Individual Life Research Articles

Is ignorance bliss? Evaluating information awareness and life satisfaction through the lens of perceived air pollution: The case of Beijing, China

Our study presents fresh insight into the impacts of air-related information accessibility and policy awareness on citizen's life satisfaction, through the lens of perceived air pollution sources. It is widely accepted that disclosing information about air pollution adversely affects an individual's life satisfaction. However, the impact of information accessibility and public policy awareness on life satisfaction remains poorly understood in real-life contexts and their interrelationship warrants exploration. Earlier studies suggested that public scrutiny via information disclosure is a means to lower air pollution levels, potentially enhancing life satisfaction through improved air quality perception and reduced health risks. However, much of that research was based on the flawed presumption that all individuals can access and understand this officially disclosed information. They overlooked the actual availability of information and public reflections on relevant policies that were influenced by their perception of air pollution. This research gap highlights the need for in-depth evidence of the impacts of information accessibility and policy awareness on life satisfaction. Employing a covariance-based Structural Equation Modelling, our study analyses the views of 1867 Beijing residents in 2022. We assessed information accessibility, policy awareness, perceived air pollution sources, life satisfaction, and socio-demographic characteristics covering two time periods: a) before the COVID-19 pandemic and b) during its normalisation phase. Our findings reveal that both information accessibility and policy awareness significantly and positively affect life satisfaction in both periods. Moreover, the indirect parameter analysis underscores the presence of significant heterogeneity when considering the mediating role of impacts of perceived air pollutants. The results of this study offer a novel contribution regarding the relationship between air pollution information accessibility, policy awareness, and life satisfaction.

ADL ACTIVITY OF DAILY LIVING DAN KUALITAS HIDUP PASIEN PASCA STROKE ISKEMIK

Ischemic stroke, also referred to as non-hemorrhagic stroke, results in the death of brain tissue due to impaired blood flow, primarily caused by blockages in the cerebral or cervical arteries and, less commonly, in the cerebral veins. This condition profoundly affects various aspects of an individual's life, including physical, emotional, psychological, cognitive, and social well-being. Following a stroke, many individuals experience reduced independence and mobility, which significantly detracts from their quality of life. Often, they face self-care deficits and require assistance to gradually regain the ability to perform activities of daily living (ADL) independently. This study aims to elucidate the strong relationship between ADL independence and the quality of life of post-ischemic stroke patients at Abdul Aziz Hospital in Singkawang City. Employing an analytic observational design with a cross-sectional approach, the research involved a sample of 60 respondents selected from the Neurology Polyclinic at RSUD dr. Abdul Aziz through purposive sampling. Data analysis was conducted using the Spearman Rank test with a 95% confidence level. The results indicate a significant relationship between ADL independence and the quality of life of these patients, as demonstrated by a p-value of 0.000 (p < α) and a correlation strength of 0.514, categorized as moderate (0.40 – 0.599). These findings highlight that the level of independence in activities of daily living is intrinsically linked to the quality of life for post-ischemic stroke patients.

A mindfulness-based intervention for Substance Use Disorder in a Brazilian vulnerable population: a feasibility mixed method study.

