Innovative Informatics Research Articles

31st Summer Institute in Nursing Informatics: Embracing Healthcare Complexity Through Informatics Innovations.

Seckman, Charlotte PhD, RN-BC, FAANEditor(s): Carter-Templeton, Heather PhD, RN-BC, FAAN Author Information

The Innovative Informatics Approaches of High-Throughput Technologies in Livestock: Spearheading the Sustainability and Resiliency of Agrigenomics Research.

For more than a decade, next-generation sequencing (NGS) has been emerging as the mainstay of agrigenomics research. High-throughput technologies have made it feasible to facilitate research at the scale and cost required for using this data in livestock research. Scale frameworks of sequencing for agricultural and livestock improvement, management, and conservation are partly attributable to innovative informatics methodologies and advancements in sequencing practices. Genome-wide sequence-based investigations are often conducted worldwide, and several databases have been created to discover the connections between worldwide scientific accomplishments. Such studies are beginning to provide revolutionary insights into a new era of genomic prediction and selection capabilities of various domesticated livestock species. In this concise review, we provide selected examples of the current state of sequencing methods, many of which are already being used in animal genomic studies, and summarize the state of the positive attributes of genome-based research for cattle (Bos taurus), sheep (Ovis aries), pigs (Sus scrofa domesticus), horses (Equus caballus), chickens (Gallus gallus domesticus), and ducks (Anas platyrhyncos). This review also emphasizes the advantageous features of sequencing technologies in monitoring and detecting infectious zoonotic diseases. In the coming years, the continued advancement of sequencing technologies in livestock agrigenomics will significantly influence the sustained momentum toward regulatory approaches that encourage innovation to ensure continued access to a safe, abundant, and affordable food supplies for future generations.

Vaccine safety in Australia during the COVID-19 pandemic: Lessons learned on the frontline.

Surveillance of Adverse Events Following Vaccination in the Community (SAEFVIC), Victoria's vaccine safety service for reporting adverse events following immunisation (AEFI), has provided integrated spontaneous surveillance and clinical services for individuals affected by AEFI since 2007. We describe SAEFVIC's response to the COVID-19 vaccine program, and reflect on lessons learned for vaccine safety. The massive scale of the Australian COVID-19 vaccine program required rapid adaptations across all aspects of SAEFVIC's vaccine safety services. Collection of AEFI reports was streamlined and expanded, incorporating both spontaneous and active surveillance data. Dramatically increased report volumes were managed with additional staffing, and innovations to automate, filter, and triage reports for priority follow up. There were two major adverse events of special interest (AESI): thrombosis with thrombocytopaenia syndrome and myocarditis, with multiple other AESI also investigated. Rapid escalation mechanisms to respond to AESI were established, along with AESI-specific databases for enhanced monitoring. Vaccine education and training resources were developed and public-facing vaccine safety reports updated weekly. Frequent communication with local and national government and regulatory bodies, and consultation with specialist groups was essential. The COVID-19 vaccine program has highlighted the importance of vaccine safety in supporting public confidence in vaccines and informing evidence-based immunisation policy. Supporting the COVID-19 vaccine program has required flexibility in adapting to policy changes and evolving vaccine safety signals, careful triage and prioritisation, informatics innovation, and enhanced engagement with the public regarding vaccine safety. Long-term investment to continue strengthening vaccine safety systems, building on lessons learned, will be essential for the ongoing success of Australian vaccination programs.

Spatial Transcriptomic Analysis of a Diverse Patient Cohort Reveals a Conserved Architecture in Triple-Negative Breast Cancer.

Spatial transcriptomics profiling of a diverse cohort of triple-negative breast cancers and innovative informatics approaches reveal a conserved cellular architecture across cancers and identify proportional differences in tumor cell composition by race.

Innovations: Virtual Pathology Recruitment.

