Infiltration Behavior Research Articles

Surgical management of conventional ameloblastoma: a retrospective cohort study over the past 21 years.

Conventional ameloblastoma presents infiltrative behavior and its treatment ranges from enucleation combined with adjuvant therapies to marginal/segmental resection. The purpose of this study is to present a cohort of twenty-four patients with ameloblastoma treated in the same institution after marginal/segmental resection for the past 21 years. All cases had diagnosis confirmation by incisional biopsy. Patients with an unconfirmed diagnosis and missing follow-up information were excluded. Data were categorized into clinicopathological, surgical and recurrence aspects. Thirteen patients were females (54%). The mean age was 40.2 years. Mandible was the most affected site (91%). The mean length of the lesions was 4.10cm (± 2.06) and the multilocular aspect was predominant (83%). Root resorption (37.5%), tooth displacement (45.8%) and cortical perforation (45.8%) were noticed. Histologically, most of the cases were follicular (n = 19,79%). Microscopic analysis showed positive margins in four cases. Patients were treated by marginal (n = 19) and segmental (n = 5) resections. Recurrence occurred in two cases (8.33%). Both primary and recurrent ameloblastomas were treated through marginal resections and no recurrence was observed during the past 9 and 5 years after the last intervention, respectively. The overall mean follow-up was 79.25 months and patients are still monitored over these years. Marginal/segmental resection of conventional ameloblastoma is associated with a low recurrence rate.

Numerical Simulations of a Permeability Test on Non-Cohesive Soil Under an Increasing Water Level

With the intensification of global climate change, extreme rainfall events are occurring more frequently. Continuous rainfall causes the debris flow gully to collect a large amount of rainwater. Under the continuous increase in the water level, the water flow has enough power to carry plenty of loose solids, thus causing debris flow disasters. The intensity of the soil is reduced with the infiltration of rainwater, which is one of the key causes of the disaster. The rise in the water level affects the infiltration behavior. There have been few previous studies on infiltration under variable head. In order to understand the infiltration behavior of soils under the action of water level rises, this paper conducted an indoor permeability test on non-cohesive soil under the condition of an increasing water level. A numerical model was established using the finite element analysis software, Abaqus 6.14, and the pore pressure was increased intermittently to simulate the intermittent increase in the water level. Thereafter, the permeability coefficient and seepage length were changed to interpret the changes in the flow velocity and rate in the permeability test of the non-cohesive soil. The results showed that the finite element numerical simulation method could not reflect the particle movement process in the soil. The test could better reflect the through passage and void plugging phenomenon in soil; when the permeability coefficient alone changed, the velocity of the measuring point with higher velocity changed more violently with the permeability coefficient; when the length of soil seepage diameter was uniformly shortened, the velocity of water flow increased faster and faster.

Chronic hearing loss turns out being a calcified chondroid mesenchymal neoplasm with FN1::FGFR2 fusion.

A 53 year old female presented with a six-year history of right-sided slow deterioration in hearing and a feeling of pressure in the right ear. The patient had not experienced any pain but reported some paresthesia of the right half of the tongue, whereas no further other cranial nerve deficits were evident. The otoscopy was unremarkable as well as the rest of the clinical ENT examination except for a slight asymptomatic swelling of the right cheek. Imaging findings showed an expansive tumor infiltrating and destroying the right lateral skull base. The tumor was partially composed of cystic/regressive lesions with high contrast media uptake. The tumor had high-signal intensity with water-sensitive sequences (T2w) and was hypointense on T1w images. We performed a tumor resection via a transparotideal-infratemporal approach. Histologically, the tumor was composed of granular variably calcified chondroid matrix with extensive regressive changes and granulation-like tissue reaction associated with calcinosis and crystal deposition. Molecular analysis of the tumor via the TruSight- RNA-Fusion panel detected a fusion involving FN1::FGFR2, consistent with "calcified chondroid mesenchymal neoplasm" (CCMN), a rare tumor entity recently defined by Liu et al 2021. In regular follow-up care no residual tumor has been detected in imaging studies (MRI and CT) within 2 years and 4 months. The biology and consequently the radio sensitivity cannot be defined precisely since long term results are missing due to the first description of this entity in 2021. As a consequence, surgical resection is recommended as the treatment of choice. Thorough clinical and radiological follow-up is mandatory as local recurrences are to be expected due to the infiltrative behavior. In case of a loco regional recurrence the fusion with FGFR2 may represent a therapeutic option for a targeted therapy on molecular level.

