Cinnamomum Burmannii Research Articles

Synergistic effects of cinnamaldehyde and cinnamic acid in cinnamon essential oil against S. pullorum

Cinnamon is an important spice crop that is widely cultivated in tropical regions. In this study, the antibacterial activities of four accessions of cinnamon essential oil (CEO) belonging to three different species (CEO1 and CEO4, Cinnamomum cassia Presl. (Lauraceae) bark; CEO2, Cinnamomum zeylanicum Blume (Lauraceae) bark; CEO3, Cinnamomum burmannii Blume (Lauraceae) bark) toward Salmonella enterica subsp. enterica serovar pullorum (S. pullorum) were evaluated by microdilution assay and kinetic analysis. The minimum inhibitory concentration (MIC) of the CEOs were all 0.31 mg/mL, and kinetic analysis suggested that the lag phase and maximum specific growth rate of bacteria were concentration dependent. Furthermore, to explore the synergistic antibacterial effects between main components and minor components, the volatile constituents of CEOs were determined by gas chromatography–mass spectrometry (GC–MS). Cinnamaldehyde (CM) (57.73 %–91.79 %) was the principal constituent in CEO1–CEO4 (p < 0.05), with CEO3 having the highest CM contents. Screening of the active minor compounds isolated from CEOs showed that cinnamic acid (CA), salicylaldehyde, α-pinene, o-anisaldehyde with MIC value of 0.31–2.5 mg/mL had better antibacterial activity. A synergistic effect against S. pullorum was observed when CA was combined with CM. To explore the potential synergistic mechanism, the membrane glycerophospholipid (GPL) composition of S. pullorum was characterized by ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS). CM, CA, and their combination regulated the levels of most phosphatidylethanolamines (PEs), phosphatidylglycerols (PGs), phosphatidic acids (PAs), and some cardiolipins (CLs).

FAKTOR-FAKTOR YANG MEMPENGARUHI VOLUME EKSPOR KAYU MANIS INDONESIA

Cinnamon is one of indonesia's plantation export commodities that is quite potential and has expectations for the country's foreign exchange receipts. Cinnamon is not Indonesia's main export commodity, but cinnamon is indonesia's main plantation commodity and has great potential to be exported. There are conditions that are not in line between the production volume and the export volume of Indonesian cinnamon where the production volume shows a downward trend, while the export volume shows an increasing trend. This study aims to analyze what factors influence the export volume of Indonesian cinnamon and find out what factors have the most dominant influence on the export volume of Indonesian cinnamon. This research uses quantitative research design with literature study method. Data in this study in the form of time series data includes annual data during the period 1989 - 2018 (30 years). Data analysis techniques used are classical assumption test analysis, multiple linear regression analysis, and statistical test analysis. The results showed that the variable export price of cinnamon, the real exchange rate of rupiah against usd, indonesia's real GDP, and the area of Indonesian cinnamon land had a significant effect on the export volume of Indonesian cinnamon, while the variable amount of cinnamon production and the real GDP of the USA had an insignificant effect on the export volume of Indonesian cinnamon. The most dominant factor affecting the export volume of Indonesian cinnamon is the export price of cinnamon.

The Effect of Cinnamomum burmannii Water Extraction Against Staphylococcus aureus, Enterobacter spp., Pseudomonas aeruginosa, and Candida albicans: In Vitro Study

Indonesian cinnamon (Cinnamomum burmannii) is a native plant of Indonesia that has a lot of potential. The most consumed part is the bark. This study aims to examine the antimicrobial effect of Cinnamomum burmannii bark extract on various types of pathogenic microbes, namely Staphylococcus aureus, Enterobacter spp., Pseudomonas aeruginosa, and Candida albicans. An experimental study using a water extract (infusion) of Cinnamomum burmannii bark and a microbial test obtained from the Faculty of Pharmacy, Widya Mandala Catholic University, Surabaya. The antimicrobial effect test was carried out by the microdilution method in 96-well-microplate to determine the Minimum Inhibitory Level (MIC) and implantation on solid media to determine the Minimum Kill Rate (KBM). The MIC and KBM against Staphylococcus aureus were 625-1,250 ppm and 1,250-2,500 ppm, respectively. MIC and KBM for Enterobacter spp., Pseudomonas aeruginosa, and Candida albicans were not found at the highest concentrations tested at 10,000 ppm. Cinnamomum burmannii extract can be used as a potential ingredient with antimicrobial effects, especially against Gram-positive bacteria. Future studies should pay attention to the quality of simplicia, particle size, and the most effective extraction methods extracting antimicrobial substances from simplicia

