Influence Of Tobacco Smoking Research Articles

The influence of tobacco smoking on the outcomes achieved by root coverage procedures: An updated systematic review.

This updated version of a systematic review (SR) originally published in 2009 evaluated the effect of smoking on the clinical outcomes achieved with root coverage (RC) procedures in the treatment of gingival recession (GR) defects. This SR includes randomized controlled trials, controlled clinical trials, and case series with a minimum follow-up of 6 months. Eligible studies involved GR defects without interproximal tissue loss submitted to RC procedures, as well as outcome measures from smokers (i.e., those smoking 10 or more cigarettes per day at baseline) and nonsmokers, recorded separately. Three electronic databases were searched up to March 31, 2024. Random effects meta-analyses were conducted thoroughly. A total of 12 studies reporting on 181 smokers and 162 nonsmokers, submitted to different RC procedures, were included. Half of these trials were originally included in the 2009 SR, whereas the other half (six studies) were included in this update. Nonsmokers experienced greater reductions in GR and gains in clinical attachment level compared to smokers. Pooled estimates comparing smokers and nonsmokers who received coronally advanced flap (CAF) alone and subepithelial connective tissue graft (SCTG) + CAF showed that nonsmokers achieved greater mean root coverage (MRC) in both treatments. Significant differences in MRC of 10.85% (95% CI, 1.92 to 19.77) and 22.04 (95% CI, 14.25 to 29.83), favoring nonsmokers, were identified for CAF and SCTG + CAF, respectively. Similarly, nonsmokers treated with SCTG + CAF displayed superior number of sites exhibiting complete root coverage (CRF) when compared with smokers (risk ratio, 4.12; 95% CI, 1.73 to 9.80). Smoking negatively impacts the outcomes of RC procedures, particularly those achieved by SCTG-based procedures. Smoking was linked to poorer RC outcomes. These outcomes highlight the critical need to integrate smoking cessation into periodontal treatment plans.

Abstract 1251: Tobacco smoke alters the adaptive landscape of lung adenocarcinoma and influences the strength of epistatic interactions

Abstract Tobacco smoke produces both mutagenic and physiological effects, altering the mutation rate of cells and the selection acting on them in the damaged lung environment, and facilitating its role in driving cancer progression. In addition to these gene-by-environment interactions, gene-by-gene epistatic interactions also shape the adaptive landscape, influencing the evolutionary trajectories of cancer. Understanding the influence of tobacco smoke on the epistatic trajectories of lung cancer progression would help guide the development of targeted therapies that are more effective for smoker or never-smoker populations. To address this need, we constructed a continuous-time Markov chain model for the evolutionary trajectories of lung adenocarcinoma (LUAD), the most common subtype of lung cancer and the most frequent subtype among never-smokers. Using thousands of tumor sample sequences aggregated across studies, we profiled the trajectories of LUAD in smokers and never-smokers and estimated the rates at which mutations are gained from each possible set of pre-existing mutations, or genetic states. We then accounted for differences in baseline mutation rates to quantify the selective benefit of mutations. We find that epistasis is prevalent in LUAD, with several strong synergistic interactions—such as between RB1 and EGFR mutations- and antagonistic interactions-such as between EGFR and KEAP1 or KRAS mutations. Additionally, we identify non-additive epistatic effects: STK11 mutations are synergistic with KEAP1 and KRAS mutations but do not experience additional selection when both are mutated. In contrast, GNAS mutations are not synergistic with KEAP1 or RBM10 mutations alone but are synergistic with their co-mutation. Smoking has a large influence on the adaptive landscape, with several common mutations being preferentially selected in never-smoker cancers, including EGFR, SMAD4, GNAS, and PIK3CA mutations. KEAP1, STK11, and KRAS mutations are preferentially selected in smoker cancers. Smoking’s physiological influence also affects the strength of certain epistatic interactions, such as between STK11 and KEAP1 mutations. Overall, we find that smoking not only increases the mutation rate of lung cells but also substantially alters the adaptive landscape of lung adenocarcinoma, leading to clinically relevant differences in selection on mutations between smoker and never-smoker cancers. We additionally detect frequent pairwise and higher-order epistatic effects in LUAD that may inform the personalized application of targeted therapies. Citation Format: Krishna Dasari, Jorge Alfaro-Murillo, Jeffrey Townsend. Tobacco smoke alters the adaptive landscape of lung adenocarcinoma and influences the strength of epistatic interactions [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1251.