Cancer CytopathologyEarly View INNOVATIONS: THE LATEST IN SOCIAL MEDIA & INFORMATICS Innovations: Virtual Pathology Recruitment Xiaoyin “Sara” Jiang MD, Corresponding Author Xiaoyin “Sara” Jiang MD sara.jiang@duke.edu orcid.org/0000-0002-3069-3130 Department of Pathology, Duke University, Durham, North Carolina, USA Correspondence Xiaoyin “Sara” Jiang, Department of Pathology, Duke University, Durham, NC, USA. Email: sara.jiang@duke.eduSearch for more papers by this authorEmilio Madrigal DO, Emilio Madrigal DO orcid.org/0000-0002-4836-444X Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USASearch for more papers by this author Xiaoyin “Sara” Jiang MD, Corresponding Author Xiaoyin “Sara” Jiang MD sara.jiang@duke.edu orcid.org/0000-0002-3069-3130 Department of Pathology, Duke University, Durham, North Carolina, USA Correspondence Xiaoyin “Sara” Jiang, Department of Pathology, Duke University, Durham, NC, USA. Email: sara.jiang@duke.eduSearch for more papers by this authorEmilio Madrigal DO, Emilio Madrigal DO orcid.org/0000-0002-4836-444X Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USASearch for more papers by this author First published: 04 October 2022 https://doi.org/10.1002/cncy.22651Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Early ViewOnline Version of Record before inclusion in an issue RelatedInformation

Türk Hemşirelik Tarihindeki Lider Hemşireler ve Cerrahi Hemşireliğinin Gelişimi

Hemşirelik, kadınların bakım verici rolünü savaşlar sırasında yaralı askerlerin bakımını sürdürmeleriyle başlamış olsa da modern hemşirelik Florence Nightingale’in çevre kuramı ve çalışmalarının da etkisiyle başlamıştır. Nightingale’in çalışmaları profesyonel hemşirelik biliminin temellerini oluşturmuştur. Ülkemizde ise hemşirelik eğitimi ilk olarak 1876’dan sonra Meşrutiyet Dönemi’nde başlamıştır. Doktor Besim Ömer Paşa tarafından 1913 yılında Hilal-i Ahmer merkezinde, 1914-1915 yılları arasında Darülfünun’da, 1916 yılında ise Kadırga Doğum Kliniği’nde hemşirelik eğitim kursları açılmıştır. Çanakkale’den vapurla İstanbul’a ağır yaralıları taşıyan ve aynı zamanda ameliyatların da yapıldığı Reşit Paşa Hastane Gemisi’nde görev yapan tek Türk hemşire olarak bulunan Safiye Hüseyin Elbi, 1925’te açılan Kızılay Hemşire Okulu kurucularından olmuştur. 1924 Amiral Bristol mezunu olan Esma Deniz İbrahim, Columbia Üniversitesi’nde eğitimini sürdürmüş ve 1930’ta yurda dönmüştür. O da Safiye Hüseyin Elbi gibi Türk Hasta Bakıcılar Cemiyeti’nin (Türk Hemşireler Derneği) kurucuları arasında yer almaktadır. İnsanlık tarihinin varoluşu ile başlayan cerrahinin tarihi dünden bugüne bazen durağan olsa da çoğu zaman hızlı gelişimler göstermiştir. 19. yüzyıl başlarında ise ameliyathane hemşireliğinin bir çalışma alanı olarak kabul görmesiyle profesyonel cerrahi hemşireliğinin temelleri atılmıştır. Günümüzde cerrahi hemşiresi, hastanın cerrahi kliniğe kabul edilmesiyle başlayan, ameliyat sırası ve sonrası dönemde evde bakımı ile rehabilitasyonunu da içeren uzun bir süreçte hastanın bakımını sürdüren profesyonel bir meslek üyesidir. Cerrahi teknik, teknoloji ve bilişim alanlarındaki yenilikler, cerrahi hemşirelerinin sürekli değişimini ve gelişimini zorunlu kılmaktadır. Bu gerekçeyle hemşirelik bilimi ve uygulamalarının geliştirilmesinde sorumluluğu bulunan hemşire liderler, kurum ve kuruluşlar, meslek üyeleri ortak stratejiler belirlemeli, uygun düzenlemelerle uygulamaya geçirmelidir. Bu derleme ile Türk hemşirelik tarihi ile ilişkili olarak cerrahi hemşireliğinin geçmişten günümüze geçirmiş olduğu tarihsel süreç incelenmiş ve gelecekteki durumuna yönelik bir değerlendirme yapılmıştır.