Cinnamomum species: Spices of immense medicinal and pharmacological values

Cinnamon has been in use by humans for thousands of years, as early as 2,000 B.C. The Arabs transported cinnamon via cumbersome land routes, resulting in a limited, expensive supply that made the use of cinnamon a status symbol in Europe in the Middle Ages. Cinnamomum belonging to the family Lauraceae is a large genus comprising more than 200 species that grow in Asia, Australia and Pacific Islands. The species that are commercially important are Cinnamomum zeylanicum Blume (syn. C. verum JS Presl.), C. cassia Blume, C. tamala Nees and C. camphora Seib. Various related species are also cultivated as a source of cinnamon spice, including Chinese cassia (Cinnamomum cassia), Vietnamese or Saigon cinnamon (C. loureiroi), Indonesian cinnamon (C. burmannii) and Malabar cinnamon (C. citriodorum). Out of these, C. zeylanicum is the most used commercial species all over the world and largely cultivated in Sri Lanka and India. The cinnamon crop grows well at an altitude of 300–350 m to 1000 m above sea level and requires average temperature of 27°C and annual rainfall of 1500–2500 mm. Proximity to sea, humid conditions and salt water are favourable condition for the crop. The essential oil from cinnamon contains phenyl propanoids, monoterpenoids, sesquiterpenoids and oxygenated sesquiterpenoids. Cinnamon has several effective medicinal and pharmacological properties controlling human ailments like diabetes, Alzheimer's disease, cancer, arthritis, heart disease, indigestion, teeth decay etc. An updated account of geographical distribution, cultivation practices, harvesting, active constituents, biological and medicinal properties and value added products of cinnamomum species are discussed herein.

Revealed comparative advantage and constant market share analysis of Indonesian cinnamon in the world market

Revealed comparative advantage and constant market share analysis of Indonesian cinnamon in the world market

The Efficacy of Cinnamon Extract ( Cinnamomum burmannii ) on Reducing Staging Acute Kidney Injury in Ischemia Reperfusion (IR) Model

A B S T R A C TIntroduction. Acute kidney injury (AKI) is defined as sudden decline in theglomerular filtration rate, resulting in the retention of nitrogenous wastes, such asurea and creatinine in plasma. Cinnamomum burmannii is known as a anti-inflammatory renoprotective agent, although the precise mechanism is not wellunderstood. This study aimed to elucidate the effectiveness of Cinnamomumburmannii extract in decreasing creatinine level of acute kidney injury Ischemiareperfusion (IR) model. Method. We performed Ischemia reperfusion (IR) in maleWistar rat to induce acute kidney injury. The rat (n=30) were divided into six groups:IR, 1 group treated with methylprednisolone as a control (IR+M), 3 groups treatedwith different oral Cinnamomum burmannii extract doses (50mg/kg (IR+EKM1),100mg/kg (IR+EKM2), and 200 mg/kg (IR+EKM3), and a Sham operation (SO)group. AKI stage reduction based on serum creatinine levels, before and aftermodeling, before and after the cinnamon extract intervention. Creatinine levels werequntified by spectrophotometry and analyzed by SPSS. Result. Cinnamomumburmannii extract lowers creatinine levels; significant (P &lt;0.05). 200 mg / kgbb isthe effective dose of lowering creatinine levels in the IR model. Conclusion.Cinnamomum burmannii extract reduced serum creatinine levels associated withdecreased acute renal staging in the IR model.

