Inelastic Compression Research Articles

Can Air-Inflated Compression Provide Higher Inelastic Compression?

Can Air-Inflated Compression Provide Higher Inelastic Compression?

Effects of lower limb muscle strengthening on interface pressure in older adults undergoing inelastic compression: Randomized controlled clinical trial.

To analyze the effects of lower limb muscle strengthening on interface pressure (IP), static stiffness index (SSI), dynamic stiffness index (DSI), and walking pressure amplitude (WPA) in older adults undergoing inelastic compression therapy. Forty-three healthy older adults of both sexes (Age: 66.2 ± 4.4 years) met the eligibility criteria and completed all stages of the study (Resistance Training - RT: N = 20; Control - CONT: N = 23). Body composition, strength and functional mobility of lower limbs, IP, SSI, DSI, and WPA were evaluated before and after intervention. The two-way ANOVA with repeated measures demonstrated a significant time-group interaction effect on muscular strength for 1-RM [F (1, 41) = 21.091; p ≤ 0.001], IP in the orthostatic position [F (1, 41) = 5.124; p ≤ 0.05], minimum WPA [F (1, 41) = 10.999; p ≤ 0.05], maximum WPA [F (1, 41) = 8.315; p ≤ 0.05], DSI minimum (F (1, 41) = 4.608; p ≤ 0.05), DSI maximum (F (1, 41) = 8.926; p ≤ 0.05), and on the delta DSI (F (1, 41) = 7.891; p ≤ 0.05). In RT group, the increase in lower limb muscle strength was accompanied by an increase in IP in foot dorsiflexion and plantar flexion maneuvers, both in the standing position (DSI) and during gait (WPA).

Соmplex Medical Rehabilitation for Cancer-related Lower Limbs Lymphedema: a Prospective Comparative Randomized Study of 60 Patients

INTRODUCTION. The management of patients with secondary lymphedema of the lower extremities associated with radical treatment of pelvic cancer (Cancer Related Lymphedema) is extremely problematic due to persistent impairment of the draining function of regional lymph nodes due to intraoperative dissection and subsequent radiation therapy. AIM. To compare the effectiveness of complex medical rehabilitation using the kinesio taping method and innovative non-stretchable compression bandages in patients with secondary lymphedema of the lower extremities associated with radical treatment of pelvic cancer. MATERIAL AND METHODS. The study involved 60 patients with stages I-III Cancer Related Lymphedema (according to the classification of Savchenko T.V., Pokrovsky A.V., 2004) who underwent radical treatment for various forms of pelvic cancer (gynecological cancer in women and prostate cancer in men), randomized into 2 groups (30 people each). A comprehensive rehabilitation was carried out in the main group (n=30), including sequential manual lymphatic drainage, skin care, kinesio taping, therapeutic gymnastics in the gym; Adjustable Non-stretchable Compression Bandages (circaid juxtafit, Germany). Meanwhile, a Complex Decongestive Therapy was performed in the comparison group (n=30), which is considered as the gold standard of conservative treatment of lymphedema of the lower extremities, including manual lymphatic drainage, skin care, Multi-layered limb banding using Inelastic compression Bandages. In order to evaluate the anti-edematous effect the dynamics of the circumferences of the lower extremities, waist circumference and hip circumference, the Ankle Range of Motion were examined using goniometry, bio-impedancemetry. Laser Doppler Flowmetry was used to evaluate microcirculatory parameters. RESULTS AND DISCUSSION. There was a decrease in swelling and thickening of the skin in the thigh, a decrease the external genitalia edema in patients with Cancer Related Lymphedema in both groups after a course of rehabilitation. There was a regression of swelling of the feet and lower legs in patients of both groups (p<0.05) after treatment, which was confirmed by a decrease in the circumferences of the lower limbs. There was an increase in the Ankle Range of Motion (dorsiflexion) from 17.50±1.26° to 19.25±1.52° (p<0.05) in the main group and from 17.90±1.44° to 18.59±1.10° (p<0.05) in the comparison group. According to the bio-impedancemetry data, there was a decrease in the extracellular fluid content both in the main group and the comparison group by 2.64% and 2.83%, (p<0.05) respectively. There was also a comparable decrease in the total fluid content by 2.67% in the main group and 1.90% (p<0.05) in the comparison group. There were a decrease in body weight by 2.49% and 1.52% (p<0.001), a decrease in fat mass by 2.62% and 4.01% (p<0.05) in both groups respectively after the course of treatment. According to the Laser Doppler Flowmetry data, there were an improvement in the indicators of myogenic tone of arterioles and secretory activity of the endothelium, as well as elimination of venular congestion in patients of both groups (p<0.05). CONCLUSION. Regression of edema in Cancer Related Lymphedema can be achieved as a result of the use of manual lymphatic drainage which stimulates the outflow of lymph through lymphatic watersheds into adjacent lymphatic territories with intact regional lymph nodes, which was achieved in both groups. The lymphatic drainage effect of manual lymphatic drainage was supported by the daily compression profile of bandages (Multi-layered Inelastic Bandages and Adjustable Non-stretchable Compression Bandages) in patients of both groups. Our study showed that the use of kinesio tapes leveled the difference in compression of approximately 10-15 mmHg between the bandages used (50 mmHg/~60 mmHg).

