The use of robotics in the process industry has shown a stable, increasing trend, according to survey reports, reducing the exposure of operators to critical operations, mainly during maintenance. Moving from full manual (FM) to human-robot teaming (HRT) operations is expected to reduce the risks for operators and increase operational efficiency. The methods used to assess system performances require an adaptation. Traditional risk assessment techniques are no longer adapted to analyze the new way of working; the previous methods proposed for HRT systems have been criticized for their fragmentation, complexity, and lack of validation.This study proposed an integrated framework, including the qualitative and quantitative stages, to investigate the risk-based system performance and compare the full manual and human-robot teaming scenarios in pressurized tank inspection operations. The outputs demonstrated that the integrated framework worked for FM and HRT system performance assessment, considering multiple element types and their interdependencies, generating knowledge that can be exploited to reduce the system's risk and choose among different operational alternatives.