Individual Pulses Research Articles

Grand-Expert spectrometer for metal analysis: current status and analytical capabilities

This paper presents the characteristics of the modern Grand-Expert spectrometer for the analysis of metals and alloys. The spectrometer has an updated optical scheme and a new spectrum analyzer to solve a wide range of analytical tasks. The analytical capabilities of the spectrometer were investigated for the analysis of steels and high-purity copper and aluminum as an example. For each of the bases, the updated optical scheme made it possible to realize new opportunities for controlling the homogeneity of the sample material and the presence of micro-inclusions on the sample surface and for determining low impurity contents in the pure metal bases. The spectrometer uses a modern semiconductor spark generator with adjustable frequency, current intensity, and duration of individual spark pulses. Spectra of metal samples for individual spark pulses were obtained in real time for the investigated sample. The operation of the spectrometer in different modes and with different exposure times was tested to select the optimal parameters of calibration characteristics. Computer control provides full synchronization of the generator mode setting, argon feeding, and spectrum registration. For steels, we selected sparking modes with high stability of spectral line intensities and analyte concentrations, and for pure metals (copper and aluminum), modes providing low detection limits of impurity elements and good stability of the results.

Transmission of Binaural Cues by Bilateral Cochlear Implants: Examining the Impacts of Bilaterally Independent Spectral Peak-Picking, Pulse Timing, and Compression.

Acoustic hearing listeners use binaural cues—interaural time differences (ITDs) and interaural level differences (ILDs)—for localization and segregation of sound sources in the horizontal plane. Cochlear implant users now often receive two implants (bilateral cochlear implants [BiCIs]) rather than one, with the goal to provide access to these cues. However, BiCI listeners often experience difficulty with binaural tasks. Most BiCIs use independent sound processors at each ear; it has often been suggested that such independence may degrade the transmission of binaural cues, particularly ITDs. Here, we report empirical measurements of binaural cue transmission via BiCIs implementing a common “n-of-m” spectral peak-picking stimulation strategy. Measurements were completed for speech and nonspeech stimuli presented to an acoustic manikin “fitted” with BiCI sound processors. Electric outputs from the BiCIs and acoustic outputs from the manikin’s in-ear microphones were recorded simultaneously, enabling comparison of electric and acoustic binaural cues. For source locations away from the midline, BiCI binaural cues, particularly envelope ITD cues, were found to be degraded by asymmetric spectral peak-picking. In addition, pulse amplitude saturation due to nonlinear level mapping yielded smaller ILDs at higher presentation levels. Finally, while individual pulses conveyed a spurious “drifting” ITD, consistent with independent left and right processor clocks, such variation was not evident in transmitted envelope ITDs. Results point to avenues for improvement of BiCI technology and may prove useful in the interpretation of BiCI spatial hearing outcomes reported in prior and future studies.

Compact Laser Driver for Ultrasonic Arbitrary Position and Width Pulse Sequences Generation

Laser ultrasound offers several benefits in comparison to immersion or air-coupled ultrasound: it directly generates stress on the sample surface; it has a wide bandwidth and a small acoustic source can be produced. Conventionally, high-power pulsed lasers are required therefore equipment is bulky and expensive. Here we propose to use mid-power laser diodes, which are small and low cost. To solve the low signal amplitude problem with lower power lasers, the use of spread spectrum signal, arbitrary position, and width binary pulse sets is proposed. To date, a laser driver for this task has not been available. This article describes the development of such a compact driver, where the essential electronics occupy an area of $10\,\,\times20$ mm. The whole system with a fixture for kinematic mount is comparable in size to a conventional piezoelectric ultrasonic transducer. The driver can supply pulse sets of up to 40 A. Individual pulse duration can vary between 20 and 1000 ns (0.5–25-MHz ultrasound range) and the total pulse train duration is limited by the laser type used. Experiments show that up to 10- $\mu \text{s}$ long pulse sets can be used at 10-A current, without laser degradation. Current waveforms, beam profile, and optical response signals were measured for three rectified topologies. It was concluded that the GaN-based constant current switch topology has the best performance, but a power MOSFET in a source current feedback topology can also be used to generate pulses down to 20 ns. Photoacoustic response signals from chirp and phase shift keying modulation have been demonstrated.

