Increase In Latency Research Articles

Analysis on the Application of Exercise in Resolving Increased Sleep-Onset Latency

As insufficient sleep has been coined a “public health epidemic” by the U.S Centers for Disease Control and Prevention (CDC), interventions should be executed as to ease the global crisis. Currently, considerable accounts of research have been done using various outcome measures as to help put a stop to the health crisis. Moreover, a decrease in sleep quality and times is often times caused by the delay in overall sleep-onset latency. Exercise and sleep are thought to be interconnected, however, uncertainty is present around the debate of whether or not exercise may affect sleep-onset latency. This article examines the various accounts of research done on the topic by analyzing current studies through literature review, attempting to form a comprehensive and thorough conclusion based on current findings, while simultaneously introducing the severity, background and biological basis behind the issue to provide further insight on the correlation between exercise and sleep-onset latency. However, conflicting results and conclusions were found, most likely due to multivariate aims, creating a variety of contrasting variables such as differing demographics, settings, and outcome measures. Nonetheless, through compilation of various sources, new insight can be made regarding how an increase in sleep-onset latency can be combated with consideration of definitive demographics and settings. Moreover, while a generalization can not be made based on the research conducted in this article, exercise can still be utilized and applied in specific circumstances.

Vestibular-evoked myogenic potentials and video head impulse test in cochlear otosclerosis

BackgroundOtosclerosis is one of the most common causes of hearing loss in adults with clinical onset between 20 and 40 years of age. Vestibular symptoms may be the most agonizing and primary symptom in cases with otosclerosis, so the assessment of patients is important. The vestibular-evoked myogenic potentials test (VEMP) is used to assess the saccular and the utricular functions using cervical and ocular vestibular-evoked myogenic potentials (cVEMP and oVEMP), respectively. The video head impulse test (vHIT) which measure vestibulo-ocular reflex (VOR) to rapid impulsive head acceleration in the plane of each semicircular canal (SCC) has allowed quantitative monitoring of each canal function.MethodsTwenty subjects with bilateral otosclerosis were studied, ranging in age from 30 to 55 years, divided into two groups. One group consisted of 10 adult patients with bilateral conductive otosclerosis. The second group consisted of 10 adult patients with bilateral mixed otosclerosis. All the patients underwent cVEMP and oVEMP, using a BC 500Hz tone burst stimulus and vHIT in three planes, left anterior right posterior (LARP), right anterior left posterior (RALP), and lateral SCCs.ResultsThe findings indicate statistically significant differences in the peak-to-peak amplitudes of cVEMP and oVEMP in the two studied groups, and the mixed cases had lower amplitudes than conductive cases and a significant increase in p13 latencies. Also, there is a statistically significant difference in the lateral SCC gain between the two groups, as mixed cases had lower gain than conductive cases, but not for anterior or posterior SCCs, with no gain less than 0.8 in all three canals.ConclusionThe findings suggested that the saccule is more liable to be affected by cochlear otosclerosis followed by the utricle. The three SCCs are mostly spared.

Effects of inhibition of Nav1.3, Nav1.7, and Nav1.8 channels on pain-related behavior in Speke's hinge-back tortoise (Kinixys spekii).

Comparative studies using reptiles as experimental animals in pain research could expand our knowledge on the evolution and adaptation of pain mechanisms. Currently, there are no data reported on the involvement of voltage-gated sodium ion channels on nociception in reptiles. The aim of this study was to investigate the involvement of Nav1.3, Nav1.7, and Nav1.8 ion channels in nociception in Speke's hinge-back tortoise. ICA 121341 (selective blocker for Nav1.1/Nav1.3), NAV 26 (selective blocker for Nav1.7), and A803467 (selective blocker for Nav1.8) were used to investigate the involvement of Nav1.3, Nav1.7, and Nav1.8, respectively. The chemicals were administered intracoelomically thirty minutes before the start of nociceptive tests. ICA 121341 did not cause a significant decrease in the time spent in pain-related behavior in all the nociceptive tests. NAV 26 and A8034667 caused a statistically significant decrease in the mean time spent in pain-related behavior in the formalin and capsaicin tests. Only A803467 caused a statistically significant increase in the mean latency to pain-related behavior in the hot plate test. NAV 26 and A803467 had no observable side effects. In conclusion, Nav1.7 and Nav1.8 are involved in the processing of chemically induced inflammatory pain in Speke's hinge back tortoise. In addition, Nav1.8 are also significantly involved in the development of thermal-induced pain-related behavior in this species of reptile. However, our results do not support the involvement of Nav1.3 on the development of chemical or thermal induced pain-related behavior in the Speke's hinge back tortoise.

