Incredible Strides Research Articles

State Shopping for a Baby

The incredible strides made in the field of assisted reproductive technology (ART) over the past several decades have helped countless individuals throughout the world actualize their dreams of starting a family using surrogacy. Social acceptance of surrogacy has also increased, with many societies even welcoming the practice. Technological advancements and changing social norms have helped facilitate a growing need for surrogacy.

Advancements in siRNA delivery using nanotechnology for reproductive tract cancers: From targeting to enhancing treatment efficacy

Cancers of the reproductive system, which include those of the cervix, uterus, ovaries, fallopian tubes, and vagina, are major global health concerns. Even with improvements in traditional therapies such as radiation and chemotherapy, managing these tumors is still difficult, frequently associated with side effects, and has limited effectiveness. Targeted cancer therapy now has better options, thanks to the development of small interfering ribonucleic acid (siRNA) as a potentially effective therapeutic procedure through the ribonucleic acid interference (RNAi) technique in recent years. Nevertheless, there are many challenges in the clinical translation of siRNA, especially in terms of delivering drugs effectively to tumor-specific areas while reducing off-target effects. Nanotechnology has emerged as a transformative perspective that could show a promising approach for providing a revolutionary solution to the problems related to siRNA delivery. By carefully crafting nanocarriers, including liposomes, polymeric nanoparticles, and lipid nanoparticles, scientists have made incredible strides toward improving the bioavailability, stability, efficacy, and selectivity of siRNA treatments. Furthermore, due to their customizable characteristics, nanocarriers could be used to target specific tumors of the reproductive tract, enhancing the effectiveness of the treatment by taking advantage of tumor-specific indicators and microenvironments. In this review, we will summarize and delve into leveraging the synergistic benefits of targeted delivery and enhanced therapeutic potency using the RNAi technique. These innovative strategies hold immense potential to reshape the treatment landscape, offering new hope for patients with these devastating reproductive tract malignancies.

Artificial Intelligence Ethics and Fairness: A study to address bias and fairness issues in AI systems, and the ethical implications of AI applications

Artificial intelligence (AI) has made incredible strides in several fields, revolutionising business and everyday life. Thoughts regarding the moral ramifications and fairness of AI systems have grown in prominence along with its fast development. This article explores the crucial issues of AI fairness and ethics, concentrating on ways to detect and reduce prejudice in AI systems while also discussing larger ethical implications. The paper emphasises the possible repercussions of biased decision-making while highlighting the many forms and sources of bias that might develop in AI models. There are several methods and strategies to deal with bias in AI systems, including data pretreatment, algorithmic changes, and transparency measures. In an effort to balance justice and efficacy, the trade-offs between fairness goals and overall model performance are examined. The article also emphasises how crucial it is for AI systems to be transparent and understandable in order to foster accountability. For the purpose of establishing ethical AI development and deployment practises, regulatory issues and ethical decision-making frameworks are also investigated. This study emphasises the need of ongoing research and development of moral AI systems to guarantee a just and equitable future for AI applications via in-depth analysis and case studies.

Secure health Care Systems Using Blockchain Technology

With the technological innovation that is spreading around the globe, smart healthcare and biomedical advancements have always been a big issue to be improved in every way: The Internet of Things (IoT) has made incredible strides in the sharing of healthcare data and triggering the related necessary actions in the modern world, with ever-evolving internet models automating and digitalizing numerous industrial and household implementations. With the technological innovation that is sweeping the globe, smart healthcare and biomedical advancement have always been a vital issue to be improved in every way. The Internet of Things (IoT) has made incredible strides in sharing healthcare data and triggering the essential activities connected with it in the modern world, with ever-evolving internet models automating and digitalizing numerous industrial and household applications. With the technological innovation that is sweeping the globe, smart healthcare and biomedical advancement have always been a vital issue to be improved in every way.The Blockchain Technology has experienced numerous changes since its debut. There has been research that has shown a variety of ways to organize the conventional system's access control mechanism. In recent years, blockchain technology has also demonstrated exceptional dependability in a variety of industries, including smart homes, healthcare, banking, information storage management, security, and others.

