the safety profile of WB, yet the effects of leukoreduction and pathogen reduction on WB hemostatic function are not well characterized. Blood from 32 healthy group O donors was divided into treatment groups (n = 8 for each group): untreated, pathogen reduced (PR+ ), leukoreduced using an in-line filter (LR+ ), or PR+ LR+ . Units were stored without agitation for 21 days between 1° and 6°C, with sampling on days 0 (pre- and post-treatments), 1, 3, 5, 10, 15, and 21 for hemostatic function as assessed by thromboelastometry, thrombin generation, platelet activation factors, and platelet impedance aggregometry. From day 3 (D3) to D15 of storage, platelet count was reduced in PR+ /LR+ units compared to PR- /LR- units. From D10 to D21 of storage, maximum clot firmness (MCF) was reduced in PR+ /LR+ units compared to PR- /LR- units. From D3 to D21 of storage, platelet aggregation was reduced in PR+ /LR+ units compared to PR- /LR- units. Total thrombin generation was similar in all groups from D0 to D21. The combination of LR with a platelet-sparing filter and PR significantly reduces hemostatic function compared to either treatment alone or untreated WB. The clinical consequences of LR and PR of WB in patients with severe bleeding should be examined in trials before both are used in combination in patients.

Synthesis and Design of Lumped-Element Filters in GaAs Technology Based on Frequency- Dependent Coupling Matrices

A novel synthesis method for lumped-element bandpass filters is proposed on the basis of frequency-dependent coupling matrices, which can preserve the moderate bandwidth response matching with coupling matrix prototype better. The available element values of resonators and inverters with the acceptable quality factor are determined by adjusting normalized slope parameters or reference susceptance parameters. To validate the design approach, two third-order inline filters with the fractional bandwidth of 20% at a center frequency of 3 GHz are designed and fabricated in the GaAs HBT technology. Good agreement is obtained between the simulated and measured results. The measured shape factors K20dB of the two filters with and without external couplings are 1.8 and 1.85, respectively. The filter followed by a one-stage amplifier also demonstrates the high frequency selectivity.

Enhancing the efficiency of disc membrane chromatography modules by using a flow directing layer

Disc membrane chromatography modules are widely used for laboratory-scale protein separations. These have high radial to axial aspect ratios, with the inlet and the outlet being located at the centre. This results in a huge variability in flow path lengths. Also, the radial velocity in the feed side header decreases very significantly in an outward direction, while that in the permeate side header increases in an inward direction. Therefore, the flow paths closer to the axis of the membrane disc have higher average velocity compared to those closer to the periphery. Consequently, the solute residence time distribution within the disc membrane chromatography module is very large, which results in broad flow-through and eluted peaks and early breakthrough of bound solutes. In this paper, we discuss a simple but effective solution to this problem which involves the incorporation of a flow directing layer (FDL) within the membrane module. The FDL could be placed either in the front or at the rear of the membrane disc. The presence of FDL results in equalization of path lengths within the module, leading to narrowing of residence time distribution, and thereby improvement in separation efficiency. Modules housing strong cation exchange membrane discs having two different bed volumes of 0.4 mL (40 mm diameter) and 4.7 mL (60 mm diameter) were designed and fabricated in-house. The impact of using FDL on both the front side (F-FDL) and the rear side (R-FDL) was investigated. The separation efficiency of the membrane modules was assessed using salt tracer experiments, breakthrough protein binding, and ternary protein separation carried out in the bind-and-elute mode. The results confirmed that the use of the FDL significantly enhanced the separation efficiency. In addition to membrane chromatography, this approach of using an FDL could be extended to other membrane disc based modules such as in-line and syringe filters and membrane reactors.

Polarization-Controlled Switching of Dual-Wavelength Lines with Orthogonal Polarization in Erbium-Doped Fiber Ring Laser.

By incorporating an inline switching filter, which is comprised of a polarization-diversified loop (PDL), two fiber Bragg gratings (FBGs) with different resonances, and three quarter-wave plates (QWPs), we propose a dual-wavelength-switchable erbium-doped fiber (EDF) ring laser that can select and switch between two lasing lines with orthogonal polarization. The proposed laser is composed of EDF, a 980 nm laser diode, a wavelength-division-multiplexing coupler, a rotatable linear polarizer, an optical isolator, a 3 dB optical coupler, and the inline switching filter. At a special combination of the orientation angles of the three QWPs, the inline filter can offer a different transmittance according to input polarization, e.g., reflection spectra of one and the other of the two FBGs for linear horizontally and vertically polarized input light, respectively. At this special combination of the QWPs, one of two different resonances of the two FBGs can be selected by varying laser cavity polarization through the adjustment of the orientation angle of the rotatable linear polarizer. Consequently, switching operation between two laser lines with orthogonal polarization at the two FBG resonance wavelengths could be obtained by properly controlling cavity polarization. The polarization extinction ratio of each lasing line was measured as more than 19.9 dB.

Phlebitis in Intravenous Amiodarone Administration: Incidence and Contributing Factors.

Intravenous amiodarone is the gold-standard treatment for arrhythmias, but phlebitis is a common adverse effect. To determine the incidence and contributing factors of amiodarone-induced phlebitis and examine phlebitis severity. A systematic review was conducted of articles published before February 2016 in the Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, MEDLINE, Embase, Web of Science, and gray databases (Bielefeld, Lenus, EUGrey, RIAN, and DART). All studies in which amiodarone-induced phlebitis was a primary or secondary outcome were included. Meta-analysis was not appropriate because of study heterogeneity. Studies of the same contributing factors were analyzed together. In the 20 included studies, phlebitis incidence ranged from 0% to 85%. Increasing the infusion concentration from 1.2 mg/mL to 1.8 mg/mL increased the phlebitis rate (P < .001). Total amiodarone doses greater than 1 g resulted in higher phlebitis rates than did doses less than 0.45 mg (P < .001). Most infusion durations and rates were not correlated with phlebitis incidence. However, phlebitis incidence was lower with bolus administration than with longer infusions (P = .002). The use of in-line filters and nursing guidelines significantly reduced phlebitis rates (P < .001) and phlebitis severity. The most common phlebitis severity grades, in descending order, were 0, 1, 2, 3, and 4. Understanding factors that increase the risk of amiodarone-induced phlebitis can guide better practice. In-line filters and nursing guidelines should always be implemented when administering intravenous amiodarone. Increased surveillance is required when higher dosages and concentrations are used.

A Novel Magnetic Coupling for Miniaturized Bandpass Filters in Embedded Coaxial SIW

In this paper, embedded coaxial substrate integrated waveguide (CSIW) filters with innovative magnetic couplings are presented and studied. By creating the loading capacitance of a combline topology using inner layers of a low-temperature co-fired ceramic (LTCC) stack-up, it is possible to achieve resonator miniaturization while improving the spurious-free band and providing full-packaged solutions. Moreover, a new magnetic coupling scheme consisting of short-ended stripline probes is proposed and analyzed in detail, both for direct and external couplings. An in-line three-pole filter at L-band is designed, manufactured, and measured proving how the proposed approach can be used for designing wideband bandpass filter (BPF) with extremely compact size. The designed BPF is centered at 1.5 GHz with 10 % fractional bandwidth (FBW), while the layout size is just 35 × 9.5 mm 2 . The experimental results validate the coaxial SIW technology that allows for, at the same time, easy integration, compact size, flexible design, and enhanced stop-band performance.