Lipid Profile Indices Research Articles

THE EFFECTS OF 12 WEEKS BASIC GYMNASTICS EXERCISES ON BODY COMPOSITION AND LIPID PROFILES IN OBESE CHILDREN

Obesity is a major health concern in the world because it is associated with many diseases. It has been shown that basic gymnastics exercises effectively prevent and treat this problem. Therefore, the present study investigated the effect of 12 weeks of basic gymnastics exercises on body composition and lipid profile in obese girls. In this quasi-experimental study, with a design pre-test-post-test and a control group, 30 obese girls with Body Mass Index (BMI) at or above the 95th percentile and the average age of 9.4 years, were selected purposefully and were divided into 2 groups (Basic gymnastics training, and control) randomly. The training protocol was implemented for 12 weeks, three times a week, and 45 minutes for each session incrementally. Body composition and lipid profile indices were measured in two stages: pre-test and post-test. In order to analyze the data, multivariate covariance tests were used. The results of the study showed that the exercise intervention significantly reduced the fat percentage and BMI index in obese children (p≤0.001). In addition, a significant decrease in total cholesterol, triglyceride, and Low Density Lipoprotein Cholesterol (LDL-C) and a significant increase in High Density Lipoprotein Cholesterol (HDL-C) were observed (p≤0.002). These findings indicate the beneficial effects of basic gymnastics training on body composition and lipid profile in obese children. Therefore, the use of basic gymnastics training is recommended to improve these factors.

The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats.

The fat distribution in the body determines the risk of cardiometabolic problems such as heart disease and diabetes. Some dietary supplements, such as selenium and zinc, possess lipolytic and anti-angiogenic functions, which may be a useful strategy in reducing the risk of cardiometabolic complications. This study evaluated the effect of zinc (Zn), selenium (Se), and their combined supplementation on cardiometabolic risk factors in male Wistar rats in two nutritional models, including caloric restriction (CR) and high-fat diet (HFD). The 48 male Wistar rats were divided into three diet groups (HFD and CR and normal diet (ND)). The HFD group was subdivided into four groups (N=8 rats in each group) that received (HFD+Se), (HFD+Zn), (HFD+Zn+Se), and HFD alone as the control group, respectively. After 8 weeks of intervention, biochemical tests were performed on serum levels, including measurement of lipid profile (triglyceride, Cholesterol, LDL and HDL) and glycemic indices (fasting blood sugar, insulin and insulin sensitivity markers). The results showed that supplementation significantly improved the lipid profile (P <0.001). A comparison of glucose homeostasis indices in the study groups also showed a significant difference. The serum level of glucose was higher in the HFD group than in the intervention groups (P <0.001). Also, the rate of improvement of lipid profile and glycemic indexes in the group receiving the combination of two supplements showed a better trend than those receiving zinc and selenium alone. However, the values were statistically significant only for glucose homeostasis indices (P <0.001). Although obesity is a multifactorial condition, controlling other risk factors, zinc and selenium and their combined supplementation can lead to promising solutions for the treatment of obesity-induced glucose and lipid homeostasis disorders.

The potential effects of metformin and/or sitagliptin on leptin/adiponectin ratio in diabetic obese patients: a new therapeutic effect.

To explore how metformin, alone or in conjunction with sitagliptin, affects the leptin/adiponectin ratio in obese type 2 diabetes mellitus patients. The case-control study was conducted from March to August 2021 at the Department of Clinical Pharmacology, College of Medicine, Mustansiriyah University, Baghdad, Iraq, and comprised adult, obese type 2 diabetes mellitus patients of either gender and age-matched healthy controls. The MT group included patients taking metformin 1g/day, MTS group had patients taking metformin 1g/day plus sitagliptin 100mg/day, and the control group comprised healthy subjects. Serum levels of human leptin and adiponectin were recorded along with body mass index, blood pressure, lipid profile and glycaemic indices. Data was analysed using SPSS 20. Of the 90 subjects, 62(69%) were patients; 36(40%) in MT group and 26(29%) in MTS. The control group had 28(31%) individuals. The mean age of the patient groups was 48.62±8.17 years, and male: female ratio was 49:41, mean age of controls was 47.64± 5.77 years with the same male to female ratio as that of the patients. Leptin levels were higher in patients compared to controls (p=0.002), and leptin levels were lower in MTS (89.93±9.51) than MT group (93.69±13.69). Patients in MT (30.57±6.31) and MTS (32.99±7.10) groups had lower adiponectin levels than controls (48.83±9.21) (p=0.001). MT and MTS patients had a greater leptin-to-adiponectin ratio than controls (p=0.0001). Leptin-to-adiponectin ratio could be a viable marker for assessing risks related to type 2 diabetes mellitus and other health conditions.