Automatic Pulse Classification for Artefact Removal Using SAX Strings, a CENTER-TBI Study.

High-resolution, waveform-level data from bedside monitors carry important information about a patient's physiology but is also polluted with artefactual data. Manual mark-up is the standard practice for detecting and eliminating artefacts, but it is time-consuming, prone to errors, biased and not suitable for real-time processing.In this paper we present a novel automatic artefact detection technique based on a Symbolic Aggregate approXimation (SAX) technique which makes it possible to represent individual pulses as 'words'. It does that by coding each pulse with a specified number of letters (here six) from a predefined alphabet of characters (here six). The word is then fed to a support vector machine (SVM) and classified as artefactual or physiological.To define the universe of acceptable pulses, the arterial blood pressure from 50 patients was analysed, and acceptable pulses were manually chosen by looking at the average pulse that each 'word' generated. This was then used to train a SVM classifier. To test this algorithm, a dataset with a balanced ratio of clean and artefactual pulses was built, classified and independently evaluated by two observers achieving a sensitivity of 0.972 and 0.954 and a specificity of 0.837 and 0.837 respectively.

A Neurostimulator IC With Impedance-Aware Dynamic-Precision One-Shot Charge Balancing

This letter presents the design, development, and experimental characterization of a current-mode neurostimulator IC with a safe one-shot charge imbalance compensation, achieved through real-time energy-efficient interface impedance extraction. Thanks to embedding the compensation adjustments in the individual pulse parameters, the technique guarantees no unintentional stimulation during neutralization, imposes no significant time constraints on the rest periods, and allows for on-the-fly and impedance-aware control on the charge accumulation safety threshold. The balancing circuit consumes 37.6μW for conducting electrode voltage monitoring, impedance extraction, and neutralization. A 24-channel IC with the proposed charge balancer embedded in each channel is fabricated in a standard 0.18μm CMOS technology and is experimentally validated using electrical and in vitro measurements and is compared to the state of the art.

Landscape‐Scale Plant Water Content and Carbon Flux Behavior Following Moisture Pulses: From Dryland to Mesic Environments

AbstractRain pulses followed by interstorm drying periods are the fundamental units of water input into ecosystems on subweekly time scales. It is essential to understand landscape‐scale vegetation responses on these unit time scales as they may describe sensitivity of landscape water, carbon, and energy cycles to shifts in rainfall intensity and frequency, even if the average seasonal precipitation remains unchanged. Because pulse investigations are primarily carried out in drylands, little is known about the characteristics and extent of ecosystem plant pulse responses across the broader range of climates and biomes. Using satellite‐based plant water content (from vegetation optical depth) and plant carbon uptake observations from eddy covariance towers across the continental United States climate gradient (dry to humid), we characterize large‐scale plant carbon and water uptake responses to rain pulses during spring and summer months. We find that while all ecosystems in the study region show discernable plant water content and carbon flux responses to rain pulses, drier ecosystems exhibit more frequent and longer duration responses. Unlike mesic environments, drylands show significantly different responses under varying antecedent soil moisture and pulse magnitude conditions; the largest water and carbon uptakes follow large pulses on initially wet soils. We detect soil moisture thresholds primarily in drylands, which can partly explain dryland vegetation's different responses under dry and wet conditions. We conclude that vegetation responds to individual pulses of water availability across all climates and therefore a range of ecosystems are sensitive to rainfall distributions beyond simple seasonal precipitation totals.