The effect of particle size, meteorological parameters, and building airtightness on particulate matters infiltration

Introduction: The present study analyzed the infiltration behavior of size- fractionated particles and the influencing parameters. Materials and methods: The studies were carried out in two apartments under varying conditions of airtightness, utilizing real-time surveillance of Particulate Matters (PM0.3, PM1.0, PM2.5, PM10), along with air exchange rates and meteorological factors. The seasonal variations of the indoor dissemination of particulate matters have been also discussed. Results: The analysis of correlations indicated a strong dependency of indoor Particulate Matter (PM) concentrations on outdoor levels. However, the penetration patterns varied across different particle sizes. The highest contribution to outdoor PM10 was observed for PM 2.5-10 while indoors, the predominant particle size was among the finer categories, PM0.3-1.0. Moreover, window air-tightening appeared to decrease the overall effective leakage area of the building envelope, which in turn slightly lowered the ratio of indoor to outdoor PMs as well as the infiltrability for particles of all sizes. However, this intervention did not alter the distribution of particles within indoor environments.The most penetrated particles were observed in the size range 0.3-1.0 µm and then PM<0.3 µm, and the least in the size range 2.5-10 µm. Conclusion: Particle dimensions and external sources primarily influenced the degree of particle infiltration, significantly overshading the impact of weather-related factors. The relationship between indoor and outdoor particulate matter was diminished by the airtightness of windows, particularly for larger particles. No notable difference was observed in the infiltrability and indoor distribution of particles of varying sizes between the winter and fall seasons.

Advanced imaging reveals enhanced malignancy in glioblastomas involving the subventricular zone: evidence of increased infiltrative growth and perfusion.

Glioblastoma's infiltrative growth and heterogeneity are influenced by neural, molecular, genetic, and immunological factors, with the precise origin of these tumors remaining elusive. Neurogenic zones might serve as the tumor stem cells' nest, with tumors in contact with these zones exhibiting worse outcomes and more aggressive growth patterns. This study aimed to determine if these characteristics are reflected in advanced imaging, specifically diffusion and perfusion data. In this monocentric retrospective study, 137 glioblastoma therapy-naive patients (IDH-wildtype, grade 4) with advanced preoperative MRI, including perfusion and diffusion imaging, were analyzed. Tumors and neurogenic zones were automatically segmented. Advanced imaging metrics, including cerebral blood volume (CBV) from perfusion imaging, tissue volume mask (TVM), and free water corrected fractional anisotropy (FA-FWE) from diffusion imaging, were extracted. SVZ infiltration positively correlated with CBV, indicating higher perfusion in tumors. Significant CBV differences were noted between high and low SVZ infiltration cases at specific percentiles. Negative correlation was observed with TVM and positive correlation with FA-FWE, suggesting more infiltrative tumor growth. Significant differences in TVM and FA-FWE values were found between high and low SVZ infiltration cases. Glioblastomas with SVZ infiltration exhibit distinct imaging characteristics, including higher perfusion and lower cell density per voxel, indicating a more infiltrative growth and higher vascularization. Stem cell-like characteristics in SVZ-infiltrating cells could explain the increased infiltration and aggressive behavior. Understanding these imaging and biological correlations could enhance the understanding of glioblastoma evolution.