Metformin and Caffeine’s Influence on Lipid Profile Indices of Streptozotocin-Induced Dyslipidemia in an Animal Model

Dyslipidemia has been linked to insulin resistance and hyperglycemia. Hyperglycemia, which is the outcome of either insufficient insulin production or insensitivity to insulin, is the hallmark of diabetes mellitus (DM). In this study, thirty-six (36) male Wistar rats with diabetes induced by streptozotocin were used to determine the effect of metformin and caffeine on blood glucose levels and lipid profile indices. The rats weighed between 150 and 200 grams and were split into six groups of six animals each at random. Group A was given unlimited access to chow (Grower feed) and water adlibitum. Group B was administered 60 mg/kg of streptozocin (STZ) without any medication, while Group C was given 60 mg/kg of STZ together with 50 mg/kg of metformin. Groups D and E were administered 60 mg/kg of streptozocin and 25 mg/kg and 50 mg/kg of caffeine, for a duration of 21 days respectively. Group F was given 50 mg/kg of caffeine together with 50 mg/kg of metformin for a duration of 21 days. After performing a post-hoc LSD comparison and using ANOVA to analyze the results, the lipid profile and blood glucose level were deemed significant at p&lt;0.05. A paired t-test was used to analyze body weight. Rats with diabetes had reduced body weight, whereas those receiving metformin and caffeine treatments had noticeably increased body weight. The findings demonstrated that whereas metformin and caffeine therapy greatly reduced blood glucose levels, STZ caused hyperglycemia in group B. However, diabetic rats had considerably higher levels of triglycerides (TG) and total cholesterol (TC), which were reduced by metformin and caffeine administration. HDL activity was considerably increased after treatment with metformin and caffeine, despite the rats' reduced HDL levels in group B. Rats with diabetes had considerably elevated levels of LDL and VLDL, and therapy with metformin and caffeine markedly restored their activity. The study shows that caffeine plus metformin may be utilized to control the lipid profile and blood glucose levels in diabetic rats.

Effects of 12-weeks resistance training and vitamin E supplementation on aminotransferases, CTRP-2, and CTRP-9 levels in males with nonalcoholic fatty liver disease: a double-blind, randomized trial

BackgroundNonalcoholic fatty liver disease (NAFLD) involves excessive liver fat accumulation and is closely linked to oxidative stress, which contributes to liver inflammation and damage. This study aimed to evaluate how interventions such as resistance training (RT) and vitamin E supplementation (VES) can modulate markers of NAFLD and key proteins regulating glucose and lipid metabolism, such as C1Q/TNF-related proteins (CTRPs).MethodsForty participants with NAFLD (mean age: 32.4 ± 8.2 years) were randomly assigned to one of four groups for 12 weeks: placebo (PLB), VES, PLB + RT, and VES + RT. VES was administered at 800 IU/day in a double-blind manner. The RT regimen included eight exercises at 60–80% of one-repetition maximum (1RM), with three sets of 8–12 repetitions, performed three times per week. Pre- and post-intervention assessments included body composition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lipid profile, glycemic control, CTRP-2, CTRP-9, and 1RM evaluations.ResultsFollowing the interventions, there was a significant improvement in body composition, lipid profile, glycemic control, and 1RM indices in the exercise groups compared to non-exercise groups (p < 0.05). AST and ALT levels decreased in all groups (p < 0.05) compared to the PLB group. There was also a significant difference between the VES + RT group and both the VES and PLB + RT groups (p < 0.05). CTRP-2 and CTRP-9 levels decreased in the exercise groups compared to non-exercise groups (p < 0.05), and their changes showed a marked correlation with body composition, lipid profile, and glycemic control indices (p < 0.05).ConclusionsThis study highlights the benefits of RT on various health parameters among NAFLD patients. While adding VES to RT resulted in greater decreases in aminotransferases, it did not provide further improvements in other variables. Additionally, enhancements in body composition, lipid profile, and glycemic control indices were possibly associated with decreased levels of CTRPs.Trial registrationRegistered retrospectively in the Iranian Registry of Clinical Trials (IRCT20220601055056N1) on December 21, 2023. Access at https://irct.behdasht.gov.ir/trial/69231.