Expansion dynamics and radiation absorption in plumes induced by irradiation of a copper target by single and multiple nanosecond laser pulses in the doughnut beam mode

The two-dimensional kinetic simulations of the plume expansion process induced by irradiation of a copper target in argon background gas with nanosecond laser pulses in the doughnut beam mode are performed. The target is irradiated by single and double laser pulses, as well as by bursts consisting of up to 35 individual pulses. The simulations are based on a hybrid computational model that includes the direct simulation Monte Carlo method, where the ionization and absorption of laser radiation are considered. The numerical results are systematically compared with the results obtained for a Gaussian beam at the same pulse energy, peak fluence, and peak intensity. The structure of the plumes induced by a doughnut beam is found to drastically differ from the structure of the plumes induced by a Gaussian beam. The doughnut beam initially induces a toroidal shock wave. The self-interaction of this shock at the axis of symmetry results in the formation of multiple internal shock waves that strongly increase the plume temperature and density. The interaction between plumes induced by a double pulse in the doughnut beam mode occurs in two distinct regimes depending on the beam size and inter-pulse separation time. At a relatively small peak laser fluence, the effect of plasma shielding in the plumes induced by a burst of pulses in the doughnut beam mode is found to be smaller compared to the case of a Gaussian beam. At a relatively large fluence, the simulations reveal the opposite trend, but the amount of vaporized material is found to be always larger for a doughnut beam than for a Gaussian one. The obtained results suggest that the absorption of laser radiation in plasma plumes induced by nanosecond laser pulses can be tuned by changing the radial distribution of energy in the incident laser beam.

The POLAR gamma-ray burst polarization catalog

Context.Despite over 50 years of research, many open questions remain about the origin and nature of gamma-ray bursts (GRBs). Linear polarization measurements of the prompt emission of these extreme phenomena have long been thought to be key to answering a range of these questions. The POLAR detector was designed to produce the first set of detailed and reliable linear polarization measurements in the 50 − 500 keV energy range. During late 2016 and early 2017, POLAR detected a total of 55 GRBs. The analysis results of 5 of these GRBs have been reported, and were found to be consistent with a low or unpolarized flux. However, previous reports by other collaborations found high levels of linear polarization, including some as high as 90%.Aims.We study the linear polarization for the 14 GRBs observed by POLAR for which statistically robust inferences are possible. Additionally, time-resolved polarization studies are performed on GRBs with sufficient apparent flux.Methods.A publicly available polarization analysis tool, developed within the Multi-Mission Maximum Likelihood framework (3ML), was used to produce statistically robust results. The method allows spectral and polarimetric data from POLAR to be combined with spectral data from theFermiGamma-ray Burst Monitor (Fermi-GBM) and theNeil Gehrels SwiftObservatory to jointly model the spectral and polarimetric parameters.Results.The time-integrated analysis finds all results to be compatible with low or zero polarization with the caveat that, when time-resolved analysis is possible within individual pulses, we observe moderate linear polarization with a rapidly changing polarization angle. Therefore, time-integrated polarization results, while pointing to lower polarization, are potentially an artifact of summing over the changing polarization signal and thus washing out the true moderate polarization. We therefore caution against overinterpretation of any time-integrated results inferred herein and encourage the community to wait for more detailed polarization measurements from forthcoming missions such as POLAR-2 and LEAP.

Partial Discharges in HVDC Insulation with Superimposed AC Harmonics

This paper describes the influence of AC harmonics in HVDC systems on one of the main indicators of high voltage insulation deterioration, partial discharge. HVDC systems may be subject to various disturbances including harmonics and ripples in the form of pulsating voltages. Experiments, performed on model void specimen at DC voltage with selected superimposed harmonics, are described. A novel approach for recording partial discharges at DC, based on synchronization with selected superimposed harmonics, is proposed. In this way individual partial discharge pulses, occurring during a given measurement time, are accumulated with respect to the phase angles of certain harmonics. The partial discharge inception threshold is analyzed for cases where the DC level is held constant and the AC magnitude and harmonic frequency are varied and for cases where the DC level is varied and the AC magnitude is held constant. In addition, a long term aging test where insulating paper and resin impregnated paper was subjected to pure DC voltage and DC containing 12th harmonic 600 Hz, is described. The aging test shows that the superimposed harmonic content resulted in an amplification of partial discharge presence. By mapping the discharge spots occurring on the void surface, it is possible to quantify the level of erosion in both cases. It was observed that in case of harmonic crest voltage being below partial discharge PD inception level the DC component is crucial, however when harmonics magnitude is above the inception voltage the role of AC is dominant relative to DC. Thus, the presence of harmonics may result in a strong acceleration of the deterioration of insulating materials subjected to DC voltage.