Substance Use Disorder (SUD) is a chronic condition that impacts various facets of an individual's life, and society as a whole. The Mindfulness-Based Relapse Prevention (MBRP) protocol is an innovative intervention that can help to prevent relapse, particularly when used as a post-treatment approach. However, although there is significant evidence of its effectiveness in studies from high-income countries (HICs), there is a dearth of studies examining its feasibility and efficacy in low- and middle-income countries (LMICs). Thus, this study investigates the feasibility of MBRP as an adjunct to outpatient treatment for SUD in a socially vulnerable Brazilian population. The study employed a mixed-methods design in eight Psychosocial Care Centers for Alcohol and Drugs (CAPS-ad) in the city of São Paulo, and involved 140 participants, 24 healthcare professionals and 7 CAPS-ad managers. In total, 17 MBRP intervention groups were conducted. The study assessed qualitative indicators of acceptability, demand, implementation, adaptation, integration, and limited efficacy testing through group interviews, in-depth interviews and field diary records. It also included limited efficacy testing of the protocol using a quantitative pre-post pilot study to investigate consumption behavior, using the Timeline Followback (TLFB) assessment method; depression, using the Center for Epidemiologic Studies Depression (CES-D) scale; anxiety, using the state trait anxiety index (STAXI-2); craving, using the Penn Alcohol Craving Scale (PACS); readiness to change, using the Readiness-to-Change Ruler (RCR); and severity of dependence, using the Severity of Dependence Scale (SDS). The qualitative data were triangulated with the quantitative data to comprehensively evaluate the feasibility of the intervention. The sample comprised socially vulnerable participants with a high dropout rate, primarily due to social factors. Despite facing challenges in respect of regular engagement and initial cultural misperceptions of meditation, the intervention showed positive acceptance and mental health benefits, including impacts on consumption behavior. The study emphasizes the importance of adapting the format of the protocol to better suit vulnerable populations, and to ensure its effective integration into the public healthcare system. Future research should explore protocol modifications, assess its effectiveness in different contexts, and conduct cost-benefit analyses for broader implementation.

Parent-Led Applied Behavior Analysis to Impact Clinical Outcomes for Individuals on the Autism Spectrum: Retrospective Chart Review.

Autism spectrum disorder (ASD) can have traits that impact multiple domains of functioning and quality of life, which can persevere throughout life. To mitigate the impact of ASD on the long-term trajectory of an individual's life, it is imperative to seek early and adequate treatment via scientifically validated approaches, of which applied behavior analysis (ABA) is the gold standard. ABA treatment must be delivered via a behavior technician with oversight from a board-certified behavior analyst. However, shortages in certified ABA therapists create treatment access barriers for individuals on the autism spectrum. Increased ASD prevalence demands innovations for treatment delivery. Parent-led treatment models for neurodevelopmental conditions are effective yet underutilized and may be used to fill this care gap. This study reports findings from a retrospective chart review of clinical outcomes for children that received parent-led ABA treatment and intends to examine the sustained impact that modifications to ABA delivery have had on a subset of patients of Montera, Inc. dba Forta ("Forta"), as measured by progress toward skill acquisition within multiple focus areas (FAs). Parents received ≥40 hours of training in ABA prior to initiating treatment, and patients were prescribed focused (<25 hours/week) or comprehensive (>25-40 hours/week) treatment plans. Retrospective data were evaluated over ≥90 days for 30 patients. The clinical outcomes of patients were additionally assessed by age (2-5 years, 6-12 years, 13-22 years) and utilization of prescribed treatment. Treatment encompassed skill acquisition goals; to facilitate data collection consistency, successful attempts were logged within a software application built in-house. Improved goal achievement success between weeks 1-20 was observed for older age, all utilization, and both treatment plan type cohorts. Success rates increased over time for most FAs, with the exception of executive functioning in the youngest cohort and comprehensive plan cohort. Goal achievement experienced peaks and declines from week to week, as expected for ABA treatment; however, overall trends indicated increased skill acquisition success rates. Of 40 unique combinations of analysis cohorts and FAs, 20 showed statistically significant positive linear relationships (P<.05). Statistically significant positive linear relationships were observed in the high utilization cohort (communication with P=.04, social skills with P=.02); in the fair and full utilization cohorts (overall success with P=.03 for the fair utilization cohort and P=.001 for the full utilization cohort, and success in emotional regulation with P<.001 for the fair utilization cohort and P<.001 for the full utilization cohort); and in the comprehensive treatment cohort (communication with P=.001, emotional regulation with P=.045). Parent-led ABA can lead to goal achievement and improved clinical outcomes and may be a viable solution to overcome treatment access barriers that delay initiation or continuation of care.

Decrease in walking ability with increased functional connectivity between multiple brain areas in Parkinson's disease: a functional near-infrared spectroscopy study.