Biomass erosion and its effect on heat carrying performance of alumina heat carrier during multiple cycle sintering in solar photothermal coupled with biomass gasification

Biomass coupled with solar photothermal gasification technology is an efficient technology using solar to provide energy by heat carrier for biomass gasification. However, the heat carrier that transferred heat to the biomass feedstock can be eroded by the effects of biomass ash, with the erosion problem worsening as the number of cycles increased. The erosion and adhesion caused by multiple sintering of corn stalk ash (CSA) to heat carrier particles (Al2O3) were investigated. K and Si elements in CSA are the main elements that erode Al2O3 particles, and their erosion depth increases with the number of sintering cycles. The erosion process of CSA on heat carriers deepens with multi-sintering, but the infiltration behavior of CSA can be fairly prevented due to the generation of high fusion minerals during erosion. The infiltration characteristics of CSA change abruptly upon contact, influencing the erosion behavior during the cyclic sintering process.

Experimental study on infiltration behavior of slurry containing excavated sand into saturated sand

Experimental study on infiltration behavior of slurry containing excavated sand into saturated sand

Preparation of MgO-MgAl2O4 refractories doped with La2O3 and the wetting permeation behavior by alkaline slag

Alkaline slags play a crucial role in modern smelting processes, underscoring the necessity for researching novel refractories and their interaction mechanisms concerning wetting and infiltration. This study investigates the influence of La2O3 doping on the wettability and infiltration behavior between MgO-MgAl2O4 refractories and alkaline slag, introducing a theoretical evaluation method. The study explored the effects of La2O3 doping on the physical properties, mechanical properties, and thermal shock resistance of the samples, as well as the interface reactions between the samples and slag. Results indicate that La2O3 doping from 0 to 3 wt% enhances sintering performance by promoting the formation of LaAlO3, thereby reducing the apparent porosity from 18.25 % to 15.01 % and increasing the bulk density from 2.85 g·cm−3 to 3.34 g·cm−3. Cold compressive strength improves from 166.24 MPa to 178.42 MPa, while the residual strength retention ratio after thermal shock rises from 86.57 % to 88.65 %. Regarding the interface reaction between slag and samples, CaO and SiO2 react with internal MgO in the samples to form low-melting compounds and high-melting solid solutions. These compounds block pores, weaken slag erosion, and enhance the slag resistance of the samples. As the La2O3 doping amount increases from 0 to 3 wt%, the contact angle between the samples and slag increases, resulting in a greater residual volume of slag and a reduced depth of the slag infiltration layer. The penetration depth of the slag gradually decreases from 102.54 μm to 47.84 μm. This study offers new strategies for optimizing the manufacturing process and selection of refractories.

Characteristics of Overburden Damage and Rainfall-Induced Disaster Mechanisms in Shallowly Buried Coal Seam Mining: A Case Study in a Gully Region

Shallow coal mining in gully regions has resulted in significant subsidence hazards and increased the risk of surface water inflow into mining panels, compromising the sustainability of surface water management and underground resource exploitation. In this study, the chain disaster process caused by shallow coal seam mining and heavy rainfall is quantitatively analyzed. The findings reveal that shallow coal seam mining leads to the formation of caved and fractured zones in the vertical direction of the overlying rock. The fractured zone can be further classified into a compression subsidence zone and a shear subsidence zone in the horizontal direction. The shear subsidence zone is responsible for generating compression and shear deformations, intercepting rainfall runoff, and potentially triggering landslides, necessitating crack landfill treatments, which are critical for promoting sustainable mining practices. The HEC-RAS program was utilized to integrate annual maximum daily rainfall data across different frequencies, enabling the establishment of a dynamic risk assessment model for barrier lakes. Numerical simulations based on unsaturated seepage theory provide insights into the infiltration and seepage behavior of rainfall in the study area, indicating a significant increase in saturation within lower gully terrain. Precipitation infiltration was found to enhance the saturation of the shallow rock mass, reducing matric suction in unsaturated areas. Finally, the disaster chain is discussed, and recommendations for managing different stages of risk are proposed. This study offers a valuable reference for the prevention and control of surface water damage under coal mining conditions in gully regions.

Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice

Molecular pathways mediating systemic inflammation entering the brain parenchyma to induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in mice during the first 6 hours of peripheral lipopolysaccharide (LPS)-evoked systemic inflammation (6 hpi), the plasma level of adenosine quickly increased and enhanced the tone of central extracellular adenosine which then provoked neuroinflammation by triggering early astrocyte reactivity. Specific ablation of astrocytic Gi protein-coupled A1 adenosine receptors (A1ARs) prevented this early reactivity and reduced the levels of inflammatory factors (e.g., CCL2, CCL5, and CXCL1) in astrocytes, thereby alleviating microglial reaction, ameliorating blood-brain barrier disruption, peripheral immune cell infiltration, neuronal dysfunction, and depression-like behaviour in the mice. Chemogenetic stimulation of Gi signaling in A1AR-deficent astrocytes at 2 and 4 hpi of LPS injection could restore neuroinflammation and depression-like behaviour, highlighting astrocytes rather than microglia as early drivers of neuroinflammation. Our results identify early astrocyte reactivity towards peripheral and central levels of adenosine as an important pathway driving SAE and highlight the potential of targeting A1ARs for therapeutic intervention.

Microplastics supply contaminants in food chain: non-negligible threat to health safety.

The occurrence of microplastics (MPs) and organic pollutants (OPs) residues is commonly observed in diverse environmental settings, where their interactions can potentially alter the behavior, availability, and toxicity of OPs, thereby posing risks to ecosystems. Herein, we particularly emphasize the potential for bioaccumulation and the biomagnification effect of MPs in the presence of OPs within the food chain. Despite the ongoing influx of novel information, there exists a dearth of data concerning the destiny and consequences of MPs in the context of food pollution. Further endeavors are imperative to unravel the destiny and repercussions of MPs/OPs within food ecosystems and processing procedures, aiming to gain a deeper understanding of the joint effect on human health and food quality. Nevertheless, the adsorption and desorption behavior of coexisting pollutants can be significantly influenced by MPs forming biofilms within real-world environments, including temperature, pH, and food constituents. A considerable portion of MPs tend to accumulate in the epidermis of vegetables and fruits, thus necessitating further research to comprehend the potential ramifications of MPs on the infiltration behavior of OPs on agricultural product surfaces.

Infiltration, runoff, and slope stability behaviors of infinite slope with macropores based on an improved Green-Ampt model

Infiltration, runoff, and slope stability behaviors of infinite slope with macropores based on an improved Green-Ampt model

Comparing, slurry infiltration characteristics between calcareous and silica sands based on slurry infiltration column tests and CT scanning

Calcareous sand, also known as bioclastic deposits, has distinct composition and morphological characteristics compared to siliceous sand. The exploration of the South China Sea has revealed a high potential for slurry pressure balanced (SPB) shield tunnelling in coastal areas that pass through calcareous sand strata. However, the impact of the differences between calcareous sand and siliceous sand on filter cake formation remains unclear. This study aimed to investigate the slurry infiltration characteristics of calcareous sand and siliceous sand (with Fujian sand as a representative) with the same permeability coefficient through micro slurry infiltration column tests. The macroscopic differences in slurry infiltration between the two media were observed. The sand columns were scanned before and after slurry infiltration using a CT scanner, allowing for the reconstruction of both the original particles’ topology and the pore network of the sand column. A pore network model was established, and the Dijkstra algorithm was used to identify the dominant particle infiltration paths, with flow resistance serving as the weight criterion for evaluating pore connectivity performance. The study found that the differences in particle topology and connectivity of the pore network were the fundamental mechanisms underlying the macroscopic slurry infiltration behaviors between different types of sands. These differences also explained the influence of particle size on the slurry infiltration characteristics for the same type of sand. The findings shed light on the fundamental mechanisms driving the differences in slurry infiltration behaviors and provide insights into the influence of particle size on slurry infiltration characteristics within the same type of sand.

