The present study addresses a comparative analysis of the potentials of Airborne Visible and infrared imaging spectrometer -next generation (AVIRIS-NG) data, with respect to Landsat-8 Operational Land Imager (OLI) data for mapping of sporadic exposures of mafic cumulates within the anorthosite intrusion and delineation of major lithological units of Sittampundi layered complex. AVIRIS-NG and Landsat-8 OLI data were initially compared using scene-based relative signal-to-noise ratio (SNR) analysis. Subsequently, spectral anomaly maps were generated to map different lithological rock units using the constrained energy minimization (CEM) approach. Spectral maps derived using CEM were further filtered by low-pass filtering to control the false-positive result. Spectral angle mapper (SAM) classification technique was applied to analyze the suitability of AVIRIS-NG and Landsat-8 OLI data for lithological mapping. Confusion matrix analysis was carried out to assess the SAM classified maps. The first vertical derivative (FVD) map of magnetic anomaly and field evidence/geological exposures were used to validate the results. SNR analysis indicates the superior signal strength of AVIRIS-NG data than Landsat-8 OLI data. Moreover, combined analysis based on CEM and SAM of remote sensing data and FVD of magnetic anomaly reveals that the false-positive area indicating metagabbro/mafic cumulate is lower in AVIRIS-NG data than Landsat-8 OLI data. This is because of the relatively poor SNR, spectral and spatial resolutions of Landsat-8 OLI data; however, it can be good enough for mapping of metagabbro/mafic cumulate when AVIRIS-NG data is unavailable.