Introduction. Infectious diseases make a significant contribution to the recurrence and disability, and therefore cause economic damage to the country, which is an indisputable argument in favor of the creation of a system of rehabilitation of children with infectious diseases.The objective of the study was the economic justification of the need to organize a multidisciplinary children’s rehabilitation center, including after infectious diseases. Material and methods. Based on the long-term experience of the only center in the Russian Federation for the treatment of children’s infections and the data of the statistical service we calculated the economic effect obtained as a result of reducing the recurrence of infectious diseases and disability caused by them among the child population.Results. The study found that the annual economic losses associated with the treatment of relapses of infectious diseases among children would be 4.344 billion rubles and 39.713 billion rubles due to the payment of disability benefits. The economic loss associated with the reduction of days of incapacity of parents obliged to care for children who need care due to infectious diseases is 2.791 billion rubles. In addition, the indirect economic loss caused by the under-produced products and the GDP decline due to the disability of such children already in working age is 30.102 billion rubles.Conclusion. We proved the significant economic effect that would be received at the opening of the rehabilitation center for children. The economic effect is caused by the reduction of both direct and indirect economic losses.