Incorporating Machine Learning Algorithms Research Articles

Machine Learning Approach to Support the Detection of Parkinson's Disease in IMU-Based Gait Analysis

Recent advances in data analysis and wearable sensors for human movement monitoring can promote objective and accurate clinical evaluation of neurological symptoms and improve outcome measures in clinical trials [1–3]. The aim of this study was to combine modern technique of data analysis and wearable sensors to determine which supervised machine learning (ML) algorithm can most accurately classify people with Parkinson’s disease (pwPD) from speed-matched healthy subjects (HS) based on a selected minimum set of IMU-derived gait features. Twenty-two gait features were extrapolated from the trunk acceleration patterns of 81 pwPD and 80 HS, including spatiotemporal, pelvic kinematics, and acceleration-derived gait stability indexes. After a three-level feature selection procedure, seven gait features were considered for implementing five ML algorithms: support vector machine (SVM), artificial neural network, decision trees (DT), random forest (RF), and K-nearest neighbors. Accuracy, precision, recall, F1 score, AUC and generalization error were calculated. SVM outperformed the other ML algorithms in terms of classification metrics (test accuracy = 0.86; F1 score = 0.85; AUC = 0.85) and generalizability (generalization error = 2.95%) in classifying the gait impairment of pwPD compared with speed-matched healthy subjects, using a selected dataset of gait features based on lower trunk acceleration data. Although significantly lower than SVM, tree-based algorithms revealed good classification performances with low generalization errors (RF: test accuracy= 0.86; F1 score = 0.85; AUC = 0.85), and lower computational demand than SVM. ANN was similar to DT in terms of classification metrics but showed significantly higher generalization error (7.26%) than tree-based algorithms and SVM and higher computational demand than the other ML algorithms. Even though KNN showed the fastest time performance, its classification metrics were the lowest. We proposed a feature selection procedure based on the combination of filter, wrapper, embedded, and domain-specific methods that was effective in lowering the risk of overrepresenting multicollinear gait features in the model, resulting in a lower risk of overfitting in the test performances by increasing the explainability of the results at the same time. Because of their accurate results, their simplicity of understanding, and explanability, DT and RF algorithms could represent useful tools for the comprehension of gait disorders by making clinicians participate in the decision process. This is the first time that the accuracy and generalizability of the most performed ML algorithms in classifying pwPD gait abnormalities based on gait data from a single lumbar-mounted IMU have been compared. The findings of this study could be used to incorporate machine learning algorithms into software that processes gait data from lumbar-mounted IMUs. Future research could focus on finding the best tree- based model for classification and prediction problems in gait analysis.

Fish Species Image Classification Using Convolutional Neural Networks

This paper demonstrates the classification of various fish species using different machine learning methods. By incorporating machine learning algorithms, modeling, and training, the project classifies fish species using neural networks with the help of multiple features like length, width, and more. Ultimately, this project attempts to analyze the differences between determining fish species with PyTorch and TensorFlow. Convolutional Neural Networks (CNN) is a powerful algorithm used in image classification problems. Python has various libraries which can be used to build a model for the same purpose; the ultimate goal of this study is to see whether using different libraries will affect the accuracy. I would like to see whether new and more advanced methods can be used to classify large schools of fish rather than only in labs. I developed separate Python codes using PyTorch and TensorFlow individually. Using each code, I obtained results and, in the end, performed a comparative study between both to come to my conclusion. My main findings were that PyTorch gave a more accurate prediction than TensorFlow. I believe this was the case because the PyTorch code incorporated neural networks with more layers, so it increased the training and validation accuracy. From here, it is evident that while neither method necessarily possesses setbacks, PyTorch has a significant edge in accuracy (99.75% to 87.22%). Therefore, when scientists apply classification with CNN, PyTorch may be more optimal for producing better results.

Logistic regression and artificial neural network-based simple predicting models for obstructive sleep apnea by age, sex, and body mass index.

