Deviation Increase Research Articles

The effect of septal flash on left ventricular function and systolic synchrony in patients with complete left bundle branch block and preserved left ventricular ejection fraction

Objective To evaluate the effect of septal flash (SF) on left ventricular function and systolic synchrony in patients with complete left bundle branch block (CLBBB) and preserved left ventricular ejection fraction (LVEF) by two-dimensional speckle-tracking imaging (2D-STI). Methods Sixty CLBBB patients with preserved LVEF were selected, and 30 healthy individuals serving as control group. The SF of CLBBB patients were evaluated using 2D-STI, and the CLBBB patients were categorized into two groups (SF group and NSF group) based on the present SF. Conventional echocadiography and 2D-STI were performed for all individuals. Results ①SF was present in 53.3% of CLBBB patients with preserved LVEF and was not present in control group. ②LV longitudinal peak stain of global (LS-G) in SF group was lower than those in both control group and NSF group (P 0.05). ③Compared with control group, there were significant increase of left atrial dimension and Mitral E/e′ and decrease in mitral E/A and mitral e′ in SF group and NSF group (P 0.05). ④There was an increase in standard deviation of time to peak systolic strain for the 18 LV segments (LV-SDt) in SF group and NSF group, and the LV-SDt in SF group was higher than that in NSF group (P<0.01). Conclusions SF is present in 53.3% of CLBBB patients, patients of CLBBB with SF have lower left ventricular systolic function and systolic synchrony. Key words: Echocardiography; Bundle-branch block; Ventricular function, left; Septal flash; Strain

Natural History of Postoperative Adding-On in Adolescent Idiopathic Scoliosis: What Are the Risk Factors for Progressive Adding-On?

Purpose To investigate the natural history of distal adding-on in adolescent idiopathic scoliosis (AIS) and to identify risk factors for its progression. Methods Sixty-one AIS patients with distal adding-on occurrence were included. We further classify distal adding-on into progressive and nonprogressive group according to its natural evolution. The first radiograph indicating initiation of adding-on (primary adding-on) and the last follow-up radiograph were compared in terms of the deviation of the first vertebra below instrumentation from the CSVL and the angulation of the first disc below instrumentation. Compared to primary adding-on, progressive adding-on was defined as a further increase of deviation > 5 mm or a further increase of angulation > 5°. Risk factors associated with the progression of adding-on were analyzed. Results Among 61 patients diagnosed with distal adding-on, 24 (39.3%) were progressive and 37 (60.7%) were nonprogressive. Lower Risser grade, open triradiate cartilage, and lowest instrumented vertebra (LIV) proximal to Substantially Stable Vertebra (SSV) were found to be significantly associated with the progressive adding-on. Besides, the distal adding-on was more likely to progress for patients with higher left shoulders than right ones after surgery. Conclusions The risk factors for the progression of adding-on included skeletal immaturity, LIV proximal to SSV, and higher left shoulders after surgery.

Non-specific factors of immunity in the pathogenesis of bronchial asthma in children

The role of nonspecific immunity factors in the pathogenesis of bronchial asthma in children with different clinical forms and degrees of severity of its course has been investigated in the work. A total of 228 children with BA who were aged from 5 to 14 years were examined. We determined the complement titer (C0) in the serum, components of complement C2 and C3a, the protein component of blood serum of properdin, and the level of total serum IgE. The data were statistically processed using Student's t-test. In patients with non-allergic form of BA, the greatest increase in deviation from the norm was noted in relation to the circulating immune complexes (CIC)(t = 16.74). The second ranking place occupies an increased content of C3a (t = 8.21), then in descending order from IgE (t = 4.55) to C0 (t = 1.89). Rating of the degree of deviation from the norm of indices of nonspecific immunity in patients with atopic BA has shown that, in contrast to patients with non-allergic form of BA, the main pathogenetic role belongs to reactive hypersensitivity (IgE; t = 17,39). The value of immunocomplex hypersensitivity in atopic form of BA is in the second ranked place. In children with mixed BA, an intermediate pathogenetic variant was identified, which consisted in approximately equal activity of both immunocomplex and reactive reactions with a certain dominant of the first: from CIC (t = 13.66) to IgE (t = 11.19). Thus, the obtained data confirm that in the pathogenesis of bronchial asthma in children is involved immunocomplex immunological mechanism (type III according to Gell-Coombs), which enhances immunospecific reactions, aggravating the severity of the course of the disease. In the blood serum of children with bronchial asthma, there is a decrease in the protein component properdin, which is consumed to activate the alternative (properdin) complement pathway through C3a, nonspecific immunological mechanisms are able to stimulate and maintain chronic allergic inflammation in the bronchopulmonary system in children with bronchial asthma.

