With the increasing global warming concerns, appropriate agronomic practices for improving crop yields while reducing greenhouse gases (GHGs) emissions are essential for sustainable agricultural production. However, little information is available if these benefits can be achieved simultaneously in arid pastoral agriculture systems with irrigation and nitrogen (N) management. We assumed that the local practiced irrigation (600 mm) and N (300 kg ha −1 ) applications for spring wheat in the arid regions of Northwest China are excessive, and optimizing irrigation-N rates would improve the resource use efficiency of alfalfa and reduce GHGs emissions. A two-year field study (2015–2016) was conducted to investigate the effects of irrigation regimes (I L , 300 mm; I M , 450 mm; and I H , 600 mm) and N application rates (F 0 , 0; F L , 150; F M , 225; and F H , 300 kg ha −1 ) on forage yield, resource use efficiency, and GHGs emissions from alfalfa fields. The GHGs emissions during alfalfa growing seasons were assessed by analyzing gas samples using the static chamber-gas chromatography method. High irrigation and N application (I H F H ) was associated with elevated GHGs emissions, global warming potential, and greenhouse gas intensity, but lower irrigation water productivity (IWP) and partial factor productivity of N (PFP N ). Reducing the irrigation and N rates decreased the GHGs emissions but differently affected alfalfa yield and resource use efficiencies. Among all the treatments, I M F L and I H F L resulted in the highest alfalfa yields, IWP, and PFP N . However, I M F L showed a good trade-off between yield benefits and environmental performance manifested by lower GHGs emissions, GWP, and GHGI. The I M F L reduced the cumulative emissions of nitrous oxide by 67.83% and 67.16%, carbon dioxide by 31.05% and 34.60%, GWP by 61.72% and 70.40%, and GHGI by 74.37% and 79.78%, while increased alfalfa yield by 49.24% and 46.45%, IWP by 99.05% and 94.97%, and PFP N by 198.44% and 192.90% compared to I H F H . Regardless of all the treatments, the alfalfa field acted as a CH 4 sink during both crop-growing seasons. Our results suggest that the application of 450 mm irrigation and 150 kg N ha −1 could be used as an appropriate management strategy for enhancing resource use efficiencies and mitigating GHGs emissions, GHGI, and GWP from alfalfa fields. The findings can provide an opportunity for greenhouse gas mitigation without alfalfa forage yield reduction following the proper irrigation and fertilization regimes in the arid region of northwest China and areas with similar agro-climatic conditions. • Intensive irrigation and fertilization increase GHGs emissions and global warming potential. • Enhancing resource use efficiency with suitable irrigation and N rates mitigate GHGs emissions. • Soil moistures and inorganic N contents are the major factors regulating GHGs emissions. • 450 mm irrigation and 150 kg N ha –1 maintain high alfalfa yields and minimize environmental impacts.