Introduction

Introduction Eric Bain-Selbo More than a decade ago, a relatively small group of scholars worked with Mercer University Press to launch the International Journal of Religion and Sport. The co-editors at the time were Christopher J. Anderson and Gordon Marino. The plan was to publish just once a year. But after that first volume in 2009, it was another four years before another volume was published. The co-editors for that volume were Eric Bain-Selbo and Andrew Parker. That volume was the last one published. Despite the good work of everyone involved, it just may not have been the right time for the journal. So, what’s different now? Just in the decade since the last volume of the journal, incredible strides have been made in the study of sport and religion. There now is a regular session on “Religion, Sport, and Play” at the American Academy of Religion. Springer launched a monograph series in religion and sport. Dozens of books have appeared and more and more young scholars are working on research in this area. So, when Terry Shoemaker and I were contacted by Catholic University of America Press about reviving the journal (with a slight name change), we not only agreed to serve as co-editors, we agreed enthusiastically and with confidence. The field of sport and religion has grown so significantly that we are confident that a journal can not only survive but can thrive. It is with that enthusiasm and confidence that we share this first issue with you. With this first issue, we thought it would be appropriate to have scholars in the field reflect on our history, the current state of scholarship, and where we might go in the future. These relatively short but very rich pieces accomplish several goals. First, they document much of the history of this area of study and memorialize some of the key figures in its development. Second, they provide some critical assessment of the scholarship happening today. And, third, they provide valuable insights as to where scholars can take (or should take) their research in the future. [End Page 1] A feature of every issue of the journal will be “Current Issues Conversations.” We will be bringing together a number of scholars, athletes, fans, and others in the sports industries for focused panels on pressing issues in the area of sport and religion. We kick off this special section of the journal with a panel discussion of the controversial Kennedy v. Bremerton School District case that was decided by the Supreme Court in June 2022. We hope that these discussions help readers expand their knowledge about important current issues and think more critically about a host of issues related to sport and religion. Finally, we’re taking the standard book review section and expanding it to a Book and Media Review section. This expansion will allow us to continue publishing book reviews, but also provides scholars with an opportunity to review relevant video games, television shows, documentaries, and movies. Interested in doing a review? Please let us know. As we move forward with the journal, we hope readers will reach out to us to provide feedback about the journal. And, of course, we are always interested in your scholarship. Please let us know if you have a completed article, something in the works, or just an initial idea for which you would like our feedback. [End Page 2] Copyright © 2023 The Catholic University of America Press

Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications.

Metal agents have made incredible strides in preclinical research and clinical applications in recent years, but their short emission/absorption wavelengths continue to be a barrier to their distribution, therapeutic action, visual tracking, and efficacy evaluation. Nowadays, the near-infrared window (NIR, 650-1700 nm) provides a more accurate imaging and treatment option. Thus, there has been ongoing research focusing on developing multifunctional NIR metal agents for imaging and therapy that have deeper tissue penetration. The design, characteristics, bioimaging, and therapy of NIR metal agents are covered in this overview of papers and reports published to date. To start with, we focus on describing the structure, design strategies, and photophysical properties of metal agents from the NIR-I (650-1000 nm) to NIR-II (1000-1700 nm) region, in order of molecular metal complexes (MMCs), metal-organic complexes (MOCs), and metal-organic frameworks (MOFs). Next, the biomedical applications brought by these superior photophysical and chemical properties for more accurate imaging and therapy are discussed. Finally, we explore the challenges and prospects of each type of NIR metal agent for future biomedical research and clinical translation.

Machine learning models can predict bottlenose dolphin health status from whistle recordings

Recently, there have been incredible strides in applying machine and deep learning methods to predict the presence of disease states in humans from recordings of voice. Pattern analyses of dolphin whistles have historically depended on human operators visually and audibly differentiating between sound types. The training and implementation of machine and deep learning strategies for audio analyses reduce human bias and may improve feature detection. Our team at the Navy Marine Mammal Program in San Diego, CA has developed a substantial vocal catalog of whistle recordings for a group of focal dolphins. Additionally, an extensive health history database for each animal is maintained as part of a preventive medicine program. Together, these result in a unique, labeled dataset comprised of tens of thousands of whistles (input) emitted during differing health states (output) that have been leveraged for training machine and deep learning models to classify health status from whistles. We present preliminary results that suggest that health information may be encoded across dolphin whistle characteristics, similar to changes in the human voice. Further, we describe the applied goals for testing and implementing these innovative tools for early predicting changes in dolphin health status from non-invasive recordings.

Business continuity beyond COVID-19: Lessons learned and the ‘illusion of preparedness’

The COVID-19 pandemic has forced organisations to react swiftly to an evolving crisis and find creative solutions in real time. In a relatively short period, remote access, employee hardware requirements and flexible work schedules have significantly raised people’s expectations regarding what constitutes a ‘normal’ level of preparedness. However, have organisations capitalised on the lessons learned from the event to improve operational practices and business opportunities, or has the situation merely created an illusion of preparedness? This paper describes the incredible strides made over the last two years before exploring the key lessons that have been overlooked and discussing the potentially misleading sense of readiness that threatens to prevail.

