Abstract
Background: Hypercholesterolemia is a condition where cholesterol levels in the body exceed the normal range. In Indonesia, the development of traditional medicine is carried out by examining plants known for their medicinal qualities, including cinnamon ( Cinnamomum burmannii). There are many nutritional components contained in cinnamon, such as cinnamaldehyde. This has been suggested as a substance that can reduce cholesterol and triglyceride levels. This study was conducted to determine the efficacy of cinnamon in reducing total cholesterol levels of mice (Mus musculus) given high-fat feed. Methods: This is an experimental study with a pre-post control study design. The groupings were performed by a simple random sampling method. There were five groups (n=6/group): 1) Negative control (aquadest); 2) positive control of high-fat containing food (HFC; quail's yolk); 3) HFC + cinnamon extract (CE; dose 2mg/20g body weight (BW); 4) HFC + CE (dose 4mg/20gBW); 5) HFC + CE (dose 8mg/20gBW). The study was conducted for 28 days. The intervention of CE started on day 15 and ended on day 28. Measurement of total cholesterol and BW of mice was performed on days 0, 14 and 28. Results: A decrease in the total cholesterol of mice ( p = 0.001) was found in the groups that consumed CE. However, there was not a significant change between groups in mice BW ( p = 0.419). Conclusions: Providing cinnamon extract ( Cinnamomum burmannii) for 28 days could decrease total cholesterol levels in mice compared to those not given cinnamon extract when consuming high-fat containing foods.
Highlights
This shows that in the K1 group given quail yolk succeeded in increasing cholesterol in mice with a significant difference compared to the K0 group, which was only given aquadest
In the present study showed cinnamon (Cinnamomum burmannii) extracts proved can be lowering of total cholesterol level for 14 days after consuming high-fat containing foods in mice models compared to does not given cinnamon
Mourad Akdad Department of Biology, Faculty of Science and Technology Errachidia (FSTE), Errachidia, Morocco This study aimed to evaluate the effect of cinnamon extract
Summary
The aim of the study to determine cinnamomum burmannii effective in reducing total cholesterol levels of mice (Mus musculus) given high fat feed. It was not clear the question about the effect of plant on the lipid profile. In the present study we believe that the increase of cholesterol levels due to quail egg yolk could be decreased with cinnamon by its ability to block HMG-CoA reductase enzyme and suppress lipid peroxidation through increased antioxidant enzyme activity[18]. The study aims to determine the efficacy of Cinnamomum burmannii in lowering total cholesterol levels of mice (Mus musculus) given high-fat feed.
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