The association between paternal depressogenic cognitive styles during pregnancy and offspring depressogenic cognitive styles: an 18-year prospective cohort study.

BackgroundPreventing the development of depressogenic or negative cognitive styles could also prevent the development of depression, a leading public health problem worldwide. Maternal negative cognitive styles are a modifiable risk factor for the development of negative cognitive styles in offspring. However, evidence on the role of paternal negative cognitive styles is inconclusive and there have only been a few small studies, which may also have lacked statistical power.MethodsWe used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) to investigate the association between paternal negative cognitive styles, measured when mothers were 18 weeks pregnant, and offspring negative cognitive styles 18 years later (N = 6,123). Associations were calculated using linear regression models, before and after adjustment for confounders including maternal negative cognitive styles. We compared associations before and after controlling for depression in parents and offspring, and used multiple imputation to reduce biases that may have arisen due to missing data.ResultsA two‐standard deviation increase in paternal negative cognitive style was associated with a 3‐point increase in offspring negative cognitive style (95% CI 1.36–4.37). This association remained after adjustment for confounders and was independent of depression in both parents and offspring. The effect size was equivalent to that of maternal negative cognitive style, and was also independent of maternal negative cognitive style.ConclusionsOur results suggest that fathers should be included in individual‐ and family‐based interventions designed to prevent the development of depressogenic cognitive styles in adolescent offspring. This could possibly also prevent the development of depression.

Serum C-reactive protein in adolescence and risk of Schizophrenia in adulthood: A prospective birth cohort study from Finland

Meta-analyses of cross-sectional studies confirm an increase in circulating inflammatory markers during acute psychosis. Longitudinal studies are scarce but are needed to understand whether elevated inflammatory markers are a cause or consequence of illness. We report a longitudinal study of serum CRP level in adolescence and subsequent risk of schizophrenia and related psychoses in adulthood in the Northern Finland Birth Cohort 1986. Serum high-sensitivity CRP was measured at age 15/16 years in 6,362 participants. ICD-10 diagnoses of schizophrenia and related psychoses were obtained from centralised hospital inpatient and outpatient registers up to age 27 years. Adolescent CRP was associated with subsequent schizophrenia. The adjusted odds ratio (OR) for schizophrenia by age 27 years for each standard deviation (SD) increase in CRP levels at age 15/16 years was 1.25 (95% CI, 1.07–1.46), which was consistent with a linear, dose–response relationship (p-value for quadratic term 0.23). Using CRP as a categorical variable, those with high (>3 mg/L) compared with low (

Effect of density heterogeneity on absorbed dose with CyberKnife Synchrony Respiratory Tracking System

Objective To measure the actual absorbed dose of the target in the QUASAR Respiratory Motion Phantom using the CyberKnife Synchrony Respiratory Tracking System, and to evaluate the effect of density heterogeneity on the absorbed dose of tumor gross target volume (GTV). Methods Nine groups were obtained by making different patterns of QUASAR phantom: rib thickness of 0, 20, and 50 mm, and motion amplitudes of 0, 10, and 15 mm. The nine groups were treated with static computed tomography (CT) in different time phases of four-dimensional CT (4DCT) plan, with the same beam and number of monitor units, and the 4D accumulated dose was calculated. The doses of static and 4D plans were calculated using Ray-tracing and Monte Carlo algorithms, and the absorbed doses of GTV in the nine groups were measured at the same time. Results There were a decrease in calculated absorbed dose of GTV and an increase in deviation between the planned and actual dose, with the increases in simulated rib thickness and motion amplitude. Conclusions The density heterogeneity has an impact on the absorbed dose of GTV. Both static CT and 4DCT plan can evaluate the absorbed dose of GTV in case of small rib thickness and motion amplitude, and 4DCT plan with Monte Carlo algorithm may be the optimal method for evaluation of the absorbed dose of GTV in case of large rib thickness and motion amplitude (deviation<3%) Key words: CyberKnife; Synchrony system; Tissue heterogeneous; Absorbed dose

