Abstract
The study was aimed at exploring and describing the main parameters of neuromuscular joint function in young adult leptin-resistant C57Bl/Ks-db+/+m (db/db) mice. The experiment was carried out on 10 4-month-old male db/db mice and 10 male wild-type control mice, using stimulation electroneuromyography to assess M-wave parameters for m. gastrocnemius and m. biceps brachii. We discovered a decrease in maximal amplitudes along with an increase in the M-wave latency and duration, indicating the presence of combined axonal and demyelinating peripheral nerve injury.
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