Surface functionalization of binder jetted steels through super-solidus liquid phase sintering and electro-spark deposition

This study proposed a surface functionalization strategy for porous binder jet additive manufacturing (BJAM) steels. The methodology involves a sequential process of super-solidus liquid phase sintering (SLPS) followed by electro-spark deposition (ESD). SLPS with varying liquid fractions was used to modify the initial surface quality of BJAM steels, creating a range of surface roughness and bulk porosity. The ability of ESD to address substrate surface roughness and porosity variation was investigated using lower (Inconel 625) and higher (WC-Co) melting point coating materials. The results revealed a clear correlation between substrate surfaces and the surface finish, uniformity, and thickness of ESD deposits. Inconel 625, with its lower melting point, showcased an infiltration behavior and high tolerance to substrate conditions. Conversely, achieving high-quality WC-Co coating necessitated prior SLPS treatment to attain substrates with minimal roughness and sub-surface porosity. This investigation provides insights into optimizing surface modifications for porous BJAM metal parts, considering different coating materials and their compatibility with substrate conditions.

Hydromechanical analysis of slurry infiltration with coupled CFD–DEM method

AbstractThe tunnel face stability is closely related to the migration behavior and clogging mechanism of the slurry particles in granular soils, which is not yet fully understood. In this study, the coupled computational fluid dynamics–discrete element method (CFD–DEM) is adopted to investigate the infiltration behavior of slurry at the particle scale. The full Johnson–Kendall–Roberts (JKR) contact model describing interparticle behavior that accounts for cohesion present even when particles are microseparated after collisions is adopted for clay‐clay or clay‐sand particles and the Hertz–Mindlin model is used for sand‐sand particles. Through simulations, the mechanism of the slurry particle's blockage is identified as physical, frictional and cohesive modes, and slurry particle migration usually undergoes the process of aggregation‐destruction‐migration‐reassembly. Meanwhile, the influences of pressure, cohesive force, and particle shape on infiltration are also analyzed. The results indicate that high pressure lengthens the infiltration path and increases the infiltration rate. The increase in cohesion enhances the effective clogging of the sand column by the slurry, and particles with smaller sphericity are more likely to clog in the sand column. These findings may enhance our understanding of the slurry infiltration mechanism and its practical application in TBM tunneling.

Discovery of a T cell proliferation-associated regulator signature correlates with prognosis risk and immunotherapy response in bladder cancer.

The efficacy of immunotherapy is heavily influenced by T cell activity. This study aimed to examine how T cell proliferation regulators can predict the prognosis and response to immunotherapy in patients with bladder cancer (BCa). T cell proliferation-related subtypes were determined by employing the non-negative matrix factorization (NMF) algorithm that analyzed the expression patterns of T cell proliferation regulators. Subtypes were assessed for variations in prognosis, immune infiltration, and functional behaviors. Subsequently, a risk model related to T cell proliferation was created through Cox and Lasso regression analyses in the TCGA cohort and then confirmed in two GEO cohorts and an immunotherapy cohort. BCa patients were categorized into two subtypes (C1 and C2) according to the expression profiles of 31T cell proliferation-related genes (TRGs) with distinct prognoses and immune landscapes. The C2 subtype had a shorter overall survival (OS), with higher levels of M2 macrophage infiltration, and the activation of cancer-related pathways than the C1 subtype. Following this, thirteen prognosis-related genes that were involved in T cell proliferation were utilized to create the prognostic signature. The model's predictive accuracy was confirmed by analyzing both internal and external datasets. Individuals in the high-risk category experienced a poorer prognosis, increased immunosuppressive factors in the tumor microenvironment, and diminished responses to immunotherapy. Additionally, the immunotherapeutic prediction efficacy of the model was further confirmed by an immunotherapy cohort (anti-PD-L1 in the IMvigor210 cohort). Our study characterized two subtypes linked to T cell proliferation in BCa patients with distinct prognoses and tumor microenvironment (TME) patterns, providing new insights into the heterogeneity of T cell proliferation in BCa and its connection to the immune landscape. The signature has prospective clinical implications for predicting outcomes and may help physicians to select prospective responders who prioritize current immunotherapy.