UJI EFEKTIVITAS ANTIBAKTERI NANO GEL BAHAN AKTIF EKSTRAK KAYU MANIS (Cinnamomum burmannii) TERHADAP Staphylococcus aureus

Nanogel preparations consist of nanoemulsions and gels, where nanoemulsion is one type of preparation that can increase drug permeability on the membrane surface. The use of cinnamon extract as an antibacterial active substance is because cinnamon (Cinnamomum burmannii) contains saponins, tannins, and flavonoids. This study aims to make nanogel preparations with the active ingredient of cinnamon extract and to determine the antibacterial effectiveness of the nanogel as the active ingredient of the cinnamon extract against Staphylococcus aureus. The manufacture of 2% cinnamon extract nanoemulsion aims to make nanoparticle-sized nanogel preparations and as an antibacterial active substance in nanogel preparations against Staphylococcus aureus bacteria. Nanogel preparations were made by adding cinnamon extract nanoemulsion with varying concentrations of F1(2%), F2(4%), F3(6%), and blank formula (F0) as the basis for nanogels without cinnamon extract nanoemulsion. The results showed that the cinnamon extract nanoemulsion could be made into nanogels to produce a thick, brown-colored gel with a characteristic cinnamon smell. The result of the pH of the preparation is 6 according to the pH of the skin, has good homogeneity, and is not irritating to the skin. The PSA test produces a nanoparticle size of 24.2 nm, and the antibacterial effectiveness test of the nanogel preparation can inhibit Staphylococcus aureus bacteria. Produced a moderate inhibition zone category (6.7-7.1 mm) and the F3 formulation (6%) was the best formulation.

Total Lactic Acid Bacteria and Antibacterial Activity in Yoghurt with Addition of Ananas comosus Merr. and Cinnamomum burmannii

Background: Diarrhea disease is one of gastrointestinal disorders which is the second leading cause of death in children under five years. Food and beverage contamination is the biggest cause of diarrhea in developing countries. Nanas madu (Ananas comosus Merr.) and cinnamon (Cinnamomum burmannii) have antibacterial properties that can inhibit the growth of Escherichia coli and Salmonella typhi causing diarrhea.Objective: This study aimed to analyze the total differences of Lactic Acid Bacteria (LAB) and antibacterial activity in yoghurt with the addition of nanas madu and cinnamon extract.Methods: This was an experimental study with various treatment in adding honey cream pineapple (0%, 20%, 40%, and 60%) and cinnamon extract (4% and 6%). Total LAB was calculated using the Total Plate Count (TPC) method and antibacterial activity was tested using Kirby Bauer method.Results: There was no significant difference in yoghurt with the addition of honey cream pineapple and cinnamon extract. Yoghurt with the highest LAB was yoghurt with addition 40% of honey cream pineapple and 6% of cinnamon extract (N40M2) with total LAB 1,43 x 1019 CFU/ml. The results of the antibacterial activity showed no significant difference of inhibition zone against S. typhi¸ while there was significant difference of inhibition zone against E. coli. The highest activity against S. typhi was yoghurt with addition 60% of honey cream pineapple and 4% of cinnamon extract (N60M1) resulting 6,81 mm inhibition zone and the highest activity against E. coli was N40M1 resulting 6,77 mm of inhibition zone. Conclusion: Total LAB yoghurt with the addition of nanas madu and cinnamon extract have met FAO and SNI standards with LAB minimum 107 CFU/ml. Antibacterial activity of all yoghurt treatment categorized as medium inhibition (5-10 mm).

Effect of Cinnamon (Cinnamomum burmannii) Bark Oil on Pancreatic Histopathology of white Rats (Rattus norvegicus) Induced with Streptozotocin

The purpose of this research was to understand the effect of the cinnamomum (Cinnamomum burmannii)bark oil (CBO) on the pancreatic histopathology white rat (Rattus norvegicus) with diabetes mellitus. Thevariables taken were the diameter and the number of Langerhans Island in the pancreatic of white male ratswhich had been induced by streptozotocin (STZ). This research using diabetic rat induced by streptozotocinintraperitoneally with single dose of 45 mg/kg BW. Samples consist of fifty rats were divided into fivegroups, negative control group (K-) was not induced by streptozotocin, which treatment by giving CMCNa 1%, positive control group (K+) was induced by streptozotocin without CBO, group P1 was induced bystreptozotocin and gave CBO 100 mg/kgBW, group P2 was induced by streptozotocin and gave CBO 200mg/kgBW, group P3 was induced by streptozotocin and gave CBO 400 mg/kgBW daily for 14 days period.The results showed that cinnamomum bark oil (CBO) with dose 200 mg/kgBW (P2) was significantly higher(p&lt;0,05) than group P1, group P3 and positive control group (K+). It can be concluded that CBO can be usedto improve pancreatic function of STZ induced in diabetic rats