Methylglyoxal accumulation contributes to accelerated brain aging in spontaneously hypertensive rats

While it is well-acknowledged that neurovascular dysfunction in hypertension is tightly associated with accelerated brain aging, we contend that the deleterious effects of hypertension may extend beyond affecting only the arteries. Methylglyoxal (MG) derived from glycolysis, is involved in the accumulation of advanced glycated end products (AGEs), which are the hallmarks of neurodegenerative disorders. Therefore, the present study aims to firstly investigate the role of MG metabolism in the hypertension-accelerated brain aging process. The results of our study indicate that the levels of MG increase with age in both the plasma and hippocampus of SHRs at 12, 16, and 30 weeks old. AGE methylglyoxal-hydro imidazoline-1 (MG-H1) is primarily localized in astrocytes, while its presence was not observed in neurons and microglia within the hypertensive hippocampus. Our observations also suggest that angiotensin II (Ang II) enhances glucose uptake and glycolysis while reducing the expression of Glo1 in cultured astrocytes. N-acetylcysteine (NAC) was found to counteract the increase in escape latency and inhibit the activation of the AGEs-RAGE axis in 30-week-old SHRs. NAC decreased Iba-1 immunofluorescence intensity, inhibited the levels of pro-inflammatory markers, and enhanced the abundance of anti-inflammatory markers in the hippocampus of SHRs. Moreover, NAC reduced the immunofluorescence signal of 4HNE and increased the content of GSH and SOD in SHRs. Finally, NAC was observed to inhibit apoptosis in the hippocampus of SHRs. Collectively, we firstly showed the enhanced accumulation of MG in the hypertensive brain, whereas the clearance of MG by NAC treatment mitigated the aging process and attenuated AGEs generation, neuroinflammation, and oxidative damage.

Latency-Energy Tradeoff in Connected Autonomous Vehicles: A Deep Reinforcement Learning Scheme

Vehicle Edge Computing (VEC)-assisted computational offloading brings cloud computing closer to user equipment (UEs) at the edge of the access network by delivering various services to the UEs with limited processing power and battery. However, in fifth-generation and beyond 5G (B5G) networks, where UEs’ service requests and locations change dynamically, the deployment of static edge server deployments may lead to an increase in latency and total energy consumption. This paper presents a latency-energy-aware, efficient task offloading scheme for connected autonomous vehicular networks. Firstly, vehicles are assembled into clusters, in which vehicle can transmit tasks to the other vehicle, while on the other hand, the VEC server is used for processing the data. We developed a joint resource allocation and offloading decision optimization problem to minimize network latency and total energy usage. Due to the non-convex character of the optimization issue, we employed the Markov decision process (MDP) to convert it to a reinforcement learning (RL) problem. Then, we used a soft-actor critic-based scheme to achieve the optimal policy for resource allocation and task offloading to reduce the total latency and energy consumption for connected autonomous vehicles. Simulation analysis reveals that the proposed scheme attains 46.6% and 17.2% lesser delay, and 28.8% and 20.0% consumes less energy than the Hybrid DRL with Genetic Algorithm (HDRL-GA) and DRL based collaborative Data Scheduling (DRL-CDSS) state-of-art schemes.

OFFSET RESPONSES IN CONDITIONS OF AUDITORY SPATIAL MASKING IN HUMANS

The influence of relative spatial positions of sound stimuli and background masker on the event related potentials (ERPs) evoked by sound offset was investigated. Sound stimuli were presented dichotically, the position of sound images was manipulated using interaural level differences. Test signals were presented in silence or against the background of a masker. Signal and masker were either co-located or separated by 90 or 180 deg of azimuth. Co-location of signal and masker resulted in amplitude decrease and latency increase in the N1, P2 and N2 components. When angular distance between signal and masker increased, the amplitude recovered almost to the initial level and the latency of all components became shorter. The present findings are in line with the view that offset response is essential for target stimulus detection in the background noise.