Age, sex, and body mass index (BMI) were associated with obstructive sleep apnea (OSA). Although various methods have been used in OSA prediction, this study aimed to develop predictions using simple and general predictors incorporating machine learning algorithms. This single-center, retrospective observational study assessed the diagnostic relevance of age, sex, and BMI for OSA in a cohort of 9, 422 patients who had undergone polysomnography (PSG) between 2015 and 2020. The participants were randomly divided into training, testing, and independent validation groups. Multivariable logistic regression (LR) and artificial neural network (ANN) algorithms used age, sex, and BMI as predictors to develop risk-predicting models for moderate-and-severe OSA. The training-testing dataset was used to assess the model generalizability through five-fold cross-validation. We calculated the area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the independent validation set to assess the performance of the model. The results showed that age, sex, and BMI were significantly associated with OSA. The validation AUCs of the generated LR and ANN models were 0.806 and 0.807, respectively. The independent validation set's accuracy, sensitivity, specificity, PPV, and NPV were 76.3%, 87.5%, 57.0%, 77.7%, and 72.7% for the LR model, and 76.4%, 87.7%, 56.9%, 77.7%, and 73.0% respectively, for the ANN model. The LR- and ANN-boosted models with the three simple parameters effectively predicted OSA in patients referred for PSG examination and improved insight into risk stratification for OSA diagnosis.

Machine-Learning-enhanced systemic risk measure: A Two-Step supervised learning approach

This paper explores ways to improve the existing systemic risk measures by incorporating machine learning algorithms into the measurement. We aim to overcome the shortcomings of existing methods that rely on restricted modeling and are difficult to tap into various data resources. To this end, this paper unifies a dynamic quantification framework for systemic risk and links it to a two-step supervised learning problem, which allows for hierarchical structure of the systemic event and the return dependence. We leverage the generalization and predictive powers of machine learning to statistically model the tail events and the co-movements of the equity returns during the shocks to the macro-economy. Our results show that most machine learning algorithms enhance the systemic risk measure’s predictive power. Numerous comparative and sensitivity backtesting studies for United States and Hong Kong markets are conducted, from which we recommend the best machine learning algorithm for systemic risk measurement.

Implementing machine learning for the identification and classification of compound and mixtures in portable Raman instruments

Portable Raman instruments provide quick, nondestructive analysis of organic and inorganic compounds, making it widely applicable in various disciplines. However, the instrument’s accuracy when analyzing pure, or multiple component mixtures is still an aspect that needs improvement. This study explored machine learning algorithms to classify single compounds, binary, ternary, and quaternary mixtures by the compound name, and the compound’s class, using seized drugs and common diluents as a model. The accuracies were ≥ 93% for most pure, binary mixtures, and quaternary mixtures algorithms. Therefore, incorporating machine learning algorithms in portable instruments, can improve the detection of unknown substances with high accuracies.

Evaluating Fishing Capacity Based on DEA and Regression Analysis of China’s Offshore Fishery

The analysis of offshore fishing capacity is of great significance and practical value to the sustainable utilization and conservation of marine fishery resources. Based on the 2004–2020 China Fishery Statistical Yearbook, data envelopment analysis (DEA) was applied for measuring fishing capacity using a number of fishing vessels, total power, total tonnage, and the number of professional fishermen as the input measures and the annual catch as the output measure. Capacity utilization had a calculated range from 80.7 to 100%, and its average is 93.5%. In the first four years of 2003–2007, the excess investment rate of fishing vessels, total tonnage, total power, and fishermen was low (<5%). There was a consistent sharp upward trend in 2007, a gradual downward trend from 2007 to 2015, and an upward trend after reaching a low point in 2015, with the highest gross tonnage of fishing vessels reaching 25.5%. Four regression models that incorporate machine learning algorithms are used, including Lasso, Ridge, KNN, and Polynomial Features. The goodness of fit for the four models was used as the evaluation index, and the offshore annual catch based on the evaluation index was proposed. The forecasting annual catch of the polynomial model can reach 0.98. Furthermore, a comparative simulation of the DEA incorporating the polynomial model was carried out. The results show that DEA can evaluate input factors under the conditions of a given range, and the polynomial model has more advantages in forecasting annual catches. Furthermore, the combined application of DEA and polynomial model was used to analyze and discuss the management policies of China’s offshore fishery, which can provide help and reference for future management.

Predicting stock returns with financial ratios: A new methodology incorporating machine learning techniques to beat the market

ABSTRACT This study proposes a methodology incorporating machine learning algorithms to predict stock returns and construct portfolios that beat the market. The performance evaluation is based on the statistical metrics as well as the return and Sharpe ratios of the portfolios. Additionally, a new performance evaluation metric, Safe-Side, is introduced to address the needs of conservative portfolio managers and investors. The results provide strong evidence that the machine learning algorithms can be used to predict the stock returns with approximately 86% classification accuracy. The proposed methodology also provides guidance for investors and portfolio managers for their portfolio selection problems.

