Inhibition Of Tricarboxylic Acid Cycle Research Articles

Conditions affecting inhibition of tricarboxylic acid cycle by fluoroacetate in rat liver mitochondria.

In presence of fumarate, rat liver mitochondria responds with citrate accumulation to fluoroacetate poisoning. This response is not sex-dependent. There is a time lag to the inhibitory effect of fluorocompounds on respiration. Ratios of respiration of fluoroacetate and control system of starved and fed animals were in close agreement. Testosterone did not abolish the effect of fluoroacetate on citrate accumulation. whereas progesterone significantly reversed it only on liver mitochondria of male rats. Progesterone, like DNP, when in combination with fluoroacetate, inhibited respiration. In normal nutritional states irradiation does not significantly increase citrate accumulation in the liver mitochondria of male rats.