Initiation Mechanism Research Articles

Collaboration and resource sharing in the multidepot time-dependent vehicle routing problem with time windows

Concerns about energy conservation and emission reduction have highlighted the importance of environmentally sound logistics networks in urban areas. These networks are deeply intertwined with urban traffic systems, where variations in transit speeds can significantly increase the energy consumption and carbon emissions of delivery vehicles, compromising the environmental sustainability of urban deliveries. To address this, we propose a multidepot time-dependent vehicle routing problem with time windows, enhancing route planning flexibility and resource configuration. Our approach begins with a route spatiotemporal decomposition method to estimate vehicle travel times and emissions based on varying vehicle speeds. We then develop a multiobjective mixed integer linear programming model that aims to minimize total operating costs, the number of vehicles, and carbon dioxide emissions. A hybrid heuristic algorithm combining spectral clustering, multiobjective ant colony optimization, and variable neighborhood search is proposed to solve the model. This algorithm incorporates collaboration and resource sharing strategies, a pheromone initialization mechanism, a novel heuristic operator that accounts for time dependency, and a self-adaptive update mechanism, enhancing both solution quality and algorithm convergence. We compare the performance of our algorithm with that of the CPLEX solver, multiobjective ant colony optimization, non-dominated sorting genetic algorithm-Ⅲ, and multiobjective particle swarm optimization. The results demonstrate the superior convergence, uniformity, and spread of our proposed algorithm. Furthermore, we apply our model and algorithm to a real-world case in Chongqing, China, analyzing optimized results for different time intervals and vehicle speeds. This study offers robust methodologies for theoretically and practically addressing the multidepot time-dependent vehicle routing problem with time windows, contributing to the development of economical, efficient, collaborative, and sustainable urban logistics networks.

Temperature and pressure effects on the decomposition mechanisms of 2,6-diamino-3,5-dinitropyrazine-1-oxide crystal: ab initio molecular dynamics study.

The decomposition process of 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105) crystal at high temperatures (2500 and 3390K) and detonation pressure of 33.4 GPa coupled with temperatures were studied by ab initio molecular dynamics simulations. The results show that the initial decomposition mechanism of LLM-105 is the same under different conditions. The product analysis indicates that high temperature is conducive to the formation of N2 and CO2, but inhibited the formation of H2O. It is found that the formation mechanism of H2O is the same under different conditions, which involves the reaction between OH radical and H radical. Although the detailed processes of the formation of N2 are different, they all involve the reaction between nitrogen-containing fragments, and its core is the formation of intermediates with R1-NN-R2 structure. The core of the formation of CO2 under different conditions is to form the intermediate R1-CO-R2 with carbonyl structure, and then generate the fragment with -OCO- structure, and finally generate CO2. This research may provide new insights into the initiation and subsequent decomposition mechanisms of energetic materials under extreme conditions. The LLM-105 supercell was constructed using the Materials Studio 7.0 package. AIMD simulations were performed in the CASTEP package. AIMD simulations adopted NVT and NPT ensemble, and the temperature was controlled by Nosé thermostat, while the pressure was controlled by Andersen barostat. Besides, DFT calculations were carried out at the B3LYP/6-311 + G(d,p) level using the Gaussian 09 package.

Sulfamethoxazole removal and ammonium conversion in microalgae consortium: Physiological responses and microbial community changes

