Increase In Life Expectancy Research Articles

Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression.

The increasing life expectancy has led to a higher incidence of age-related neurodegenerative conditions. Within this framework, neuroinflammation emerges as a significant contributing factor. It involves the activation of microglia and astrocytes, leading to the release of pro-inflammatory cytokines and chemokines and the infiltration of peripheral leukocytes into the central nervous system (CNS). These instances result in neuronal damage and neurodegeneration through activated nucleotide-binding domain and leucine-rich repeat containing (NLR) family pyrin domain containing protein 3 (NLRP3) and nuclear factor kappa B (NF-kB) pathways and decreased nuclear factor erythroid 2-related factor 2 (Nrf2) activity. Due to limited effectiveness regarding the inhibition of neuroinflammatory targets using conventional drugs, there is challenging growth in the search for innovative therapies for alleviating neuroinflammation in CNS diseases or even before their onset. Our results indicate that interventions focusing on Interleukin-Driven Immunomodulation, Chemokine (CXC) Receptor Signaling and Expression, Cold Exposure, and Fibrin-Targeted strategies significantly promise to mitigate neuroinflammatory processes. These approaches demonstrate potential anti-neuroinflammatory effects, addressing conditions such as Multiple Sclerosis, Experimental autoimmune encephalomyelitis, Parkinson's Disease, and Alzheimer's Disease. While the findings are promising, immunomodulatory therapies often face limitations due to Immune-Related Adverse Events. Therefore, the conduction of randomized clinical trials in this matter is mandatory, and will pave the way for a promising future in the development of new medicines with specific therapeutic targets.

What the future holds: cystic fibrosis and aging.

Cystic fibrosis (CF) is one of the most common genetic diseases with around 70,000 affected patients worldwide. CF is a multisystem disease caused by a mutation in the CF transmembrane conductance regulator gene, which has led to a significant decrease in life expectancy and a marked impairment in the quality of life for people with CF (pwCF). In recent years, the use of highly effective CFTR modulator therapy (HEMT) has led to improved pulmonary function, fewer CF exacerbations, lower symptom burden, and increased weight. This has coincided with an increased life expectancy for pwCF, with mean age of survival being now in the 50s. This being a major breakthrough, which the CF population has hoped for, pwCF are now facing new challenges by growing old with a chronic respiratory disease. In this mini review, we are attempting to summarize the current knowledge of the aging process and its effect on CF disease and its manifestations including new developments, the current research gaps and potential future developments in the field to allow healthy aging for the CF community.

Venous Thromboembolism in Children: The Rivaroxaban Experience.

The incidence of venous thromboembolism (VTE) in the pediatric population has increased more than 10-fold in the last 20 years, as a consequence of the advancement of resuscitation and surgical techniques and the global increase in life expectancy of children suffering from chronic pathologies. Monitoring anticoagulant therapy to achieve outcomes within the target range in childhood VTE, parenteral administration of medications, and frequent blood tests in children are often cumbersome. Availability of safe and effective oral agents with pediatric data to support use would be of clear benefit. A physiologically based pharmacokinetic model was developed to estimate the appropriate dosing schedule for rivaroxaban in children. This incorporated growth/maturation and variability in anthropometrics (e.g., body height, weight, and body mass index), anatomy (e.g., organ weight), physiology (e.g., blood flow rates), metabolism and excretion. Rivaroxaban use in pediatric population underwent a complete investigational program, consisting mainly of one phase I pharmacokinetics/pharmacodynamics trial, three phase II trials, one phase III trial. The phase III trial enrolled 500 patients from birth to <18 years and documented the efficacy and safety of rivaroxaban regimens at dose equivalent to the adult 20 mg dose for the prevention of fatal or symptomatic nonfatal recurrent VTE and major bleeding versus heparin or vitamin K antagonists. Results were similar to those in rivaroxaban studies in adults. The efficacy and safety of rivaroxaban in children reported in the EINSTEIN JUNIOR trial provide further support to previous trials in adults (EINSTEIN Program), which demonstrate a favorable profile for the use of rivaroxaban for the management of VTE in challenging patient populations. Other clinical evidence contributing to the use of rivaroxaban among different risk groups in pediatric VTE population confirms the consistency with principal trial. Our review aims to describe the rationale for using rivaroxaban oral suspension in clinical practice and to summarize its multiple indications in each vascular bed (e.g., cerebral venous thrombosis, symptomatic or asymptomatic central venous catheter-associated thrombosis), etiology, and patients setting.

