In a rapidly changing business environment, innovative behavior within an organization is emphasized for a company to continuously develop and succeed. This study specifically identified various factors (self-leadership, entrepreneurship, and innovative behavior) that support such innovative behavior. Self-leadership refers to the ability of members to voluntarily and actively perform leadership roles within an organization. In relation to this, innovation behavior includes the act of introducing new ideas and leading change within the organization. This study examined the interaction between self-leadership and innovation behavior, focusing on empirical research on how entrepreneurship mediates the relationship between the two factors. For this purpose, a survey was conducted targeting 335 office workers over the age of 20, and among the collected questionnaires, 326 questionnaires, excluding 9 that were judged to have response bias, were used for analysis. For data analysis, SPSS Statistics ver 26.0 and Amos ver 23.0 programs, which are widely used in the social science field, were used, and the research results are as follows. First, self-leadership was found to have a positive influence on entrepreneurship and innovative behavior, and entrepreneurship was found to have a positive influence on innovative behavior. In other words, it was confirmed that the higher the self-leadership, the higher the entrepreneurship spirit, and the higher the entrepreneurship spirit, the higher the innovative behavior. Second, the indirect path from self-leadership to innovation behavior through entrepreneurship was found to be significant. Past studies have often emphasized the importance of innovative behavior, but have not sufficiently identified how individual factors can lead to and promote such behavior. This study further expanded the understanding of innovation by specifically examining how leadership style (self-leadership), an individual-level resource, functions in the relationship with innovative behavior. We hope that this study will serve as basic data to improve the organization's capabilities to respond to future challenges and opportunities and strengthen the organization's agility to change.