Lipid profile and anthropometry indices of franchised fast-food consumers in South Western states in Nigeria

Background: Franchised fast foods are known for their unique tastes as it contains a number of spices that makes it delicious. Daily busy schedules have made consumption of franchised fast foods (FFFs) an easy option and control of our food choices even at home. Objective: This research investigated the lipid profile and anthropometric indices of consumers of franchised fast foods (FFFs) in South-Western States in Nigeria. Methods: This was a cross-sectional study in South-West Nigeria and comprised three states: Lagos, Oyo, and Ogun. 300 respondents were recruited from ten (10) purposively selected fast-food outlets in Ikeja, Abeokuta and Ibadan cities, Nigeria. Standardized method for assessing plasma lipid profile was used. A well-structured and pretested questionnaire was used for the survey. The statistical analysis was done using 95% confidence interval and an error percentage of 5%. Results: The major consumers of FFFs are single, younger adults, educated, and relatively high-income earners. Majority of male (39% and 23%) and females (33% and 41%) have excellent and good health status respectively. Significant association was observed between BMI and HDL-C (p=0.009) of male, and Significant differences existed among the BMI and all lipid profiles of female respondents (p&lt;0.050). Conclusion: The study conclude that both genders are at risk of age-related NCDs in the future due to inadequate physical activity and dependence on FFFs. The consumption of FFFs is common among young people, high-income earners and educated people.

Therapeutic effect of fenugreek supplementation on type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials

IntroductionNumerous clinical trials have investigated the effects of fenugreek, a traditional herbal medicine, on type 2 diabetes mellitus (T2DM). However, the results from these studies have been inconsistent. Therefore, we aimed to perform a meta-analysis on the effects of fenugreek supplementation on weight, body mass index (BMI), lipid profile, and glycemic indices in patients with T2DM. MethodsWe searched PubMed, Scopus, Embase, ISI Web of Science, and Cochrane Library databases to identify clinical trial studies until October 2023. The data were analyzed using a random-effects model and presented as the weighted mean difference (WMD) along with the associated 95 % confidence interval (CI). ResultsA total of 19 studies were included in the meta-analysis. The results indicated a significant impact of fenugreek supplementation on lowering fasting plasma glucose (FPG) (WMD: 20.32 mg/dl; 95 % CI: 26.65 to −13.99), hemoglobin A1C (HbA1c) (WMD: 0.54 %; 95 % CI: 0.80 to −0.28), homeostatic model assessment of insulin resistance (HOMA-IR) (WMD: 0.36; 95 % CI: 0.67 to −0.05), total cholesterol (TC) (WMD: 33.10 mg/dL; 95 % CI: 64.31 to −1.88), low-density lipoprotein cholesterol (LDL-C) (WMD: 29.14 mg/dL; 95 % CI: 55.45 to −2.83), BMI (WMD: 0.73 kg/m2; 95 % CI: 1.40 to −0.07), and increasing the high-density lipoprotein cholesterol (HDL-C) (WMD: 5.68 mg/dL; 95 % CI: 3.51 to 7.85). However, the effect on fasting insulin, triglycerides, and weight was not significant. ConclusionsFenugreek supplementation has been shown to improve FPG, HbA1C, HOMA-IR, TC, LDL-C, HDL-C, and BMI in patients with T2DM. The overall results suggest that fenugreek may have protective and therapeutic effects on T2DM parameters.

Effect of 5:2 intermittent fasting diet versus daily calorie restriction eating on metabolic-associated fatty liver disease-a randomized controlled trial.