The content of coumarin in the commercial samples of cinnamon bark and cinnamon-containing dietary supplements available on the Serbian market

Cinnamon bark is used worldwide due to its characteristic flavour and medicinal properties. Ceylon cinnamon or “true” cinnamon bark refers to the dried inner bark of the shoots of Cinnamomum verum J. Presl, originated from Sri Lanka. The bark of some other species of this genus, Cinnamomum cassia Blume (Chinese cinnamon), C. burmanni (Nees &amp; T. Nees) Blume (Indonesian cinnamon), and C. loureiroi Nees (Saigon cinnamon) are also marketed and sold as cinnamon. They are characterised by a significantly higher amount of coumarin compared to Ceylon cinnamon bark. Since coumarin may be potentially hepatotoxic, the aim of this study was to determine coumarin level in commercial samples of cinnamon bark and in cinnamon-containing dietary supplements present on the Serbian market. HPLC analysis showed lowest coumarin content in Ceylon cinnamon bark samples (0.08-0.15 mg g-1), whereas other samples contained a significantly higher amounts of coumarin (1.38-5.80 mg g-1). Cinnamon based dietary supplements contained 0.007-1.19 mg coumarin/tablet. The obtained results indicate that the majority of commercial samples of cinnamon bark on the Serbian market do not originate from the Ceylon cinnamon but from other species of this genus, and that consumed amount of certain products should be taken into account since the tolerable daily intake of coumarin is limited.

Phytochemical composition and antioxidant activity of Cinnamomum burmannii Blume extracts and their potential application in white chocolate

This study aims at determining the potentials of cinnamon (Cinnamomun burmannii) extracts to improve the health-promoting properties of white chocolate. LC-HRMS analysis was employed to obtain information regarding the phytochemical content while the phosphomolybdenum, FRAP and DPPH assays were used to determine antioxidant activity of cinnamon extract. Furthermore, the cinnamon extract was loaded into nanoparticles before adding it to white chocolate. The results show that cinnamon extracts contained phenols up to 310 mg EE and possessed antioxidant activity up to 260 mg TAE per gram of dry extract depending on the extraction mode (i.e., traditional and ultrasonic-assisted method) and the solvent type. The cinnamon extract contained catechin, epicatechin, procyanidin B2, quercitrin, 3,4-dihydroxybenzaldehyde, protocatechuic acid and cinnamic acid at levels of 51, 53, 1396, 13, 1138, 228 and 934 µg/g of dry extract, respectively. The encapsulated cinnamon extract increased the phenolic content of white chocolate from 47.6 to 1060.6 µg EE/g.

Effect of Cinnamomum burmannii Stew on Glucose Fasting Blood Levels in Adult Prediabetes in Makassar

BACKGROUND: Prediabetes is a condition that precedes the onset of diabetes mellitus (DM), DM disagreement, and penalties are needed through the management of prediabetes.&#x0D; AIM: This study aimed to study the effect of giving cinnamon stems (Cinnamomum burmannii) for 14 days on the levels of fasting adult blood sugar (glukosa darah puasa [GDP]) in prediabete adults in Makassar City.&#x0D; METHODS: This research method uses a quasi-experimental randomized pre-test design with a control group. There are 28 samples from a total of 167 communities in the working area of Pampang and Antara Community Health Center who have diabetes risk factors. Levels of GDP, Anthropometry, knowledge level, and 24-h recall were taken from samples that were divided into two groups of cinnamon stew studio with a dose of 10 g + education for the intervention group and education for the control group. Data were analyzed using the will-coxon test and the Mann–Whitney test.&#x0D; RESULTS : The results showed that significant changes in GDP after giving cinnamon stew and education in the intervention group (p = 0.032), there was a change in GDP levels but not significant after providing education in the control group (p = 0.197), for the average difference change in GDP in the group intervention (−4.14) is greater than the control group (−2.50) but the magnitude of change in GDP is not significant, whereas there is no significant difference in GDP levels between the intervention group and the control group after the intervention (p = 0.270). Consumption of 10 g of cinnamon stew for 14 days can reduce fasting blood sugar levels.&#x0D; CONCLUSION: Based on the results of the study, there were significant changes in GDP after giving cinnamon stew and education in the intervention group, there was a change in GDP levels but not significant after providing education in the control group, the average change in the intervention group was greater than the control group but the change in GDP not significant, there was no significant difference in GDP levels between the intervention group and the control group after the intervention.