Utilizing High Performance Computing to Improve the Application of Machine Learning for Time-Efficient Prediction of Buildings’ Daylighting Performance

Architects often investigate the daylighting performance of hundreds of design solutions and configurations to ensure an energy-efficient solution for their designs. To shorten the time required for daylighting simulations, architects usually reduce the number of variables or parameters of the building and facade design. This practice usually results in the elimination of design variables that could contribute to an energy-optimized design configuration. Therefore, recent research has focused on incorporating machine learning algorithms that require the execution of only a relatively small subset of the simulations to predict the daylighting and energy performance of buildings. Although machine learning has been shown to be accurate, it still becomes a time-consuming process due to the time required to execute a set of simulations to be used as training and validation data. Furthermore, to save time, designers often decide to use a small simulation subset, which leads to a poorly designed machine learning algorithm that produces inaccurate results. Therefore, this study aims to introduce an automated framework that utilizes high performance computing (HPC) to execute the simulations necessary for the machine learning algorithm while saving time and effort. High performance computing facilitates the execution of thousands of tasks simultaneously for a time-efficient simulation process, therefore allowing designers to increase the size of the simulation’s subset. Pairing high performance computing with machine learning allows for accurate and nearly instantaneous building performance predictions.

Incorporation of high accuracy surface modeling into machine learning to improve soil organic matter mapping

Digital soil mapping approaches related to soil organic matter (SOM) are crucial to quantify the process of the carbon cycle in terrestrial ecosystems and thus, can better manage soil fertility. Recently, many studies have compared machine learning (ML) models with traditional statistical models in digital soil mapping. However, few studies focused on the application of hybrid models that combine ML with statistical models to map SOM content, especially in loess areas, which have a complicated geomorphologic landscape. In this study, the trend prediction used two ML models, i.e., gradient boosting modeling and random forest (RF), and a traditional stepwise multiple linear regression plus interpolated residuals generated from two classic geostatistical models, i.e., ordinary kriging and inverse distance weighting, and a high accuracy surface modeling (HASM) were implemented to map SOM content in the Dongzhi Loess Tableland area of China. A total of 145 topsoil samples and heterogeneous environmental variables were collected to develop the hybrid models. Results showed that 18 variables related to soil properties, climate variables, terrain attributes, vegetation indices, and location attributes played an important role in SOM mapping. The models that incorporate ML algorithms and interpolated residuals to predict SOM variation were found to have a better ability to handle complex environment relationships. The HASM model outperformed traditional geostatistical models in interpolating the residuals. In contrast, RF combined with HASM residuals (RF_HASM) gave the best performance, with the lowest mean absolute error (1.69 g/kg), root mean square error (2.30 g/kg), and the highest coefficient of determination (0.57) and concordance correlation coefficient (0.69) values. Moreover, the spatial distribution pattern obtained with RF_HASM yielded a spatial distribution of SOM that better fit the actual distribution pattern of the study area. In conclusion, these results suggest that RF_HASM is particularly capable of improving the mapping accuracy of SOM content at the regional scale.

Estimating the effect of central bank independence on inflation using longitudinal targeted maximum likelihood estimation

Abstract The notion that an independent central bank reduces a country’s inflation is a controversial hypothesis. To date, it has not been possible to satisfactorily answer this question because the complex macroeconomic structure that gives rise to the data has not been adequately incorporated into statistical analyses. We develop a causal model that summarizes the economic process of inflation. Based on this causal model and recent data, we discuss and identify the assumptions under which the effect of central bank independence on inflation can be identified and estimated. Given these and alternative assumptions, we estimate this effect using modern doubly robust effect estimators, i.e., longitudinal targeted maximum likelihood estimators. The estimation procedure incorporates machine learning algorithms and is tailored to address the challenges associated with complex longitudinal macroeconomic data. We do not find strong support for the hypothesis that having an independent central bank for a long period of time necessarily lowers inflation. Simulation studies evaluate the sensitivity of the proposed methods in complex settings when certain assumptions are violated and highlight the importance of working with appropriate learning algorithms for estimation.

Nonparametric conditional density estimation in a deep learning framework for short-term forecasting

Short-term forecasting is an important tool in understanding environmental processes. In this paper, we incorporate machine learning algorithms into a conditional distribution estimator for the purposes of forecasting tropical cyclone intensity. Many machine learning techniques give a single-point prediction of the conditional distribution of the target variable, which does not give a full accounting of the prediction variability. Conditional distribution estimation can provide extra insight on predicted response behavior, which could influence decision-making and policy. We propose a technique that simultaneously estimates the entire conditional distribution and flexibly allows for machine learning techniques to be incorporated. A smooth model is fit over both the target variable and covariates, and a logistic transformation is applied on the model output layer to produce an expression of the conditional density function. We provide two examples of machine learning models that can be used, polynomial regression and deep learning models. To achieve computational efficiency, we propose a case–control sampling approximation to the conditional distribution. A simulation study for four different data distributions highlights the effectiveness of our method compared to other machine learning-based conditional distribution estimation techniques. We then demonstrate the utility of our approach for forecasting purposes using tropical cyclone data from the Atlantic Seaboard. This paper gives a proof of concept for the promise of our method, further computational developments can fully unlock its insights in more complex forecasting and other applications.

