In this paper, the on-line quality control feature of the injection molding machine based on the statistical process of thermoplastics product has been developed. The optimal process begins with collecting data and setting up the parameter of the injection machine according to the design of experiment. Four control parameters are set up on Demag Ergotech 200-840 Dragon. A series of tests using a body-outdoor led lamp has been conducted by means of both approaches simulation-based and experimental-based by which is injected using two-cavity injection mold. In simulation mode, clamping force and total weight were assigned as final responses, while total weight only is used as a response in experiment mode. The molded-parts were validated using thirty samples that are divided into a three-batch production process. The application of the on-line statistical quality check feature in the injection molding machine can be used as a quality control method by setting up barrel temperature, screw-back position, injection speed, and injection pressure.