Gait disturbances significantly impact the mobility and quality of life of individuals with Parkinson's disease (PD). This study aims to delve into the cortical mechanisms underlying gait disorders in PD, specifically focusing on the prefrontal cortex (PFC), premotor cortex (PMC), and primary somatosensory cortex (PSC). To compare the functional connectivity of the PFC, PMC, and PSC regions during walking between individuals with PD and healthy controls. The study included 30 individuals with PD (mean age 62.40 ± 7.16 years) and 22 healthy older adults (mean age 60.95 ± 6.34 years). All participants were requested to walk back and forth at a comfortable pace for 30 s over a 10-meter course three times. A mobile functional near-infrared spectroscopy (fNIRS) system was employed to evaluate the oxyhemoglobin concentration change (∆HbO2). To assess the interactions between the PFC, PMC, and PSC, the connectivity strength between different fNIRS channels was computed. Individuals with PD in the off-state exhibited significantly decreased walking speed and shorter stride length compared to the healthy controls. For six brain regions including the left (L) and right (R) PFC, PMC, and PSC, no significant differences in functional connectivity within each region were found between the PD and control groups. However, when it comes to the functional connectivity between every two regions, the PD group exhibited stronger functional connectivity than the control group in the LPFC-LPMC, LPFC-RPMC, LPFC-LPSC, RPFC-LPMC, RPFC-LPSC, LPMC-LPSC, LPMC-RPSC, and RPMC-RPSC. Positive correlations were found between gait performance (speed and stride length) and functional connectivity within the RPMC as well as between the RPMC and the RPSC. Individuals with PD exhibit notable gait disturbances and increased functional connectivity in brain regions responsible for sensorimotor integration and motor function in their off-state. Strengthening the functional connectivity within the RPMC and between the RPMC and the RPSC could be a potential target for future treatments of gait impairments in PD.

Synergistic effects of human umbilical cord mesenchymal stem cells/neural stem cells and epidural electrical stimulation on spinal cord injury rehabilitation

Spinal cord injury (SCI) is a severe neurological condition marked by a complex pathology leading to irreversible functional loss, which current treatments fail to improve. Epidural electrical stimulation (EES) shows promise in alleviating pathological pain, regulating hemodynamic disturbances, and enhancing motor function by modulating residual interneurons in the lower spinal cord. Cell transplantation (CT), especially using human umbilical cord mesenchymal stem cells (hUCMSCs) and neural stem cells (NSCs), has significantly improved sensory and motor recovery in SCI. However, the limitations of single treatments have driven the exploration of a multifaceted strategy, combining various modalities to optimize recovery at different stages. To comprehensively investigate the effectiveness of in situ transplantation of hUCMSCs/NSCs combined with subacute epidural electrical stimulation in a murine spinal cord crush injury model, providing valuable references for future animal studies and clinical research. In this study, we first examined neural stem cell changes via mRNA sequencing in an in vitro Transwell co-culture model. We then explored cell interaction mechanisms using proliferation assays, differentiation assays, and neuron complexity analysis. For animal experiments, 40 C57BL/6 mice were assigned to four groups (Injury/EES/CT/Combination). Histological evaluations employed HE and immunofluorescence staining, while electrophysiological and behavioral tests assessed motor recovery. Quantitative data were reported as mean ± standard error, with statistical analyses performed using GraphPad Prism and SPSS. Initially, we found that NSCs in the in vitro co-culture model showed a unique expression profile of differentially expressed genes (DEGs) compared to controls. GO/KEGG analysis indicated these DEGs were mainly linked to cell differentiation and growth factor secretion pathways. Neuronal and astrocytic markers further confirmed enhanced NSC differentiation and neuronal maturation in the co-culture model. In vivo, live imaging and human nuclei immunofluorescence staining revealed that transplanted cells persisted for some time post-transplantation. Histological analysis showed that during acute inflammation, both the stem cell and combined therapy groups significantly inhibited microglial polarization. In the chronic phase, these groups reduced fibrotic scar formation and encouraged astrocytic bridging. Behavioral tests, including swimming and gait analysis, demonstrated that combined CT and EES therapy was more effective than either treatment alone. In summary, the combined therapy offers a promising approach for spinal cord injury treatment, providing superior outcomes over individual treatments. Our findings underscore the potential of a combined treatment approach utilizing stem cells transplantation and EES as an effective strategy for the comprehensive management of spinal cord crush injury in mice. This integrated approach holds promise for enhancing functional recovery and improving the quality of life for individuals with spinal cord injury (SCI).