Cigarette smoke and intestinal microbiota - what do we know?

The gut microbiota is a unique structure that is normally in an equilibrium state and performs a huge number of diverse functions. Cigarette smoke modifies the intestinal microbiota through a variety of mechanisms and affects the work of enzymes associated with oxidative stress, the mucin layer and the expression of proteins of dense contacts of the intestinal mucosa, the balance of acids and bases in the colon. And this is in addition to the direct toxic effects of many components of tobacco smoke and the spread of bacteria directly from cigarettes. The article examines the data of modern literature on the complex and ambiguous mechanisms of the influence of tobacco smoke and its individual components on the gut microbiota.

Influence of tobacco smoking on the functional state of the vascular endothelium in young people

The present article investigates the effect of tobacco smoking on the functional state of the vascular endothelium in healthy young people without other risk factors for coronary heart disease and arterial hypertension. Based on the analysis of the results obtained by rheoplethysmography, the endothelium-dependent and endothelium-independent responses according to Celermajer D.S.(1992) were studied. The increase in pulse blood flow to reactive hyperemia in students - smokers and non- smokers was analyzed. It was found that tobacco smoking has an adverse effect on the functional state of the vascular endothelium, namely endothelium-dependent vasodilation, which may further be a trigger for the development of a number of diseases of the cardiovascular system.

Sex and age disparities in the influence of tobacco smoking on depression: Evidence from the Taiwan Biobank.

The global tobacco epidemic poses a notable challenge to global health due to its association with various tobacco-related diseases. Although tobacco smoking is associated with depression, the exact mechanism by which tobacco smoking increases the risk of depression is unclear. This study explored the potential effects of tobacco smoking on depression. We used data in the analysis from the Taiwan Biobank of 27916 individuals recruited from 2015 to 2020. To investigate the associations between tobacco use and depression, the results of the depression-measuring subscale of the Patient Health Questionnaire-4 as well as data on participants' tobacco consumption and other relevant covariates, were analyzed. Participants who smoked were more likely to report depression than those who did not smoke (AOR=1.50; 95% CI: 1.21-1.86). Furthermore, depression was significantly higher in women who smoked than in their male counterparts (females: AOR=1.68; 95% CI: 1.27-2.23, and males: AOR=1.32; 95% CI: 0.96-1.80). Women aged <55 years and who smoked were more likely to report depression, whereas this trend was not observed in those aged ≥55 years (<55 years: AOR=1.75; 95% CI: 1.23-2.48), and ≥55 years: AOR=1.58; 95% CI: 0.97-2.56). Tobacco smoking is a significant factor associated with depression, particularly in younger women. The increasing prevalence of tobacco use for years among younger women in Taiwan might contribute to shifts in the associations between depression and tobacco use in women.

Risk factors for the development of bronchopulmonary pathology in workers producing synthetic polyacrylonitrile fiber

Aim of the study was to assess the risk of bronchopulmonary pathology in workers of the production of synthetic polyacrylonitrile fiber as a result of exposure to harmful chemicals and smoking tobacco products . Material and methods . During the periodic medical examination , the function of external respiration and adherence to smoking in 137 employees were studied , medical records were analyzed (025/u accounting form ). Hygienic assessment of working conditions was carried out on the basis of the results of in-situ sanitary and hygienic studies . Results and discussions . As a result of a hygienic assessment of working conditions , it was found that workers engaged in the production of polyacrylonitrile fiber are subject to the combined intermittent effects of harmful chemicals of hazard classes 1–3 ( acrylonitrile , methyl acrylate , hydrocyanide , ammonia , sodium rhodanide , sulfuric acid , methanol , isopropyl alcohol , ethylene glycol ), the content of which in the working area exceeded the maximum permissible concentrations in 1.6% of samples . The occupational risk of developing bronchopulmonary diseases in groups of workers who smoke is assessed as unacceptably high , while in people exposed to harmful chemicals , its level is 28.46 times higher than in people who are not exposed to these effects . The risk of the formation of ventilation disorders in groups of smoking workers is unacceptably high , while its level is 2.46 times higher in workers exposed to harmful chemicals than in non-workers in such conditions . In groups of workers exposed to harmful chemicals , the occupational risk of obstructive disorders is unacceptably high , in the group of smokers the risk is 2.32 times higher . Conclusions . Among the employees of the enterprise producing synthetic polyacrylonitrile fiber , the influence of tobacco smoking on the development of bronchopulmonary pathology is higher than the influence of harmful working conditions , and the use of smoking tobacco products significantly increases the negative effect of chemical pollutants .