Monitoring Land Change of Cover in Al-Rusafa District In Baghdad City by using Remote Sensing and GIS Techniques

Change detection of land surface is critical to execute precise data about territory of study for any sorts of arranging improvement. Technologies of Remote Sensing and GIS and have accomplished incredible strides to tackle the investigation issues like changes of land cover. The point of that study is to deliver guides of land front of Al-Rusafa District on year 2000, 2018 to screen the potential the expectable changes especially in vegetation land and metropolitan or built land, furthermore, identify the cycle of city settlement. Two multi-transient satellite picture information, Upgraded Topical Mapper picture information from 2000 and OLI Satellite picture information from 2018 were utilized in that task. That study direction is the major approach of classification approach to supply divided maps, and cover of land categories were recognized and map. Spectral indices (NDVI, NDBI, NDWI) utilized to identify the changes of expanding and diminishing land the change detection in (Arc Map 10.5 ) Envision was utilized to identify the urban development and the concentrated alters encompassing the urban regions. Cellular automata of Markov was utilized to mimic the patterns of land utilize and change of cover the period of 2000 to 2018 cross-tabulation lattices between diverse stages were delivered to interpret the patterns of change of covers from one cover land to another, these measurement information straight forwardly regions communicated the alter of land cover. The results about appear these demonstrate that around (31.8 %) of Change from one Kind of land cover to another one though around (68.2 %) of the region Remained unaltered between (2000, and 2018)..

Bioprinting: From Tissue and Organ Development to in Vitro Models.

Bioprinting techniques have been flourishing in the field of biofabrication with pronounced and exponential developments in the past years. Novel biomaterial inks used for the formation of bioinks have been developed, allowing the manufacturing of in vitro models and implants tested preclinically with a certain degree of success. Furthermore, incredible advances in cell biology, namely, in pluripotent stem cells, have also contributed to the latest milestones where more relevant tissues or organ-like constructs with a certain degree of functionality can already be obtained. These incredible strides have been possible with a multitude of multidisciplinary teams around the world, working to make bioprinted tissues and organs more relevant and functional. Yet, there is still a long way to go until these biofabricated constructs will be able to reach the clinics. In this review, we summarize the main bioprinting activities linking them to tissue and organ development and physiology. Most bioprinting approaches focus on mimicking fully matured tissues. Future bioprinting strategies might pursue earlier developmental stages of tissues and organs. The continuous convergence of the experts in the fields of material sciences, cell biology, engineering, and many other disciplines will gradually allow us to overcome the barriers identified on the demanding path toward manufacturing and adoption of tissue and organ replacements.

Women and Wealth: Financial Propinquity to Business Success

Around the globe, women’s income and wealth are increasing as never before. Prevailing economic, demographic, and technological changes are growing women’s financial strength and independence. Be it finance, marketing, supply chain or ICT based industry, women have made incredible strides, both at professional and social fronts, particularly in the two decades. Today they are better educated, well placed and have greater accountability in the corporate world and are frontrunners in many professions. Consequently, women, particularly in developing countries like India and China have become economic powerhouses. They not only significantly contribute to GDP but also are becoming a substantial untapped market for the wealth management industry. In this context, this study is an attempt to discuss the much talked about, but less understood, issue of women’s wealth management in the Indian context. The study is intended to explore financial planning awareness among working women and their attitude towards wealth management. The findings will help wealth managers and financial planners to develop a deeper understanding of female investors’ goals and priorities, investment patterns of the working women and to gain insight into gender specific investment behaviour of Indian investors.

The millennial generation of Sikhs in North America

ABSTRACTMillennial Sikhs are second- or in some cases third-generation children born in North America in the last two decades of twentieth century. They have been actively involved in the process of ‘renewal and re-definition’ of the Sikh tradition. Cross-cultural encounters heighten their sense of identity. They constantly draw from their Sikh inheritance the universal values of social justice and equality to reach out to their non-Sikh neighbors and to fight against discrimination and injustice. Their principal strategy has been to downplay the Punjabi cultural traditions of their parents and to highlight the universal aspects of their faith in their dealings. Although they have consciously stayed away from the ‘factional politics’ of gurdwaras, they have made incredible strides in Sikh activism and political arena.

