Background: Tobacco consumption, especially hookah, is one of the major behavioral health problems that has been more prevalent among young people and adolescents in recent years. Therefore, identifying the influential factors in tobacco consumption is essential for planning preventive measures. This study investigates the relationship between cultural, social, political, and economic factors with hookah smoking in Iranian adolescents. Materials and Methods: The present research is a systematic review study, which was conducted by examining data through PubMed, ProQuest, Google Scholar, Ovid, Magiran, SID, Science, Cochrane Medlib, and Medex Iran databases between 2000-2024 using the keywords hookah, tobacco, cultural, the teenager has been collected. In the initial search, 500 articles were retrieved, which were then screened at different stages (removing duplicate articles [300], reviewing titles and abstracts [170], and full-text [13]). Finally, 17 papers that passed the researchers’ criteria were reviewed carefully. Results: The results of the studies showed that various factors influence hookah consumption among adolescents, which were divided into social, economic, political, cultural, and psychological factors. Numerous factors influence adolescents’ inclination toward hookah consumption, with the most important ones being planned advertisements, incorrect knowledge, and attitudes about the harms of hookah, easy and affordable access, sensory attractions, peer encouragement, cultural acceptance of hookah, and a means to fill leisure time. Conclusion: It is recommended to focus on promoting culture and increasing awareness, effective advertising, increasing leisure-time activities for adolescents, enforcing laws prohibiting hookah use in public places, increasing tobacco prices, and enhancing recreational facilities.