A meta-review of the impact of compression therapy on venous leg ulcer healing.

This meta-review aimed to appraise and synthesise findings from existing systematic reviews that measured the impact of compression therapy on venous leg ulcers healing. We searched five databases to identify potential papers; three authors extracted data, and a fourth author adjudicated the findings. The AMSTAR-2 tool was used for quality appraisal and the certainty of the evidence was appraised using GRADEpro. Data analysis was undertaken using RevMan. We identified 12 systematic reviews published between 1997 and 2021. AMSTAR-2 assessment identified three as high quality, five as moderate quality, and four as low quality. Seven comparisons were reported, with a meta-analysis undertaken for five of these comparisons: compression vs no compression (risk ratio [RR]: 1.55; 95% confidence interval [CI] 1.34-1.78; P< .00001; moderate-certainty evidence); elastic compression vs inelastic compression (RR: 1.02; 95% CI: 0.96-1.08; P< .61 moderate-certainty evidence); four layer vs <four-layer bandage systems (RR: 1.07; 95% CI: 0.82-1.40; P< .63; moderate-certainty evidence); comparison between different four-layer bandage systems (RR: 1.08; 95% CI: 0.93-1.25; P= .34; moderate-certainty evidence); compression bandage vs compression stocking (RR 0.95; 95% CI 0.87-1.03; P= .18; moderate-certainty evidence). The main conclusion from this review is that there is a statistically significant difference in healing rates when compression is used compared with no compression, with moderate-certainty evidence. Otherwise, there is no statistically different difference in healing rates using elastic compression vs inelastic compression, four layer vs <four-layer bandage systems, different four-layer bandage systems, or compression bandages vs compression stockings.

Feasibility and initial efficacy of a multimodal swelling intervention after total knee arthroplasty: A prospective pilot study with historical controls

