The flow of third-grade nanofluid over a stretched surface is analyzed with a particular focus on the transport of heat due to melting by taking into account both homogeneous and heterogeneous reactions. To account for various effects, the energy equation incorporating viscous dissipation, Joule heating and radiation is considered, as well as the influence of thermophoresis and Brownian motion. A similarity transformation is used to simplify the expressions such that the model is analyzable. Utilizing the homotopic technique, series solutions are obtained, and a convergence result is established. Our investigation based on this series solution explores the impact of different factors on the flow model, and demonstrates that increasing the melting parameter leads to a decrease in temperature, entropy rate and concentration, while to an increase in velocity.