Application of New Technology in Education: Design and Implementation of Graduate Certificate Model Based on Intelligent Graph Element Technology

Modern information technology empowers education and infuses new vigor into educational innovation. However, current university diplomas are old-fashioned, not connected to information technology, and easy to copy. Two-dimensional code technology, widely popular in China because of its intuitive, simple, convenient, and other advantages, should be integrated into the field of education. Two-dimensional code technology is the advanced form of graphic code technology. However, through the analysis of the current situation of graphic code technology research and education applications including two-dimensional code, there are no actual cases of graphic code technology applied to graduation certificates, leaving a blank field of research. This is mainly due to the defects and limitations of the existing graphic code technology, so a new intelligent graph element technology (IGET) is proposed here. Intelligent graph element technology integrates the functional advantages of two-dimensional code and overcomes the issues of certificates being easy to forge and difficult to verify, by adding intuitive, discernible, and valuable new functions, suitable for the functional requirements of the graduation certificate. Based on intelligent graph element technology, a novel graduation certificate management system model is constructed here, and a graduation certificate is designed and implemented. Compared with the traditional graduation certificate, the graduation certificate based on intelligent graph elements has the advantages of being intuitive and readable, and having information security, a large amount of information, and intelligent anti-counterfeiting, verification, and traceability mechanisms. The application of intelligent graph element technology in the design and research of college graduation certificates opens a new window of digitization and informatization innovation for traditional college graduation certificates, and provides reference for other innovative applications of intelligent graph element technology in the field of education.

Medical Devices Management System Based on Blockchain Technology

Abstract The recent use of digital Distributed Ledger Technology (DLT) in the healthcare domain can surpass the existing limitations in the centralized IT systems, such as the lack of security, access control or immutability of the electronic health information. If we discuss about clinical information, this innovative informatics advance gives back the control to the data owner. In decentralized environments, smart contracts allow trustable agreements grounded by irreversible transactions, which permit transparency and traceability. Moreover, smart contracts are the living heart of the decentralized applications that run on DTL. In this work, our attention is focused on medical equipments that helps health staff to diagnose and treat patients keeping much of their clinical data taken in dynamics. Hence, we propose a smart contract-based decentralized application framework for the management of devices, targeting also medical services, meant to facilitate the interaction of the involved entities. Our testing environment is the Ethereum platform, extensively used recently in the healthcare domain, being itself a smart operating system that allows decentralized applications to run on it.

Innovation in Informatics to Improve Clinical Care and Drug Accessibility for Rare Diseases in China.

Background: In China, there are severe unmet medical needs of people living with rare diseases. Relatedly, there is a dearth of data to inform rare diseases policy. This is historically partially due to the lack of informatics infrastructure, including standards and terminology, data sharing mechanisms and network; and concerns over patient privacy protection. Objective: This study aims to introduce the progress of China's rare disease informatics platform and knowledgebase, and to discuss critical enablers of rare disease informatics innovation, including: data standardization; knowledgebase construction; national policy support; and multi-stakeholder participation. Methods: A systemic national strategy, delivered through multi-stakeholder engagement, has been implemented to create and accelerate the informatics infrastructure to support rare diseases management. This includes a disease registry system, together with more than 80 hospitals, to perform comprehensive research information collection, including clinical, genomic and bio-sample data. And a case reporting system, with a network of 324 hospitals, covering all mainland Chinese provinces, to further support reporting of rare diseases data. International standards were incorporated, and privacy issues were addressed through HIPAA compliant rules. Results: The National Rare Diseases Registry System of China (NRDRS) now covers 166 rare diseases and more than 63,000 registered patients. The National Rare Diseases Case Reporting System of China (NRDCRS) was primarily founded on the National Network of Rare Diseases (NNRD) of 324 hospitals and focused on real-time rare diseases case reporting; more than 400,000 cases have been reported. Based on the data available in the two systems, the National Center for Health Technology Assessment (HTA) of Orphan Medicinal Products (OMP) has been established and the expert consensus on HTA of OMP was produced. The largest knowledgebase for rare disease in Chinese has also been developed. Conclusion: A national strategy and the coordinating mechanism is the key to success in the improvement of Chinese rare disease clinical care and drug accessibility. Application of innovative informatics solutions can help accelerate the process, improve quality and increase efficiency.