Cytotoxic Effect of Andrographis paniculata Associated with 2-Aminoethyl Dihydrogen Phosphate in Triple-Negative Breast Cells.

Cancer stands out as a major global public health concern and a significant impediment to increasing life expectancy worldwide. Natural bioactives derived from plants are renowned for their efficacy in treating various types of cancer. Andrographis paniculata (Burm.f.) is a well-known plant traditionally employed in diverse medical systems across the globe. The 2-AEH2P monophosphoester, a molecule intricately involved in phospholipid turnover, demonstrates antiproliferative effects across a broad spectrum of cancer types. This study aims to assess the antitumor, antiproliferative, and pharmacological effects of andrographolide at different concentrations, both individually and in conjunction with 2-aminoethyl dihydrogen phosphate. The cytotoxicity of the treatments was evaluated using the colorimetric MTT method, cell cycle phases, mitochondrial electrical potential, and markers expression via flow cytometry, while the pharmacological effects were assessed using SynergyFinder software 3.0. Treatments with A. paniculata, isolated at concentrations of 10%, 30%, and 50% of andrographolide, induced cell death in tumor cells, resulting in a reduction in mitochondrial electrical potential and alterations in cell cycle phases, particularly a decrease in the population of MDA MB-231 cells in the G0/G1 phase. The combination treatments exhibited significant cytotoxicity toward tumor cells, with minimal toxicity observed in normal fibroblast cells FN1. This led to a reduction in mitochondrial electrical potential and cell cycle arrest in the S phase for MDA MB-231 cells. Across all concentrations, the combined treatments demonstrated a synergistic pharmacological effect, underscoring the efficacy of the association. There was a change in the markers involved in cell death, such as p53, caspase 3, Bcl-2, and cytochrome c, suggesting the induction of regulated cell death. Markers associated with progression and proliferation, such as cyclin D1 and p21, corroborate the findings for cytotoxicity and cell cycle arrest.

The role of family support in the self-rated health of older adults in eastern Nepal: findings from a cross-sectional study

BackgroundNepal’s low fertility rate and increasing life expectancy have resulted in a burgeoning older population. For millennia, filial piety shaped family cohesion and helped Nepali older adults achieve positive outcomes, but recently, it has been eroding. Furthermore, there are not enough institutional support options or alternatives to family-based care to deal with the biosocial needs of older adults. This study explored the association between family support and self-rated health among Nepali older adults.MethodsA community-based cross-sectional survey in eastern Nepal’s two districts, Sunsari and Morang, interviewed 847 older adults (≥ 60 years). The final analytical sample was 844. Participants were asked whether they received assistance with various aspects of daily life and activities of daily living from their families. Multivariable logistic regression examined the association between family support and self-rated health.ResultsParticipants who received support with various aspects of daily life had 43% higher odds of good health, but after adjusting for control variables, the result only approached statistical significance (p = 0.087). Those who received family assistance with activities of daily living had nearly four times higher odds (OR: 3.93; 95% CI: 2.58 – 5.98) of reporting good health than participants who lacked this support.ConclusionsGiven the important role of family support in Nepali older adults’ health, government programs and policies should create a conducive environment to foster family-based care until more comprehensive policies for older adults’ care can be put into effect. The results of this study can also help shape the global aging environment by highlighting the need for family support in older care, particularly in low-income nations with declining traditional care systems and weak social security policies.

Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies.

