Abstract This paper analyzes the effect of the inlet end-wall boundary layer on the secondary flow of a low pressure turbine airfoil cascade at Reynolds number 2 × 105 using RANS and implicit large-eddy simulations (LES). The results are compared against experimental data obtained at two low-speed linear cascade facilities, one located at the Whittle Laboratory of the University of Cambridge and the other at the Polytechnic University of Madrid. The RANS turbulence model is the k−ω−γ−Reθt and no sub-grid scale model has been used in the LES. An unstructured mesh of hexahedra and prisms is used, with high order elements used in the boundary layer region to better describe the airfoil shape in the LES. Two inlet end-wall boundary layers that produce different secondary flow patterns are analyzed: a laminar thin velocity profile and a turbulent thick velocity profile with several inlet turbulent intensities. The agreement between LES numerical predictions and experimental measurements of the position and intensity of the secondary vortices is very good for both cases. RANS simulations are much cheaper in terms of computational cost and reasonably predict most of the flow features, except when the inlet turbulence is low and turbulent transition prediction becomes critical. The effect of the inlet velocity profiles and inlet turbulence on the secondary flow structure is quite pronounced. The velocity profile thickness determines the spanwise penetration of the passage vortex, and different inlet turbulence intensities modify its mixing. Higher inlet turbulence intensities lead to a decrease of the secondary losses due to the passage vortex and an increase of end-wall losses.