An Analysis of Human Nature in Fromm's Humanistic Thought

In contemporary society, the problem of human existence has increasingly aroused the common concern of all mankind, and the rich and colorful material life has enriched people's daily life, but the spiritual life of human beings is relatively impoverished, and the great abundance of material wealth to a certain extent makes people enslaved to material things, and the spiritual life of individuals is in a state of imbalance. While elaborating on the actual state of human existence, Fromm's humanistic thought critically exposes the social problems caused by the development of productive forces, and fundamentally points out the confusion of human beings, on the basis of which it indicates that we can realize the breakthrough of the state of human beings' gradual dissolution in a certain way, so as to generate a brand-new space for the survival of human beings. In this way, human beings will be able to find their way out of numbness and self-loss, and thus step into the “kingdom of existence”. Fromm's anthropological point of view mainly centers on human nature, including three aspects: human nature, human nature alienation, and human nature liberation. This paper is a brief analysis of this aspect of human nature.

The Effect of Financial Education on Increasing Financial Literacy

That financial literacy is part of economic literacy that is important to develop through educational activities. Financial literacy is very important especially for individuals because this financial aspect is a determinant in finding individual life needs. although there are still individuals who have not implemented good financial literacy in their lives. As is the case with students of SMK Negeri 1 Tugala Oyo which is one of the vocational schools in Tugala Oyo District, North Nias Regency. This study aims to determine how much influence Financial Education has on improving Financial Literacy at SMK N 1 Tugala Oyo, North Nias Regency. This study uses a quantitative method, respondents are students of SMK Negeri 1 Tugala Oyo as many as 65 people, where researchers collect data using questionnaires, then conduct validity studies, and data reliability tests, correlation coefficients, classical assumption tests (normality test, multicollinearity test, heteroscedasticity test), simple linear regression, coefficient of determination, and t-test. The results of the study showed that the influence of financial education on increasing financial literacy at SMK Negeri 1 Tugala Oyo was 22.4% and 77.6% was influenced by other factors that were not influenced by this study.

Spinal muscle characteristics during three different types of locomotion activities among college students with idiopathic scoliosis

Background contextPhysical activities such as walking and climbing stairs are pervasive in human daily life. Individuals with scoliosis frequently encounter dysfunction in their muscle recruitment. Multiple studies have corroborated the presence of muscle dysfunction in individuals diagnosed with scoliosis. However, there is currently a noteworthy research gap regarding the exploration of changes in muscle characteristics and disparities from those observed in individuals without scoliosis during everyday activities, specifically stair climbing.PurposeThis study aims to examine the unique patterns of muscle activity during daily life in individuals with scoliosis and distinguish the specific differences between scoliosis patients and the healthy controls. The findings of this study are significantly important for the future accurate assessment of scoliosis and the development of rehabilitation treatment plans.Study designCase–control study.Sample sizeTwenty eight idiopathic scoliosis patients and twenty eight controls.Outcome measuresRoot Mean Square(RMS), Maximum Voluntary Isometric Contraction(MVIC)%, RMS ratio(RMS convex / RMS concave).MethodsThe surface electromyography (sEMG) device used in this study was the Delsys Trigno, with a sampling frequency of 1500 Hz. It recorded the activation level, peak contraction, and average activation level of the erector spinae (at T6, T10, and L3 levels), gluteus maximus, gluteus medius, external oblique, and rectus abdominis muscles during three different types of locomotion for both the 28 individuals with idiopathic scoliosis and the 28 control participants.ResultsThe movement patterns of the idiopathic scoliosis patients significantly differ from those of the normal population during level walking and ascending or descending stairs. In level walking, there is an asymmetry in the activation levels of the T6 and L3 erector spinae muscles, with lower activation on the convex side compared to the concave side. Similarly, during stair ascent, the activation of the T6 and T10 erector spinae muscles is asymmetric, with higher activation on the convex side than the concave side. Moreover, during stair descent, the activation of the T6 erector spinae muscle is asymmetric, with higher activation on the convex side than the concave side.ConclusionsDuring level walking and stair activities, idiopathic scoliosis patients exhibit pronounced abnormal movement patterns that significantly differ from those of the control group. Under different activity conditions such as level walking, ascending and descending stairs, idiopathic scoliosis patients demonstrate abnormal muscle activation in different segments of the spine. It is crucial for clinicians to prioritize the symmetry of muscle activation in the spinal region of idiopathic scoliosis patients and consider incorporating symmetry training for these muscles.