The improvement of human living conditions has led to an increase in average life expectancy, creating a new social and medical problem-aging, which diminishes the overall quality of human life. The aging process of the body begins with the activation of effector signaling pathways of aging in cells, resulting in the loss of their normal functions and deleterious effects on the microenvironment. This, in turn, leads to chronic inflammation and similar transformations in neighboring cells. The cumulative retention of these senescent cells over a prolonged period results in the deterioration of tissues and organs, ultimately leading to a reduced quality of life and an elevated risk of mortality. Among the most promising methods for addressing aging and age-related illnesses are pharmacological, genetic, and cellular therapies. Elevating the activity of aging-suppressing genes, employing specific groups of native and genetically modified cells, and utilizing senolytic medications may offer the potential to delay aging and age-related ailments over the long term. This review explores strategies and advancements in the field of anti-aging therapies currently under investigation, with a particular emphasis on gene therapy involving adeno-associated vectors and cell-based therapeutic approaches.

Cost-Effectiveness of Adjuvant Olaparib for Patients With Breast Cancer and Germline BRCA1/2 Mutations

The OlympiA trial found that 1 year of adjuvant olaparib therapy can improve distant disease-free survival and overall survival from early-stage breast cancer in patients with a germline BRCA1/2 mutation. However, olaparib, an oral poly-adenosine diphosphate ribose polymerase inhibitor, is estimated to cost approximately $14 000 per month in the US. To estimate the incremental cost-effectiveness of adjuvant olaparib compared with no olaparib in eligible patients. In an economic evaluation from a health care system perspective, the cost-effectiveness of adjuvant olaparib was analyzed using a Markov state-transition model. The model simulated costs and lifetime health outcomes of 42-year-old women with high-risk early-stage breast cancer and a known BRCA1/2 mutation who completed definitive primary therapy and neoadjuvant or adjuvant systemic therapy. The study was conducted from August 2021 to July 2023. The effectiveness of olaparib was based on the findings of the OlympiA randomized clinical trial, and other model parameters were identified from the literature. The model was calibrated to the 1-, 2-, 3-, and 4-year distant disease-free and overall survival observed in the OlympiA trial, and olaparib was assumed to reduce the risk of distant recurrence only in the first 4 years. One year of adjuvant olaparib or no adjuvant olaparib. Incremental cost-effectiveness ratio (ICER) in 2021 US dollars per quality-adjusted life-year (QALY) gained. All outcomes were discounted by 3% annually. In the base case, adjuvant olaparib was associated with a 1.25-year increase in life expectancy and a 1.20-QALY increase at an incremental cost of $133 133 compared with no olaparib. The resulting ICER was approximately $111 000 per QALY gained. At a willingness-to-pay threshold of $150 000 per QALY, olaparib was cost-effective at its 2021 price and in more than 92% of simulations in probabilistic sensitivity analysis. The results were sensitive to assumptions about the effectiveness of olaparib and quality of life for patients with no disease recurrence. In this study, from a US health care system perspective, adjuvant olaparib was a cost-effective option for patients with high-risk, early-stage breast cancer and a germline BRCA1/2 mutation.

Pengaruh Penambahan Tens Pada Quadricep Setting Exercise Untuk Mengurangi Nyeri Dan Meningkatkan Aktivitas Fungsional Pada Lansia Pederita Osteoarthritis Genu Di Rumah Sakit Citama

Abstract: Osteoarthritis is a cause of disability in the elderly where its prevalence will increase along with the increasing life expectancy of the global population (Sacitharan, 2019). According to the World Health Organization in 2013, it is estimated that by 2050 people aged over 60 years will account for more than 20% of the world's population, of which 15% have symptoms of Osteoarthritis, while a third experience severe disability, namely being unable to carry out daily activities (Nos et al. , 2020). Impairments that arise include (1) pain felt around the knee joint and pain when bending the knee, (2) weakness of the muscles that drive the knee joint, (3) limited range of motion (LGS) of the knee. The purpose of this study was to determine the effect of adding TENS on Quadricep exercise settings to reduce pain and increase functional activity in elderly people with osteoarthritis genu. The data collection method used a quasi-experimental design with a pre and post design with a control group design. The data collected was tested for normality with Shapiro Wilk. Normal distribution, effect test using paired t-test. The results of the paired t-test obtained a value of p = 0.0001 (p &lt;0.05) in pain and obtained a value of p = 0.0002 (p &lt;0.005) an increase in functional activity in the treatment group I. The treatment group II obtained a value of p = 0.0004 (p &lt;0 .05) in pain and 0.0003 (p&lt;0.05) increased functional activity. The conclusions obtained from this study are 1) Quadricep setting exercise can reduce pain and increase functional activity in elderly people with osteoarthritis genu. 2) The addition of TENS to Quadricep exercise settings can reduce pain and increase functional activity in elderly people with osteoarthritis genu.&#x0D; Keywords: Osteoarthritis knee/knee, Quadricep setting exercise, pain, functional activity