Potency of Cinnamomum burmannii as Antioxidant and α Glucosidase Inhibitor and Their Relation to Trans-Cinamaldehyde and Coumarin Contents

Cinnamon (Cinnamomum spp) is one of important export commodity for Indonesia. With annual production capacity about 103.594 tons, Indonesia is one of main cinnamon’s exporter especially to United States. Recently the utilization of cinnamon is developed, where not only use as spices but also use in pharmaceutical and cosmetic industries. The development of cinnamon’s use of course might lead to the market growth.. But on the other side arise an issue about coumarin content, where Cinnamomum burmannii issued to have higher content of this hepatotoxic compound than Cinnamomum verum or Cinnamomum zeylanicum. This research result showed that, although coumarin content of Indonesian Cinnamomum burmannii is higher than Cinnamomum zeylanicum but the difference is not too significant. C. burmannii collected from Gunung. Mas, West Java has coumarin content of 0.0030 % which is slightly higher than C. zeylanicum (0.0017 %). This research result also shown that antioxidant activity and α glucosidase inhibition activity is related to polyphenol and flavonoid content.

Simultaneous Natural Deep Eutectic Solvent-Based Ultrasonic-Assisted Extraction of Bioactive Compounds of Cinnamon Bark and Sappan Wood as a Dipeptidyl Peptidase IV Inhibitor.

Cinnamon bark (Cinnamomum burmannii) and sappan wood (Caesalpinia sappan) have been reported to be beneficial for Type-2 Diabetes Mellitus (T2DM) and the combination is commonly used by Indonesian herbal industries. In the present study, the simultaneous extraction of bioactive compounds from both plants was conducted using natural deep eutectic solvent (NADES), their content analyzed using high-performance liquid chromatography (HPLC), and their dipeptidyl peptidase IV (DPP IV) inhibitory activity evaluated. An additional in silico molecular docking analysis was conducted to ensure their activity. The results showed that NADES (with a composition of choline chloride–glycerol) extraction from cinnamon and sappan wood had DPP IV inhibitory activity of 205.0 and 1254.0 µg/mL, respectively. Brazilin as a marker substance from sappan wood was responsible for the DPP IV inhibitory activity, while none of the marker substances chosen for cinnamon bark (trans-cinnamaldehyde, coumarin, and trans-cinnamic acid) were found to have significant DPP IV inhibitory activity. These results were confirmed by molecular docking conducted in brazilin, trans-cinnamaldehyde, coumarin, and trans-cinnamic acid.

A New Apocarotenoid of Cinnamomum burmannii

A new apocarotenoid, burmannic acid (1), was isolated from the roots of Cinnamomum burmannii (Nees & T. Nees) Blume (Lauraceae). The structure of the new apocarotenoid was elucidated by chemical and physical evidence.

Physicochemical Characteristics and Consumer Acceptance of Bagged Indonesian Green Tea (Camellia sinensis) Formulated with Cinnamon Bark (Cinnamomum burmannii) and Lemon (Citrus limon) Peel

Green tea is a popular functional beverage mostly due to its high antioxidant activity. However, based on preliminary study, the taste such as its bitterness and flavour were somehow disliked by Indonesian consumers, and therefore formulation with other materials such as the addition of cinnamon and lemon peel may bring an advantage.This research was aimed to study the effect of formulation of bagged Indonesian green tea with cinnamon and lemon peel to the physicochemical characteristics of the tea and its consumer acceptance. Evaluation on the effect of different steeping time while brewing those tea formulas was also reported. The formula being investigated was F1, F2, and F3 with green tea: cinnamon: lemon peel at the ratio of 70:15:15, 70:12:18, and 70:9:21, respectively.Tea brewing was performed at 100°C, followed by a steeping time (L) at 1, 3, and 5 minutes. The results indicated that the addition of more cinnamon and longer steeping time had increased total phenol and antioxidant activity of the brewed tea. Based on the consumer acceptance test, the formula ofgreen tea: cinnamon:lemon peel at 70:15:15 along with 3 minutes steeping time, was generally scored highest for degree of liking but the ratio of 70:12:18 was the most accepted or preferred for aroma.The best treatment was achieved on the ratio of green tea:cinnamon:lemon peel = 70:12:18, under 5 minutes steeping time. The best treatment provided a pH of 5.13, lightness (L*) at 44.93, redness(a*) at -2.50, yellowness (b*) at 16.93, total phenol of 59.82 mgGAE.g-1, and IC50 of 59.39 ppm.

