The treatment compliance is a phenomenon actively studied, due to the proved significant impact on medical care effectiveness. Within the study framework, the treatment compliance in dispensary patients, its relationship with individual characteristics of patients and the effectiveness of dispensary observation were studied. The questionnaire survey in the format of face-to-face standardized interview was carried out. The questionnaire consisted of passport section to record social hygienic characteristics of patients. It also included questions concerning effectiveness of dispensary observation. The special section included the Morisky-Green scale to evaluate treatment compliance. The comparative analysis was implemented concerning the results of questionnaire survey, the data of dispensary observation control cards concerning time of planned visits and also data of outpatient medical records concerning prescriptions of medications. The statistical data processing was performed using software SPSS v. 22. The correlation coefficient was considered as significant at p<0.05. No correlation between individual characteristics of respondents and effectiveness of dispensary observation was established (p>0.05). No correlation between age, marital status, education, employment and treatment compliance according the Morisky-Green scale was established (p>0.05). The correlation coefficients were significant between treatment compliance according the Morisky-Green scale and well-being (r=0.46 p=0.003), fact of hospitalization because of exacerbation of chronic diseases (r=0.71, p<0,001), awareness of planned visit date (r=0.44, p=0,004) and fact of permanent application of medicinal therapy (r=0.62, p<0,001). The partial correlation was established between treatment compliance and planned visit date (r=0.27, p<0,001), fact of permanent application of medicinal therapy (r=0.06, p=0,73). However, partial correlation is absent in case of exclusion of such sign as fact of hospitalization. The negative correlation was established between treatment compliance and time period elapsed after hospitalization (r=-0.69, p<0,001).