The everyday life occupations of older women in social vulnerability in Brazil

ABSTRACT Population aging is widely discussed due to the impacts of increased life expectancy, especially in socially vulnerable populations. This descriptive-exploratory qualitative study aims to understand older women’s perceptions of their occupations in a socially vulnerable community. The participants were 11 women, aged 60 years or older, living in Vila Marçola, Aglomerado da Serra, Minas Gerais, Brazil. Semi-structured interviews were carried out and the content was analyzed by using thematic analysis. Findings indicated four care dimensions: 1) Household care and caring for other people, 2) Community care, 3) Self-care, and 4) Expanding the experiences of care in old age. Older, mostly black, and poor women from Vila Marçola highlighted the unequal living conditions in Brazil. These women were overloaded with occupations, especially paid and unpaid household care, and did not have access to or stability in other occupations. However, retirement allowed them to participate in educational and social projects, increasing their occupational repertoire. This study contributes to the construction of intersectional knowledge in the field of occupational science, expanding the understanding of the socio-cultural dimensions that involve the diversity of people around the world, especially in situations of social vulnerability.

PROVISION OF HEALTH SERVICES TO THE POPULATION AND DEMOGRAPHIC DEVELOPMENT: THE CASE OF AZERBAIJAN

The purpose of the research – the study aims to evaluate the progress made in Azerbaijan's healthcare system, considering recent developments. This includes assessing their impact on life expectancy at birth, a crucial indicator of population reproduction. Additionally, the research seeks to identify potential avenues for future development in light of existing challenges. The methodology of the research – descriptive analysis and comparative analysis methods were used in the research. The practical importance of the research - deeply understanding the current state of the healthcare sector is crucial for successfully implementing the activities outlined in the demographic development concept, which aims to improve the population's quality of life. This research lays the groundwork for future analyses that will utilize econometric models to explore the intricate relationship between health and demographic indicators. The results of the research - recent reforms in Azerbaijan's healthcare system have broadened access to medical services for the population, leading to a notable increase in life expectancy. Notably, the establishment of the Institute of Family Physicians and the enhanced collaboration between public and private medical institutions have played a crucial role in tackling key challenges. These include addressing regional disparities in healthcare deve­lopment indicators and increasing the share of healthcare expenditures within the national GDP. The originality and scientific novelty of the research - the processes in the healthcare system were analyzed comprehensively, linking them to demographic indicators. This descriptive analysis revealed positive trends in the field of medicine, accompanied by an increase in life expectancy.

ANTITUMOR EFFECTIVENESS OF THE COMBINED APPLICATION OF BACTERIA OF THE GENUS BIFIDOBACTERIUM AND B. SUBTILIS IMV B-7724 LECTIN

Summary. Aim: to investigate of the antitumor effectiveness of the combined use of bacteria of the genus Bifidobacterium and the extracellular metabolite (lectin) of B. subtilis IMV B-7724. Object and methods: studies were performed on Balb/c mice (n = 52). Ehrlich adenocarcinoma was used as an experimental model. Starting from the 2nd day after the transplantation of tumor cells, the animals of the experimental groups were injected with lectin B. subtilis IMV B-7724 (s/c, 1 mg/kg of body weight, No. 10), B. animalis (per os, 7×105 CFU/ mouse, No. 10) or used their combination. The frequency of transplantation (%), the latent period of tumor emergence, the volume of tumors (mm3), and the life expectancy of animals were evaluated. Statistical processing of the results was carried out according to generally accepted methods of variational statistics. Results: administration of B. subtilis IMB B-7724 lectin (both alone and in combination with B. animalis) to mice with Ehrlich adenocarcinoma resulted in a significant inhibition of tumor growth. The tumor growth inhibition index was 55.0 and 50.5%, respectively. the animals of these groups were also characterized by a statistically significant increase in life expectancy compared to the control group: by 61.4 and 50.0%, respectively. The use of B. animalis alone did not have such a pronounced effect. Conclusion: on the Ehrlich adenocarcinoma model, a pronounced antitumor effect (inhibition of primary tumor growth, increase in life expectancy), both with the combined use of B. animalis and B. subtilis IMV B-7724 lectin, and with the separate administration of the bacterial lectin was demonstrated. The use of B. animalis alone did not affect the dynamics of tumor growth and the life expectancy of animals.