BackgroundSwelling after total knee arthroplasty (TKA) is often profound and persistent, increasing risks of DVT, infection, and wound dehiscence, and impairing rehabilitation. We investigated the feasibility and initial efficacy of a multimodal swelling control intervention (MSI), comprised of an inelastic adjustable compression garment (CG), manual lymph drainage (MLD) massage, and home exercise program (HEP) after total knee arthroplasty (TKA) compared to a control group. MethodsSixteen individuals (mean age 64.7 ± 7.1y) performed MSI for three weeks after TKA, through day 21 (D21). Outcome measures included patient satisfaction, safety, patient adherence, and swelling measured by Single Frequency Bioimpedance Assessment (SF-BIA). All outcomes were measured preoperatively and at postoperative D4, D7, D14, D21 and, three weeks after discontinuing MSI, on D42. Efficacy of MSI was calculated with Hedge’s g effect size estimates using the SF-BIA ratios for MSI versus CONTROL (N = 56; mean age 64.3 ± 9.3y) at key post operative time points. ResultsPatient satisfaction was 93% with no adverse events. Adherence to CG, MLD, and HEP were 85%, 99%, and 97% respectively. Peak swelling reduction with MSI was at D21 (Hedges’ g = 1.60 at D21 (95% CI 0.99, 2.21)). Minimal change in swelling was observed three weeks after cessation of MSI on D42. ConclusionsThe self-administered MSI program is feasible and demonstrated strong initial efficacy to control swelling after TKA. Minimal rebound swelling was observed once MSI was withdrawn at D21. Future studies should examine the efficacy of inelastic adjustable compression in a randomized controlled trial.

Dynamic fracture of SiO2 films due to laser-induced confined micro-explosion at the Si/SiO2 interface: time-resolved imaging and finite-element simulation

Laser induced fracture of brittle solid films can be employed in transfer of brittle functional materials in a solid phase. The fracture process is driven by the confined laser-matter interaction (micro-explosion) near the interface of the donor film with the carrier substrate, and it is often difficult to preserve the structural integrity of the ejected donor segment (flyer) due to various dynamic damage phenomena. In this work, we consider SiO2 films grown on a silicon substrate by PECVD as a model system for studying laser-induced fracture of brittle solid films. The phenomena of the SiO2 flyer ejection and fragmentation at higher energies are studied experimentally using time-resolved imaging after irradiation by 10 ps 355 nm laser pulses, and computationally using a multiphysics finite-element model of the process. The results suggest that an intact transfer requires the fracture phenomena to be limited to the crack propagation from the edges of the laser-induced interface cavity to the surface of the film, while the dynamic tensile failure and inelastic shock compression can be the main reasons for the flyer damage and fragmentation.

Progressive collapse analysis of a truss transmission tower-line system subjected to downburst loading

Transmission tower-line systems are vulnerable to failure when subjected to downbursts. For the long-span structure in which towers and wires extend for many kilometers, the collapse of one tower probably triggers the progressive collapses of towers along the line. Therefore, this study tries to probe the progressive collapse mechanisms of a tower-line system by fully coupled dynamic simulations. The downburst wind field is generated based on the empirical model by Chen & Letchford. A refined brace element is developed to have capacities of considering several failure modes in a member, such as the inelastic compression buckling, tension yielding and fractures, which is helpful to accurately capture the nonlinear behavior of towers subjected to downburst loading. The motion equations of the system are solved through the explicit central difference method that is programmed using MATLAB. The reliabilities of the developed element and program are validated against experiments and commercial software ANSYS, respectively. To identify the effects of the movement paths of downbursts on progressive collapse patterns of tower-line systems, three load cases (LCs) with different downburst paths are defined. For each LC, the time histories of displacements at tower tops and the middle of each span are presented. Additionally, the collapse scenarios at representative moments are plotted. The results indicate that the progressive collapse patterns of tower-line systems are greatly affected by downburst center movement paths. Downbursts with the same intensity but different paths probably lead to the collapse of one or three towers in the system. The dynamic behavior of wires is also important, which could cause local failures of tower heads.

