This study aimed to understand the knowledge of Portuguese citizens about air quality and the extent to which the concerns about specific environmental problems can motivate their acquaintance of information. Moreover, this study also allowed to understand which information about air quality needs further dissemination to provide the citizens with all the available tools and the correct knowledge. For this, a national online survey about air quality perception was conducted, where 1131 answers were obtained and two different populations were compared: the general population and a sub-population from an urban-industrial area of Lisbon metropolitan area that had experienced frequent air pollution events in the past. Air pollution was considered the environmental topic of higher concern among this sub-population (61.4%), while in the general population it ranked thirdly (27.4%). Generally, the sub-population showed higher knowledge about air quality than the general population, with 61% being able to identify at least one air pollutant. The perception of the local air quality was also very different between populations, with 61% of the sub-population considering it poor or very poor, while only 14% of the general population had the same perception, which highlights the different levels of concern between populations. A weak knowledge about air pollutants (50% of the general population could not identify any air pollutant) and an erroneous perception of the contribution of the different pollution sources to air quality levels were found. More than 50% of the respondents of both populations were considered to not have enough information regarding the air quality in their area of residence, with the national air quality database being unknown to almost everyone. Overall, strong efforts should be made to increase the awareness about the importance of air quality, which may promote a higher acceptance of the implementation of future actions to improve air quality.