Interleaved LDPC Decoding Scheme Improves 3-D TLC NAND Flash Memory System Performance

Although NAND flash memory does a lot of work in effectively using Error Correcting Code(ECC) to reduce Uncorrectable Bit Error Rate(UBER). However, if the Frame Error Rate(FER) is not reduced, the lower UBER cannot effectively reduce the read latency of the flash memory system. This phenomenon is especially evident at the end of the flash memory lifetime, where conventional methods significantly reduce the UBER but not to zero, and the remaining error bits are still evenly distributed throughout the flash memory page, resulting in a significant increase in read latency. In this paper, an interleaved LDPC decoding scheme is proposed. By re-evaluating the flash memory channel during the decoding process, the codewords in the flash memory page are corrected frame by frame, and the problem of high FER is solved at the end of the flash memory lifetime. Compared with the conventional algorithm, the proposed method can reduce the FER by up to 34%, reduce the average decoding iterations by 63.4%, and reduce the read latency by up to 65%.

Target number influences strategy use by rats (Rattus norvegicus) in the traveling salesperson problem.

The traveling salesman problem (TSP) is an optimization problem in which the goal is to find the shortest possible route that passes through each of a set of points in space. The TSP is of interest not only in the fields of mathematics, computer science, and engineering, but also in cognitive and behavioral research to study problem-solving and spatial navigation. Humans are able to complete even complex TSPs with a high degree of efficiency, and distance minimization in TSP analogs has been observed in a variety of nonhuman species as well. Tasks based on the TSP also have the potential for translational research on cognitive and neurological disorders such as Alzheimer's disease. The current experiment was designed to examine the effects of target number on TSP performance in rats. After pretraining, rats were tested once on each of several target configurations, and their travel routes were recorded. We examined the routes for general efficiency, as well as evidence for strategy use including the nearest neighbor (NN) strategy and crossing avoidance. Our results indicate that latency and route length increase in proportion to the number of targets. Rats also showed a strong tendency to avoid path crossing, and to select NN targets, which strengthened with increasing target numbers. Taken together, our results indicate that travel efficiency decreases linearly in relation to the target number rather than the number of possible routes, which grows factorially with a target number. Additionally, spatial memory and route selection strategy are also affected by an increasing number of targets. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

O050 The Dose and Timing Relationship between Caffeine and Subsequent Sleep

Abstract Introduction There is currently a lack of evidence to guide recommendations for the consumption of caffeine to mitigate its effects on sleep. Therefore, the aim of this study was to investigate the effect of caffeine dose and timing combinations on subsequent sleep. Methods Twenty-three healthy adult males with a moderate habitual caffeine intake (<300mg/d) participated in a randomised, repeated-measures study. Participants completed seven conditions, including a placebo and two caffeine doses (100mg and 400mg) consumed at three different time points (12, eight, and four hours prior to habitual bedtime) with a 48-hour washout period. Sleep was measured using in-home partial polysomnography and subjective sleep diaries. Linear mixed effects models were used to estimate the effect of each caffeine condition on sleep characteristics. Results Caffeine negatively impacted sleep when compared to the placebo. The largest impact was observed when the highest dose of caffeine (400mg) was consumed closest to bedtime, with a 54.0 minute reduction in total sleep time (p=<0.001), a 10.2% reduction in sleep efficiency (p= <0.001), a 14.4 minute increase in sleep onset latency (p=0.047), a 25.3 minute increase in wake after sleep onset (p=<0.001), a 5.5% increase in the proportion of light sleep (N1&N2)(p=0.029), and a 4.55% reduction in deep sleep (N3)(p=0.026). Discussion The largest decrements in sleep occurred when caffeine was consumed at a high dose in close proximity to bedtime. These findings highlight the importance of considering the amount and timing of caffeine intake when aiming to minimise the effect of caffeine on subsequent sleep.

