The problem and the aim of the study. One of the priorities of the modern school is informatization and individualization of education. Its implementation can be facilitated by the e-portfolio as a tool for evaluating students’ individual educational results, optimizing work with information, and supporting the design of a non-linear structure for presenting materials. The purpose of the research is to study the possibilities of using the interactive multifunctional cloud portfolio for implementing individual educational routes for students in the course of project activities. Research methods. The methodology is based on the analysis of the didactic potential of the e-portfolio technology, support for UNESCO initiatives, state education development programs. The analysis and synthesis of literature on the problem of using interactive tools in the digital school, processing of test results and electronic content of the portfolio are applied. The experiment involved 52 students of classes 5-10, who study at gymnasium in Kirovo-Chepetsk (Russian Federation). The designed portfolio was implemented in the environment of the Unified Regional Information System for Education of the Kirov Region. Pearson's chi-squared test (χ2 ) was used for statistical data processing. Results. The model of the interactive multifunctional cloud portfolio was developed, which determines its structure, including the sections "My individual educational route", "My lessons", "My studios", "My affairs". The implementation of the model in the unified regional information system made it possible to change the nature of the interaction between participants of educational relations in the experimental group; improve the quality of the provision of services in electronic form; determine priority areas for development for each student, etc. Statistically significant differences in qualitative changes in the pedagogical system were revealed (χ2 = 9.302; p < 0.05). In conclusion, the features of using the proposed portfolio model are described: the principles of the unity of education and upbringing, individualization, variability, reflection and cooperation, etc. The difficulties of the proposed innovations are formulated: the need to clearly define the didactic functions of the projected portfolio; the problem of choosing digital tools; accuracy of task formulation, etc. Keywords: digitalization of education, individualization of education, e-portfolio, cloud technology, project, unified regional information system