The effect of oral administration of tauroside Sx1 on the accumulation of influenza virus and histological changes in the lungs of mice

The constant threat of a new viral pandemic gives special urgency to the search for new effective means of preventing and treating influenza infection. The article examines the effect of oral administration of saponin tauroside Sx1, obtained from the leaves of Crimean ivy, on the development of infection caused by influenza virus A/WSN/1/33(H1N1), and histological changes in the lungs of infected mice. It was revealed that oral administration of saponin tauroside Sx1 at a dose of 200 mcg/mouse day or 11.8 mg/kg/day for three days after infection led to an almost twofold statistically significant increase in the average life expectancy of infected animals from 6.50±0.67 to 11.10±2.19 days. The protective activity of tauroside Sx1 was established when administered orally in the early stages of influenza infection in mice. The protective effect of saponin is manifested in a significant increase in the average life expectancy and normalization of the structure of lung tissue in infected animals. The results obtained indicate the prospects for further study of saponin tauroside Sx1 as a potential component of anti-influenza drugs.

Does subjective life expectancy matter in purchasing life insurance among middle-aged and older adult? Evidence from China.

Population-wide increase in life expectancy is a source of aggregate longevity risk. Life insurance is a natural instrument to manage the risk. Previous studies used chronological age to examine the relationship between aging and life insurance purchase, which ignored the impact of subjective life expectancy-the real perception of remaining time. Therefore, this study aims to fill the lack in this area and to explore in depth the relationship between subjective life expectancy and purchasing life insurance among middle-aged and older adult at micro perspective. This paper utilizes data from the China Health and Retirement Longitudinal Study (CHARLS) over a period of 4 years to construct both Probit and Tobit models. The findings reveal that subjective life expectancy positively affects the likelihood of participation and the extent of life insurance among the middle-aged and older adult population in China. IV model estimation results show good robustness of the results. Meanwhile, there is also heterogeneity in the effect with respect to gender, hukou, education and wealth. The findings provide new perspective to explain the subjective motivation of purchasing life insurance in China.

The Relationship between Quality of Sleep with Hypertension Rate in among Elderly

Background: The quality of sleep is a crucial determinant of overall health and well-being, particularly among the elderly population. A person who has reached the age of 60 is considered to be elderly. One of Indonesia's indices of human development is the increase in life expectancy. Several factors, including irregular sleep, a lack of exercise, and stress, contribute to the recurrence of hypertension in the elderly with elevated blood pressure symptoms. Hypertension is an increase in blood pressure in the arteries. Hyper means excessive pressure or tension. Hypertension is a blood pressure or heart rate that is higher than normal because of narrowing arteries or other disorders. The aim of this study was to examine the relationship between sleep quality and the recurrence rate of hypertension in the elderly. Methods: The research design is correlational, using cross-sectional methods. The study randomly selected 83 participants from the population of all hypertension patients in the working area of the Jampangkulon Health Centre in the Sukabumi Regency. The univariate and bivariate data analyses employed the chi-square test. Results: The results showed that the P value of 0.000, which means &lt;0.05, indicates a relationship between sleep quality and the recurrence rate of hypertension in the elderly in the working area of the Jampangkulon Health Centre, Sukabumi Regency. Conclusion: The study results indicate that there is a relationship between sleep quality and the rate of recurrence of hypertension in the elderly. The present study will help elderly individuals who experience recurrences of hypertension to maintain and improve their healthcare to achieve optimal health.