INNOVATIVE FOOTWEAR DESIGN FOR AUTISTIC INDIVIDUALS: MERGING AESTHETICS AND SENSORY NEEDS

The integration of repetitive visual patterns and geometric shapes in footwear design for autistic individuals presents an innovative approach that transcends mere aesthetics. This strategy aims to address the sensory and emotional needs of users, highlighting the importance of visual stimuli in promoting focus and mental organization—key elements for those facing sensory challenges. Research indicates that emphasizing symmetry and repetition in design can create visually pleasing footwear while also facilitating better concentration. Various studies suggest that the perceptual abilities and visual processing strategies of autistic individuals can be harnessed to foster richer and more effective learning experiences, aiding in the development of essential social and cognitive skills. Furthermore, the selection of comfortable materials and the consideration of ergonomic design are crucial to ensure that the shoes are not only visually appealing but also functional and comfortable for everyday wear. By focusing on these aspects, footwear can serve as more than just a fashion statement; it can become a tool for enhancing the quality of life for autistic individuals. The thoughtful combination of art, comfort, and sensory experience in shoe design promotes inclusion and celebrates the uniqueness of each individual. This approach fosters a deep connection between the user and the product, ultimately contributing to a more supportive and understanding environment for those on the autism spectrum.

An Analytical Theoretical Study of Terrorism According to the Social Action Theory of ‘Talcott Parsons’ as an Instance of Sociological Theories

The main focus of sociology is presenting the social life of people and their behaviours, whether in groups or societies. Sociology, usually, is defined as a field of research which studies the social interaction between people and their behaviours. Thus the sociological theories and scholars have given great importance to social action concept. In this study, which is an extract from a PhD dissertation, the terrorism has analysed sociologically according to the Talcott Parsons’ theory of social action. Since terrorism is one of the common social phenomena around the world, it has various factors and reasons that vary according to the communities’ nature of life. Terrorism, also, is a concept which used for any violent acts committed by an organization, an individual or a group. It has been experienced by humanity in many different ways throughout different eras. Therefore this study has tried to determine a theoretical framework for analysing and reviewing this phenomenon besides talking about it according to the reality of society and its most important causes and effects on the life of society and individuals. Because the Parsons’ theory serves the study aims and gives us the opportunity of conducting and analysing the study in a more detailed approach, it has been utilised for the current study. The main aim of the study is to analyse the phenomenon of terrorism from the perspective of “Talcott Parsons' theory of social action as a sociological theory”.