A Survey on Internet of Things Architectures

Abstract Internet of Things is a platform where every day devices become smarter, every day processing becomes intelligent, and every day communication becomes informative. While the Internet of Things is still seeking its own shape, its effects have already stared in making incredible strides as a universal solution media for the connected scenario. Architecture specific study does always pave the conformation of related field. The lack of overall architectural knowledge is presently resisting the researchers to get through the scope of Internet of Things centric approaches. This literature surveys Internet of Things oriented architectures that are capable enough to improve the understanding of related tool, technology, and methodology to facilitate developer’s requirements. Directly or indirectly, the presented architectures propose to solve real-life problems by building and deployment of powerful Internet of Things notions. Further, research challenges have been investigated to incorporate the lacuna inside the current trends of architectures to motivate the academics and industries get involved into seeking the possible way outs to apt the exact power of Internet of Things. A main contribution of this survey paper is that it summarizes the current state-of-the-art of Internet of Things architectures in various domains systematically.

Improving competitiveness in the member states of the Eurasian Economic Union: a blueprint for the next decade

The Eurasian Economic Union (EAEU) has made incredible strides in becoming an integrated body over the past 10 years, and is becoming part of a broader global process of economic regionalism that is shaping economic competitiveness. This paper applies a SWOT analysis to current and projected EAEU member states, and identifies where the difficulties and opportunities for the EAEU’s member countries will be in improving competitiveness in the coming years. The key conclusions are that the EAEU’s own institutional arrangements may foster competitiveness if it is able to remove some of the barriers to innovation that currently exist in the bloc’s member states.

Accountability in Networked Governance: Learning from a case of landscape‐scale forest conservation

AbstractDespite incredible strides in transboundary collaborative conservation, many challenges remain. A networked governance approach recognizes a diverse pool of participants, linkages across multiple levels of organization and the diffusion of authority horizontally across spatial scales. Much is understood about the basic form and function of networked governance, namely the ways in which it overcomes weaknesses of traditional hierarchical structures, but less is known about the democratic quality of newer forms of governance. There are implications for traditional forms of accountability for the practice of network governance. They are not lost but their dimensions are changed, hinging less on punishment and more on reward. To examine this dynamic, we use a mixed‐methods approach and grounded theory to explore the social relationships that make up a conservation network in the United States and Canada. Interview analysis from the Roundtable on the Crown of the Continent suggests that accountability comes through authentic engagement, is based on a ‘logic of appropriateness’ rooted in normative persuasion and still draws from traditional hierarchy. Social network analysis shows positions of brokerage and bridging help to maintain network connections between actors. Leveraging these characteristics of the network and the relationships formed through the process of landscape forest governance, we suggest there may be an overall net gain in accountability. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment

2015 NSGC Presidential Address: Gifts of genetic counselors: life's leadership lessons.

Good morning everyone. It is a pleasure to be here with all of you and an honor to be the incoming President of NSGC. The theme of my speech is leadership so it is really special for me to have Jay Flanagan introduce me. There is nothing better for a mentor than to share the podium with a former student who is about to assume his own leadership role in the AEC subcommittee! Congratulations Jay! There are times that I still need to pinch myself to believe that it is true. I am in awe at the amazing skills, energy, resources, and talks shared with us over the course of the conference. Thank you to the presenters for sharing their experiences and making the conference a huge success and thank you to the AEC subcommittee for the countless hours of hard work over the course of the year to provide us with this fantastic opportunity. NSGC was built on a strong foundation, which is a true credit to the vision and perseverance of our founding members. For the past 20 years, I have watched NSGC mature and grow into an influential organization that has a seat at important tables. Genetic counselors are an important part of medical care. What is nice about this statement? Others agree! We have made some incredible strides and should be proud of our efforts. I would like to share a little bit about myself and share some highlights from the path I followed. Then I’d like to share with you my vision for the coming year. I graduated in 1995 from Sarah Lawrence with a talented group of classmates; many of whom have gone on to hold their own leadership roles in the profession. During the first year of my career, I like many of you, was busy learning the responsibilities of a new job, planning a wedding and studying for the boards. However, at the AEC in 1996, I listened to the presentations with a different ear, because all of the items from the previous year were under my belt and I could start to envision what my career might look like long term. It hit me that I worked really hard to complete my training, pass the board exam, and enter a profession that I had really grown to enjoy in such a short time. I had a lot of years ahead of me to practice as a genetic counselor and I wanted to get involved so that I could contribute to the growth of the profession. In turn, this would ensure that the profession continued to fuel the spark that had intrigued me so much in the first place and took a direction that would fuel my passion over the course of my career. As luck would have it, BRCA1 and BRCA2 were found while I had been in my second year of graduate school. The handful of us practicing in cancer genetics at the time met under the leadership of Rob Pilarski, Cate Walsh-Vockley, June Peters, and Mary Ahrens to discuss the issues we faced. Through the vision, need for support in a new sub-specialty, and the need to develop a protocol for counseling families with a potential inherited cancer predisposition, the Cancer SIG was born and became a model for other SIGs to follow. That pivotal development happened because a group of people who were struggling to find the best way to care for our patients in this new era put an idea into motion. I was also working in Iowa at the time, which did not have many genetic counselors. It was extremely important for me to network at the AEC so I could bring ideas back to the state and attempt to stay abreast of the new trends. I volunteered early on with the education committee and practice issues committee. I volunteered to chair a subcommittee inside of the Cancer SIG, which became the start of my leadership tract. As the needs of our profession grew, my interests became more diverse. I volunteered to work on the projects that interested me and were in some way pertinent to my job (frankly all of the tasks were relevant). The volunteer time Presented at the 2014 National Society of Genetic Counselors Annual Education Conference; September, 2014