Sanitary energy costs

Energy production and consumption are essential to the development of industrial societies. It has been shown that there is a strong correlation between the increase in life expectancy and the amount of energy per capita, but that this effect reaches a plateau at a value of less than a quarter of that of current Western societies. In addition to energy consumption, the interaction between energy and health is dominated by the effects of environmental pollution.

Key challenges in the dietary intake structure and cutting edge technologies for optimizing nutrition to protect the health of the Russian рopulation

This article presents an analysis of some of the results of the work of the Federal Research Center for Nutrition and Biotechnology (Center) in recent years, highlighting the most important, promising areas of Nutrition Science and Food Hygiene that need further development. The priority area of Center functioning is scientific support for the implementation of the Doctrine of Food Security of the Russian Federation (Decree of the President of the Russian Federation dated January 21, 2020 No. 20), Decree of the President of the Russian Federation dated July 21, 2020 No. 474 «On the national development goals of the Russian Federation for the period until 2030 «in terms of ensuring an increase in life expectancy and improving the life quality of the population, the Strategy for Improving the Quality of Food Products in the Russian Federation until 2030 (Order of the Government of the Russian Federation dated June 29, 2016 No. 1364-r). The Center coordinates all research on medical nutrition problems in the Russian Federation within the framework of the work of the Problem Commission on Nutrition Hygiene of the Scientific Council of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, the Scientific Council of the Russian Academy of Sciences on Medical Nutrition Problems, the Scientific and Technical Committee of the Comprehensive Scientific Program «Priority Research in the Field of Nutrition of the Population», Profile Commission on Dietetics of the Expert Council in the Field of Health of the Ministry of Healthcare of Russian Federation, ensuring the implementation of their results with the participation of members of the Consortium "Healthcare, Nutrition, Demography". The most important area of the Center's work is scientific and expert support in the field of international and national technical regulation of the production and turnover of foods and raw materials, in particular, the work of the Russian national contact point of the Codex Alimentarius Commission (established by FAO and WHO), as well as the work of the Russian side in the Eurasian Economic Commission regarding the preparation of proposals for technical regulations of the Customs Union in the field of food safety, evaluation of draft technical regulations and amendments and additions to them.

The comparative analysis of health care systems

Within the framework of the national development goal of the Russian Federation "preservation of population, health and well-being of people" the target indicator "the increase of life expectancy up to 78 years" is to be achieved by 2030. The achievement of this value is also directly affected by functioning of of health care system. In 2015, the United Nations, within the framework of the Sustainable Development Goals for the period up to 2030, formulated the task that implies ensuring of universal health services coverage "including financial risk security, access to qualitative essential medical and sanitary services and access to safe, effective, qualitative and inexpensive essential medications and vaccines for all". In the course of the study, methodology was developed that permitted to calculate values of performance indicators of main health care systems (financial support and infrastructure development) and to conduct comprehensive comparative analysis with values of particular public health indicators. The study results confirmed possibility of such comparisons. The stable direct relationship between such indicators as "current health expenditure (CHE) per capita", "current health expenditure (CHE) as percentage of gross domestic product (GDP)", "UHC Service Coverage Index", "life expectancy" was revealed. The inverse dependency between such indicators as "out-of-pocket expenditure as percentage of current health expenditure (CHE)" and "UHC Service Coverage Index" as well as between "UHC Service Coverage Index" and "total NCD mortality rate" and "probability of premature dying from non-infectious diseases" was determined.

Assessment of Oral Health Status and Factors Associated with Oral Health-related Quality of Life among Geriatric Population in Rural South India – A Community-based Cross-sectional Study