Mining of candidate genes involved in the biosynthesis of dextrorotatory borneol in Cinnamomum burmannii by transcriptomic analysis on three chemotypes.

BackgroundDextrorotatory borneol (D-borneol), a cyclic monoterpene, is widely used in traditional Chinese medicine as an efficient topical analgesic drug. Fresh leaves of Cinnamomum trees, e.g., C. burmannii and C. camphor, are the main sources from which D-borneol is extracted by steam distillation, yet with low yields. Insufficient supply of D-borneol has hampered its clinical use and production of patent remedies for a long time. Biological synthesis of D-borneol offers an additional approach; however, mechanisms of D-borneol biosynthesis remain mostly unresolved. Hence, it is important and necessary to elucidate the biosynthetic pathway of D-borneol.ResultsComparative analysis on the gene expression patterns of different D-borneol production C. burmannii samples facilitates elucidation on the underlying biosynthetic pathway of D-borneol. Herein, we collected three different chemotypes of C. burmannii, which harbor different contents of D-borneol.A total of 100,218 unigenes with an N50 of 1,128 bp were assembled de novo using Trinity from a total of 21.21 Gb clean bases. We used BLASTx analysis against several public databases to annotate 45,485 unigenes (45.38%) to at least one database, among which 82 unigenes were assigned to terpenoid biosynthesis pathways by KEGG annotation. In addition, we defined 8,860 unigenes as differentially expressed genes (DEGs), among which 13 DEGs were associated with terpenoid biosynthesis pathways. One 1-deoxy-D-xylulose-5-phosphate synthase (DXS) and two monoterpene synthase, designated as CbDXS9, CbTPS2 and CbTPS3, were up-regulated in the high-borneol group compared to the low-borneol and borneol-free groups, and might be vital to biosynthesis of D-borneol in C. burmannii. In addition, we identified one WRKY, two BHLH, one AP2/ERF and three MYB candidate genes, which exhibited the same expression patterns as CbTPS2 and CbTPS3, suggesting that these transcription factors might potentially regulate D-borneol biosynthesis. Finally, quantitative real-time PCR was conducted to detect the actual expression level of those candidate genes related to the D-borneol biosynthesis pathway, and the result showed that the expression patterns of the candidate genes related to D-borneol biosynthesis were basically consistent with those revealed by transcriptome analysis.ConclusionsWe used transcriptome sequencing to analyze three different chemotypes of C. burmannii, identifying three candidate structural genes (one DXS, two monoterpene synthases) and seven potential transcription factor candidates (one WRKY, two BHLH, one AP2/ERF and three MYB) involved in D-borneol biosynthesis. These results provide new insight into our understanding of the production and accumulation of D-borneol in C. burmannii.

The benefit of cinnamon (Cinnamomum burmannii) in lowering total cholesterol levels after consumption of high-fat containing foods in white mice (Mus musculus) models

Background: Hypercholesterolemia is a condition where cholesterol levels in the body exceed the normal range. In Indonesia, the development of traditional medicine is carried out by examining plants known for their medicinal qualities, including cinnamon ( Cinnamomum burmannii). There are many nutritional components contained in cinnamon, such as cinnamaldehyde. This has been suggested as a substance that can reduce cholesterol and triglyceride levels. This study was conducted to determine the efficacy of cinnamon in reducing total cholesterol levels of mice (Mus musculus) given high-fat feed. Methods: This is an experimental study with a pre-post control study design. The groupings were performed by a simple random sampling method. There were five groups (n=6/group): 1) Negative control (aquadest); 2) positive control of high-fat containing food (HFC; quail's yolk); 3) HFC + cinnamon extract (CE; dose 2mg/20g body weight (BW); 4) HFC + CE (dose 4mg/20gBW); 5) HFC + CE (dose 8mg/20gBW). The study was conducted for 28 days. The intervention of CE started on day 15 and ended on day 28. Measurement of total cholesterol and BW of mice was performed on days 0, 14 and 28. Results: A decrease in the total cholesterol of mice ( p = 0.001) was found in the groups that consumed CE. However, there was not a significant change between groups in mice BW ( p = 0.419). Conclusions: Providing cinnamon extract ( Cinnamomum burmannii) for 28 days could decrease total cholesterol levels in mice compared to those not given cinnamon extract when consuming high-fat containing foods.