High temperature infiltration behavior and reaction characteristics of Colima volcanic ashes on gadolinium zirconate coatings deposited by atmospheric plasma spraying

Volcanic ashes are considered a serious threat to the aircraft industry. At high temperatures, they inflict severe thermochemical damage to the typical 7 wt.% yttria-stabilized zirconia thermal barrier coatings that protect the aircraft turbine. There is a need to evaluate alternative materials with excellent resistance to infiltration of molten siliceous particles, such as gadolinium zirconate. In this work, free-standing thermal barrier coatings of gadolinium zirconate were manufactured by atmospheric plasma spraying, varying deposit parameters to obtain different relative densities to evaluate the infiltration of molten Colima volcanic ashes for 1 h and 10 h at 1250 °C. The infiltration depth and the reaction products resulting from each interaction, were studied by different characterization techniques. In general, the coatings show high resistance to the infiltration of the volcanic ashes, reaching infiltration depths between 50 µm and 80 µm after 10 h of infiltration time. In this sense, gadolinium zirconate coatings are excellent candidates against the infiltration of Colima volcanic ashes compared to the typical yttria-stabilized zirconia-based thermal barrier coatings.

An Experimental Investigation of the Mechanism of Hygrothermal Aging and Low-Velocity Impact Performance of Resin Matrix Composites.

Resin matrix composites (RCs) have better thermal and chemical stability, so they are widely used in engineering fields. In this study, the aging process and mechanism of two different types of resin-based three-dimensional four-way braided composites (H15 and S15) under different hygrothermal aging conditions were studied. The effect of aging behavior on the mechanical properties of RCs was also studied. Three different aging conditions were studied: Case I, 40 °C Soak; Case II, 70 °C Soak; and Case III, 70 °C-85% relative humidity (RH). It was found that the hygroscopic behavior of RCs in the process of moisture-heat aging conforms to Fick's second law. Higher temperatures and humidity lead to higher water absorption. The equilibrium hygroscopic content of H15 was 1.46% (Case II), and that of S15 was 2.51% (Case II). FT-IR revealed the different hygroscopic mechanisms of H15 and S15 in terms of aging behavior. On the whole, the infiltration behavior of water molecules is mainly exhibited in the process of wet and thermal aging. At the same time, the effect of the aging process on resin matrices was observed using SEM. It was found that the aging process led to the formation of microchannels on the substrate surface of S15, and the formation of these channels was the main reason for the better moisture absorption and lower mechanical strength of S15. At the same time, this study further found that temperature and oxygen content are the core influences on post-aging strength. The LVI experiment also showed that the structural changes and deterioration effects occurring after aging reduced the strength of the studied material.

Exérese de adenocarcinoma de cólon retal e reconstrução do ânus

Intestinal tumors in dogs, while relatively uncommon, often exhibit an infiltrative and aggressive behavior, necessitating thorough clinical staging for optimal therapeutic and surgical planning. This case report describes a canine patient with a highly aggressive neoplasm that required extensive surgical intervention. The tumor encompassed the perineal region, tail, anus, and a portion of the vagina. A 10 cm margin of the rectum, a 3 cm lateral margin, and a sentinel lymph node (iliac) were resected during surgery. Post-surgical recovery was followed by adjuvant therapy and postoperative chemotherapy.

An Enhanced Vacuum-Assisted Resin Transfer Molding Process and Its Pressure Effect on Resin Infusion Behavior and Composite Material Performance.

In this paper, an enhanced VARTM process is proposed and its pressure effect on resin infusion behavior and composite material performance is studied to reveal the control mechanism of the fiber volume fraction and void content. The molding is vacuumized during the resin injection stage while it is pressurized during the mold filling and curing stages via a VARTM pressure control system designed in this paper. Theoretical calculations and simulation methods are used to reveal the resin's in-plane, transverse, and three-dimensional flow patterns in multi-layer media. For typical thin-walled components, the infiltration behavior of resin in isotropic porous media is studied, elucidating the control mechanisms of fiber volume fraction and void content. The experiments demonstrate that the enhanced VARTM process significantly improves mold filling efficiency and composite's performance. Compared to the regular VARTM process, the panel thickness is reduced by 4% from 1.7 mm, the average tensile strength is increased by 7.3% to 760 MPa, the average flexural strength remains at approximately 720 MPa, porosity is decreased from 1.5% to below 1%, and the fiber volume fraction is increased from 55% to 62%.