Peripheral pulse multi-Gaussian decomposition using a modified artificial bee colony algorithm

Time-domain analysis is one of widely used methods to acquire physiological information from peripheral pulse waves. It is crucial to precisely extract features from pulse waves so that classifications can be performed to distinguish differences with high accuracy. Curve fitting has been proved to be more effective than points-based detection for modeling pulse signal trends, and the Gaussian function is a popular model because its bell shape is like an individual pulse. The pulse decomposition problem is exactly an optimization problem, which can be solved by swarm algorithms. In this study, we use Gaussian-mixture functions to fit practical pulse waves by an artificial bee colony (ABC) algorithm. A modified ABC (MABC) algorithm is compared with classical ABC for performance evaluation. MABC is adapted from the classical ABC by modifications in searching strategies of employed bees, onlooker bees, and scout bees. It is concluded that MABC converges quickly under limited iteration times and is effective up to a dimension of 30 for a single complete cycle. We collected pulse waves from a group of 46 healthy volunteers and a group of 69 type-2 diabetic candidates in a clinic. A support vector machine (SVM) with radial basis functions (RBFs) was used for classification after pulse decomposition; the training and test data were obtained randomly at a 7:3 ratio. The largest accuracy averaged 89.1% by considering combinations of the first, third, and fourth center location values, and the first amplitude value of Gaussian functions.

Characterizing Radio Frequency Magnetic Radiation of Initial Upward Leader Stepping in Triggered Lightning With Interferometric Lightning Mapping

AbstractIn summer of 2019, the bandwidth of magnetic field sensor with relatively high sensitivity was extended to 1.2 MHz during the triggered lightning experiment of Field Experiment Base on Lightning Sciences, China Meteorological Administration (CMA‐FEBLS) in Conghua, Guangdong Province. The measurements with the new magnetic fields reveal the presence of microsecond‐scale magnetic pulses during the entire duration of upward positive leader (UPL), including the quiet stage when only few signals can be discerned in previous observations, which indicates that the UPL generally propagates in a stepwise manner during the initial stage of triggered lightning. Synchronous mapping observations from the broadband VHF interferometer shows that the VHF radiation corresponds to the onset of individual magnetic pulses, indicating that the VHF signals are radiated by the breakdown processes of individual stepping, and these breakdown events launch the meter‐scale current pulses as the radiation source of individual magnetic pulses.

Femtosecond Double-Pulse Laser Ablation and Deposition of Co-Doped ZnS Thin Films.

Nanostructured thin films of Co-doped zinc sulfide were synthesized through femtosecond pulsed laser deposition. The scheme involved ablation of physically mixed Co and ZnS with pairs of ultrashort pulses separated in time in the 0–300 ps range. In situ monitorization of the deposition process was carried out through a simultaneous reflectivity measurement. The crystallinity of generated nanoparticles and the inclusion of Co in the ZnS lattice is demonstrated by transmission electron microscopy and energy dispersive X-ray microanalysis (TEM-EDX) characterization. Surface morphology, Raman response, and photoluminescence of the films have also been assessed. The role of interpulse temporal separation is most visible in the thickness of the films obtained at the same total fluence, with much thicker films deposited with short delays than with individual uncoupled pulses. The proportion of Co in the synthesized doped ZnS nanoparticles is found to be substantially lower than the original proportion, and practically independent on interpulse delay.