Forced Returns and Fragile Lives: Strategies for Safeguarding Syrian Refugees and Ensuring Their Protection

Abstract The article discusses the deportation of Syrian refugees from Lebanon and Turkey between 2017 and 2024. It attempts to bring light on the experiences of these refugees facing forced returns, emphasising the human consequences and complicated causes underlying such actions. The purpose of this article is to raise awareness about the deportation of Syrian refugees and the urgent need for collective action to address this humanitarian disaster and preserve the lives of vulnerable individuals affected by forced repatriation. Using the descriptive analytical approach, this article investigates the legislative frameworks and international commitments that should safeguard refugees from forced repatriation. The Universal Declaration of Human Rights (udhr), The 1951 Convention Relating to the Status of Refugees and its 1967 Protocol and rules of International Humanitarian Law will be used as a standard for the definition and legal framework of refugee’s rights. The article dives into the obstacles that host countries confront, including as social, economic, and political pressures. It also emphasises the necessity of advocacy activities and protective measures to defend Syrian refugees’ rights and well-being. The findings of the article are expected to benefit Syrian refugees and raise awareness about their situation, which will contribute preserve their lives and well-being.

Life and Death in Yu Hua’s Novels——Taking To Live and The Seventh Day as Examples

Yu Hua’s works have consistently excelled in exploring the fundamental meaning of life within tales of hardship and tragedy. Through a series of books such as To Live and The Seventh Day, Yu Hua has crafted multiple tragic stories featuring characters from different historical periods and with diverse personalities, thereby expressing his unique perspectives on life and death. The existing studies mostly analyze the life and death plot in isolation and lack an analysis of the influence of traditional culture on the formation of their concepts. This paper will take the original texts of the novels To Live and The Seventh Day as the basis, and use the method of textual analysis to analyze the views of life and death in the novels. Through the study, it is found that Yu Hua’s works present a unique new style of death aesthetics and life philosophy concepts. Through the research, it is discovered that Yu Hua’s works exhibit a unique new aesthetic of death and philosophy of existence. Yu Hua, a trailblazer in avant-garde literature, integrates traditional views on life and death with contemporary societal concerns. Through an exploration of the fragility of human physiology and the resilience of the human spirit, Yu Hua’s works offer a fresh perspective on life and death for individuals grappling with existential uncertainties. This aids in guiding individuals to seek the significance of their own lives and adopt an objective stance towards mortality.

Adolescent Autonomy and Family Authority: A Bedtime Negotiation Based Perspective

For adolescents, consultation with their parents about bedtime is an awareness of personal autonomy and an understanding of legal norms and the relationship between authority and the governed. The article analyzes the difference between the ideal bedtime and real-life flexibility, emphasizing parents’ adaptability in rule-setting and respect for children’s autonomy. At the same time, the protection of children’s rights under international law and the different definitions of children in various cultural and legal contexts were emphasized. The article’s conclusion shows that, given the specific circumstances of each adolescent and the uniqueness of the family environment, it is impossible to prescribe a fixed bedtime suitable for all adolescents simply. This conclusion underscores the need to consider individual differences and practical life needs when setting family rules, as well as the importance of maintaining family order while respecting children’s autonomy.

SENSORY-FOCUSED FOOTWEAR DESIGN: MERGING ART AND WELL-BEING FOR INDIVIDUALS WITH AUTISM

The application of art in footwear design presents a unique opportunity to enhance the well-being of children and adults with autism by incorporating controlled sensory stimuli. This approach integrates natural elements—like trees, flowers, and serene colors—into shoes, creating a calming sensory experience. Colors such as blue, green, and lilac are strategically chosen for their soothing effects, fostering emotional stability and reducing stress. Research indicates that these hues promote relaxation, with blue associated with tranquility, green symbolizing nature, and lilac evoking spirituality. The texture of the footwear plays a crucial role as well, incorporating raised patterns inspired by natural forms to provide subtle, relaxing tactile stimulation. This allows for pleasant sensory interaction, particularly for individuals sensitive to excessive stimuli. Comfort is further enhanced by the inclusion of soft, non-slip insoles that distribute weight evenly and ensure safety, especially in environments where slips may occur. Recent studies reinforce the importance of creating environments that promote calm and comfort, highlighting innovative solutions that improve quality of life for individuals with sensory challenges. The design of therapeutic gardens and the development of responsive smart clothing illustrate a growing recognition of the benefits of integrating art and nature into everyday experiences. Overall, this focus on empathetic and inclusive design reflects a societal shift toward understanding and addressing the unique needs of those with autism. By prioritizing sensory-friendly features in everyday products, the integration of art into footwear not only enhances aesthetic value but also contributes significantly to emotional and physical well-being, creating a more inclusive world.