Exaggerated response to pattern reversal visual evoked potential among migraineurs

Objective Visual evoked potential recording has reported ambiguous results among migraineurs, thus the present study explored the association of check-size and reversal rates on the latency and amplitude of pattern reversal VEP among migraineurs. Method and material Monocular VEP responses for both eyes were recorded in 133 migraineurs and 111 controls. Checkerboard pattern with phase reversal frequency of 0.5, 1, 2 and 4 Hz and check-size of 16 × 16, 32 × 32, 64 × 64 and 128 × 128, i.e. spatial frequency of 0.475, 1.029, 2.056 and 4.112 cycle per degree (cpd) were used to record 100 responses each. Three-minutes gap was given after change of reversal frequency to a higher rate for next cycle of 4 check-size records. Result A linear increase in latencies was observed with decreasing check-size in both groups, but migraineurs had significantly higher latencies at a given reversal rate. Amplitudes A1 and A2 were higher among migraineurs and amplitude A2 showed an inverted ‘U’ shaped trend with maximum amplitude at 32 × 32 check size (1.029 cpd) in both groups, with an exaggerated response among migraineurs. Check-size 32 × 32 i.e. spatial frequency of 1.029 behaves differently than other larger or smaller check-sizes. Conclusion Variable VEP response for different visual stimuli may be due to differential activation of respective retinocortical pathways and cortical areas. The highest amplitude at modest check-size suggests a contributory role of foveal-parafoveal fibres in migraineurs. Exaggerated physiological response to visual stimuli may be responsible for higher amplitudes and prolonged latencies among migraineurs.

Assessing changes in sleep across four weeks among adolescents randomized to incentivized cannabis abstinence

BackgroundWithdrawal from cannabis use is associated with sleep disturbances, often leading to resumption of use. Less is known about the impact of abstinence on sleep in adolescence, a developmental window associated with high rates of sleep disturbance. This study investigated effects of sustained abstinence on self-reported sleep quality and disturbance in adolescents reporting frequent cannabis use. MethodsNon-treatment seeking adolescents, recruited from school screening surveys and the community, with frequent cannabis use (MAge=17.8, SDAge=1.7, 47% female, 45% non-white) were randomized to four weeks of biochemically-verified abstinence, motivated via contingency management (CB-Abst, n=53), or monitoring without an abstinence requirement (CB-Mon, n=63). A mixed-effects model was used to predict change in Pittsburgh Sleep Quality Index (PSQI) scores. ResultsParticipants in CB-Abst reported higher overall PSQI scores than those in CB-Mon (M=1.06, p=0.01) indicating worse sleep during the four-week trial. Sleep disruptions in CB-Abst increased during Week 1 of abstinence (d=0.34, p=0.04), decreased during Week 2 (d=0.36, p=0.04), and remained constant for the rest of the trial. At Week 4, sleep was comparable to baseline levels for those in CB-Abst (p=0.87). Withdrawal-associated sleep disruption in the CB-Abst group was circumscribed to increases in sleep latency (b=0.35; p=0.05). ConclusionsCannabis abstinence in adolescents was associated with transient delayed onset of sleep initiation falling asleep during the first week of abstinence. Findings highlight withdrawal-associated changes in sleep latency as an intervention target for supporting adolescents attempting abstinence. Future research should use objective measures of sleep and focus on elucidating mechanisms underlying sleep disturbances with cannabis use and withdrawal.

Therapeutic Effects of Geranium Oil in MPTP-Induced Parkinsonian Mouse Model.

Parkinson's disease (PD) is an incurable neurodegenerative disease characterized by motor and non-motor disabilities resulting from neuronal cell death in the substantia nigra and striatum. Microglial activation and oxidative stress are two of the primary mechanisms driving that neuronal death. Here, we evaluated the effects of geranium oil on 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) mouse model for PD, on microglial activation, and oxidative stress. We demonstrate that oral treatment with geranium oil improved motor performance in this model. The therapeutic effects of geranium oil were observed as a significant increase in rotarod latency and distance among the mice treated with geranium oil, as compared to vehicle-treated MPTP mice. Geranium oil also prevented dopaminergic neuron death in the substantia nigra of the treated mice. These therapeutic effects can be partially attributed to the antioxidant and anti-inflammatory properties of geranium oil, which were observed as attenuated accumulation of reactive oxygen species and inhibition of the secretion of proinflammatory cytokines from geranium oil-treated activated microglial cells. A repeated-dose oral toxicity study showed that geranium oil is not toxic to mice. In light of that finding and since geranium oil is defined by the FDA as generally recognized as safe (GRAS), we do not foresee any toxicity problems in the future and suggest that geranium oil may be a safe and effective oral treatment for PD. Since the MPTP model is only one of the preclinical models for PD, further studies are needed to confirm that geranium oil can be used to prevent or treat PD.