Applying saliency-map analysis in searches for pulsars and fast radio bursts

Context. We investigate the use of saliency-map analysis to aid in searches for transient signals, such as fast radio bursts and individual pulses from radio pulsars. Aims. Our aim is to demonstrate that saliency maps provide the means to understand predictions from machine learning algorithms and can be implemented in pipelines used to search for transient events. Methods. We implemented a new deep learning methodology to predict whether any segment of the data contains a transient event. The algorithm was trained using real and simulated data sets. We demonstrate that the algorithm is able to identify such events. The output results are visually analysed via the use of saliency maps. Results. We find that saliency maps can produce an enhanced image of any transient feature without the need for de-dispersion or removal of radio frequency interference. The maps can be used to understand which features in the image were used in making the machine learning decision and to visualise the transient event. Even though the algorithm reported here was developed to demonstrate saliency-map analysis, we have detected a single burst event, in archival data, with dispersion measure of 41 cm−3 pc that is not associated with any currently known pulsar.

Classification and comparison of AC and DC partial discharges by pulse waveform analysis

This study aims to classify and compare AC and DC partial discharge (PD) based on PD pulse waveform analysis. To achieve this goal, we designed a testbed that enables precise measurements of individual PD pulses. The testbed is used for collecting data from four different types of PDs including cavity, surface, corona, and floating potential discharges generated by individual PD source samples. All samples were examined under AC, positive DC, and negative DC electrical stresses, through which we captured thousands of PD pulses. We classify the waveforms of each PD type into representative groups associated to their discharge mechanisms. The statistical data of the measured pulses are utilized to identify the differences between AC and DC PDs while the clustered patterns of PD amplitude versus their temporal characteristics serve as a means to classify the types of PDs under AC and DC electrical stresses.

Inter-Temporal Production Performance of Pulse Crops:In Indian Context

The present study investigates to growth and relative contribution of area and yield in production of green gram, black gram chickpea, pigeon pea and lentil pulse crops in India. The study period (1998-99 to 2017-18) is divided into three periods viz., period-I (1998-99 to 2007-08), period-II (2008-09 to 2017-18) and period-III (1998-99 to 2017-18). Time series data on area, production and yield were collected from Directorate of Pulses Development, Bhopal, Directorate of Economics and Statistics, Department of Agriculture and Cooperation, Government of India. The semi-log model, Cuddy-Della Valle instability index and decomposition analysis models were used to analyze the CAGR, instability and relative contribution of area, yield and interaction components. The study clearly finds that area and production of green gram (Vigna radiata) is notified highest compound annual growth rate 1.84 and 1.76 percent respectively, during period-I. In case of yield highest growth rate is reported in black gram (0.26 percent) during the same period. During second period, highest CAGR in area, production and yield is found in black gram at 6.00, 10.30 and 4.10 percent respectively. During all three periods, instability in area, production and yield was very low, except total pulse in second period. The decomposition analysis of production is revealed that yield effect and area effect are major sources of output growth in kharif and rabi pulses, respectively. The Identified growth rate in individual pulse crop is a great informative work because it provides chronological background of how the cultivation of pulses persuades the life of farmers either in negative or positive way. The study also tries to know the peak or trough in past cultivation of pulses crops.

Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head

PurposeTo measure parameters of the cardiac cycle-induced pulsatile light absorption signal (plethysmography signal) of the optic nerve head (ONH) and to compare parameters between normal subjects and patients with different stages of glaucoma.Patients and methodsA recently developed video ophthalmoscope was used to acquire short video sequences (10 s) of the ONH. After image registration and trend correction, the pulsatile changing light absorption at the ONH tissue (excluding large vessels) was calculated. The changing light absorption depends on the pulsatile changing blood volume. Various parameters, including peak amplitude, steepness, time-to-peak, full width at half maximum (FWHM), and pulse duration, were calculated for averaged individual pulses (heartbeats) of the plethysmography signal. This method was applied to 19 healthy control subjects and 91 subjects with ocular hypertension, as well as different stages of primary open-angle glaucoma (17 subjects with ocular hypertension, 24 with preperimetric glaucoma, and 50 with perimetric glaucoma).ResultsCompared to the normal subjects, significant reductions (p < 0.001) in peak amplitude and steepness were observed in the group of perimetric glaucoma patients, but no significant difference was found for time-to-peak, FWHM, and pulse duration. Peak amplitude and steepness showed high correlations with RNFL thickness (p < 0.001).ConclusionsThe presented low-cost video-ophthalmoscope permits measurement of the plethysmographic signal of the ONH tissue and calculation of different blood flow-related parameters. The reduced values of the amplitude and steepness parameters in perimetric glaucoma patients suggest decreased ONH perfusion and blood volume. This outcome is in agreement with results from other studies using OCT angiography and laser speckle flowgraphy, which confirm reduced capillary density in these patients.Registration site: www.clinicaltrials.gov, Trial registration number: NCT00494923

Modeling the temporal-spatial nature of the readout of an electronic portal imaging device (EPID).

In real-time electronic portal imaging device (EPID) dosimetry applications where on-treatment measured transmission images are compared to an ideal predicted image, ideally a tight tolerance should be set on the quantitative image comparison in order to detect a wide variety of possible delivery errors. However, this is currently not possible due to the appearance of banding artifacts in individual frames of the measured EPID image sequences. The purpose of this work was to investigate simulating banding artifacts in our cine-EPID predicted image sequences to improve matching of individual image frames to the acquired image sequence. Increased sensitivity of this method to potential treatment delivery errors would represent an improvement in patient safety and treatment accuracy. A circuit board was designed and built to capture the target current (TARG-I) and forward power signals produced by the linac to help model the discrete beam-formation process of the linac. To simulate the temporal-spatial nature of the EPID readout, a moving read out mask was applied with the timing of the application of the readout mask synchronized to the TARG-I pulses. Since identifying the timing of the first TARG-I pulse affected the location of the banding artifacts throughout the image sequence, and furthermore the first several TARG-I pulses at the beginning of "beam on" are not at full height yet (i.e., dose rate is ramping up), the forward-power signal was also used to assist in reliable detection of the first radiation pulse of the beam delivery. The predicted EPID cine-image sequence obtained using a comprehensive physics-based model was modified to incorporate the discrete nature of the EPID frame readout. This modified banding predicted EPID (MBP-EPID) image sequence was then compared to its corresponding measured EPID cine-image sequence on a frame-by-frame basis. The EPID was mounted on a Clinac 2100ix linac (Varian Medical Systems, Palo Alto, CA). The field size was set to 21.4 28.6cm2 with no MLC modulation, beam energy of 6MV, dose rate of 600MU/min, and 700MU were delivered for each clockwise (CW) and counter-clockwise (CCW) arc. No phantoms were placed in the beam. The dose rate ramp up effect was observed at the beginning irradiations, and the identification and timing of the radiation pulses, even during the dose rate ramp up, were able to be quantified using the TARG-I and forward power signals. The approach of capturing individual dose pulses and synchronizing with the mask image applied to the original predicted EPID image sequence was demonstrated to model the actual EPID readout. The MBP-EPID image sequences closely reproduced the location and magnitude of the banding features observed in the acquired (i.e., measured) image sequence, for all test irradiations examined here. The banding artifacts observed in the measured EPID cine-frame sequences were reproduced in the predicted EPID cine-frames by simulating the discrete temporal-spatial nature of the EPID read out. The MBP-EPID images showed good agreement qualitatively to the corresponding measured EPID frame sequence of a simple square test field, without any phantom in the beam. This approach will lead to improved image comparison tolerances for real-time patient dosimetry applications.

