Abstract Many scholars performed the analysis by using the non-Newtonian fluids based on the nano and hybrid nano particles in blood arteries to investigate the heat transport for cure in several diseases. These performances are presented to investigate the blood flow behaviour with extended form of the novel tetra hybrid Das and Tiwari nanofluid system attached by the Carreau fluid. The assessment of energy transport has been achieved based on the thermal radiation, heat source/sink, Joule heating, and viscous dissipation. The obtained partial differential equation from physical problem is transformed into ordinary differential equations (ODEs) by using the similarity variables. Furthermore, system of nonlinear ODEs attached with boundary conditions are transported into the system of first-order ODEs with initial conditions. For the numerical solution of obtained ODEs, the numerical solutions have been performed based on the RK method. The numerical results are plotted through figures, tables, and statistical graphs. Magnetic forces and inclined magnetic effects are caused to reduce velocity of blood. Temperature of blood within the arteries is increased by increasing the parameter of thermal radiation.