Microalgae (Mychonastes sp.) consortium was investigated for nutrient and antibiotics removal and its responses to varying sulfamethoxazole (SMX) concentrations (0–1000 μg/L) in ammonia-rich wastewater. The results showed that the introduction of SMX (100–1000 μg/L) slightly improved ammonium nitrogen removal efficiency instead of inhibition. Swift SMX degradation was observed across all SMX-treated systems, with the highest SMX removal efficiency (96 %) at an SMX concentration of 100 μg/L. Biodegradation remained the dominant SMX removal mechanism, contributing 78 % of SMX removal at an SMX concentration of 800 μg/L, while adsorption and photolysis played minor roles. Addition of SMX augmented biomass and lipid productivity, but decreased chlorophyll contents in the microalgae consortium. Furthermore, extracellular polymeric substance (EPS) production correlated positively with SMX input concentration, with the microalgae consortium exposed to 800 μg/L SMX displaying the most pronounced stimulation of protein production (51.5 ± 2.0 mg/g DCW) and polysaccharides production (74.8 ± 3.9 mg/g DCW). In response to an increase in SMX concentrations, enzyme activities associated with antioxidant defense, such as superoxide dismutase (SOD), peroxidase (POD) and malondialdehyde (MDA) increased, the catalase (CAT) decreased, indicating an initial defense mechanism. Concurrently, the relative abundance of Mychonastes sp. within the consortium rose from 87 % at 300 μg/L SMX to 99.9 % at 800 μg/L SMX. while Shannon indices of the bacterial community increased from 1.415 to 2.867. This shift inhibited the initially dominant Saprospiraceae bacteria, facilitating the profound increase of adapted Aquimonas. These findings demonstrate the feasibility of the simultaneous removal of antibiotics and nutrients from wastewater with a microalgae consortium system.

Mechanism of initiation and propagation of surface cracks in gun bore under thermomechanical coupling impact

Surface cracks in gun bore may exacerbate rifling ablation and wear and in turn shorten barrel life. Thermomechanical coupling finite element (FE) models of bore are established and the dynamic responses of the bore under high-temperature and high-pressure are numerically simulated. The stress distribution characteristics on the inner surface are analyzed and the effects of autofrettage, number of firings and harden layer on the stress distribution are discussed. Based on the stress distribution characteristics, FE models with two initial cracks on the ledge of land surface are set up and the propagation, interaction and intersection of the cracks are numerically simulated, considering the effect of the distance between the two cracks. Based on simulation results, the initiation and propagation pattern and mechanism of the cracks on the inner surface are analyzed. An ablation test system was designed and produced, and used to experimentally verify the initiation and propagation mechanism of the cracks. The observed crack patterns on the inner surface of a real gun bore are also used to illustrate the mechanism obtained in this work. Understanding of the initiation and propagation mechanism of cracks in gun bore can be applied to improve and optimize the design of barrels.

The Influence of a Lubricant Medium on the Development of Fretting Wear in an Interference Fit Connection

Fretting wear is a phenomenon occurring in many engineering objects, including push fit connections. In view of a large number of factors conducive to wear development, it is difficult to describe the mechanism of wear initiation and development. Therefore, various methods are sought to limit wear development. The use of a lubricant may be one of those ways. The aim of this article is to present the results of testing the influence of a lubricant medium on the development of fretting wear in interference fit connections. As a lubricant medium, MoS2 and Whitmore greases were used. For that purpose, wear tests were first conducted on the shaft/sleeve tribological kinematic pair, and then observations and laboratory measurements were performed. The observations demonstrated the presence of fretting wear traces on all tested samples, irrespective of the tribological kinematic pair being tested. The main kind of damage consisted of material build-ups which, during operation, become oxidised and, while moving along the connection, caused local abrasion and micropits. The best results in restricting the development of fretting wear were achieved with Whitmore grease.

Microscopic characterisation of brittle fracture initiation in irradiated and thermally aged low-alloy steel welds of a decommissioned reactor pressure vessel

Microstructure has a significant effect on material's integrity and in a heterogeneous weld microstructure the discontinuities affect the brittle fracture initiation and propagation and determine the fracture toughness. The knowledge of brittle fracture initiation mechanisms in high-Mn/high-Ni welds is limited. The brittle fracture initiation behaviour of the decommissioned Barsebäck Unit 2 reactor pressure vessel (RPV) welds of high-Mn/high-Ni weld metal from three different locations, the RPV head and the beltline regions, were investigated and compared with specimens from the surveillance program with high fluence. Systematic fractography has been performed on impact and fracture toughness specimens and the main features of the brittle fracture initiation in the component weld are presented and discussed. Two main types of initiators are identified as the weakest links to initiate the cleavage fracture and the initiation mechanism is found independent from the operation condition. The high-fluence surveillance specimens have a larger amount of intergranular cracking. The cleavage fracture initiation appears to be independent of the operation conditions but dependent on the welding process and metallurgical features. The findings aid in the development of improved material-property correlations which will result in better computational tools for predicting aging of welds based on microstructure.