Abstract Introduction: In recent times, there is an increase in life expectancy leading to demographic transition toward aging population in both developed and developing countries. Oral health represents a major concern for general health; hence, the oral health of older people is increasingly important. One particularly meaningful factor is the number of teeth which provide information about the functionality of the masticatory system, an esthetic smile as well as an esthetic profile. Losing teeth can be psychologically traumatic, socially damaging, and functionally limiting, thereby affecting the quality of life (QoL). Aim: The aim of this study was to assess the oral health status and factors associated with poor oral health-related QoL in geriatric population (aged &gt;60 years) in rural South India. Materials and Methods: A community-based cross-sectional study was conducted among 437 elderly in Kaniyambadi block of Vellore district. Sociodemographic details were collected directly by face-to-face interview, and the elderly were subjected to oral examination for oral health status. Oral health-related quality of life (OHrQoL) was measured using the Geriatric Oral Health Assessment Index (GOHAI). Factors associated with poor OHrQoL were analyzed using multiple logistic regression. Results: The study population comprised 31.1% (n = 136) of males and 68.9% (n = 301) of females, with a mean age of 68 (standard deviation – 6.9) years. On oral examination, the prevalence of dental caries and any type of edentulism was 51.5% (n = 225) and 82.4% (n = 360), respectively. The prevalence of complete edentulism was 10.1% (n = 44). By assessing oral health-related quality of life using the revised GOHAI tool, 30 (6.9%) had high scores between 34 and 36, 166 (38%) had scores between 31 and 33, and 241 (55.1%) had low scores (≤30). In the multivariate analysis, age &gt;70 years (odds ratio [OR] =1.92, 95% confidence interval [CI] = 1.2–3.06, P = 0.006), male gender (OR = 1.78, 95% CI = 1.05–3.3, P = 0.033), and edentulism/severe tooth loss (OR = 8.64, 95% CI = 3.19–23.87, P &lt; 0.001) had significantly higher odds for poor OHrQoL. Edentulism/severe tooth loss was also significantly associated with undernutrition (OR = 12.5, 95% CI = 6.56–23.81, P &lt; 0.001). Conclusion: The burden of dental caries and edentulism in rural South India was high. The prevalence of edentulism had a significant impact on the OHrQoL. This study highlights the need for researchers to understand the importance of edentulism and its impact on overall health of the elderly, thereby focusing on health programs inclusive of oral health promotion and prevention.

Oocyte Aging: A Multifactorial Phenomenon in A Unique Cell.

The oocyte is considered to be the largest cell in mammalian species. Women hoping to become pregnant face a ticking biological clock. This is becoming increasingly challenging as an increase in life expectancy is accompanied by the tendency to conceive at older ages. With advancing maternal age, the fertilized egg will exhibit lower quality and developmental competence, which contributes to increased chances of miscarriage due to several causes such as aneuploidy, oxidative stress, epigenetics, or metabolic disorders. In particular, heterochromatin in oocytes and with it, the DNA methylation landscape undergoes changes. Further, obesity is a well-known and ever-increasing global problem as it is associated with several metabolic disorders. More importantly, both obesity and aging negatively affect female reproduction. However, among women, there is immense variability in age-related decline of oocytes' quantity, developmental competence, or quality. Herein, the relevance of obesity and DNA-methylation will be discussed as these aspects have a tremendous effect on female fertility, and it is a topic of continuous and widespread interest that has yet to be fully addressed for the mammalian oocyte.

Comparative Analysis of Primary Health Care Organization Models: Global Experience and the Republic of Kazakhstan

At present, the Republic of Kazakhstan is facing an increase in chronic diseases and an aging population, which presents new challenges to the healthcare system. A comparative analysis of primary health care organization models based on global experience and the experience of the Republic of Kazakhstan can contribute to the improvement of the primary health care system, increasing its accessibility and quality, and improving the health of the country's population. The purpose of this study is to evaluate and compare the primary health care systems of leading countries to improve the understanding and effectiveness of population health care at the global level.In recent years, significant achievements have been observed in global health, such as an increase in life expectancy, a decrease in child mortality, and increased access to drugs and vaccines. However, XXI century healthcare systems require innovative approaches and significant investments to overcome challenges such as aging populations and the growth of chronic diseases. In this context, primary health care becomes a key component of sustainable health system development, playing an important role in the prevention, diagnosis, and treatment of common diseases. The importance of a comparative analysis of primary health care organization models in different countries lies in identifying unique features, achievements, and barriers of each. Through analysis and research, effective strategies can be developed to improve population health and increase accessibility and quality of medical care, providing a basis for the development of effective public health strategies.