Serum phospholipid fatty acids, dietary patterns and type 2 diabetes among urban Ghanaians

BackgroundPreviously, a “purchase” pattern (rich in vegetable oil, manufactured foods, red meat and poultry, fruits, and vegetables) was identified among adults in urban Ghana and was inversely associated with T2D, while a “traditional” pattern (rich in fish, palm oil, plantain, green-leafy vegetables, beans, garden egg, fermented maize products,) increased the odds of T2D. To investigate, if specific fatty acids (FAs), partly reflecting the intakes of certain food groups and cooking methods, might explain the observed diet-disease relationships, serum phospholipid fatty acid profiles were characterized and their relationships with blood lipids that are common risk factors for T2D were analyzed.MethodsThe relative proportions of 28 FAs (%) in 653 Ghanaians without T2D were measured by gas chromatography. In a cross-sectional analysis, the associations of FAs with dietary patterns and with serum lipids that are likely involved in T2D development were investigated. The FAs distributions across dietary pattern scores were examined. Standardized beta coefficients (β) were calculated for the associations of dietary pattern scores (per 1 standard deviation (SD) increase) with FAs. Across the tertiles of selected diet-related FAs, adjusted means of serum triglycerides, cholesterol, HDL-cholesterol and LDL-cholesterol were calculated.ResultsIn this mainly female (76%), middle-aged (mean age: 46.4, SD: 15.3 years) and predominately overweight study population (mean body mass index: 25.8, SD: 5.4 kg/m2), saturated FAs (SFAs) contributed 52% to total serum FAs, n-6 polyunsaturated FAs (PUFAs) 27%, monounsaturated FAs 12%, n-3 PUFAs 9% and trans FAs (TFAs) <1%. The “purchase” pattern was related to lower proportions of n-3 PUFAs (β per 1 score SD: −0.25, p < 0.0001), but higher proportions of linoleic acid (LA) (β per 1 score SD: 0.24, p < 0.0001). The “traditional” pattern was characterized by lower proportions of arachidic acid (β per 1 score SD: −0.10, p = 0.001). LA was inversely associated with triglycerides, but positively with HDL-cholesterol and LDL-cholesterol.ConclusionsIn this Ghanaian population, serum FA profiles reflected the intake of key components of dietary patterns, such as fish and vegetable oil. FAs from manufactured foods (SFAs) and deep-fried meals (TFAs) did not contribute to the observed associations between dietary patterns and T2D. Still, LA might partly explain the health-beneficial effect of the “purchase” pattern.

Food variety, dietary diversity, and type 2 diabetes in a multi-center cross-sectional study among Ghanaian migrants in Europe and their compatriots in Ghana: the RODAM study

PurposeThe importance of dietary diversification for type 2 diabetes (T2D) risk remains controversial. We investigated associations of between- and within-food group variety with T2D, and the role of dietary diversification for the relationships between previously identified dietary patterns (DPs) and T2D among Ghanaian adults.MethodsIn the multi-center cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) Study (n = 3810; Ghanaian residence, 56%; mean age, 46.2 years; women, 63%), we constructed the Food Variety Score (FVS; 0–20 points), the Dietary Diversity Score (DDS; 0–7 points), and the Diet Quality Index-International (DQI-I) variety component (0–20 points). The associations of these scores, of a “rice, pasta, meat and fish” DP, of a “mixed” DP, and of a “roots, tubers and plantain” DP with T2D were calculated by logistic regression.ResultsThe FVS was inversely associated with T2D, adjusted for socio-demographic, lifestyle, and anthropometric factors [odds ratio (OR) for T2D per 1 standard deviation (SD) increase: 0.81; 95% confidence interval (CI) 0.71–0.93]. The DDS and the DQI-I variety component were not associated with T2D. There was no association of the “mixed” DP and the “roots, tubers and plantain” DP with T2D. Yet, the “rice, pasta, meat and fish” DP is inversely associated with T2D (OR for T2D per 1 SD increase: 0.82; 95% CI 0.71–0.95); this effect was slightly attenuated by the FVS.ConclusionsIn this Ghanaian population, between-food group variety may exert beneficial effects on glucose metabolism and partially explains the inverse association of the “rice, pasta, meat and fish” DP with T2D.