Towards enhanced corrosion resistance of PS-PVD TBCs in marine environments by structural design

Thermal barrier coatings (TBCs) prepared by plasma spray-physical vapor deposition (PS-PVD) applied in marine environments encounter a critical challenge of corrosion-induced failure. In this paper, yttria-stabilized zirconia (YSZ) TBCs with different microstructures were prepared via PS-PVD by varying powder feeding rates to investigate the influence of microstructural modifications on corrosion resistance. The effects of structural gradient, initial deposition mechanism, and pore distribution on corrosion resistance were explored. Additionally, the inhibition mechanisms of capillary effect and chemical reaction on molten salt penetration were confirmed. Finally, a microstructure gradient strategy for PS-PVD TBCs was proposed. The structurally graded TBCs tailored using this strategy exhibited excellent corrosion resistance, with the molten salt corrosion resistance surpassing that of conventionally processed PS-PVD TBC by over 50 %. These outcomes highlight the promising potential of the microstructure gradient strategy for enhancing the corrosion resistance of PS-PVD TBCs.

Design and Optimization Analysis of an Adaptive Knee Exoskeleton

To solve the problem of undesired relative motion of human-machine interaction positions caused by misalignment of the human-machine joints rotation axis of the knee exoskeleton, this study designed an adaptive knee exoskeleton based on a gear-link mechanism (GLM) by considering the human body as a component of the exoskeleton mechanism. Simultaneously, the concept of the wearable area (WA) was proposed, which transformed the operation of aligning the exoskeleton rotation axis with the human knee joint rotation axis into a "face alignment point" in the sagittal plane, reducing the difficulty of aligning the human-machine joint rotation axis. In the kinematic analysis of GLM, the phenomenon of instantaneous movement of the central axis of the human knee joint was considered. Based on the kinematic model, the WA, velocity transfer ratio, and initial position static stiffness of GLM were analyzed. The NSGA-II optimization algorithm was used to optimize the size parameters of GLM, which increased the WA by 18.4%, the average velocity transfer ratio by 4.98%, and the average initial position static stiffness by 6.01%. Finally, the ability of the exoskeleton to absorb movement displacement (MD) was verified through simulation, and the good human-machine kinematic compatibility of the exoskeleton was verified through wearable tests conducted on the initial mechanism principle prototype.

Effect of over-ageing on the tensile and torsional fatigue properties of the AlSi7Cu0.5 Mg0.3 precipitation-hardened cast aluminium alloy

The objective of this work is to evaluate the influence of over-ageing on the high cycle fatigue behaviour of the AlSi7Cu0.5Mg0.3 cast aluminium alloy. It is generally accepted that over-ageing has a large influence on the behaviour of these materials, however its effect on the fatigue strength is less understood. This work provides an experimental investigation of the effect of over-ageing on high cycle fatigue strength in both tensile and torsional loading conditions. It is shown that the torsional fatigue strength is more sensitive to over-ageing when compared to the tensile fatigue strength and that the fatigue defect sensitivity is negligible for torsional loads, in contrast to tensile loading conditions. The experimental results indicate that this is due to a change in the crack initiation mechanism, going from initiation in the matrix for torsion loads to initiation from casting defects for tensile loads. An original two-steps approach is proposed to rationalise the effect of over-ageing on the fatigue strength, with particular emphasis on decoupling the respective contributions from defects and the mechanical properties. This approach is used to build normalised Kitagawa-Takahashi diagrams that highlights the reduced defect sensitivity under tensile loads for the most severe over-ageing condition.

Electric field induced dissociation of a confined hydrogen molecule

The effect of a static electric field ionization on the neutral hydrogen molecule H2 confined in a spherical potential well is studied, as a simple model for the chemical activation of molecular species in a medium. Quantum diffusion Monte Carlo is employed with complete account of electron correlation. Field-induced ionization and dissociation are discussed, for different values of the confinement radius and electric field strength. This study allows to highlight the mechanism of electric field initiation of chemical reactions in fluids at different pressures, without the details of a specific chemical environment.

