Background: COVID-19 was declared a pandemic by WHO in early 2020. Infection by the SARS-Cov-2 virus causes varying mortality in various regions. This research aimed to determine the predictors of mortality in COVID-19 patients treated at dr. Soediran Mangun Sumarso Regional General Hospital. Methods: This was an analytical observational study with a cross-sectional design. The study subjects were COVID-19 patients from polymerase chain reaction (PCR) examination results who were treated at dr. Soediran Mangun Sumarso Regional General Hospital. Clinical and laboratory data along with outcome status during treatment were obtained from medical records. Bivariate analysis was carried out for variables, such as age, gender, and comorbid factors, and determining predictors of mortality from the results of examinations of O2 saturation, leukocyte numbers, D-dimer, and CRP. Bivariate analysis of prognostic variables used the chi-square test. Results: A total of 81 (25.20%) patients died, out of a total of 258 patients. Factors and predictors of death in patients positive with COVID-19 were elderly over 60 (p=0.031), an increase in leukocyte (AL) count (p=0.010), and D-dimer (p=0.030) above the normal limit (p=0.850). Conclusion: Predictor factors for mortality in COVID-19 patients treated at Dr. Soediran Mangun Sumarso Regional General Hospital was aged over > 60 and increased leukocyte numbers, D-dimer, and CRP rate above the normal limits