Neuromuscular Joint Function Impairment in Leptin-Resistant Mice

The study was aimed at exploring and describing the main parameters of neuromuscular joint function in young adult leptin-resistant C57Bl/Ks-db+/+m (db/db) mice. The experiment was carried out on 10 4-month-old male db/db mice and 10 male wild-type control mice, using stimulation electroneuromyography to assess M-wave parameters for m. gastrocnemius and m. biceps brachii. We discovered a decrease in maximal amplitudes along with an increase in the M-wave latency and duration, indicating the presence of combined axonal and demyelinating peripheral nerve injury.

Highly-Efficient Low-Latency HARQ Built on NOMA for URLLC: Radio Resource Allocation and Transmission Rate Control Aspects

Hybrid automatic repeat request (HARQ) is an essential technology that efficiently reduces the transmission error rate. However, for ultra-reliable low latency communications (URLLC) in the 5th generation mobile communication systems and beyond, the increase in latency due to retransmission must be minimized in HARQ. In this paper, we propose a highly-efficient low-latency HARQ method built on non-orthogonal multiple access (NOMA) for URLLC while minimizing the performance loss for coexisting services (use cases) such as enhanced mobile broadband (eMBB). The proposed method can be seen as an extension of the conventional link-level non-orthogonal HARQ to the system-level protocol. This mitigates the problems of the conventional link-level non-orthogonal HARQ, which are decoding error under poor channel conditions and an increase in transmission delay due to restrictions in retransmission timing. In the proposed method, delay-sensitive URLLC packets are preferentially multiplexed with best-effort eMBB packets in the same channel using superposition coding to reduce the transmission latency of the URLLC packet while alleviating the throughput loss in eMBB. This is achieved using a weighted channel-aware resource allocator (scheduler). The inter-packet interference multiplexed in the same channel is removed using a successive interference canceller (SIC) at the receiver. Furthermore, the transmission rates for the initial transmission and retransmission are controlled in an appropriate manner for each service in order to deal with decoding errors caused by error in transmission rate control originating from a time varying channel. We show that the proposed method significantly improves the overall performance of a system that simultaneously provides eMBB and URLLC services.

Hyperbaric Oxygen Therapy Attenuates the Whole Brain Radiotherapy-Induced Progressive Cognitive Dysfunction via Promoting Hippocampal Neurogenesis in Rats

Radiation therapy is a widely used brain tumor treatment; however, it can cause significant effects on the central nervous system, including neurogenesis impairment, microglia activation, and oxidative stress, leading to brain injury. Hyperbaric oxygen therapy (HBOT) has been shown to benefit various neurological conditions, but its effect on radiation-induced brain injury damage remains limited. This study aims to investigate the impact of HBOT on radiation-induced neurogenesis impairment, microglia activation, and lipid peroxidation levels, and also aim to assess the therapeutic potential of HBOT on preventing irradiation-induced brain injury. This study used a rat model that delivered different doses (2, 4, 10 Gy) of whole-brain radiation therapy (WBRT). The rats were divided into two groups: one received HBOT, and the other acted as the control (normal baric air, NBA) group. HBOT was performed on day 8 of post-radiation once per day for five consecutive days a week for four weeks. The rats were subjected to different irradiation dosages as described, followed by administration of 5-chloro-2'-deoxyuridine (CldU) immediately at day 0 or day 0 to day 7 and 5-iodo-2'-deoxyuridine (IdU) at day 2 or day 14 to day 28 following WBRT to detect serially replicating cells. Then the rats underwent behavioral tests to assess their cognitive and motor function every week. Brain tissues were collected and analyzed to evaluate neurogenesis, microglia activation, lipid peroxidation, and antioxidant levels using immunofluorescence stain and ELISA on days 7 and 28 of post-WBRT. The radial maze was used to measure spatial learning and memory in rats. Compared with the 0 Gy-WBRT group, the 2 Gy-, 4 Gy-, and 10 Gy-WBRT groups of rats displayed a significant increase in latency. Seven days of post-WBRT, the newly proliferation cells (IdU positive) and serial replicating cells (CldU+IdU double positive) in the hippocampal dentate gyrus were significantly increased but were coupled with apoptosis. The alterations in the cellular composition of the dentate gyrus area were observed on days 7 and 28 post-WBRT, including increased newborn neuroblast and neuron, but half underwent apoptosis, which is associated with microglia phagocytosis and results in cognitive impairment. The lipid peroxidation was significantly increased on day 28 of post-WBRT. HBOT improves cognitive function by attenuating the WBRT-induced lipid oxidation, newly-formed cell apoptosis, and microglia phagocytosis. Our present study suggests that HBOT may have a potential role in mitigating the effects of irradiation-induced brain injury by maintaining neurogenesis and reducing lipid peroxidation.