Experience of using an adjustable inextensible compression bandage in a patient with secondary lymphedema of the right upper limb

Introduction. Secondary upper-extremity lymphedema is most commonly caused by lymphadenectomy and radiotherapy (RT) of regional lymph nodes. Lymphatic edema differ in the fact that they lead to fibrotic changes in tissues, as the lymph contains up to 2–4% of protein, which causes a specific histopathological response. Proteins, as well as tissue protein-polysaccharide complexes, undergo transformations leading to pathological collagenization, and then to hyalinization and sclerosis. A vicious circle of pathological processes stemming from biophysical and chemical changes in proteins and polysaccharides with metabolic disorders occurs. Compression therapy is the most important component of the fight against both upper- and lower-extremity edema of various origins at any stage of the disease.The aim is to assess the postoperative stabilization of the upper-extremity edema state due to the patient’s self-bandaging using inelastic bandages and the possibility of personalized adjustment of pressure to be applied at the required level. The article provides indications for the use of an adjustable inelastic compression bandage to stabilize edema, and reviews a clinical example of its postoperative use in a patient with grade 4 secondary right upper-extremity lymphedema. Particular emphasis is placed on the versatility of adjustable inelastic compression bandage and the expediency of its widespread use in clinical practice.Conclusion. Simplicity and ease of use with an option to self-adjust and maintain the stable level of therapeutic pressure throughout the entire period of medical rehabilitation, as well as minimization of doctor’s involvement, allow us to recommend the adjustable inelastic compression bandage for effective use in wide clinical practice.

Use of Sponge-Foam Inserts in Compression Bandaging of Non-Healing Venous Leg Ulcers.

Objective: Venous leg ulcers (VLUs) caused by chronic venous insufficiency are difficult to treat. Outcomes after compression therapy and the current standard of care often used in conjunction with other options vary widely. We examined the effects of foam inserts on sub-bandage pressures in patients with VLUs and compared use of foam inserts in elastic and inelastic compression bandaging.Methods: Six patients (≥20 years old) with VLUs and skin perfusion pressure >40 mmHg were included. Each patient underwent weekly treatment regimens of debridement, dressing changes, and dual sponge-insert application followed by elastic (n=3) or inelastic (n=3) compression bandaging. The median resting sub-bandage pressures of the ulcer beds, wound sizes, and healing percentages were recorded. Wound beds were biopsied before and after treatment for histological assessment. Nine healthy volunteers served as controls during preliminary testing.Results: With proper sub-bandage pressures (>35 mmHg), the average healing time was 88.0±66 days, which was shorter than anticipated (i.e., ≥6 months). Combining large and local sponge-foam inserts increased sub-bandage pressures regardless of the compression bandage selected, with marked improvements seen in deeper wounds.Conclusion: Layering one or two sponge-foam inserts beneath compression bandages facilitates uniform and optimal wound-bed pressure, which accelerates the healing of VLUs.

Lymphedema Rehabilitation Using Self-Adaptive Inelastic Compression in Breast Cancer: A Proof-of-Principle Study

Inelastic compression (IC) has been proposed as a therapeutic option in the management of breast cancer-related lymphedema (BCRL). To date, no studies have investigated the reliability of IC in the rehabilitative management of BCRL. Thus, we aimed at evaluating the safety and tolerability of an instantly adjustable IC device for BCRL patients. We included BCRL patients referred to an Oncological Rehabilitation Unit. They were subjected to complex decongestion therapy using a self-adaptive IC device. The primary outcome was safety and tolerability of IC in the rehabilitation treatment of BCRL patients. Secondary outcomes were: BCRL volume modifications; disability; quality of life; IC application time. Outcomes were assessed at the baseline (T0), at the end of the 2-week rehabilitation treatment (T1), and at 1 month (T2). Nine BCRL women, mean aged 56.7 ± 4.4 years, were enrolled. None showed side effects, except for a low discomfort and moderate swelling reported by 1 patient (11.1%). BCRL volume significantly reduced at T1 (p = 0.001) with a positive trend at T2. IC timing was significantly reduced at T1 (p = 0.035) and T2 (p = 0.003). Taken together, these findings suggested that IC could be considered as a safe, well-tolerated, and effective tool in the rehabilitative management of BCRL patients.