Skill achievement and returns in developing countries: Evidence from adult skills surveys

AbstractUsing novel adult skills surveys, this article analyses cross‐country patterns in skill achievement and labour market returns, comparing the outcomes for a subset of developing countries with the results previously found for high‐income economies. Apart from displaying lower average cognitive skills, developing countries also exhibit wider disparities in levels of skills by subgroups of educational attainment, gender, and parental education. Meanwhile, baseline estimates of returns to skills reveal that a one‐standard deviation increase in literacy skills is associated with an earnings increase of 14.6% in developing countries, which is statistically indistinguishable from the average returns of 17.7 estimated for developed countries. Nonetheless, there is considerable heterogeneity in the returns across developing countries, with the lowest estimates found in Armenia and Ukraine at 2% (not statistically significant) and 6%, respectively, and the highest reported in Kenya at above 30%. Differences in the type of employment opportunities and the degree of employment selection in these labour markets are important determinants of the observed gap in returns. International comparisons of returns should take this into consideration.

Inflammatory biomarkers as independent predictive and prognostic markers in metastatic colon cancer patients over several treatment lines.

e15084 Background: The aim of this study is to quantify the value of the inflammatory biomarkers neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), C-reactive protein (CRP) level and the advanced lung cancer inflammation index (ALI) as predictive and prognostic markers for treatment and survival outcomes over the first three chemotherapy lines in metastatic colorectal cancer (mCRC) patients. Methods: 258 patients with mCRC undergoing palliative chemo(immuno-)therapy were included in this retrospective study. Primary endpoints were 6-month progression free survival (PFS) and overall response rate (ORR) during 1st-line, 2nd-line, and 3rd-line treatment, and 6-month OS during best supportive care. Results: In multivariable analysis adjusting for polychemotherapy, 1 standard deviation (SD) increase in NLR was associated with a 8.5% absolute lower ORR in first line (95%CI: 11-7, p &lt; 0.0001), 3% lower ORR in second line (4-2, p &lt; 0.0001), and 3% lower ORR in third line (8-2, p = 0.24), respectively. The other inflammatory markers were not significantly associated with ORR. Regarding PFS, a higher NLR was consistently associated with higher risk of progression or death across all treatment lines, with rising hazard ratios (HR) over treatment lines (HR 1.30, p = 0.021 first line); (HR 1.37, p &lt; 0.0001 second line); (HR 1.44 , p = 0.042 third line). The PLR was associated with 6 month PFS over all lines. (HR 1.43 (95%CI 1.09 – 1.88, p = 0.009 first line); (HR1.67 (95%CI 1.34 – 2.09, p &lt; 0.0001 second line) and (HR 1.43 (95%CI 1.04 – 1.98, p = 0.029 in third line)) For CRP, the prognostic association was significant in the first two chemotherapy lines and in case of BSC. (HR 1.49 (95%CI 1.23 – 1.80, p &lt; 0.0001 first line); (HR1.25 (95%CI 1.06 – 1.47, p = 0.007 second line); (HR 1.09 (95%CI 0.81 – 1.48, p = 0.552 third line and HR 1.43 (1.15 – 1-79, p = 0.002 in BSC)). More detailed results concerning the other biomarkers will be presented at the meeting. Conclusions: Our data demonstrate that inflammatory biomarkers are important and independent indicators of response to antineoplastic chemotherapy, relevant not only in first, but also in later treatment lines.