Embedded Intelligence on FPGA: Survey, Applications and Challenges

Embedded intelligence (EI) is an emerging research field and has the objective to incorporate machine learning algorithms and intelligent decision-making capabilities into mobile and embedded devices or systems. There are several challenges to be addressed to realize efficient EI implementations in hardware such as the need for: (1) high computational processing; (2) low power consumption (or high energy efficiency); and (3) scalability to accommodate different network sizes and topologies. In recent years, an emerging hardware technology which has demonstrated strong potential and capabilities for EI implementations is the FPGA (field programmable gate array) technology. This paper presents an overview and review of embedded intelligence on FPGA with a focus on applications, platforms and challenges. There are four main classification and thematic descriptors which are reviewed and discussed in this paper for EI: (1) EI techniques including machine learning and neural networks, deep learning, expert systems, fuzzy intelligence, swarm intelligence, self-organizing map (SOM) and extreme learning; (2) applications for EI including object detection and recognition, indoor localization and surveillance monitoring, and other EI applications; (3) hardware and platforms for EI; and (4) challenges for EI. The paper aims to introduce interested researchers to this area and motivate the development of practical FPGA solutions for EI deployment.

Personalized cognitive training: Protocol for individual-level meta-analysis implementing machine learning methods

Accumulating evidence suggests that cognitive training may enhance well-being. Yet, mixed findings imply that individual differences and training characteristics may interact to moderate training efficacy. To investigate this possibility, the current paper describes a protocol for a data-driven individual-level meta-analysis study aimed at developing personalized cognitive training. To facilitate comprehensive analysis, this protocol proposes criteria for data search, selection and pre-processing along with the rationale for each decision. Twenty-two cognitive training datasets comprising 1544 participants were collected. The datasets incorporated diverse training methods, all aimed at improving well-being. These training regimes differed in training characteristics such as targeted domain (e.g., working memory, attentional bias, interpretation bias, inhibitory control) and training duration, while participants differed in diagnostic status, age and sex. The planned analyses incorporate machine learning algorithms designed to identify which individuals will be most responsive to cognitive training in general and to discern which methods may be a better fit for certain individuals.

Data-Driven Feature-Based Newsvendor: A Distributionally Robust Approach

In this paper, we study the feature-based newsvendor problem in the context of available historical demand observations and related demand covariates. The demand distribution conditioned on these features is based on general kernel estimation methods that can incorporate machine learning algorithms, such as the random forest. To account for estimation errors, we propose a distributionally robust optimization (DRO) approach that contains all distributions close to the estimated conditional demand distribution under a discrepancy measure based on the cumulative distribution functions. Interestingly, we show that the DRO problem with such an ambiguity set admits a closed-form solution for the newsvendor loss. In addition, we show that the optimal solution produced by this approach converges to the optimal inventory decision asymptotically and provides a finite-sample performance guarantee. The results of numerical experiments with synthetic and real-world data sets show that compared with other approaches, our model performs well in terms of the out-of-sample cost and computational time.

When to Stop Reviewing in Technology-Assisted Reviews

Technology-Assisted Reviews (TAR) aim to expedite document reviewing (e.g., medical articles or legal documents) by iteratively incorporating machine learning algorithms and human feedback on document relevance. Continuous Active Learning (CAL) algorithms have demonstrated superior performance compared to other methods in efficiently identifying relevant documents. One of the key challenges for CAL algorithms is deciding when to stop displaying documents to reviewers. Existing work either lacks transparency—it provides an ad-hoc stopping point, without indicating how many relevant documents are still not found, or lacks efficiency by paying an extra cost to estimate the total number of relevant documents in the collection prior to the actual review. In this article, we handle the problem of deciding the stopping point of TAR under the continuous active learning framework by jointly training a ranking model to rank documents, and by conducting a “greedy” sampling to estimate the total number of relevant documents in the collection. We prove the unbiasedness of the proposed estimators under a with-replacement sampling design, while experimental results demonstrate that the proposed approach, similar to CAL, effectively retrieves relevant documents; but it also provides a transparent, accurate, and effective stopping point.

Cuffless Blood Pressure Monitoring: Promises and Challenges.