Both 5:2 IF diet (intermittent fasting) and daily caloric restriction eating had been suggested for management of MAFLD (Metabolic-Associated Fatty Liver Disease), this study aimed to evaluate the effects of 5:2 IF diet on body weight and metabolic parameters in adults with MAFLD, in comparison to daily caloric restriction eating. This single-center, double-blind, prospective, randomized controlled trial included 60 patients with MAFLD, who were administered either a 5:2 IF diet limited calories consumed for 2 days each week with no restrictions on the remaining 5 (Group 5:2 IF diet) or a daily calorie restriction eating (Group daily calorie restriction). Fibrotouch-B instrument assessment, ultrasound assessment of hepatic steatosis, anthropometric indices and body composition analysis, blood sample measurements were conducted during two distinct visits: initially on the day of study commencement (T1), and subsequently at the conclusion of the 12-week intervention period (T2). In comparison to daily calorie restriction eating, the 5:2 IF diet significantly decreased the proportion of hepatic steatosis ≥moderate (29.6% vs. 59.3%, p = 0.028) and the degree of hepatic fibrosis F ≥ 2 (3.7% vs. 25.9%, p = 0.05), and fewer percentage of patients were diagnosed with fatty liver via upper abdominal ultrasound in the 5:2 intermittent fasting diet group (33.3% vs. 63.0%, p = 0.029). Additionally, the CAP (controlled attenuation parameter) and LSM (liver stiffness measurements) value were significantly lower in the 5:2 IF diet group (p < 0.05). No statistically significant differences were observed between the two groups in terms of weight, BMI (body mass index), WC (waist circumference), HC (hip circumference), and WHR (waist to hip ratio). Similarly, there were no significant differences in lipid profile, glycemic indices and adverse events (p > 0.05). In summary, although both 5:2 IF diet and daily caloric restriction eating achieved similar effect on body weight, liver enzymes, lipid profile and glycemic indices after 12 weeks treatment, 5:2 IF diet demonstrates better improvement in fibrosis and steatosis scores independently from weight regulation. Consequently, it is anticipated to emerge as a viable dietary modality for lifestyle intervention among patients diagnosed with MAFLD. https://www.crd.york.ac.uk/PROSPERO, identifier ChiCTR2400080292.

Relationship between Vitamin D Insufficiency, Lipid Profile and Atherogenic Indices in Healthy Women Aged 18-50 Years.

Although vitamin D insufficiency has been correlated with an increased risk of cardiovascular disease (CVD), there are few data on the association between 25-hydroxyvitamin D (25(OH)D) and atherogenic indices predictive of CVD. This study investigated the relationship of vitamin D status with lipid profile and atherogenic indices in adult women in Morocco. Three hundred women aged 18 to 50 years from Meknes were included. Fasting 25(OH)D and lipid concentrations were assayed by a one-step electrochemiluminescence-based immunoassay and an enzymatic method, respectively. Atherogenic indices (atherogenic index of plasma (AIP), atherogenic coefficient (AC), non-HDL cholesterol (non-HDL-C), Castelli risk indices I and II (CRI-I and II), and CHOLIndex (CI)) were calculated using conventional lipid parameters. Logistic regression models and operating characteristic curve (ROC) analysis were used to assess the relationship of the variables and estimate the threshold of 25(OH)D levels associated with high atherogenic indices. 25(OH) D below 20 ng/mL was significantly associated with an enhanced risk of hypertriglyceridemia and elevated values of AIP, AC, non-HDL-C, and CRI-I with an OR (95% CI) of 4.904 (1.856-12.959), 3.637 (2.149-6.158), 3.589 (1.673-7.700), 2.074 (1.215-3.540), and 2.481 (1.481-4.123), respectively. According to the ROC analysis, the likelihood of hypertriglyceridemia and high values of AIP, AC, non-HDL-C, and CRI-I were associated with 25(OH)D thresholds ≤15.15 ng/mL, ≤17.5 ng/mL, ≤19.8 ng/mL, ≤20.1 ng/mL, and ≤19.5 ng/mL, respectively, all p < 0.01. Based on the atherogenic indices, this study indicates that vitamin D below 20 ng/mL may increase the risk of cardiovascular disease in adult women. Additional health measures are essential to raise awareness among women and health professionals of preventing and controlling cardiovascular risk factors, particularly among young individuals.

Relationship between Atherogenic Indexes and Fasting Blood Sugar among Diabetic Patients

