Abstract
Circadian rhythms play an important role in determining the strength of the immune response. It has previously been shown that leukocyte mobilization from the bone marrow fluctuates over the course of the day. In addition, leukocyte homing to organs contributes to an oscillatory cell count in the circulation. However, it is currently unclear which factors determine oscillations in blood cellularity. Serum transfer experiments with donor serum harvested at different times of the day revealed increased leukocyte numbers in the circulation at specific times. These increases could be blocked by pharmacological targeting of inflammatory cytokines. In addition, germ‐free mice exhibited lower leukocyte counts at specific times and reduced oscillations in overall cellularity. Together, our data point to an important role of inflammatory cytokines in determining oscillatory blood leukocyte counts in the steady state.Support or Funding InformationWe are very thankful for our funding agencies: European Research Council (ERC), Deutsche Forschungsgemeinschaft (DFG), Integrated Research Training Group 914 / Sonderforschungsbereich 914 of the Ludwig‐Maximilians‐Universitaet Muenchen, International Max Planck Research School for Life SciencesThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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