Introduction The various changes that have occurred in recent decades have directly affected the health of workers, especially the psychosocial risks that cause physical or psychological illness. Psychosocial risk factors are important in the health care process, including how work is organized, time arrangements are determined, social relationships occur, and content and workload are structured, in terms of mental and social demands for each worker. Objective Verify the influence of work organization on the psychosocial risks of workers. Methodology A systematic review of the literature was performed using Methodi Ordinatio, which allowed the ranking of relevant works on the subject. Thirteen papers were selected for an in-depth analysis. Results The rate of mental and behavioral disorders is higher, respectively, in the Brazilian states of Rio Grande do Norte, Minas Gerais, Pernambuco, Rio de Janeiro, Distrito Federal, Santa Catarina, Rio Grande do Sul, Bahia, São Paulo and Paraná; with public administration workers being the most affected. It was demonstrated that the main causes of psychosocial risks are related to the working day (long hours and intense work rhythm), followed by lack of resources and problems of interpersonal relationships. Discussion and conclusion Measures to prevent psychosocial risks will depend on the situation with which the risk is associated, and organizational intervention in the prevention and management of these risks is of great importance. KEYWORDS: Ergonomics, Psychosocial, Occupational Medicine, Occupational Health, Safety at Work.