Effect of Computerized Systems on the Organizational Performance: Evidence from Selected Public Organizations from Iringa Municipality

This study investigated the impact of computerized systems on public organizations in Iringa Municipality, focusing on the Computerized Accounting System (CAS) and the Government Electronic Payment Gateway (GePG). A mixed research approach and a cross-sectional design were employed, with 100 randomly selected employees from a population of 145 participating through questionnaires and interviews. Data analysis utilized descriptive statistics and multiple regression. The findings revealed that a majority (84.6%) of TRA employees had received training related to computerized systems. Similarly, IRUWASA and TANESCO had a significant portion of trained employees (71.4% and 90.9% respectively). Within IMC and RBWB, 85.7% of employees had attended training, while Mkwawa University and RUWASA showed high training attendance rates at 80%. Concerning network availability, most TRA employees (76.9%) reported inconsistent network availability. This issue was prevalent among IRUWASA and TANESCO employees (63.6% and 90.9% respectively), as well as within IMC and RBWB. The first objective's findings indicated a significant negative impact of system downtime on performance (p-value = 0.000). A one-unit increase in system downtime corresponded to a performance decrease of -0.004. Conversely, training had a positive and significant impact on performance (p-value = 0.013), with a one-unit increase resulting in a performance increase of 0.011. Latency had a significant negative effect (p-value = 0.000), where a one-unit increase in latency led to a performance decrease of -0.039. In light of these findings, it is recommended that public organizations allocate resources for the enhancement and modernization of computerized systems. This should include investments in more robust hardware, software, and network solutions, as well as comprehensive training programs

A systematic review of congestion control in internet of vehicles and vehicular ad hoc networks: Techniques, challenges, and open issues

SummaryThe Internet of Vehicles (IoV) integrates various technologies to enable real‐time data exchange between vehicles, pedestrians, roadside units, unmanned aerial vehicles, road‐added things, and so forth. IoV is an improved internet‐enabled vehicular ad hoc network (VANET), which is similarly affected by data traffic aggravated by time‐variant network density and the network's topological and informational changes. A high density of simultaneous vehicular communication leads to channel saturation and data congestion, which leads to rapid increases in data loss, packet latency, and lower service quality. Due to the importance of real‐time data communications in high dynamic networks, we used the systematic literature review (SLR) approach to identify 54 articles up to May 2023 to discuss the ways to deal with data traffic congestion in VANETs and IoV networks as well as existing and upcoming issues in this area.

Adaptive spike threshold dynamics associated with sparse spiking of hilar mossy cells are captured by a simple model.

Hilar mossy cells (hMCs) in the dentate gyrus (DG) receive inputs from DG granule cells (GCs), CA3 pyramidal cells and inhibitory interneurons, and provide feedback input to GCs. Behavioural and in vivo recording experiments implicate hMCs in pattern separation, navigation and spatial learning. Our experiments link hMC intrinsic excitability to their synaptically evoked in vivo spiking outputs. We performed electrophysiological recordings from DG neurons and found that hMCs displayed an adaptative spike threshold that increased both in proportion to the intensity of injected currents, and in response to spiking itself, returning to baseline over a long time scale, thereby instantaneously limiting their firing rate responses. The hMC activity is additionally limited by a prominent medium after-hyperpolarizing potential (AHP) generated by small conductance K+ channels. We hypothesize that these intrinsic hMC properties are responsible for their low in vivo firing rates. Our findings extend previous studies that compare hMCs, CA3 pyramidal cells and hilar inhibitory cells and provide novel quantitative data that contrast the intrinsic properties of these cell types. We developed a phenomenological exponential integrate-and-fire model that closely reproduces the hMC adaptive threshold nonlinearities with respect to their threshold dependence on input current intensity, evoked spike latency and long-lasting spike-induced increase in spike threshold. Our robust and computationally efficient model is amenable to incorporation into large network models of the DG that will deepen our understanding of the neural bases of pattern separation, spatial navigation and learning. KEY POINTS: Previous studies have shown that hilar mossy cells (hMCs) are implicated in pattern separation and the formation of spatial memory, but how their intrinsic properties relate to their in vivo spiking patterns is still unknown. Here we show that the hMCs display electrophysiological properties that distinguish them from the other hilar cell types including a highly adaptive spike threshold that decays slowly. The spike-dependent increase in threshold combined with an after-hyperpolarizing potential mediated by a slow K+ conductance is hypothesized to be responsible for the low-firing rate of the hMC observed in vivo. The hMC's features are well captured by a modified stochastic exponential integrate-and-fire model that has the unique feature of a threshold intrinsically dependant on both the stimulus intensity and the spiking history. This computational model will allow future work to study how the hMCs can contribute to spatial memory formation and navigation.