Influence of the Effective Intensity of Laser-Pulse Radiation on the Rate of Multiphoton Processes

The influence of uncertainty in intensity of radiation of individual laser pulses on probabilities of multiphoton ionization/photodetachment is analyzed quantitatively. Both multiphoton (using an example of an F− anion) and tunnel regimes are studied. It is demonstrated that intensity fluctuations substantially change probabilities of the discussed processes. As to the tunnel regime, the role of fluctuations is negligibly small not only in the region of saturation but also far from it in this case.

The pulse of morphogenesis: actomyosin dynamics and regulation in epithelia.

Actomyosin networks are some of the most crucial force-generating components present in developing tissues. The contractile forces generated by these networks are harnessed during morphogenesis to drive various cell and tissue reshaping events. Recent studies of these processes have advanced rapidly, providing us with insights into how these networks are initiated, positioned and regulated, and how they act via individual contractile pulses and/or the formation of supracellular cables. Here, we review these studies and discuss the mechanisms that underlie the construction and turnover of such networks and structures. Furthermore, we provide an overview of how ratcheted processivity emerges from pulsed events, and how tissue-level mechanics are the coordinated output of many individual cellular behaviors.

An ionizing radiation acoustic imaging (iRAI) technique for real-time dosimetric measurements for FLASH radiotherapy.

FLASH radiotherapy (FLASH-RT) is a novel irradiation modality with ultra-high dose rates (>40Gy/s) that have shown tremendous promise for its ability to enhance normal tissue sparing while maintaining comparable tumor cell eradication toconventional radiotherapy (CONV-RT). Due to its extremely high dose rates, clinical translation of FLASH-RT is hampered by risky delivery and current limitations in dosimetric devices, which cannot accurately measure, in real time, dose at deeper tissue. This work aims to investigate ionizing radiation acoustic imaging (iRAI) as a promising image-guidance modality for real-time deep tissue dose measurements during FLASH-RT. The underlying hypothesis is that iRAI can enable mapping of dose deposition with respect to surrounding tissue with a single linear accelerator (linac) pulse precision in real time. In this work, the relationship between iRAI signal response and deposited dose was investigated as well as the feasibility of using a proof-of-concept dual-modality imaging system of ultrasound and iRAI for treatment beam co-localization with respect to underlying anatomy. Two experimental setups were used to study the feasibility of iRAI for FLASH-RT using 6MeV electrons from a modified Varian Clinac. First, experiments were conducted using a single element focused transducer to take a series of point measurements in a gelatin phantom, which was compared with independent dose measurements using GAFchromic film. Secondly, an ultrasound and iRAI dual-modality imaging system utilizing a phased array transducer was used to take coregistered two-dimensional (2D) iRAI signal amplitude images as well as ultrasound B-mode images, to map the dose deposition with respect to surrounding anatomy in an ex vivo rabbit liver model with a single linac pulse precision. Using a single element transducer, iRAI measurements showed a highly linear relationship between the iRAI signal amplitude and the linac dose per pulse (r2 =0.9998) with a repeatability precision of 1% and a dose resolution error <2.5% in a homogenous phantom when compared to GAFchromic film dose measurements. These phantom results were used to develop a calibration curve between the iRAI signal response and the delivered dose per pulse. Subsequently, a normalized depth dose curve was generated that agreed with film measurements with an RMSE of 0.0243, using correction factors to account for deviations in measurement conditions with respect to calibration. Experiments on the ex-vivo rabbit liver model demonstrated that a 2D iRAI image could be generated successfully from a single linac pulse, which was fused with the B-mode ultrasound image to provide information about the beam position with respect to surrounding anatomy in real time. This work demonstrates the potential of using iRAI for real-time deep tissue dosimetry in FLASH-RT. Our results show that iRAI signals are linear with dose and can accurately map the delivered radiation dose with respect to soft tissue anatomy. With its ability to measure dose for individual linac pulses at any location within surrounding soft tissue while identifying where that dose is being delivered anatomically in real time, iRAI can be an indispensable tool to enable safe and efficient clinical translation of FLASH-RT.