Disorders in lipid profile levels participate in the generation of atherogenic dyslipidaemia, complications in patients with type 2 diabetes (T2DM), one of the strongest markers in predicting cardiovascular disease (CVD). In this study we investigated the fast blood sugar (FBS), lipid profile, and atherogenic indexes [atherogenic index of plasma (AIP); cardiac risk ratio (CRR); cardioprotective index (CPI); atherogenic coefficient (AC)] were calculated in males and females and compared control groups. There was a low positive correlation between FBS with a lipid profile ranging from (r = 0.334, P &lt;0.043), to (r = 0.459, P &lt; 0.027), and a very strong between atherogenic indexes with a lipid profile ranging from (r = 0.804, P &lt; 0.000) to (r = 0.950, P &lt;0.000). Conversely, there was a strong negative correlation between CPI and lipid profile ranging from (r = - 0.663, P &lt; 0.000) &amp; (r = - 0.768, P &lt; 0.000) and a very strong negative correlation with LDL (r = - 0.900, P &lt; 0.000) &amp; (r = - 0.905, P &lt; 0.000) in male. In females, the correlation was positive and recorded at (r = 0.213, 0.361) between FBS and TG &amp;VLDL. Besides, very strong correlation between AIP with TG (r = 0.954, P &lt;0.000), TC (r = 0.572, P &lt;0.000), and VLDL (r = 0.456, P &lt;0.029). While the correlation was strong between AC with LDL (r = 0.829, P &lt;0.000), it was very strongly positive with TC (r = 0.943, P &lt;0.000), finally, the correlation value in CPI was highly negative and ranged from (r = - 0.774, P &lt;0.000), to (r = - 0.909, P &lt;0.000), for TC and LDL respectively. In conclusion, the participants with high levels of FBS possess a highly significant positive correlation with atherogenic indexes (AIP, CRR, and AC) and a negative correlation with CPI values.

Bilirubin, once a toxin but now an antioxidant alleviating non-alcoholic fatty liver disease in an autophagy-dependent manner in high-fat diet-induced rats: a molecular and histopathological analysis.

As an endogenous antioxidant, bilirubin has surprisingly been inversely correlated with the risk of non-alcoholic fatty liver disease (NAFLD). Thereupon, the current evaluation was designed to assess the positive effects of bilirubin on the autophagy flux, as well as the other pathogenic processes and parameters involved in the expansion of NAFLD. Thirty adult male rats weighing 150-200 g with free access to sucrose solution (18%) were randomly subdivided into 5 groups (n = 6). Subsequently, the animals were euthanized, and their blood specimens and liver tissue samples were collected to measure serum biochemical indices, liver histopathological changes, intrahepatic triglycerides content, and tissue stereological alterations. Furthermore, the expression levels of autophagy-related genes (Atgs) were measured to assess the state of the autophagy flux. Fasting blood glucose, body weight, as well as liver weight, liver-specific enzyme activity, and serum lipid profile indices markedly decreased in rats that underwent a six-week bilirubin treatment compared to the control group. In addition, histopathological studies showed that hepatic steatosis, fibrosis, inflammation, and necrosis significantly decreased in the groups that received bilirubin compared to the control animals. Bilirubin also caused significant alterations in the expression levels of the Atgs, as well as the Beclin- 1 protein. Bilirubin may have potential ameliorative effects on NAFLD-associated liver damage. Moreover, the beneficial effects of bilirubin on intrahepatic lipid accumulation and steatosis were comparable with the group that did not ever receive bilirubin.

Influence of Pediococcus pentosaceus GT001 on Performance, Meat Quality, Immune Function, Antioxidant and Cecum Microbial in Broiler Chickens Challenged by Salmonella typhimurium.

This study evaluated the effects of Pediococcus pentosaceus GT001 on Salmonella typhimurium (S. typhimurium)-challenged broiler chickens. Two hundred Ross 708 broiler day-old chicks with comparable weight were distributed at random into four treatments with five replicates and ten chicks per replicate. The following were the treatment groups: (B) basal diet (control); (B + S) basal diet and birds were challenged with S. typhimurium at 1.0 × 107 cfu/g; (B + P) basal diet + Pediococcus pentosaceus GT001 at 4.0 × 108 cfu/g; (B + P + S) basal diet + P. pentosaceus GT001 at 4.0 × 108 cfu/g and birds were challenged with S. typhimurium at 1.0 × 107 cfu/g. There was a significant reduction (p < 0.05) in the body weight of the Salmonella-infected birds compared to the other treatment groups. However, the FCRs of the broilers were comparable among the different treatment groups (p > 0.05). The lipid profile and liver function indices measured were significantly enhanced in the P. pentosaceus GT001-supplemented groups (B + P and B + P + S) compared to the group that was Salmonella-challenged (p < 0.05) but were similar to those in the control group. The serum antioxidant activities, such as the T-AOC, SOD, CAT, GHS-Px and MDA, were significantly improved in the P. pentosaceus GT001-supplemented groups (B + P and B + P + S) (p < 0.05). The MDA was similar in the B + P and B + P + S groups, but both were significantly lower than the control and the Salmonella groups. The administration of P. pentosaceus GT001 enhanced the lipase and amylase levels in both the serum and intestine of the broilers (p < 0.05). The immunoglobin (IgA, IgG, IgM) and cytokine (IL-10 and IL-6) levels in the serum were significantly higher in the B, B + P and B + P + S treatment groups (p < 0.05). The immune-related organs (bursa and spleen) were significantly influenced in the birds fed with P. pentosaceus GT001. No significant variation was noted among all the dietary treatments in terms of the measured meat quality indices. The small intestinal digesta content of the Salmonella load was below a detectable range after 14 days of infection (p < 0.05). No significant differences were observed among the different treatment groups in terms of the breast pH, drip loss and meat color (p > 0.05). The inclusion of P. pentosaceus GT001 also modified the community structure in the cecum. This indicates that it has health benefits and could be incorporated in the broiler diet.