Drill core from seismically active sandstone gas reservoir yields clues to internal deformation mechanisms

AbstractEurope’s largest gas field, the Groningen field (the Netherlands), is widely known for induced subsidence and seismicity caused by gas pressure depletion and associated compaction of the sandstone reservoir. Whether compaction is elastic or partly inelastic, as implied by recent experiments, is a key factor in forecasting system behavior and seismic hazard. We sought evidence for inelastic deformation through comparative microstructural analysis of unique drill core recovered from the seismogenic center of the field in 2015, 50 yr after gas production started, versus core recovered before production (1965). Quartz grain fracturing, crack healing, and stress-induced Dauphiné twinning are equally developed in the 2015 and 1965 cores, with the only measurable effect of gas production being enhanced microcracking of sparse K-feldspar grains in the 2015 core. Interpreting these grains as strain markers, we suggest that reservoir compaction involves elastic strain plus inelastic compression of weak clay films within grain contacts.

The Synergistic, Amplifying Use of Micronized Purified Flavanoid Fraction, Proprietary Ceramide Emulsion, and Dermal Microdeformation Fuzzy Wale Compression Under Inelastic Compression for the Management of Venous Leg Ulcers

Abstract not available.

The first experience of using a system of adjustable inelastic compression wraps in the treatment of upper and lower limb lymphedema

This publication presents the results of clinical application of the system of non-extensible compression adjustable bandage in the treatment of upper and lower limb lymphedema in 14 patients over a period of 2 to 34 months. An adjustable non-extensible compression bandage was used as monotherapy for stage I–IIa congenital limb lymphedema in 5 out-of-hospital patients. Progression of edema was not registered in any case during the follow-up period of up to 34 months. In 7 patients with stage IIB-III limb lymphedema, as well as in a 41-year-old patient with a diagnosis Of: Congenital abnormality development of the lymphatic system, Neurofibromatosis type 1, a disease Recklinghausen adjustable non-stretchable compression the product is used in combination with medical compression hosiery 1–2 compression class international standard RAL-Gz 387 from early (first show after 9–11 days after surgery) and continuing in the distant (period of use up to 22 months) postoperative periods. The return of edema (more than 1 cm when measuring the circumference) of the remodeled limb was observed in 3 patients after 4 months of follow-up. At 22 months (the maximum observation period), 2 patients showed an increase in the circumference of the operated limb to 2.5 cm. The system of non-extensible compression adjustable bandage in real clinical practice shows high efficiency in achieving edema reduction in stage I lymphedema of the extremities for at least 24 months. The use of adaptive compression banding system for the prevention of edema regression after surgical interventions for stage III limb lymphedema was reliably effective for 12 months.

Damage evaluations in Supporting Porous Components using Infrared Thermography and Acoustic Emission and their Effects on Loosening Behaviour of Acetabular Cup

This study aims at experimentally revealing the effect of accumulated damages in supporting porous components on loosening behaviour using Infrared thermography(IR) and Acoustic emission(AE). Aseptic loosening is occurred due to degradation of fixing force of acetabular cups by biological effects or mechanical loading. However, effects of mechanical loading on loosening behaviors have not been observed yet. An integrated assembly of hip joint components, which is composed of stems and acetabular cups was set in distilled water in order to apply cyclic load in vitro. We developed the simulation system of loosening behaviour of acetabular cups by cyclic loading using cantilever. Damage evaluations on interface between the acetabular cup, HAp coating and supporting porous components (we call it " simulated bone ", which has similar Young ’ s modulus and density for those of cancellous bone) using AE. Additionally inelastic damage behaviour in simulated bone was simultaneously observed using IR. IR could successfully observed dissipation energy by inelastic damage accumulated during cyclic loading, which indicate its fatigue strength within shorter cyclic loading. Cyclic loading test for 1 million revealed that both lateral and angular displacement of the acetabular cup can be associated with the progress of damages in delamination of Hap coating or inelastic compression of simulated bone Loosening mechanism of the acetabular cup by cyclic loading can be considered by the contribution of both damages at the interface and in the simulated bone.