Competitive effect of copper and nickel recovery with carbonate in the fluidized-bed homogeneous granulation process.

With the rapid growth of the world's informatics innovation, printed circuit boards (PCBs) processing produces wastewaters with copper and nickel ions. This study aims to remove and recover copper and nickel ions from synthetic PCB wastewater using a fluidized-bed homogeneous granulation process (FBHGP). FBHGP is an advanced green technology that removes copper and nickel and transforms the sludge into a hard granule. The impacts on the removal and granulation of copper and nickel of the initial operating pH, molar ratio (MR) of precipitant to metal, and precipitant flow rate have been evaluated. The highest copper removal was attained at 97% at pH of 6.5 and 98% copper removal at an MR of 2.0 and 10 mL·min-1. A 93% copper granulation was achieved at the same pH, while a 94% copper granulation was also achieved at the same MR and precipitant flow rate. At a pH of 7.5, 85% nickel removal and 74% granulation were attained for a nickel. At an MR of 1.75, 82% and 74% were the highest removal and granulation. While at 25 mL·min-1, the highest removal was 83%, and 73% nickel granulation was achieved. Copper has been successfully recovered from synthetic PCB wastewater using FBHGP. At the same time, nickel needs a multi-step FBR, which is more suitable for the recovery of nickel under the same conditions applied during the same period.

Informatics for public health and health system collaboration: Applications for the control of the current COVID-19 pandemic and the next one.

Public health faces unprecedented challenges in its efforts to control COVID-19 through a national vaccination campaign. Addressing these challenges will require fundamental changes to public health data systems. For example, of the core data systems for immunization campaigns is the immunization information system (IIS); however, IISs were designed for tracking the vaccinated, not finding the patients who are high risk and need to be vaccinated. Health systems have this data in their electronic health records (EHR) systems and often have a greater capacity for outreach. Clearly, a partnership is needed. However, successful collaborations will require public health to change from its historical hierarchical information supply chain model to an ecosystem model with a peer-to-peer exchange with population health providers. Examples of the types of informatics innovations necessary to support such an ecosystem include a national patient identifier, population-level data exchange for immunization data, and computable electronic quality measures. Rather than think of these components individually, a comprehensive approach to rapidly adaptable tools for collaboration is needed.

Research on the application of 5G technology in the cultivation and construction of educational informatization innovation and entrepreneurship ability

With the increasing popularity of education informatization and the emergence of intelligent learning space, students’ demand for personalized, convenient and diversified learning content of innovation and entrepreneurship ability is becoming increasingly prominent. The fifth generation mobile communication (5G) technology is characterized by its large bandwidth, ultra-high reliability, ultra-low delay and large-scale Internet of things. College Students’ innovation and entrepreneurship education is the main theme of modern higher education and an important way to promote the transformation and development of local colleges. The quality of business plan and roadshows is one of the important means of financing for start-ups. Improving the ability of college students to write high- quality business plans and develop roadshows is not only conducive to the scientific evaluation and assessment of students’ ability, but also helps to stimulate the enthusiasm of college students for innovation and entrepreneurship, and cultivate their ability of innovation and entrepreneurship. Combined with the characteristics of contemporary college students’ innovation and entrepreneurship education, this project analyzes the problems existing in college students’ business plan writing and roadshow at this stage, and puts forward the establishment of an innovation and entrepreneurship ability training system based on the rapid development of business plan and roadshow, so as to promote the improvement of College Students’ innovation and entrepreneurship ability and provide a strong guarantee for deepening the reform of innovation and entrepreneurship education in Colleges and universities.