Influence of tobacco smoking on the functional state of the male cardiovascular system

The paper presents the data on functional state of the male cardiovascular system, depending on the period of tobacco smoking. The analysis of the research results shows that tobacco smoking leads to a significant increase in heart rate, blood pressure, pulsatility, average dynamic arterial pressure, minute blood volume, and circulatory efficiency ratio. Gradually increasing, the heart rate reached a maximum value of 86.6 (P &lt;0.001) beats per minute in the group with over 20 years of smoking, while in the control group it was 73.2.The highest level of systolic and diastolic blood pressure was 138.7 (P&lt;0.001) and 88.8 (P&lt;0.001) mm Hg. in the group of smokers with the smoking experience of more than 20 years, while in non-smokers the indicators were 114.1 and 73.9, respectively. The maximum level of pulsatility was 49.9 (P&lt;0.001) and that of average dynamic arterial pressure — 109.8 (P&lt;0.001) mm Hg., identified in the group of smokers with over 20 years of smoking, while the initial levels were 40.2 and 90.8, respectively. The range of systolic blood volume between the groups was 4.3 ml. Minute blood volume in groups of men under 20 years and over increased to 4.11 (P &lt;0.01) and 4.06 (P &lt;0.02) l/min, while in the group of non-smokers it accounted for 3.69. The increase in the duration of tobacco smoking led to a slight increase in peripheral resistance. As the smoking period lengthens, the circulatory efficiency value undergoes a gradual increase, reaching a maximum value of 4,323 (P &lt;0.001) in the group with over 20 years of smoking, while in the control group it was 1,898. The difference between the maximum and minimum circulatory efficiency values between the experimental male groups was 1.3.

PREVALENCE AND ASSOCIATED FACTORS OF TOBACCO SMOKING EXPOSURE AMONG YOUTHS IN SOUTHEAST ASIA: EVIDENCE BASED ON GLOBAL YOUTH TOBACCO SURVEY

Tobacco smoking (TS) is a leading preventable cause of death internationally. The young generation is getting addicted to smoking rapidly which is alarming for the future generation. It is essential to increase awareness about exposure to TS in the environment (TSE) among youths in Southeast Asia. This study targets to obtain a reliable prevalence and associated factors of TSE among youths in Southeast Asia, as well as, to identify the major influencing factors for smoking. The Global Youth Tobacco Study (GYTS), a nationwide representative cross-sectional survey based on school-going adolescents of tobacco consumption and underlying factors among youths was examined in this study. Datasets from Bangladesh (2013), Indonesia (2019), and Thailand (2015) representing Southeast Asia were selected to analyze the prevalence of exposure to TSE. Predictors namely fundamental features, smoking at home, enclosed public spaces and other public locations, lessons about the influence of TS in class, etc. were found associated with TS. Tobacco use among adolescents is substantially associated with their social environment (at home and public locations). In Bangladesh, Indonesia, and Thailand, correspondingly 33%, 44.5% and 39.1% of participants were exposed to TS at home. In Bangladesh, for example, exposure to TS at home was a strong predictor of adolescent TS (OR=3.64; 95% CI=2.53-5.21); in Indonesia, (OR=0.42; 95% CI=0.38-0.48); and in Thailand, (OR=0.58; 95% CI=0.45-0.74). Similarly, adolescents who were aware of their exposure to TS were less likely to smoke. TS use prevention among school-going adolescents should be every government's top goal to reduce tobacco consumption to get a healthy generation.

Tobacco smoke exposure and mitochondrial DNA copy number on neurobehavioural performance: A community study.

The influence of tobacco smoke has been a controversial and very questionable subject within the field of neurological behaviours. To examine the dose-response relationships between tobacco smoke and neurological performance, we investigated whether mitochondrial DNA copy number (mtDNAcn) mediates these relationships. We used restricted cubic spline models to estimate the dose-response relationships. A mediation model was also used to detect the mediating effect. Increased cotinine was negatively associated with auditory memory scores and a 0.51 decrease in mtDNAcn. MtDNAcn acts as a mediator between cotinine and auditory memory. Tobacco smoke levels were inversely associated with mtDNAcn and neurobehavioural changes, and there was a mediation effect between cotinine levels and auditory memory by mtDNAcn.