Associations between patient, treatment, or wound-level factors and venous leg ulcer healing: Wound characteristics are the key factors in determining healing outcomes.

Chronic venous leg ulcers are challenging to heal and often recur. This has a significant impact on older individual health and is a financial burden on health care resources. This study aimed to identify factors associated with the healing of venous leg ulcers via secondary examination of data from a previously published prospective randomized controlled trial of elastic and inelastic compression systems. The data from the 45 patients who finished the trial was reanalyzed for a hypothesis generating study. Larger ulcers, higher exudate levels, larger calf circumferences, and longer ulcer duration at baseline were associated with lack of healing at 12 weeks. There was some evidence that NSAID use was associated with an increased likelihood of nonhealing (unadjusted OR for healing, 0.13, 95% CI (0.02, 0.70)). There was no evidence that other variables, including gender and BMI, were associated with healing. The key risk factors for wound healing are largely wound based or inherent to wound development, as these were found to be the factors with the strongest associations in the analysis. Future research should address how and why these factors are associated with wound healing over a longer time frame and explore how NSAIDs may affect wound healing outcomes.

Circaid adjustable inelastic compression wraps for the treatment of lower limb edema in the venous system pathology

Symptoms of chronic venous insufficiency have been known since antiquity. The prevalence of chronic venous insufficiency in Western Europe and the USA has been reported within the range from from 1 to 40% in women and from 1 to 17% in men [1]. As reported by the European authors, the average prevalence of chronic venous insufficiency with class C2-C6 (according to the CEAP classification) among the European population reaches 30% [2]. Edema syndrome remains one of the leading manifestations of chronic venous disease. Compression therapy is one of the main ways to combat edema. The arsenal of devices for the treatment of edematous syndrome is steadily expanding with the development of medical science. Today, in addition to inelastic compression wrap and elastic compression garments, brand-new compression products, circaid adjustable inelastic compression wraps are available.

Several practical aspects of the use of adjustable inelastic compression bandages (AICB)

In the review article various indications for the use of adjustable inelastic compression bandage circaid are considered, and an actual clinical example of its successful application is given. The authors draw a conclusion about the universality of circaid bandage and the expediency of its wide use in real clinical practice.

Survey of registered nurses’ selection of compression systems for the treatment of venous leg ulcers in the UK

BackgroundVenous leg ulceration is common in older adults in the United Kingdom. The gold-standard treatment is compression therapy. There are several compression bandage and hosiery systems that can be prescribed or purchased, but it was unclear what types of compression systems are currently being used to treat venous leg ulceration within the UK. This online scoping survey of registered nurses sought to (1) to identify what compression systems are available across the UK, (2) how frequently these are in use and (3) if there are any restrictions on their use. ResultsThe results showed that registered nurses who treat patients with venous leg ulceration use a wide range of compression systems. The most frequently used systems are the ‘less bulky’ two-layer elastic and inelastic compression bandaging systems whilst two-layer hosiery was used less frequently and four-layer bandaging used infrequently. Nurses report that certain compression systems are less accessible through the usual procurement routes but this appears to be related to concerns about competency in application techniques. ConclusionsThe data in this survey provides some important insights into the issues around the use of compression therapy for venous leg ulceration in the UK. Limiting access to certain types of compression may promote patient safety but limit patient choice. There may be underuse of the types of compression that promote patient independence, such as hosiery, and over-use of potentially sub-therapeutic therapy such as ‘reduced compression’. Overall, this study suggests that further consideration is needed about the provision of compression therapy to UK patients with venous leg ulceration to optimise care and patient choice.

