Abstract
Introduction: Nearly 20% of all confirmed pregnancies end in spontaneous abortion. Misoprostol’s use in early pregnancy failure is varied and dose and route are not well established. AIM: To study the efficacy of sublingual misoprostol in causing expulsion of products of conception in early pregnancy failure.
 Methods: Women with an ultrasound diagnosis of early pregnancy failure, less than 12 weeks gestation were included in the study. Tablet Misoprostol 600 mcg was given six hourly sublingually for 3 doses. All observations were noted and analyzed. Results: Mean gestational age was 7.946+1.2 weeks. Mean induction abortion interval was 18.241+1.2 hours. Women with gestational age six to eight weeks had least mean induction-abortion interval time of 17.38+2.86. Mean dose required was 1560mcg. Efficacy of protocol was 92.85% in achieving complete abortion.
 Conclusion: The regime had 92.85% efficacy, acceptability (90%) and few side effects. Thus by using a lower dose and appropriate interval between two doses (six hours), the side effects were lessened with high efficacy.
 Keywords: Efficacy, Missed Abortion, Misoprostol.
Highlights
Introduction: Nearly 20% of all confirmed pregnancies end in spontaneous abortion
By using a lower dose and appropriate interval between two doses, the side effects were lessened with high efficacy
The mean age of women in the study was 23.79+5.1 years. 70% women came with complaints of bleeding per vagina. 30 % women had come for routine checkup and USG had shown missed abortion. 79.78% of the women had fetal pole absent or irregular gestational sac in the ultra sonographic findings
Summary
Misoprostol’s use in early pregnancy failure is varied and dose and route are not well established. AIM: To study the efficacy of sublingual misoprostol in causing expulsion of products of conception in early pregnancy failure. Methods: Women with an ultrasound diagnosis of early pregnancy failure, less than 12 weeks gestation were included in the study. Mean induction abortion interval was 18.241+1.2 hours. Women with gestational age six to eight weeks had least mean induction-abortion interval time of 17.38+2.86. By using a lower dose and appropriate interval between two doses (six hours), the side effects were lessened with high efficacy. Misoprostol-a synthetic prostaglandin E1 analogue, is cheap, stable at room temperature and effective in inducing uterine contractions[1] the regimes for its use in early pregnancy failure are varied. Pharmacokinetics show that sublingual misoprostol has the shortest onset of action, the highest peak concentration and greatest bioavailability among the routes of administration [3]
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