Carbon emissions from energy consumption caused by industrial production have become an important factor in global warming, and China now has the highest global carbon emissions, with enormous pressure to reduce emissions. The Mid-Yangtze River urban agglomeration (MYRUA), which is an important region for China, also faces the contradiction of balancing environmental protection and economic production. Currently, there is little discussion on low-carbon pollution research in the MYRUA in China. Therefore, this study takes the MYRUA as the research object, uses a slack-based model (SBM) and exploratory spatial data analysis (ESDA) to explore the spatiotemporal evolution of the industrial carbon emission efficiency (ICEE) of the MYRUA in China from 2006 to 2019, and empirically analyses the factors influencing the ICEE based on a spatial econometric model. The results show that (1) in the period 2006–2019, the ICEE in the MYRUA region generally exhibited a “jagged” trend of decreasing, then increasing until finally decreasing again. Spatially, ICEE generally exhibited a dynamic trend of being low throughout, with high-efficiency areas tending to move to the center and low-efficiency areas being scattered. (2) The global Moran's I coefficient for ICEE ranged between 0.002 and 0.213, with the highest Moran's I value and significant spatial correlation occurring in 2006, after which the value gradually decreased. On the local autocorrelation, the ICEE in 2006 exhibited an agglomeration effect and weakened after 2010. (3) In 2019, the level of industrialization (LI) and the level of external openness (LEO) in the MYRUA changed from nonsignificant to significant positive correlations, and the LEO had the largest impact. The energy consumption structure (ECS) was always significantly negatively correlated. The levels of social development (LSD) and environmental regulation (ER) changed from showing a significant positive correlation to showing a nonsignificant correlation. In conclusion, ICEE is affected by interactions of multiple factors. In the future, the ECS of the MYRUA should be continuously optimized and replaced by clean energy. In addition, foreign investment compensates for the lack of production and technology research funds, which can increase investment and promote the digitalization of manufacturing enterprises.
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