ABSTRACT What is the relationship between regional inequality and political discontent in Europe? This special issue addresses this question by studying the influence of the subnational context. Specifically, it examines the impact of unequal social conditions and economic growth on political discontent with national and international politics, as expressed in political behaviour, public opinion and policy preferences. This introduction outlines a research agenda that establishes the context of the special issue. It explains the key concepts of interest, summarises significant empirical trends, outlines explanatory models and discusses methodological challenges. In addition to establishing the research agenda that serves as the analytical framework, this introduction also presents the core findings of the special issue and discusses broader implications for future research and practice.