Microalgae as a Natural CO2 Sequester: A Study on Effect of Tobacco Smoke on Two Microalgae Biochemical Responses

Microalgae are known as the most efficient biological sequesters of carbon dioxide (CO2). Recently, they have been exploited to enhance air quality by decreasing CO2 levels and increasing oxygen (O2) concentrations. However, in public places, there are sources of toxic chemicals such as tobacco smoke that may affect the growth of microalgae. For the first time, the current study explores the influence of tobacco smoke on the cell growth, biodiesel characteristics, and biochemical composition of two strains of model microalgae. Chlamydomonas strains were treated with tobacco smoke in a sealed box for 7 days, wherein every 1 h, one cigarette was burnt. Upon exposure of microalgae to tobacco smoke, the specific growth rate (μmax) was unaffected in CHL-2220 and remained around 0.500 days−1, whereas in CHL-2221, it decreased notably from 0.445 days−1 to 0.376 days−1. In the CHL-2221, the lipid level considerably reduced from 15.55 %DW to 13.37 %DW upon exposure to tobacco smoke. In both strains, palmitic acid was the main constituent of saturated fatty acids (SFAs) that displayed significant (p &amp;lt; 0.05) decreases in response to tobacco smoke exposure. In CHL-2221, oleic acid (C18:1) presented a substantial increase from 7.64 to 17.09% in response to tobacco smoke. Moreover, exposure of CHL-2220 to tobacco smoke decreased the cetane number (CN) from 30.34 to 25.28, while in CHL-2221, it increased from 26.07 to 29.73 upon treatment. Both strains demonstrated low-quality biodiesel to be used as feedstock. Conversely, their fatty acid profile revealed their promising use as nutrient food.

Influence of tobacco smoking on the development of halitosis

BackgroundHalitosis is the general term used to describe any disagreeable odor in exhaled air, regardless of whether the odorous substances originate from oral or non-oral sources. Previous research has strongly associated tobacco smoking in the development of halitosis, as it increases the synthesis of toxic volatile sulfur compounds in diseased periodontal pockets. In this review, we summarize the etiopathology and epidemiology of halitosis as well as the current evidence on the impact of smoking by means of a meta-analysis. MethodsPubMed and Embase were searched to identify publications that reported halitosis in smokers and nonsmokers. Meta-analyses were performed if a sufficient number (n ≥ 3) of articles were available that evaluated the same outcome. ResultsThe meta-analyses showed that there was an increased risk of halitosis in current smokers versus nonsmokers (odds ratios). These results were consistent both in fixed and random effects models. Even though the interstudy heterogeneity was high (I2 = 91%), sensitivity analysis by limiting the number of studies yielded similar results, with no-to-moderate heterogeneity (I2 = 0–65%). The analysis comparing ever smokers with never smokers showed no significant difference in the risk of halitosis in ever smokers. The same effect was observed when upon stratifying the analyses on the basis of ascertainment of halitosis (self-reported or measured by a Halimeter). ConclusionsHalitosis is a common condition which can affect the quality of life of those affected. The results from this literature review and meta-analysis show that current smokers are more likely to suffer from halitosis, even if they are less likely to report it.

Tobacco smoking in non-psychotic patients with suicidal ideation

IntroductionTobacco smoking (TS) is a major public health concern worldwide because of its association with a number of unfavorable health-related outcomes. According to recent studies TS negatively affects both physical and mental health. Suicidal ideation (SI) is more prevalent in people with mental disorders than in the general population. Factors associated with the transition from SI to suicide attempt (SA) should be detected to prevent suicide in this high-risk population.ObjectivesThe aim of the study is to evaluate the influence of tobacco smoking on risk of lifetime suicide plan (SP), SA and nonsuicidal self-injury (NSSI) in patients with nonpsychotic mental disorders (NPMD) and SI.MethodsFour hundred and 78 consecutive patients with NPMD and SI were included into the study. All patients were evaluated by a psychiatrist, underwent Self-Injurious Thoughts and Behavior Interview as well as semi-structured interview designed to gather information on demographic and biographical features. Mann-Whitney, Fishers exact test, chi-square test and stepwise logistic regression were used as statistical methods.ResultsThree hundred and 24 (67.8%) patients have smoked at least 100 cigarettes in their entire life. No differences were found between smokers and non-smokers in terms of age, gender, educational and occupational statuses as well as age at onset of self-injurious thoughts and behavior, and total number of SP, SA and NSSI (all: p&gt;0.05). The lifetime smokers were at higher risk of SA (OR=2.379; 95% CI 1.58-3.581: p&lt;0.001) and NSSI (OR=1.591; 95% CI 1.064-2.38: p=0.024).ConclusionsLifetime smoking in patients with NPMD and SI is associated with SA and NSSI.

Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2.

The aim of this current study was to investigate the influence of tobacco smoke on sperm quality determined by standard parameters, on sperm DNA maturity tested by chromomycin A3 (CMA3) staining, on sperm DNA fragmentation tested by TUNEL assay and on the transcript level of sperm nuclear proteins H2BFWT, PRM1, PRM2, TNP1 and TNP2 genes quantified by RT-PCR. One hundred forty-one (141) sperm samples (43 nonsmokers (G.1) and 98 heavy smokers (G.2)) of couples undergoing ICSI were enrolled in this study. In G2, a significant decrease in standard semen parameters in comparison with nonsmokers was shown (p<.01). In contrast, protamine deficiency (CMA3 positivity) and sperm DNA fragmentation (sDF) were significantly higher in G2 than in G1 (p<.01). Furthermore, the studied genes were differentially expressed (p<.01), down-regulated in the spermatozoa of G.2 compared to that of G.1 (fold change <0.5) and were significantly correlated between each other (p<.01). Moreover, in comparison with G1, the protamine mRNA ratio in G2 was significantly higher (p<.01). It can therefore be concluded that smoking alters mRNA expression levels of H2BFWT, TNP1, TNP2, PRM1 and PRM2 genes and the protamine mRNA ratio and consequently alters normal sperm function.

The Influence of Motives and Significant others in Adolescent Tobacco Smoking: Evidence from a Survey of Secondary School Adolescents in Dar es Salaam

This study explored the psychosocial influence of tobacco smoking among secondary school adolescents in Ilala district, Dar es Salam region. Specifically, the study sought to explore the influence of significant others and motives on tobacco smoking among secondary school adolescents. A cross-sectional survey was conducted among 400 secondary school adolescents aged between 12 and 22. The findings revealed that the major motive that drives adolescents to smoke tobacco was experimentation. Other motives include; the desire to reduce frustration, pleasure, persuaded to smoke, a way of solving problem, and the habit of being sent to light up cigarette. It was further revealed that smoking cigarette as a way of keeping busy had little influence on secondary schools’ adolescents in Ilala district while the influence of close friends and brothers made a strong contribution to secondary school adolescents in Ilala district to smoke tobacco. Significant others like sister, mother and father were found to have little influence on secondary schools’ adolescents’ tobacco smoking behavior.Based on the findings of this study, it is recommended that factors such as motives and the influence of significant others need to be taken into account when considering psycho-educational intervention programs to preventing smoking.

Vitamin D Receptor Gene Polymorphisms and Cigarette Smoking Impact on Oral Health: A Case-Control Study.

Periodontal diseases are multiperspective problems resulting from numerous and diverse exposures that influence the process of initiation or progression of disease. The negative influence of tobacco smoking on oral health is well documented. The aim of the study was to analyze three SNPs in vitamin D receptor gene—rs7975232 (ApaI), rs2228570 (FokI) and rs1544410 (BsmI)—combined with oral health assessment—pH, gingival index, dry mouth, periodontitis, dry socket, redness of oral cavity mucosa, leukoplakia—in a group of cigarette smokers and in non-smokers. Moreover, the possibility of interactions between these polymorphisms and smoking was examined. When comparing the smokers and non-smokers groups, we noticed that rs1544410 heterozygotes were significantly more frequent in the first group, and for the second, both homozygotes were more frequent. Additionally, we observed the impact of interaction between the rs7975232 genotype and smoking status on gingival index. Current smoking was also associated with all analyzed oral health measures except for leucoplakia. Correlation between pH and age in both smokers and non-smokers was also present. Results of our analysis indicate that in our study group lifestyle and aging were leading factors associated with worse oral health status. However, the impact of genetic variants, and also the impact of their interaction with smoking on analyzed parameters was also visible. These results show great possibilities for all levels of prevention of oral diseases by means of education based on evidence-based medicine, but also for incorporating genetic testing and early interventions into this process for predisposed individuals.

Influence of tobacco Smoking on obstetric history of women during pregnancy

The article presents the results of the relationship of Smoking in women with a history of obstetric (OAA). The study is based on the results of a survey of 107 smokers and 136 non-Smoking women observed in the antenatal clinic for pregnancy. The study found an increase in the number of miscarriages and abortions in Smoking women compared to non-smokers. Detection of Smoking women of fertile age when attached to outpatient clinics, active detection of Smoking pregnant women, as well as Smoking relatives in the family, carrying out measures to reduce Smoking significantly reduce the likelihood of having children with chronic pathology.

