SESSION TITLE: Pulmonary Vascular Disease Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: Pulmonary hypertension (PH) is a well-known late complication in patients with congenital heart disease (CHD). The development of PH in adult patients is a poor prognostic indicator and can result in significant morbidity and mortality. Previous retrospective cohort studies have demonstrated that CHD-associated PH increases all-cause mortality 2-fold and increases health services utilization 3-fold in this population. At present, transthoracic echocardiography (TTE) remains the diagnostic modality of choice for screening patients with PH for CHD. TTE is readily available and carries low patient risk. However, transesophageal echocardiography (TEE) offers better visualization of the interatrial septum, and has shown utility in assessing and recognizing sinus venosus defects, anomalous pulmonary venous connections, and the size of an atrial septal defect (ASD) for future procedure planning. Likewise, cardiac MRI (CMR) offers unique advantages given the degree of spatial resolution, larger field of view, and the ability to quantify shunt flow and size. Thus, the aim of this retrospective case series was to evaluate the role of advanced cardiac imaging, with either CMR or TEE, in the initial work-up of patients with pulmonary hypertension and to determine the frequency of newly detected congenital heart disease. METHODS: We performed a retrospective chart review, analyzing 140 patients who currently carry diagnoses of CHD and PH. RESULTS: Of these 140 patients, 20 patients underwent either CMR or TEE as part of their PH work-up due to ill-defined or idiopathic PH. Of these 20 patients, 11 patients were found to have clinically significant CHD by either CMR or TEE, which was not detected on a prior TTE. Of these 11 patients, an ASD was found in 7 patients, while anomalous pulmonary venous return was found in 4 patients and patent ductus arteriosus was present in 2 patients. Given these findings, 7 of these 11 patients underwent either percutaneous or surgical repair. CONCLUSIONS: In conclusion, advanced cardiac imaging plays an important role in the initial workup for PH. CLINICAL IMPLICATIONS: Advanced cardiac imaging, with CMR or TEE, may help better delineate the cause of PH, and ultimately offer options for therapeutic interventions for patients with underlying CHD: including, but not limited to, percutaneous or surgical repair. DISCLOSURES: No relevant relationships by Matthew Brown, source=Web Response Chair of a Committee relationship with PHA Please note: PHA Medically Led Sessions, PHA Preceptorship Added 05/22/2020 by Jean Elwing, source=Web Response Removed 05/22/2020 by Jean Elwing, source=Web Response Educator relationship with PH CME Programs - PHA, Simply Speaking, Impact PH Please note: Intermittent, Ongoing Added 05/22/2020 by Jean Elwing, source=Web Response, value=Honoraria Principal Investigator relationship with Actelion, Arena, Reata, United Therapeutics Please note: Ongoing - University is Paid Directly Added 05/22/2020 by Jean Elwing, source=Web Response, value=Grant/Research Support Advisory Committee Member relationship with United Therapeutics Please note: $5001 - $20000 Added 06/05/2020 by Jean Elwing, source=Web Response, value=Consulting fee Principal Investigator relationship with Lung LLC, Liquidia, Phase Bio, Complexa, Gossamer Bio Please note: Ongoing - University is Paid Directly Added 05/22/2020 by Jean Elwing, source=Web Response, value=Grant/Research Support Member of a Committee relationship with PHA Please note: PHA Education Committee Added 05/22/2020 by Jean Elwing, source=Web Response Removed 05/22/2020 by Jean Elwing, source=Web Response Advisory Committee Member relationship with Liquidia, Acceleron Please note: $1001 - $5000 Added 06/05/2020 by Jean Elwing, source=Web Response, value=Consulting fee Advisory Committee Member relationship with Acceleron Please note: $5001 - $20000 Added 06/05/2020 by Jean Elwing, source=Web Response, value=Consulting fee Removed 06/05/2020 by Jean Elwing, source=Web Response Grant relationship with Kiniska Please note: $5001 - $20000 Added 05/28/2020 by David Harris, source=Web Response, value=Grant/Research Support Grant relationship with Lantheus Please note: $5001 - $20000 Added 05/28/2020 by David Harris, source=Web Response, value=Grant/Research Support No relevant relationships by Anuj Shukla, source=Web Response
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