Retracted] Innovation and Development of University Education Management Informationization in the Environment of Wireless Communication and Big Data

The development of information technology has spawned a new type of demand and management analysis model of big data. The value of data is vividly reflected in the contemporary era, and all walks of life have devoted great energy to the construction and use of informatization. The object of college education and management is the group of college students who are most closely connected with contemporary trends. Their thoughts are active, their state is changeable, and they are very sensitive to external stimuli. Such an educational situation has greatly increased the difficulty of educational management in colleges and universities. This article takes the big data research as the breakthrough point, focuses on the promotion and innovation of contemporary college education management informatization, and strives to improve the college education management informatization system by solving existing problems. The innovation of this research is to use big data technology as the starting point for improving the current stage of the education informatization work of colleges and universities, through the combination of data analysis and the latter, to realize the comprehensive informatization innovation of education management. The study used questionnaire surveys to investigate and interview some students and related managers in 5 universities in the province and conducted an objective assessment of the construction of educational management informatization in these universities and found that these five universities have common problems in this field. Research experiments have found that among the five representative universities in the province, the service awareness of education administrators is not above the fifth level. This shows that in the big data environment, the quality of education administrators cannot be ignored.

Toward more data publication of long‐term ecological observations

AbstractData papers, such as those published by Ecological Research, encourage the retrieval and archiving of valuable unpublished, undigitized ecological observational data. However, scientists remain hesitant to submit their data to such forums. In this perspective paper, we describe lessons learned from the Long‐Term Ecological Research, the Global Biodiversity Information Facility and marine biological databases and discuss how data sharing and publication are both powerful and important for ecological research. Our aim is to encourage readers to submit their unpublished, undigitized ecological observational data then the data may be archived, published and used by other researchers to advance knowledge in the field of ecology. Coupling data sharing and syntheses with the development of innovative informatics would allow ecology to enter the realm of big science and provide seeds for a new and robust agenda of future ecological studies.

Leveraging health system telehealth and informatics infrastructure to create a continuum of services for COVID-19 screening, testing, and treatment.

ObjectivesWe describe our approach in using health information technology to provide a continuum of services during the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 challenges and needs required health systems to rapidly redesign the delivery of care.Materials and MethodsOur health system deployed 4 COVID-19 telehealth programs and 4 biomedical informatics innovations to screen and care for COVID-19 patients. Using programmatic and electronic health record data, we describe the implementation and initial utilization.ResultsThrough collaboration across multidisciplinary teams and strategic planning, 4 telehealth program initiatives have been deployed in response to COVID-19: virtual urgent care screening, remote patient monitoring for COVID-19–positive patients, continuous virtual monitoring to reduce workforce risk and utilization of personal protective equipment, and the transition of outpatient care to telehealth. Biomedical informatics was integral to our institutional response in supporting clinical care through new and reconfigured technologies. Through linking the telehealth systems and the electronic health record, we have the ability to monitor and track patients through a continuum of COVID-19 services.DiscussionCOVID-19 has facilitated the rapid expansion and utilization of telehealth and health informatics services. We anticipate that patients and providers will view enhanced telehealth services as an essential aspect of the healthcare system. Continuation of telehealth payment models at the federal and private levels will be a key factor in whether this new uptake is sustained.ConclusionsThere are substantial benefits in utilizing telehealth during the COVID-19, including the ability to rapidly scale the number of patients being screened and providing continuity of care.

Main Content and Implementation Path of College Sports Informatization Construction

Information technology not only has a revolutionary influence on the development of physical education, but also plays a strategic role in the development of physical education. Based on the current situation and significance of sports informatization development in colleges and universities in China, the author makes an in-depth analysis of informatization innovation of sports teaching and research, optimization and management of sports training, physical fitness monitoring and evaluation, cloud platform construction of extracurricular sports activities and competitions, scientific material selection and talent cultivation of young athletes, and intelligent management of campus competitions. From the aspects of the development goal of college sports informatization, the establishment of information platform, the building of characteristic team, the utilization ability of sports teachers’ information and the utilization of information achievements, this paper puts forward the implementation path of college sports informatization construction, aim to provide theoretical support and practical guidance for college sports informatization construction and development in China.