Atherogenic indices in preeclamptic and eclamptic patients in North-Central Nigeria

Microvascular, placental, haematological and lipid studies suggest striking similarities between preeclampsia/eclampsia and atherosclerosis. Objective To determine the lipid profile and atherogenic indices in preeclamptic/eclamptic patients and compare with normal pregnant women. Methodology Comparative cross-sectional study conducted in North Central Nigeria. The study population was preeclamptic/eclamptic patients and normal pregnant women. A total of 192 women, comprising 96 pregnant women with preeclampsia/eclampsia and an equal number of normotensive controls were recruited consecutively by purposive sampling. Lipid profiles were estimated and atherogenic indices were calculated. Result Coronary heart disease risk ratio (CRR) and atherogenic index of plasma (AIP) showed significantly increased atherogenic potentials in subjects compared to controls. Mean ± SD CRR of subjects was 0.28 ± 0.17, Mean ± SD CRR of controls was 0.44 ± 0.24 ( p = 0.001); Mean ± SD AIP of subjects was 0.32 ± 0.42 and mean ± SD AIP of controls was 0.16 ± 0.26 ( p = 0.003). Conclusion Atherogenic indices show increased atherogenic potentials in preeclamptic/eclamptics.

Effects of a Tabata Exercise on Lipid Profile and Body Composition Indices in Overweight Boys

Effects of a Tabata Exercise on Lipid Profile and Body Composition Indices in Overweight Boys

Lipid Profile and Atherogenic Risk Assessment in Nigerian Breast Cancer Patients – A Cross-Sectional Study

Background The lipid profile and atherogenic risk indices in Nigerian breast cancer patients are largely unknown. This study evaluated the lipid profile and atherogenic risk indices of breast cancer patients in Nigeria. Methods This study involved 45 primarily diagnosed breast cancer patients and 50 normal control subjects. Total cholesterol, triglyceride, and High-density lipoprotein cholesterol (HDL-C) were measured. Low-density lipoprotein cholesterol (LDL-C) was calculated according to Friedewald formula. Atherogenic index of plasma (AIP), Atherogenic coefficient (AC), TC/HDL-C (Castelli I) and LDL-C/HDL-C (Castelli II) risk indices were all calculated. The Framingham risk assessment was calculated and categorized. Results The study group had significantly higher triglycerides (TG), and atherogenic indices than the control group (p < 0.001), while HDL-Cholesterol (HDL-C) was significantly lower in the study group (p < 0.001). Total cholesterol and LDL-Cholesterol (LDL-C) had a significant positive correlation with age (r = 0.283, p < 0.018; r = 0.272, p < 0.023); TG was significantly positively correlated with systolic and diastolic blood pressure (r = 0.320. p < 0.007; r = 0.334, p < 0.005); HDL-C had a significant negative correlation with BMI, systolic and diastolic blood pressure (r = −0.252, p < 0.035; r = −0.29, p < 0.015; r = −0.329, p < 0.005). The lipid ratios (TC/HDL-C, LDL-C/HDL-C) were significantly positively correlated with body mass index (BMI), systolic and diastolic blood pressure. The Framingham Risk Score showed that only 2 subjects in the study group (4.4%) were at a high risk of having a cardiovascular event. Conclusion Breast cancer patients have a higher prevalence of dyslipidaemia, and cardiovascular risk than the normal population.