Antidepressant Effect of Cinnamon (Cinnamomum burmannii) Bark Extract in Chronic Stress-Induced Rats

BACKGROUND: Depression is a psychiatric disorder that has become a serious health problem in the past decade. This disorder is characterized by prolonged dysphoric mood, and in more severe condition would result in decreased self-care and even life-threatening action. Serotonin is believed to play a role in the regulation of mood elation in depressive disorders. Decreased levels of serotonin in the hippocampus will cause an increased dopamine in mesolimbic dopamine neuronal cells. An effective and commonly used drug is the selective serotonin reuptake inhibitor, namely, fluoxetine. However, this agent has so many side effects, one of them is erectile dysfunction. In order to find the better treatment, exploration and discovery of therapeutic modalities need to pursued using natural materials.&#x0D; AIM: This study aimed to explore and evaluate antidepressant effects of cinnamon (Cinnamomum burmannii) extract (CE).&#x0D; METHODS: A total of 30 male Wistar rats were obtained from Eureka Research Laboratory (Palembang, Indonesia). Cinnamon simplisia was obtained from the Institute for Research and Testing of Traditional Medicine, Tawangmangu, Central Java, Indonesia. Rats were induced using chronic mild stress (CMS). CMS was a form of stress induction performed on experimental animals continuously, for 4 weeks. Forced swimming test (FST) was a test conducted to assess mobility in animal model. After induction for 4 weeks, rats were randomly divided into six groups which each contained five rats: Normal control group, CMS group (negative control), CMS + fluoxetin (Fluox 1: mg/kg), CMS + CE 25 mg/kg, the CMS + CE 50 mg/kg, and the CMS + CE 100 mg/kg. Treatment with fluoxetine or CE was given for 14 days intragastrically using gastric sonde. After treatment and FST, organ evacuation was performed and followed by immunohistochemistry and enzyme-linked immunosorbent examination.&#x0D; RESULTS: This study showed that CE with dose of 25 mg/kg BW to dose 100 mg/k BW could reduce the duration of immobility when compared to the CMS group. Clinically, CE possessed the potential to reduce the duration of immobility and potentially reduce symptoms of depression. Histologically, CE showed the potential to improve serotonin levels in the hippocampus with increasing doses. Tumor necrosis factor (TNF)-alpha expression in the hippocampus as a marker of inflammation had increased in the CMS group. CE was able to reduce the expression of TNF-alpha compared to the CMS group.&#x0D; CONCLUSION: CE possessed antidepressant efficacy by inhibiting the inflammatory process in the hippocampus so it was able to optimally increase serotonin levels in the hippocampus.

Standardization Bark of Cinnamomum burmannii Nees Ex Bl. from Five Areas of Indonesia

Background: The Cinnamomum burmannii Nees ex Bl species is a native plant that grows in many places in Indonesia. The bark of Cinnamomum burmannii Nees ex Bl (C. burmannii bark) in Indonesia is commonly used as a medicinal ingredient, but information related to specific and non-specific parameters of C. burmannii bark from several regions in Indonesia is very limited. Objective: To investigate the standardization C. burmannii bark from five areas of Indonesia. Methods: Determination of non-specific parameters and specific parameters of C. burmannii bark and metabolite profile of essential oil of C. burmannii bark Results: We found there are differences in the nature of C. burmannii bark from five regions in Indonesia. Conclusion: It can be concluded that C. burmannii bark from Mount Kerinci is the best. C. burmannii bark from Mount Kerinci showed that it had the strongest odor and the highest water-soluble extract and alcohol soluble extract as well as the highest essential oil content and the highest cinnamaldehyde content.