Recent advances and future perspectives in vector-omics.

We have reviewed recent progress and the remaining challenges in vector-omics. We have highlighted several technologies and applications that facilitate novel biological insights beyond achieving a reference-quality genome assembly. Among other topics, we have discussed the applications of chromatin conformation capture, chromatin accessibility assays, optical mapping, full-length RNA sequencing, single cell RNA analysis, proteomics, and population genomics. We anticipate that we will witness a great expansion in vector-omics research not only in its application in a broad range of species, but also its ability to uncover novel genetic elements and tackle previously inaccessible regions of the genome. It is our hope that the continued innovation in device portability, cost reduction, and informatics support will in the foreseeable future bring vector-omics to every vector laboratory and field station in the world, which will have an unparalleled impact on basic research and the control of vector-borne infectious diseases.

Donald A. B. Lindberg: Inspiring Leader and Visionary in Biomedicine, Healthcare, and Informatics.

Summary Background: As Director of the US National Library of Medicine (NLM) for 30 years, Dr. Donald A. B. Lindberg was instrumental in bringing biomedical research and healthcare worldwide into the age of genomic and translational medicine through the informatics systems developed by the NLM. Lindberg opened free access and worldwide public dissemination of all the NLM's biomedical literature and databases, thus helping transform not only biomedical research like the Human Genome Project and its successors, but also the practices of medicine and healthcare internationally. Guiding, leading, and teaching-by-example at national, regional, and global levels of biomedical and healthcare informatics, Lindberg helped coalesce a dynamic discipline that provides a foundation for the human understanding which promotes the future health of our world. Objectives: To provide historical insight into the scientific, technological, and practical clinical accomplishments of Donald Lindberg, and to describe how this led to contributions in the worldwide interdisciplinary evolution of informatics, and its impact on the biosciences and practices of medicine, nursing, and other healthcare-related disciplines. Methods: Review and comment on the publications, scientific contributions, and leadership of Donald Lindberg in the evolution of biomedical and health informatics which anticipate the vision, scholarship, research in the field, and represent the deeply ethical humanism he exhibited throughout his life. These were essential in producing the informatics systems, such as the Unified Medical Language System (UMLS), MEDLINE, PubMed, PubMed Central, and ClinicalTrials.gov , which, together with NLM training programs and conferences, made possible the interactions among researchers and practitioners leading to the past quarter-century of rapid and dramatic advances in biomedical scientific inquiry and clinical discoveries, openly shared across the globe. Conclusion: Dr. Lindberg was a uniquely talented physician and pioneering researcher in biomedical and health informatics. As the main leader in developing and funding innovative informatics research for more than 30 years as Director of the National Library of Medicine, he helped bring together the most creative interdisciplinary researchers to bridge the worlds of biomedical research, education, and clinical practice. Lindberg's emphasis on open-access to the biomedical literature through publicly shared computer-mediated methods of search and inquiry are seen as an example of ethical scientific openness.

Consumer- and patient-oriented informatics innovation: continuing the legacy of Warner V. Slack

Consumer- and patient-oriented informatics innovation: continuing the legacy of Warner V. Slack

About iSTEMIA – Innovation in Science, Technology, Engineering, Mathematics, Informatics and Arts

Then involvement is essential. You cannot stand aside as a member of a community. The real involvement presupposes first a connection at the level of understanding the phenomenon, an empathic relationship with the studied phenomena and processes, relationship that generate intuitions, leaps in understanding and knowledge, discoveries, revelations. The paper is based on the idea that information technology and communications today generate a global interaction based on a complex computer network, which forms a sphere that covers the planet, assimilated with a global intelligence, to which we can consciously adhere becoming a synapse. a global neural network.