PDS 75: Microbiome, infections and respiratory effects, Johan Friso Foyer, Floor 1, August 27, 2019, 1:30 PM - 3:00 PM Background/aim: From 2007 through 2010 the Netherlands experienced the largest recorded Q-fever outbreak to date. People living close to goat farms that reported an abortion storm (AS+) were identified as having higher risk to have Q-fever compared to persons living further away. Active mobility close to infected farms may have contributed to exposure to Coxiella burnetii, but no mobility data was available during the outbreak. During 2014-2016 we performed mobility measurements in the outbreak region using week-long Global Position System (GPS) tracking. The main goal of this study was to investigate whether daily active mobility near previously Q-fever positive farms (AS+ or bulk tank milk-positive (BM+)) was related to positive Q-fever serology in humans. Methods: From a cohort of 2494 participants we collected 941 GPS tracks. People were indicated as exposed when they entered specific distances around AS+ or BM+ farms: <500m, 500-1000m, 1000-2000m, 2000-4000m. We evaluated if only mobility in proximity to AS+, BM+ or negative goat farms influenced the risk of being Q-fever serology positive using logistic regression. We adjusted for a range of potential confounders and residential exposure, therefore mobility and living >4000m of a positive farm was grouped as unexposed. Results: Active mobility near AS+ farms translated to increased risks for positive Q-fever serology 1000-2000m: OR 5.7 (1.5-21.9), 2000m-4000m: OR 2.7 (1.2-6.0). Mobility near BM+ farms did not increase risks; maximum OR was 1.2 (0.5-2.8). We found a marginally increased risk for active mobility near negative farms, but this was not statistically significant OR 2.1 (0.4-10.5). Conclusions: Active mobility near AS+ goat farms represented an increased risk for positive Q-fever serology in study participants, BM+ and negative goat farms did not add significantly to Q-fever serology risk. If a C.burnetii related abortion storm occurs on a goat farm, active mobility near that farm should be restricted.