Convergence of Neuroinflammation, Microbiota, and Parkinson's Disease: Therapeutic Insights and Prospects.

Parkinson's disease (PD) is a complex neurodegenerative disorder. Recent evidence reveals connections between neuroinflammatory processes and intestinal microbiota alterations in the progression of this pathology. This comprehensive review explores the intricate relationships between them, highlighting their combined impact on PD. Neuroinflammation, characterized by immune activation in the central nervous system, is increasingly acknowledged as a critical factor in the development of PD. Concurrently, alterations in the gut microbiota composition have been linked to PD, suggesting a potential modulatory role in disease progression. Thus, bidirectional communication along the gut-brain axis has become pivotal in comprehending the pathogenesis of PD. Furthermore, we explore emerging therapeutic strategies that target these interconnected pathways, providing insights into potential avenues for PD treatment. The elucidation of these intricate relationships establishes a promising foundation for innovative therapeutic strategies aimed at altering disease progression and improving the quality of life for individuals affected by PD.

The Effect of the COVID-19 Pandemic on Life Satisfaction: Does Social Belonging Matter as a Mechanism and are There Differences by Age?

The effect of the COVID-19 pandemic on life satisfaction has been a topic of worldwide research, mostly indicating a drop in individual’s life satisfaction with some differences between subgroups. However, literature on related mechanisms is scarce. This study examines whether the sense of social belonging is a mechanism that explains pandemic-related changes in life satisfaction across different age groups. Using a rich longitudinal data set of the adult cohort of the German National Educational Panel Study and employing fixed effects panel regression models, we show that the COVID-19 pandemic is, on average, negatively associated with individual life satisfaction and social belonging. Yet, mediation and sensitivity analysis questions the general importance of social belonging as a relevant mechanism irrespective of individuals’ age. The results also suggest that the negative effects of the pandemic on social belonging were indeed significant for individuals with average or high pre-pandemic social belonging, while individuals with low pre-pandemic social belonging experienced an increase in their sense of social belonging. This leads to an expanded discussion of which groups of people are most affected by the impact of the COVID-19 pandemic and what other mechanisms can be hypothesized to explain this negative impact on people's life satisfaction.

Frailty and quality of life in italian older adults: implications for public health interventions

Abstract Background The increasing focus on frailty in older adults underscores the significance of a timely multidimensional assessments and early detection to avert adverse outcomes. The primary aim is to integrate digital technologies, specifically online assessment tools, for the identification of frailty and the assessment of Quality of Life (QoL) in elderly individuals. Methods A nationwide multicentric study was conducted. Seven Italian centers and regions evaluated frailty in older adults residing in the community, through a prospective observational cohort study. The chosen questionnaires, Sunfrail+ and SF-12, were implemented through an easily accessible online tool, swiftly generating final scores for each test. The cross-sectional analysis included 503 older adults. The cut off to define a person “frail” is 3 positive alerts in Sunfrail baseline items, according to the literature. Results In this sample an average of 2.31 positive alerts were generated. Significant associations were established between the number of positive warnings and SF-12 physical and mental indexes, indicated by X2=53.1 (p &amp;lt; 0.001) and X2=25.1 (p &amp;lt; 0.001), respectively. The difference between two groups (frail and not frail) in relation to QoL is statistical significantly (U di Mann Whithney p &amp;lt; 0.001). Mean QoL mental and physical indexes are 46.3 and 39.3 in frailty group, versus 51.7 and 46.5 in non frailty group, respectively. The correlation is conceptually consistent: as frailty increases, QoL decreases. Conclusions The frailty assessment associated with the QoL assessment provides relevant information to monitor the impact of prevention interventions at community level. The assessment of frailty leads the prevention intervention whose impact could be assessed also through QoL tools. This study underlines a meaningful association between assessment tools, substantiated by conceptual correlations. Key messages • Sunfrail and SF-12 are easily accessible online tool useful for identification of frailty and the assessment of Quality of Life (QoL) in elderly individuals. • The older population in Europe is increasing a timely assessment of frailty must be a public health priority.