Experimental study of permeability change of organic-rich gas shales under high effective stress

Shale permeability and its variation under high stress are vital for gas production from deep shale gas reservoirs. Most experiments of stress-dependent permeability for organic-rich shale were conducted under lower stress less than 40 MPa, therefore, shale permeability evolution under high stress is not clear. In this work, the effects of high stress on the permeability and fracture compressibility of shales were investigated experimentally. Moreover, the impact of stress cycling on permeability were also studied. Four shale samples including two intact samples and two fractured samples from Cambrian Niutitang Shale formation and Silurian Longmaxi Shale formation were used. Permeability was measured using Helium under different stress conditions, including different confining pressure, different gas pressure, and constant effective stress. The highest effective stress and gas pressure in this work was 59.5 MPa and 10 MPa, respectively. Fracture compressibilities were calculated using the stress-dependent permeability data. The results show that the permeability of the intact samples and fractured samples decreased by one order of magnitude and three orders of magnitude, respectively, with the effective stress changing from 1.5 MPa to 59.5 MPa. The shale permeability results show a two-stage characteristic and nonlinearly decreasing trend with the increase of effective stress, demonstrating that the fracture compressibility is stress dependent and decreases with stress. The permeability hysteresis occurs between the loading and unloading cycles due to the inelastic compression of the pore. The modelling results also show that the Klinkenberg constant show a positive correlation with effective stress, as effective stress reduces the fracture opening and absolute permeability.

Intermittent calf compression reverses lower limb pooling and improves cardiovascular control during passive orthostasis.

When upright, venous pooling and capillary filtration reduce the effective circulating volume and are key contributors to susceptibility to syncope (fainting). Recurrent syncope has a devastating impact on quality of life. Static calf compression garments are frequently prescribed for patients with syncope, but have questionable efficacy. Intermittent calf compression, which mimics the skeletal muscle pump to minimize pooling and filtration, is a potential alternative that holds promise for the management of syncope. We aimed to evaluate use of intermittent calf compression compared to commonly prescribed compression stockings, and determine the optimal intermittent calf compression paradigm, for improvement of orthostatic fluid shifts and cardiovascular control. We evaluated heart rate, blood pressure, stroke volume, cardiac output and peripheral resistance (finger plethysmography with Modelflow™) and calf pooling and filtration (calf circumference; strain gauge plethysmography) during a series of 10-min head-upright tilts. We first compared (protocol one) low (ICLF; 4 s on, 11 s off) and high (ICHF; 4 s on, 6 s off) frequency 0-100 mm Hg intermittent calf compression with static elastic and inelastic compression stockings and a placebo condition (n = 19, 5 males, aged 23.5 ± 0.1 years). We then compared (protocol two) ICLF applied at 0-40 mm Hg, 0-60 mm Hg, 0-80 mm Hg and 0-100 mm Hg as well as a placebo condition (n = 15, 5 males, aged 22.7 ± 0.5 years). The intervention order was randomized. In protocol one, all compression conditions significantly reduced calf circumference (p < 0.001) compared to placebo after 10-min upright; however, this reduction was greater in ICLF (-0.88 ± 0.18%) and ICHF (-1.14 ± 0.21%) conditions than both elastic (+0.49 ± 0.17%) and inelastic (-0.01 ± 0.19%) compression (p < 0.001). ICLF and ICHF, but not elastic or inelastic compression, were associated with improved stroke volume (p ≤ 0.001), allowing cardiac output to be maintained at a reduced heart rate (p < 0.001) without increases in vascular resistance responses, increasing hemodynamic reserve. ICHF showed no significant benefit over ICLF, evidenced by the lack of significant difference between ICLF and ICHF in any parameter measured. In protocol two, 0-60 mm Hg ICLF was considered the optimal intermittent compression because it was the lowest pressure that abolished the increase in calf circumference during orthostasis, while improving SV (p = 0.002), and reducing HR (p < 0.001) throughout tilt. Intermittent calf compression from 0 to 60 mm Hg ICLF is the optimal intermittent compression paradigm to ameliorate orthostatic fluid shifts and improve hemodynamic control. Commonly prescribed static calf compression garments do not improve orthostatic cardiovascular responses.