Introduction. Uterine rupture is a rare complication of induced termination of pregnancy in the second trimester. We report a case of a patient with a rupture of the unscarred uterus during a prostaglandin-induced abortion in the second trimester of pregnancy. Case Report. A 26-year-old pregnant woman was admitted to the Clinic of Gynecology and Obstetrics in the 22nd week of gestation of her fourth pregnancy due to complete absence of amniotic fluid. The patient denied previous surgeries and other diseases. Due to a poor prognosis for the fetus, the Ethics Committee approved the termination of pregnancy. The induction of abortion was started by applying two dinoprostone gels intracervically and continued by using carboprost tromethamine intramuscularly. The patient aborted after 38 hours from the start of induction. During instrumental revision of the uterine cavity, a rupture of the right side of the uterus was suspected. Ultrasound examination showed a parametrial hematoma. Laparotomy was indicated due to suspected uterine rupture. The intraoperative findings showed a hematoma located in the right parametrium and a complete rupture of the posterior wall of the uterus extending from the right vaginal fornix to the right uterine horn. A total abdominal hysterectomy with preservation of both ovaries was performed. Conclusion. Since ruptures of the unscarred uterus are rare, almost at the chance level, it is important to always keep them in mind as a potential complication of induced termination of pregnancy in the second trimester.