Hybrid finite element modeling of subsurface-originated spalling in flexible bearings with hoop stresses

The flexible bearing in a harmonic reducer undergoes structural deformation after being mounted on the cam, causing the bearing to operate under a complex stress state. A hybrid finite element model is developed to investigate crack initiation and propagation in flexible bearings with hoop stress under rolling contact fatigue loading. The model is coupled with continuum damage mechanics, and the damage evolution equation takes the maximum shear stress amplitude as the damage-causing stress since the hoop stress inevitably affects the fatigue life. The model is verified by comparison with the fatigue life of the inner ring without hoop stress. The crack initiation and spalling formation mechanisms in the inner ring assembled with the cam are analyzed in detail. Moreover, the effects of contact load and equivalent interference on the inner ring’s spalling morphology and fatigue life are studied.

Effect of chemical etching time on the fatigue behavior of Ti‐6Al‐4V produced by laser powder bed fusion

AbstractThis study focuses on the evolution of the fatigue strength of Laser Powder Bed Fusion (L‐PBF) produced Ti‐6Al‐4V as a function of the chemical etching finishing process. The aim is to identify the critical fatigue crack initiation mechanisms and the transitions between them in terms of the evolution of the surface micro‐geometry. This is done using three different geometries and six different surface states. The evolution of the crack initiation mechanisms is then used to explain the evolutions of the fatigue strength and the fatigue scatter. Chemical etching affects the fatigue life via a polishing effect, which directly influences both the finite and the high cycle fatigue domains. It is shown that chemical etching makes it possible to obtain fatigue strengths that are almost similar to those of the machined surface. However, it is also observed that etching cannot fully counteract the effects of large surface cavities caused by surface connected porosities.

Differential Expression Analysis Reveals Possible New Quaternary Ammonium Compound Resistance Gene in Highly Resistant Serratia sp. HRI.

During the COVID-19 pandemic, the surge in disinfectant use emphasised their pivotal role in infection control. While the majority of antimicrobial resistance research focuses on antibiotics, resistance to biocides, which are present in disinfectants and sanitisers, is escalating. Serratia sp. HRI is a highly resistant isolate, and through the study of this organism, the molecular mechanisms of resistance may be uncovered. Serratia sp. HRI was treated with the disinfectant benzalkonium chloride in preparation for RNA sequencing. Through mining of the RNA-Seq differential expression data, an uncharacterised Major Facilitator Superfamily (MFS) efflux pump gene was found to be up-regulated at least four-fold at four different time points of exposure. Real-time PCR revealed this uncharacterised MFS efflux gene was up-regulated after exposure to benzalkonium chloride and two additional disinfectants, didecyldimethylammonium chloride (DDAC) and VirukillTM. Additionally, expression of this gene was found to be higher at 20 min versus 90 min of exposure, indicating that the up-regulation of this gene is an initial response to biocide treatment that decreases over time. This suggests that MFS efflux pumps may be an initial survival mechanism for microorganisms, allowing time for longer-term resistance mechanisms. This work puts forward a novel biocide resistance gene that could have a major impact on biocide susceptibility and resistance.

At2-MMP is required for attenuation of cell proliferation during wound healing in incised Arabidopsis inflorescence stems.

Wound healing of partially incised Arabidopsis inflorescence stems constitutes cell proliferation that initiates mainly in pith tissues about three days after incision, and that the healing process completes in about seven days. Although the initiation mechanisms of cell proliferation have been well documented, the suppression mechanisms remain elusive. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases well-known as proteolytic enzymes in animal systems functioning in extracellular matrix remodeling during physiological and pathological processes, including tissue differentiation, growth, defense, wound healing, and control of cancer growth. In this study, we report At2-MMP might contribute to the suppression mechanism of cell proliferation during tissue-repair process of incised inflorescence stems. At2-MMP transcript was gradually upregulated from day 0 to 5 after incision, and slightly decreased on day 7. Morphological analysis of incised stem of defected mutant at2-mmp revealed significantly enhanced cell proliferation around the incision site. Consistent with this, semi-quantitative analysis of dividing cells displayed a significant increment in the number of dividing cells in at2-mmp as compared to WT. These results showed that the upregulation of At2-MMP at the later stage of wound-healing process is likely to be involved in the completion of the process by attenuating the cell proliferation.