Myo-inositol supplementation in obese patients with non-alcoholic fatty liver disease: Assessment of sirtuin-1 pathway, atherogenic and hematological parameters

BackgroundNon-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease, is closely associated with higher risks of atherosclerosis through a number of molecular cascades such as the sirtuin-1 (SIRT-1) pathway. Myo-inositol as a precursor isomer of cyclohexanehexols exerts anti-hyperlipidemic and anti-obesity features in metabolic disorders. The current study aimed to assess the effects of myo-inositol supplementation on genes expression of the SIRT-1 pathway, atherogenic indices, and hematological parameters in obese patients with NAFLD. MethodsThis double-blinded randomized clinical trial was conducted on 44 obese patients with ultrasound proven- NAFLD who received dietary recommendations and were randomly allocated into either myo-inositol (4 g/day) or placebo (maltodextrin 4 g/day) receiving groups for 8 weeks. At baseline and the end of the study mRNA expression levels of SIRT-1 pathway genes in peripheral blood mononuclear cells (PBMCs), complete blood cell count, lipid profile, and atherogenic indices were assessed. Inter-group differences were determined using analysis of covariance (by adjusting for the potential confounders) at the end of the trial. ResultsAt the end of the trial mRNA expression levels of low-density- lipoprotein receptor (LDLR) (only in myo-inositol group) and endothelial nitric oxide synthase (eNOS) (in both groups) significantly increased, compared with steady-state levels (p = 0.004 and p = 0.001, respectively). Moreover, myo-inositol supplementation significantly inhibited lectin-like oxidized- low-density lipoprotein receptor-1 (LOX-1) expression compared with the placebo group (p = 0.045). Slight improvements in Cholesterol-related atherogenic indices and hematological parameters were also observed in myo-inositol group, compared with baseline values (p < 0.05). ConclusionMyo-inositol supplementation could slightly activate SIRT-1 pathway and thereby exert marginal anti-atherosclerotic properties in obese patients with NAFLD.

Effect of Aqueous Extract of Irvingia wombolu Seeds on Lipid Profile and Atherogenic Indices in Hyperlipidemic Wistar Rats

The effect of aqueous extract of Irvingia wombolu seeds on lipid profile and atherogenic indices in hyperlipidemic wistar rats was evaluated. Forty five (45) wistar rats were grouped into five groups of nine rats each. The animals were allowed seven days acclimatization period. Group one was the control group and it received normal rat chow and water throughout the study. Groups 2 to 5 were given high fat diet for 14 days after which they were fed with normal rat chow till the end of the study. At the end of the 14 days, group 2 was not treated while group 3-5 were treated with 250, 500 and 1000mg/kg body weight aqueous extract of Irvingia wombolu seed respectively for 28 days. The lipid profile of animals was assayed three times: first after 14 days induction period (phase 1) i.e day 0 of treatment, second was taken 14 days after treatment (phase 2), third was taken 28 days after treatment (phase 3).The study lasted for 49 days and distilled water was used as a vehicle for the extract.In phase 1, there was a significant decrease (p&lt;0.05) in HDL (high density lipoprotein) level in all groups (2-5) compared to the control.there was a significant increase (p&lt;0.05) in LDL ( low density lipoprotein), Total cholesterol, Triglyceride, VLDL (very low density lipoprotein), Non HDL, Cardic risk factor, Atherogenic coefficient, Atherogenic index of plasma levels in all groups (2-5) compared to the control. All doses of aqueous extract of Irvingia wombolu seed were able to increase HDL level and decrease other lipid profile parameters and atherogenic indices in hyperlipidemic rats. Thus, aqueous extract of Irvingia wombolu seed has antidyslipidemic potential.

Efficacy of Drumstick Tree (Moringa oleifera) Leaves Powder on Lipid Profile and Hematological Indices in Chickens on a High Fat Diet

Moringa oleifera belongs to the Moringaceae family and genus Moringa. Moringa oleifera has many beneficial pharmaceutical and nutritional properties. The present study aimed to investigate the effects of dietary supplements of Moringa oleifera leaves powder after consumption of a high-fat diet on cholesterol TG, HDL, LDL, VLDL and hematological parameters such as Hb, MCV, MCH, MCHC, PCV, RBCs, WBCs, PLT neutrophil, heterophil and lymphocytes count in chicks. Golden Misri Chickens were divided into 4 groups: Group 1 (the Control group) was given Feed-13. Group 2 (Experimental Group) was given Feed-13 and mustard oil (high-fat diet) Group 3 (experimental Group) was given Feed-13 + mustard oil and 1.5% Moringa oleifera leaves powder. Group 4 (experimental Group) was given Feed-13 and 1.5% of Moringa oleifera leaves powder for four weeks. The results of the current study showed a significant (p &lt; 0.05) increase in body weight in Experimental Group 3. Experimental group 3 showed a significant increase in levels of HDL, TG, RBCs, and Hb, while significantly decreased (p &gt; 0.05) in LDL, TLC, WBCs, MCHC, MCV, MCH, TC, TP, Monocytes count, neutrophil count, and platelet counts. Moringa oleifera supplementation showed a significant reduction in cholesterol, LDL, and TC levels. The findings of this study demonstrated that powdered Moringa oleifera is a beneficial and effective dietary supplement that increases HDL, TG, Hb, and RBCs, and decreases cholesterol levels.