The Mediatory Role of Exercise Self-Regulation in the Relationship between Personality Traits and Anger Management of Athletes

This study investigates the mediatory role of exercise self-regulation role in the relationship between personality traits and anger management among athletes. The statistical population of this study includes all athlete students of Shar-e Ghods College, among which 260 people were selected as sample using random sampling method. In addition, the analysis was done using structural equation modeling and path analysis through SPSS and Amous software. The results indicated that in investigating the effect of personality traits on anger management, neuroticism impacts on anger management positively and agreeableness and conscientiousness impact on anger management negatively. In response to the second question, it was concluded that exercise self-regulation impacts on anger management positively, so that with one increase in the standard deviation of exercise self-regulation scores, 0.224 standard deviation is added to anger management. Therefore, in response to the third research question, it was concluded that exercise self-regulation mediates the effect of agreeableness and conscientiousness on anger management significantly.

Directional dependence of aluminum grain size measurement by laser-ultrasonic technique

A blade method was used to identify the relative position of pulsed and detect lasers when measuring aluminum grain size via laser-ultrasonic technique. Aluminum specimens received a variety of treatments to obtain different grain sizes. Electron backscatter diffraction data were used to obtain the parameters of the grain size calculation model. The finite element method model was established by COMSOL Multiphysics to simulate the generation and propagation of ultrasonic waves in aluminum. Both simulation and experimental data revealed that directional pattern has a significant effect on the results of grain size measurement when unpredictable deviations occur. The direction angle of the first and third ultrasonic echoes differs at the detection point when deviation occurs. Thus, the error of grain size measurement using laser-ultrasonic technique will increase when deviation increases. For the grain size measurement of aluminum using laser-ultrasonic technique, the accuracy is acceptable when deviation is no more than 0.2mm when the thickness of the specimen and diameter of the pulsed laser are set to 2mm and 1mm respectively.

Abstract MP039: Association Between Estimated 24-hour Urinary Sodium and Potassium Excretion and Blood Pressure in a Japanese Cohort: a Repeated Measure Analysis

Background: While measurement of sodium (Na) and potassium (K) from the collection of urine over a 24-hour period are associated with blood pressure, relationships with 24-hour urinary excretion estimates from more conveniently collected spot urine samples are less clear. Objectives: The purpose of this report is to examine the association of estimated 24-hour excretion of Na, K and their ratio from annually repeated spot urine samples with systolic (SBP) and diastolic (DBP) blood pressures. Methods: Data include 4,958 normotensive Japanese aged 19 to 55 years who participated in annual physical examinations over a 5-year period in the High-Risk and Population Strategy for Occupational Health Promotion Study (1999-2004). At each examination, spot urine samples were collected in the morning and blood pressure was measured following standardized procedures. 24-hour urinary excretion of Na and K were estimated from spot urine specimens using the formula of Tanaka. Adjustments were made for potential confounding from demographic, lifestyle education, body mass index, smoking, alcohol consumption and physical activity. Mixed-effects regression models were used to examine the association of the estimated 24-hour excretion of Na, K, and the sodium-to-potassium (Na:K) ratio with SBP and DBP over the 5-year period of study. Results: A one standard deviation (SD) increase in the estimated 24-hour excretion of Na (36.6 mmol/day) was associated with a 1.3 mm Hg higher SBP and a 0.8 mm Hg higher DBP (P&lt;.001). The association between Na and SBP was greater in men (1.4 mm Hg per SD) than in women (0.9 mm Hg per SD, P=.003 for interaction) and increased with age (1.0 mm Hg per SD at &lt;35 years of age, 1.2 mm Hg per SD at 35 to 45 years of age, and 1.8 mm Hg per SD at &gt;45 years of age, P&lt;.001 for interaction). Estimated 24-hour excretion of K was inversely associated with blood pressure where a one SD increase (8.9 mmol/day) was associated with a 1.1 mm Hg lower SBP and 0.7 mm Hg lower DBP (P&lt;.001). Unlike the estimated 24-hour excretion of Na, interactions between K and age or sex were absent. Estimated 24-hour Na:K ratio were positively associated with SBP and DBP, with greater effects in men than in women and increasing positive associations with age (P&lt;.01 for each interaction). Conclusions: Estimated 24-hour excretion of Na, K, and the Na:K ratio from spot urine samples have significant associations with blood pressure. Findings suggest that the less costly and more convenient collection of spot urine samples for estimating excretion of Na, K, and their ratio over a 24-hour period may be an efficient way of monitoring these electrolytes in large population-based samples.