Initiation mechanism of landslides in cold regions: Role of freeze-thaw cycles

Freeze-thaw cycles are recognized as one of the key triggers for some major landslides in cold regions around the world. Though the effects of freeze-thaw cycles on the rock strength degradation have been studied extensively, little effort has been made to qualitatively evaluate how it contributes to the evolution from a stable rock slope to a large-scale mass movement. In this study, we use a discrete element-based numerical model to simulate the entire process of the initiation of landslide under the action of freeze-thaw cycles in a slope with randomly distributed initial cracks. The main goal of this work is to quantitatively describe the landslide evolution process regarding the slope displacement, crack propagation, stress chain and load-bearing structure. Our results show the essence of the displacement evolution of a landslide subjected to freeze-thaw cycles; namely frost heave pressure induces the generation of new cracks, leading to the failure and reconstruction of the load-bearing structure of the slope. Deep-seated landslides can occur when the slope is crossed by a fault; otherwise, the slope is prone to surface erosion or shallow landslides.

Laser powder bed fusion manufactured TPMS cellular structures: Failure modeling by using initial damage concept and continuum damage mechanics model

The present study examined the compressive mechanical properties and failure modes of Schwarz P and Schwarz G Triple Periodic Minimal Surface (TPMS) cellular structures using Finite Element (FE) simulations and experimental tests. A novel approach based on the initial damage parameter, which accounts for the initial defects induced by the Laser Powder Bed Fusion (LPBF) manufacturing process, was employed to model the compression behavior of the cellular structures. Compression tests were conducted on 3 Schwarz P and 3 Schwarz G specimens. A digital camera captured the deformation patterns of the specimens, revealing that shear bands formed in the Schwarz P specimens, while the Schwarz G specimens deformed uniformly. The FE simulations utilized modified material parameters according to the Continuum Damage Mechanics (CDM) framework. Moreover, an isotropic CDM model with micro-defect closure effect was implemented to investigate the failure mechanisms of the specimens. The FE simulation results indicated that the CDM model accurately predicted the mechanical behavior of the cellular structures fabricated by the LPBF process. The Scanning Electron Microscopy (SEM) images confirmed that the specimens had manufacturing defects such as micro-voids, pores, and surface roughness and that the crack initiation locations corresponded to the maximum damage locations of the FE simulations.

The Initiation Mechanism of the Isoolefin Oligomerization Reaction in the Presence of Ethylaluminum Dichloride – Protonodonor Complex Catalysts

The mechanism of isoolefins initiation in the presence of ethylaluminum dichloride – proton donor (water, phenol, hydrochloric acid) complex catalysts has been studied by ab initio HF.3.21G. The energetics of these reactions was estimated, the values of its activation energy and thermal effects were obtained. It was found that among the studied catalysts, an increase in the activation energy of the reaction of initiation of oligomerization of isoolefins contributes to an increase in the selectivity of the process.

Monitoring and Evaluation of Debris Flow Disaster in the Loess Plateau Area of China: A Case Study

The Loess Plateau area, with complex geomorphological features and geological structure, is highly prone to geologic disasters such as landslides and debris flow, which cause great losses. To investigate the initiation mechanism of landslide and debris flow disasters and their spreading patterns, historical satellite images in the Laolang gully were collected and digitized to generate three-dimensional topographic and geomorphological maps. Typical landslides were selected for landslide thickness measurement using a standard penetrometer and high-density electrical method. Numerical models were established to simulate the occurrence and development of landslides under different working conditions and to evaluate the spreading range based on the propagation algorithm and friction law. The results show that the 10 m resolution DEM data are well matched with the potential hazard events observed in the field site. The smaller the critical slope threshold, the greater the extent and distance of landslide spreading. The larger the angle of arrival, the greater the energy loss, and therefore the smaller the landslide movement distance. The results can provide scientific theoretical guidance for the prevention and control of rainfall-induced landslide and debris flow disasters in the Loess Plateau area.