Antidiabetic effect of the mixture of Cissus polyantha and Rytigynia senegalensis in high-fat diet and streptozocin-induced diabetic rats

BackgroundIn traditional Chinese medicine (TCM) practices, many plants of the Cissus and Rytigynia genera are used to treat many diseases including diabetes mellitus.The aim of this study was to evaluate the modulating effects of the mixture of the aqueous extracts of Cissus polyantha and Rytiginia senegalensis (CPRS) on some enzymes of carbohydrate metabolism, oxidative profile, and cardiovascular parameters in diabetic rats. MethodsDiabetes was induced by a diet enriched in high-fat for 30 days associated with a single intraperitoneal injection of streptozocin (35 mg/kg). Rats with a blood glucose level greater than or equal to 200 mg/dL were selected and divided into groups. Groups 1 and 2 received distilled water. Group 3 received metformin (40 mg/kg). Groups 4 and 5 received CPRS at doses of 50 and 111 mg/kg, respectively. Glycaemia, body mass, food and water intake, insulinemia, insulin resistance and insulin secretion indices, lipid profile and cardiovascular risk indices, oxidant profile, glycogen and liver enzymes were evaluated. Histology of the pancreas and heart was performed. ResultsCPRS (50 and/or 111 mg/kg) significantly (p < 0.05 to p < 0.001) reduced water and food consumption, blood glucose, HOMA-IR, coronary risk index, cholesterol, triglyceride, LDL-c, VLDL-c, and malondialdehyde levels, as well as glucose-6-phosphatase and fructose-1,6-biphosphatase activities in diabetic animals. In contrast, CPRS (50 and/or 111 mg/kg) caused an increase (p < 0.05 to p < 0.001) in body mass, insulinemia and HDL-c levels, reduced glutathione and hepatic glycogen. HOMA-β, insulin distribution, atherogenic and cardioprotective indices as well as superoxide dismutase, catalase, glucokinase, and glucose-6-phosphate dehydrogenase activities were also increased after CPRS administration. CPRS regenerated pancreatic islet β cells and decreased leukocyte infiltration in cardiomyocytes of diseased animals. ConclusionCPRS has hypoglycemic, antidyslipidemic, and antioxidant effects, thus validating its use in traditional medicine in the treatment of diabetes mellitus and its complications.

Biogenic synthesized SeONPs by Bacillus paramycoides as antimicrobial, anticancer, antioxidant, apoptotic and hepatorenal treating agent.

Employing bacteria in nanoparticles (NPs) biosynthesis has appeared as a fast-emerging research area in green nanotechnology applications. The biosynthesis processes optimization can lead to obtaining NPs with desired sizes and suitable quantities. The goal of the current work was to synthesize selenium oxide nanoparticles (SeONPs) from Bacillus paramycoides (MCCC 1A04098), a locally isolated terrestrial bacteria, and in vitro investigate its antibacterial, anticancer, and anti-cytotoxic properties. Rats with hepatorenal injury triggered by carbon tetrachloride (CCl4) were used for the in vivo evaluation. Oxidative stress markers, lipid profile, liver and kidney function indices, as well as their histological features were measured and compared with silymarin as a reference drug. SeONPs revealed antimicrobial effect against Bacillus cereus, Staphylococcus aureus, Escherichia coli, and Candida albicans. It also showed anticancer effect on hepatic (HepG2) and breast (MCF-7) cancer cell lines in a dose dependently with apoptotic effect rather than necrosis. Treatment of CCl4 injured rats with SeONPs restored all the biochemical parameters to normal values with variable degrees and the results were confirmed by the histological pictures of liver and kidney. In conclusion, the obtained biogenic SeONPs from the local isolate of Bacillus paramycoides strain (MCCC 1A04098) showed a remarkable biomedical application including in vitro antimicrobial and anticancer activities. It also recorded in vivo antioxidant, anti-hypercholesterolemic and anti-cytoxic activities against hepatorenal injury in rats. Therefore, SeONPs synthesis by ecofriendly technique may be considered as a promising nutraceutical agent.