Simultaneous Description of Activity Coefficients and Solubility with eCPA

In the many developments of electrolyte equations of state presented over the past decades, several different properties have been in focus. A property that has not been widely used as a fitting property is salt solubility. This work presents a new parametrization of the eCPA equation of state with salt specific parameters. The focus is on accurate description of the salt solubility, and low deviation correlations are obtained for all salts investigated. The inclusion of the solubility data in the parametrization has, compared to parameters only parametrized to osmotic coefficients and activity coefficients, not significantly affected the deviations of the osmotic coefficients and activity coefficients. The average deviations of the activity coefficient does increase slightly and it was found that the increase in deviations was almost entirely due to reduced accuracy at high temperature and high molality. The model is, furthermore, compared to the activity coefficient model, Extended UNIQUAC. It is shown ...

Time Perspective in Late Adulthood: Aging Patterns in Past, Present and Future Dimensions, Deviations from Balance, and Associations with Subjective Well-Being

We examined cross-sectional aging patterns for subscales of the Swedish version of the Zimbardo Time Perspective Inventory in a population-based sample of older adults (60–90 years;N = 447). Alternative methods to assess time perspective balance (DBTP, involving a single Future dimension; S-BTP; and DBTP-E, including in addition, Future Negative), were compared and their relations to subjective well-being (SWB) were examined. Significant negative age relations were observed for Past Negative and Future Negative with a clear age-related increase in Present Fatalistic, while Past Positive, Present Hedonistic, and Future Positive were relatively stable across age. A significant age-related increase in deviation from balance was observed across methods (Cohen’sds 0.28–0.57), with the highest value for DBTP-E. Overall, S-BTP and DBTP-E were more strongly associated with SWB than DBTP (r = −0.40), with the highest value for DBTP-E (r = −0.53). Analyses of separate age groups (60–65 vs. 70–75 vs. 80–90 years) revealed a trend of weakened association with balance in old-old age, for S-BTP and DBTP-E in particular. This seemed to reflect the fact that negative views of the future are strongly related to SWB in young-old adults but diminish in importance in late senescence (80–90 years). Potential factors behind the observed patterns of results, including deficits in cognitive functioning and physical health to account for the age-related increase in present fatalism, and the potential role of a self-transcendent future time perspective for well-being in old-old age, are discussed.

Positioning Performance of Power and Manual Drivers in Posterior Spinal Fusion Procedures.

This work presents an analysis and comparison of the efficacy of two methods for pedicle screw placement during posterior spinal fusion surgery. A total of 100 screws (64 manual and 36 power driven), all placed utilizing a surgical navigation system, were analyzed and compared. Final screw placement was compared to initial surgical plans using the navigation system, and the final screw locations were analyzed on the basis of angular deviation from these planned trajectories as well as screw translation within a critical reference plane. The power driver was found to insignificantly decrease the resulting angular deviation of these pedicle screws with a mean deviation of 3.35 degrees compared to 3.44 degrees with the manual driver (p = 0.853). Conversely, the power driver was found to increase the translational distance in the critical region, with mean deviations of 2.45 mm for the power driver compared to 1.54 mm with the manual driver. The increase in translational deviation was significant (p = 0.002) indicating that there may be some loss in performance from the adoption of the power driver.