Can upper cervical manual therapy affect the blink reflex in subjects with migraine and neck pain?

ABSTRACT Background Neck pain is a common complaint among migraineurs possibly due to the anatomic connections between cervical and trigeminal afferents in the trigeminocervical complex (TCC). Manual therapy (MT) is used in the management of headache disorders, with demonstrable neurophysiological effects. The blink reflex (BR) is one method of analyzing neurophysiological effects in headache patients. The purpose of this study was to investigate the effect of upper cervical spine MT on BR in subjects with migraine and neck pain. Methods & Materials Twenty subjects were assigned to a medication plus MT (MedMT) group (n = 10) and medication plus sham MT (sham MT) group (n = 10). After random assignment, all patients underwent testing for the BR (R1, R2, R2c responses). Then, subjects in group MedMT and group sham MT received either 4 sessions of MT or sham MT to the upper cervical spine. After completion of the intervention, BR testing was repeated. Results There were no significant differences in both side R1 latency between group MT and group sham MT (P > 0.050). For both sides, R2 latencies were significantly prolonged in MedMT group compared with sham MT group (P < 0.050). Subjects in MedMT group showed significant prolongation in right and left R2c latency compared with sham MT group (P < 0.050). Discussion The present study demonstrated that upper cervical MT affected trigeminal nociceptive neurotransmission in subjects with migraine and neck pain as reflected by changes in the BR. The increase in BR late response latencies of BR indicates an inhibitory effect of upper cervical spine MT on the TCC in these subjects. Trial Registration: The trial design was registered at the Iranian Registry of Clinical Trials (IRCT ID: IRCT20160621028567N2, url: https://www.irct.ir/) before the first patient was enrolled.

Effect of Ketamine and Dexmedetomidine as Adjuvant to Total Intravenous Anesthesia on Intraoperative Cranial Nerve Monitoring in the Patients Undergoing Posterior Fossa Craniotomies-A Randomized Quadruple Blind Placebo-Controlled Study.

Objectives Total intravenous anesthesia (TIVA) is used during surgery with intraoperative neurophysiological monitoring. Addition of adjuvant may minimize suppression of potentials by reducing doses of propofol. We studied the effect of addition of ketamine or dexmedetomidine to propofol-fentanyl-based TIVA on corticobulbar motor evoked potential (CoMEP) in patients undergoing posterior fossa surgeries. Materials and Methods Forty-two patients were assigned to three groups ( n = 14 each), Group S-saline, Group D-dexmedetomidine (0.25 μg/kg/h), and Group K-ketamine (0.25 mg/kg/h). Patients received propofol and fentanyl infusions along with study drugs. CoMEPs were recorded from muscles innervated by cranial nerves bilaterally at predefined intervals (T baseline , T 2 , T 3 , T 4 , and T 5 ). Effect on amplitude and latency of CoMEPs was assessed. Results A significant fall in CoMEP amplitude was observed across all analyzed muscles at time T 4 and T 5 in saline and dexmedetomidine group as compared with ketamine group, p -value less than 0.05. A significant increase in latency was observed at T4 and T5 among groups ( p -value, D vs. K = 0.239, D vs. S = 0.123, and K vs. S = 0.001). Conclusion Both ketamine and dexmedetomidine provide and allow effective recording of CoMEPs. Ketamine emerges as a better agent especially when prolonged surgical duration is expected as even propofol-fentanyl-based TIVA adversely affects CoMEPs when used for long duration.