Progress of Experimental Studies on Oblique Detonation Waves Induced by Hyper-Velocity Projectiles

Oblique detonation waves (ODWs) are hypersonic combustion phenomena induced by oblique shock waves. When applied to air-breathing engines, ODWs offer high thermal cycle efficiency, adaptability to a wide range of flight Mach numbers, and the advantage of a short combustion chamber, making them highly promising for hypersonic propulsion applications. Despite numerous numerical studies on the heat release and multi-wave flow mechanisms of ODWs, practical applications of oblique detonation engines (ODEs) remain limited due to several technical challenges. These challenges include generating the required high-velocity test environments, achieving effective fuel and oxidant mixing, and measuring the flow field structure in hyper-velocity and high-temperature flows. These limitations hinder the development of ODEs, underscoring the importance of experimental research, particularly for understanding the initiation and propagation mechanisms of ODWs. One of the primary experimental techniques involves inducing oblique detonation using high-velocity models. This method is extensively used to study the initiation process, shock structure, initiation criteria, and ODW propagation. It is advantageous because the state of the experimental mixture is controllable, and the model state can be precisely measured. This paper reviews studies on oblique detonation induced by hyper-velocity projectiles, presenting advances in experimental methods, detonation wave structures, unsteady processes, and initiation characteristics. Additionally, we discuss the deficiencies in existing studies, noting that the current measurement methods fall short of the requirements for observing the ODW initiation process, propagation process, and fine structure. The application of advanced combustion diagnostic techniques and the exploration of the relationship between initiation processes and criteria are crucial for advancing our understanding of ODW initiation and stabilization mechanisms. Finally, we summarize the current state of experimental facilities and measurement techniques, providing suggestions for future research on the measurement of shock waves and chemical reaction zones.

A new mechanism of cancer initiation that involves the transformation of hepatocytes into preneoplastic single hepatocytes and minifoci positive for glutathione S-transferase P-form (GST-P) in rat livers: 3D analysis using a vibratome.

Cancer initiation has long been "unknowable" in biology and medicine. In 1987, however, Moore and our research group observed single hepatocytes and minifoci that were strongly positive for glutathione S-transferase P-form (GST-P) in the rat liver as early as 2 to 3 days after initiation by diethylnitrosamine prior to the induction of GST-P+ foci and nodules. The induction of GST-P+ single hepatocytes, precursors of GST-P+ foci and nodules, was considered genetic. But, the details of the induction mechanism have remained unclear despite various examinations over a long period. Male Sprague-Dawley rats (aged 6 weeks) were fed a basal diet containing either benzyl isothiocyanate (BITC, 0.5% by wt) or 2-acetylaminofluorene (AAF, 0.04%) ad libitum for appropriate time intervals. All animals were anesthetized and euthanized. The livers obtained were excised, cut into 3- to 4-mm-thick slices and fixed in cold acetone at 4 °C. The liver specimens were then sliced into 25-µm-thick sections in PBS using an automated microtome (Vibratome 1500 Sectioning System, Vibratome Products, NY, USA). Immunocytochemical staining was performed in free solution, and the results were examined via digital light microscopy (Coolscope, Nikon, Tokyo). 3D analysis using a vibratome showed that GST-P is rapidly excreted into the bile of the liver of animals in response to strong carcinogenic stress caused by promoters or initiators. "Rapid biliary excretion of GST-P" was widely and commonly observed in all hepatocytes, GST-P+ single hepatocytes, minifoci, foci and nodules under appropriate conditions. Surprisingly, on the basis of these key findings, a new mechanism of cancer initiation involving the transformation of hepatocytes into GST-P+ single hepatocytes and minifoci in animal livers was identified. In addition, the initiation process was determined to be nongenetic because mutation is an invisible rare event. This short review describes several details about breakthrough findings on cancer initiation in rat livers, the application of 3D analysis to other cancers and the importance in the genetic analysis in malignant diseases.