Rapid urbanization has increased the urban density and functional diversity, exacerbating environmental challenges such as urban heat islands (UHI), increased building energy consumption and carbon emissions, etc., hindering the sustainable urban development. Addressing these challenges requires innovative solutions that could offer the strategic cooling of urban buildings. Vertical greenery, affixed to building façades, offers a promising approach to provide benefits of cooling, energy savings, carbon reduction and urban space saving. However, there is a lack of quantitative design for integrating vertical greenery into complex urban buildings. Therefore, this study conducts a systematic investigation for low-rise, mid-rise, and high-rise buildings incorporating vertical greenery, while performing comprehensive assessments on indoor and outdoor thermal conditions, building energy usage, and carbon emissions. The findings suggest that low-rise buildings benefit from a vertical greenery layout, while mid-rise and high-rise buildings are better suited for a horizontal greenery layout. Compared to scenarios without greenery, buildings with vertical greenery experience a maximum reduction of 0.66 °C in outdoor air temperature and 0.72 °C in indoor air temperature, along with a 5.9 % decrease in energy consumption and carbon emissions. This study addresses urban challenges through a quantified vertical greenery design, offering valuable insights for sustainable urban development.