Is SNOT-22 a Reliable Tool During Periods of High Stress? A Retrospective Cohort Study.

To assess the impact of a major crisis, such as the October 7, 2023, terror attack, on SNOT-22 scores, especially the extra-rhinologic subdomains. This retrospective cohort study was conducted at the Rhinology Clinic in a Tertiary University Hospital. Patients who visit our Rhinology Clinic routinely complete the SNOT-22, a widely employed questionnaire designed for evaluating health-related quality of life in individuals with rhinologic conditions. Patients were divided into two groups: 5 weeks before the October 7 terror attack and 5 weeks after. Primary outcomes for analyses included the Sedaghat Subdomain model of the SNOT-22. Descriptive analysis and Welch's t-test were used to compare SNOT-22 subdomain scores between groups. A total of 159 patients completed the SNOT-22 questionnaire, with 60 before and 99 after October 7, 2023. A general decrease in average scores was observed across all subdomains, with a significant decrease in the Nasal subdomain (p = 0.0388). Subgroup analysis showed an increase in the Ear/Facial subdomain in Arabic and the Sleep and Function subdomains in English, though not statistically significant. In sex-based sub-analysis, female patients showed a significant decrease in the Emotions subdomain. Our study was unable to establish a direct link between the terror attack and specific SNOT-22 subdomains. However, the observed trends suggest that SNOT-22 may display variability or unreliability when used during periods of high stress. III Laryngoscope, 2024.

Sex differences in sleep deficits in mice with an autism-linked Shank3 mutation

BackgroundInsomnia is more prevalent in individuals with Autism Spectrum Disorder (ASD), can worsen core-symptoms and reduces quality of life of both individuals and caregivers. Although ASD is four times more prevalent in males than females, less is known about sex specific sleep differences in autistic individuals. Recent ASD studies suggest that sleep problems may be more severe in females, which aligns with the sex bias seen in insomnia for the general population. We have previously shown that male mice with a mutation in the high confidence ASD gene Shank3, Shank3∆C, recapitulate most aspects of the ASD insomnia phenotype. The objective of the present study was to leverage the Shank3∆C model to investigate sex-specific effects in sleep using polysomnography.MethodsAdult male and female Shank3∆C and wildtype (WT) littermates were first recorded for 24 h of baseline recordings. Subsequently, they were sleep deprived (SD) for five hours via gentle handling and allowed 19 h of recovery sleep to characterize the homeostatic response to SD. Vigilance states (rapid eye movement (REM) sleep, non-rapid eye movement (NREM) sleep and wake) were assigned by manual inspection using SleepSign. Data processing, statistical analysis and visualization were conducted using MATLAB.ResultsSex and genotype effects were found during baseline sleep and after SD. At baseline, male Shank3∆C mice sleep less during the dark period (active phase) while female Shank3∆C mice sleep less during the light period (rest phase) and sleep more during the dark period. Both male and female Shank3∆C mice show reduced spectral power in NREM sleep. We detect a significant effect of sex and genotype in sleep onset latency and homeostatic sleep pressure (sleepiness). In addition, while male Shank3∆C mice fail to increase sleep time following SD as seen in WT, female Shank3∆C mice decrease sleep time.ConclusionsOverall, our study demonstrates sex differences in sleep architecture and homeostatic response to SD in adult Shank3∆C mice. Thus, our study demonstrates an interaction between sex and genotype in Shank3∆C mice and supports the use of the Shank3∆C model to better understand mechanisms contributing to the sex differences in insomnia in ASD in clinical populations.