The main aim of this study is to provide a comprehensive understanding of the challenges and issues faced by the manufacturing sector of India. Following an analytical approach, a systematic review of the relevant studies has been done to provide a cohesive view of the disintegrated literature. The objective behind this initiative is to focus on transforming India into a manufacturing hub, creation of jobs, development of skills & innovation and also to encourage Public Private Partnership (PPP), Joint Ventures (JV), Foreign Direct Investment (FDI) inflow, and advancing Ease in Doing Business (EDB) so as to align India’s manufacturing sector into the Global Value Chain. The study found that, there will be drastic changes in the selected 25sectors of Make In India which includes fields like automobiles, aviation, biotechnology, defense, media, thermal power, oil, gas and manufacturing sectors. Thus, we can conclude that, execution of Make In India remains a big challenge despite the fact that it came at a right time. The data has been collected from the various sources which includes other research papers, publications, government websites. Also, In the proposed study, PEST analysis for business environment for make in India campaign is conducted to identify the various aspects that have a bearing on the campaign.