AACR Cancer Progress Report 2014.

Americans are more likely to survive a cancer diagnosis today than at any other time in history. In fact, thanks to the incredible strides that have been made in biomedical research, the percentage of the U.S. population living with, through, or beyond cancer has more than tripled since the U.S.

Prospects for the direct integration of E.E.C. capital markets

Over the past decade the European Economic Community has made incredible strides toward the realisation of the goals established by the architects of the Rome Treaty. The achievement of a customs union will occur a full year and a half in advance. In addition, progress has been made toward the achievement of economic union and considerable strides have been made toward uniform policies in the areas of transportation, labour, taxation and company organisation. Probably the most difficult area in which member countries have sought agreement is that of capital movements. The present article analyses the prospects for the integration of capital markets and the removal of restrictions on capital movements within the EEC. The author considers the implementation of Article 67, the origins of obstacles to further liberalisation, and the prospects for the third directive.

Grand challenge: ELSI in a changing global environment

Grand challenge: ELSI in a changing global environment

Making a Difference: Resident–Focused Models for Memory Care Facilities

For well over 30 years, design professionals have been aware of the growing proportion of the general adult assisted living facilities, for those who are challenged with different forms of dementia. The most common of these geriatric dementias is Alzheimer’s disease (AD). A current estimate maintains that AD is affecting 5% of the population between the ages of 65 and 74 (Hebert, Scherr, Bienias, Bennett, & Evans, 2003). Incredible strides have been made in the knowledgebase for treatment and care of the residents challenged with AD. Empathetic and positive treatment guidelines have been developed for adult-living facilities as well as guidelines for shoring up the fragmented families stretched and stressed by this disease (Manepalli, Desai, & Sharma, 2009). The care facilities and operators are now retooling the construction guidelines to embrace this notion of care (Facilities Guidelines Institute, 2010). Multilayered efforts are being made by a cross section of professionals to create a new place: a place called home. The song ‘‘Forever Young,’’ written by Bob Dylan in 1974, poignantly expresses this aging pandemic in its call for society to be ‘‘forever young.’’ Perhaps at 33, Dylan was beginning to see the shift in the cohort he was very much a part of, the aging of the ‘‘baby boomer’’ generation. It was a demographic he was right in the middle of when he penned the lyric for the song, a clarion prayer for strength, community, and honesty in the inevitable face of aging and death. His lyrics speak to the dignity of human condition when faced with change and death, the ultimate transition. Whether one is a physician, operator, builder, architect, or interior designer, we are all tasked by future generations to get it right before this generation passes. How will we know whether our assumptions are correct and the decisions we made in implementing new design, business, and care models were correct? One of the primary tools available to the senior care and design professionals is critical participant observation. This type of reflective scrutiny is based on the observer embedding himself into the AD culture in an attempt to experience what the resident is experiencing. With empathetic, methodical, and consistent cyclical review, new models of treatment, management, and design will be developed and evaluated over time. It is time that is creating is the growing pressure to find solutions for the population shift from individuals who have been independently productive to those who require around-the-clock supervision and care. The demographic bubble is reaching critical mass. Bob Dylan is now 71 years old. He along with his burgeoning cohort of baby boomers may well overwhelm our health care and adult care infrastructure (Wahl, Rick, Paul, & Warner, 2004). It is time to develop a flexible, affordable model that will address the current needs of the baby boomer as well as anticipate the needs of future generations. It will be a model that will facilitate compassionate care for the individual and recognize the value of the nuclear family as it knits its disparate parts into a place called home.