HEART RATE VARIABILITY, VENTRICULAR LATE POTENTIALS AND HEART RATE TURBULENCE AS INDICATORS OF CORONARY REPERFUSION IN ST SEGMENT ELEVATION MYOCARDIAL INFARCTION

Aim. To evaluate the dynamics of the parameters of autonomic balance and electrical instability of the myocardium depending on the effectiveness of the restoration of coronary blood flow in pharmacoinvasive revascularization in patients with acute ST segment elevation myocardial infarction. Material and methods . The study included 91 patients who underwent effective thrombolytic therapy (TLT) according to the ECG criteria, followed by (3-24 hour later) coronary angiography with percutaneous coronary intervention (PCI). Before and after PCI the telemetric ECG recording was conducted. The dynamics of the temporal and spectral characteristics of heart rate variability (HRV), presence of ventricular late potentials (VLP) and abnormal heart rate turbulence (HRT) were evaluated. Results. The episodes of ST-segment re-elevation by1 mm or more, lasting at least 1 min, and the dynamics of some HRV indices indicated the development of rethrombosis after TLT. The increase in the mean square deviation of normal intervals to 82.5 (64.5; 94) ms, the average value of the standard deviations of normal intervals calculated over 5-minute intervals throughout the entire recording to 37.5 (31.5; 47.5) ms, the total power of the spectrum and the power of high frequency waves, as well as the decrease in the power of ultra-low frequency waves were found after PCI in the group with a rethrombosis of the infarct-related coronary artery. The analysis of VLP in this group showed an increase in duration of the filtered QRS complex after TLT (to 128.7±34.5 ms), and the root mean square value of the last 40 ms of the QRS complex after PCI (to 49±50.3 μV). Pathological deviations of the HRT parameters (especially the onset of turbulence) independently on the absolute values were registered more often in patients with rethrombosis, and abnormal values of both HRT parameters were found only in patients with episodes of unstable coronary blood flow. Conclusion. The results are the indirect evidences of disruption of autonomic regulation of cardiac activity and increased arrhythmic readiness of myocardium in developing rethrombosis of coronary artery. The pronounced reperfusion injury of the myocardium evidently plays an important role in this process and is associated with embolization of the vessels of the microcirculatory bed, release of free radicals and alteration of cardiomyocytes, especially due to prolonged ischemia.

Dynamic properties of the Fisher–Kolmogorov–Petrovskii–Piscounov equation with the deviation of the spatial variable

We consider the problem of the density wave propagation of a logistic equation with the deviation of the spatial variable and diffusion (the Fisher–Kolmogorov equation with the deviation of the spatial variable). The Ginzburg–Landau equation was constructed in order to study the qualitative behavior of the solution near the equilibrium state. We analyzed the profile of the wave equation and found conditions for the appearance of oscillatory regimes. The numerical analysis of the wave propagation shows that, for a fairly small spatial deviation, this equation has a solution similar to that the classical Fisher–Kolmogorov equation. An increase in this spatial deviation leads to the existence of the oscillatory component in the spatial distribution of solutions. A further increase in the spatial deviation leads to the destruction of the traveling wave. This is expressed in the fact that undamped spatiotemporal fluctuations exist in a neighborhood of the initial perturbation. These fluctuations are close to the solution of the corresponding boundary value problem with periodic boundary conditions. Finally, when the spatial deviation is large enough we observe intensive spatiotemporal fluctuations in the whole area of wave propagation.

Serum uromodulin predicts graft failure in renal transplant recipients

Objective and methods: Test the ability of serum uromodulin concentrations 1–3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients.Results: uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0% and a specificity of 70.2%.Conclusion: Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.

Injection of Reactive Power for Optimization Power Loss and Voltage Deviation with a Proposed NSGA-II

The reactive power distribution affects the security and the economic performance of the power system chiefly. Although the reactive power generation is in does not cost anything in the operation phase, but it affects the whole cost by the system losses. The mentioned problem is a non-linear optimization topic with the combination of continuous and noncontinuous variables. This paper proposes a new innovative method to reach the increase in the power system deviation and transmission loss. In this study, it is tried to reach the most optimum multiple goals by based on multi objective Genetic Algorithm with Pareto optimal non-dominated solutions of OPF problem. In this study had employed the limit accept block until for put variable to the allowable limits. Simulation result shows the effect of proposes algorithm in reducing transmission loss and voltage deviation. A MNSGA-II is presented in this paper to solve the multi objective problems. The main goal is to determine the optimal combination of power outputs for all generating units that optimize the total power loss and voltage deviations while satisfying load demand (active and reactive) and operating constraints. According to results, the ability to jump out of the local optima enhanced and thus the high precision are achieved.