Influence of Tobacco Smoking on Perioperative Risk of Venous Thromboembolism.

Venous thromboembolism (VTE) is generally considered a process very different from arterial atherosclerosis. The role of tobacco is well known in arterial thrombosis. However, its role in VTE is less obvious and remains controversial. In this mini review, we analysed the literature to identify the role of active or passive smoking in perioperative VTE and the relationship between arterial atherosclerosis and VTE. We carried an Internet search in French and English including the following keywords: deep vein thrombosis, tobacco, cigarette smoking, pulmonary embolism, postoperative, postoperative, atherosclerosis. Regarding the relationship between tobacco and VTE, a total of 9 studies were identified. Studies were ranked by the risk of VTE in relation to active or passive smoking. In conclusion, the management of smoking during the perioperative period for a short-term arrest (minimum 4–8 weeks before the intervention), or long term, allows among others a reduction of arterial or venous thrombotic events. However, it is clear that the training of anaesthesiologists in the management of smoking will contribute to the reduction of this public health problem.

Influence of tobacco smoking on COVID-19 incidence and outcome

An analysis of studies of the effects of cigarette con-sumption on morbidity, severity and mortality in coro-navirus infection COVID-19. In MERS-CoV coronavi-rus disease outbreak, tobacco smoking increased the MERS-CoV infection risk and was associated with higher mortality. Studies of patients with COVID-19 show that smokers had a more severe course and adverse out-comes of COVID-19 compared with non-smokers. In par-ticular, smokers (compared with non-smokers) 1.4 times (OR 1.4; 95% CI 0.98–2.00) were more likely to have se-vere COVID-19, they were 2.4 times more likely (OR 2.4; 95% CI 1.43-4.04) required intensive care, mechanical ventilation. Factors associated with the deterioration of COVID-19 were identified, in particular, the history of smoking, body temperature of more than 37.3 °C at the time of admission, respiratory failure and age over 60, while the risks of an adverse outcome in smokers were highest compared to other factors. A meta- analysis in-cluding 7 studies showed that smokers have higher risk of severe COVID-19 compared to non-smokers (OR 1.98; 95% CI 1.29–3.05). Conclusion. Smoking cessation can reduce the risk of developing severe COVID-19 and its complications.

Табакокурение и репродуктивное здоровье: опрос студентов медицинского вуза

Табакокурение и репродуктивное здоровье: опрос студентов медицинского вуза

Tobacco smoking is an independent factor associated with retinal damage in systemic lupus erythematosus: a cross-sectional and retrospective study.

To analyze the influence of tobacco smoking on systemic lupus erythematosus (SLE) clinical features and damage. Cross-sectional and retrospective, case-control study comparing SLE patients with and without tobacco exposure. Cumulative clinical data and comorbidities were collected, and severity (Katz index) and damage (SLICC/ACR damage index) (SDI) indices were calculated. Pack-years (PY) was used to estimate lifetime tobacco exposure. A logistic regression was carried out to explore the impact of tobacco use on retinal damage. 216 patients were included. The mean age was 49years (± 12.7), 93% were females, and median disease duration was 17years [interquartile range (IQR):9-25]. Fifty-three percent of patients were smokers at some point. The median PY was 13 (IQR: 6-20.5). Only 54.8% of active smokers recalled having been informed of the negative effects of smoking, versus 83.3% of never smokers (< 0.001). In a bivariant analysis, an association between tobacco use at any time and discoid lupus [OR: 3.5(95%CI 1.5-8.9); p = 0.002] photosensitivity [OR: 2.06(95%CI 1.16-3.7); p = 0.01] and peripheral arteriopathy (p = 0.007) was found. Considering SDI item by item, a significant association with retinal damage, adjusted for age [OR: 1.03(95%CI 1-1.07); p = 0.04], was found. Using PYs, an association was found with discoid lupus (p = 0.01), photosensitivity (p = 0.03) and peripheral arteriopathy (p = 0.01), global SDI > 0 (p = 0.002) and retinal damage (p = 0.02). In a multivariate analysis exploring factors associated with retinal damage, any previous smoking history and SDI remained associated with retinal damage. Tobacco smoking is associated with cutaneous manifestations and damage and is an independent predictor of retinal damage in SLE patients.