Current BP measurements are on the basis of traditional BP cuff approaches. Ambulatory BP monitoring, at 15- to 30-minute intervals usually over 24 hours, provides sufficiently continuous readings that are superior to the office-based snapshot, but this system is not suitable for frequent repeated use. A true continuous BP measurement that could collect BP passively and frequently would require a cuffless method that could be worn by the patient, with the data stored electronically much the same way that heart rate and heart rhythm are already done routinely. Ideally, BP should be measured continuously and frequently during diverse activities during both daytime and nighttime in the same subject by means of novel devices. There is increasing excitement for newer methods to measure BP on the basis of sensors and algorithm development. As new devices are refined and their accuracy is improved, it will be possible to better assess masked hypertension, nocturnal hypertension, and the severity and variability of BP. In this review, we discuss the progression in the field, particularly in the last 5 years, ending with sensor-based approaches that incorporate machine learning algorithms to personalized medicine.

Machine-Learning-enhanced Systemic Risk Measure: A Two-Step Supervised Learning Approach

This paper explores ways to improve the existing systemic risk measures by incorporating machine learning algorithms into the measurement. We aim to overcome the shortcomings of existing methods that rely on restricted modeling and are difficult to tap into various data resources. To this end, this paper unifies a dynamic quantification framework for systemic risk and links it to a two-step supervised learning problem, which allows for hierarchical structure of the systemic event and the return dependence. We leverage the generalization and predictive powers of machine learning to statistically model the tail events and the co-movements of the equity returns during the shocks to the macro-economy. Our results show that most machine learning algorithms enhance the systemic risk measure's predictive power. Numerous comparative and sensitivity backtesting studies for United States and Hong Kong markets are conducted, from which we recommend the best machine learning algorithm for systemic risk measurement.

Validation of machine learning models to detect amyloid pathologies across institutions

Semi-quantitative scoring schemes like the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) are the most commonly used method in Alzheimer’s disease (AD) neuropathology practice. Computational approaches based on machine learning have recently generated quantitative scores for whole slide images (WSIs) that are highly correlated with human derived semi-quantitative scores, such as those of CERAD, for Alzheimer’s disease pathology. However, the robustness of such models have yet to be tested in different cohorts. To validate previously published machine learning algorithms using convolutional neural networks (CNNs) and determine if pathological heterogeneity may alter algorithm derived measures, 40 cases from the Goizueta Emory Alzheimer’s Disease Center brain bank displaying an array of pathological diagnoses (including AD with and without Lewy body disease (LBD), and / or TDP-43-positive inclusions) and levels of Aβ pathologies were evaluated. Furthermore, to provide deeper phenotyping, amyloid burden in gray matter vs whole tissue were compared, and quantitative CNN scores for both correlated significantly to CERAD-like scores. Quantitative scores also show clear stratification based on AD pathologies with or without additional diagnoses (including LBD and TDP-43 inclusions) vs cases with no significant neurodegeneration (control cases) as well as NIA Reagan scoring criteria. Specifically, the concomitant diagnosis group of AD + TDP-43 showed significantly greater CNN-score for cored plaques than the AD group. Finally, we report that whole tissue computational scores correlate better with CERAD-like categories than focusing on computational scores from a field of view with densest pathology, which is the standard of practice in neuropathological assessment per CERAD guidelines. Together these findings validate and expand CNN models to be robust to cohort variations and provide additional proof-of-concept for future studies to incorporate machine learning algorithms into neuropathological practice.

Intelligent Robotics Incorporating Machine Learning Algorithms for Improving Functional Capacity Evaluation and Occupational Rehabilitation.

Introduction Occupational rehabilitation often involves functional capacity evaluations (FCE) that use simulated work tasks to assess work ability. Currently, there exists no single, streamlined solution to simulate all or a large number of standard work tasks. Such a system would improve FCE and functional rehabilitation through simulating reaching maneuvers and more dexterous functional tasks that are typical of workplace activities. This paper reviews efforts to develop robotic FCE solutions that incorporate machine learning algorithms. Methods We reviewed the literature regarding rehabilitation robotics, with an emphasis on novel techniques incorporating robotics and machine learning into FCE. Results Rehabilitation robotics aims to improve the assessment and rehabilitation of injured workers by providing methods for easily simulating workplace tasks using intelligent robotic systems. Machine learning-based approaches combine the benefits of robotic systems with the expertise and experience of human therapists. These innovations have the potential to improve the quantification of function as well as learn the haptic interactions provided by therapists to assist patients during assessment and rehabilitation. This is done by allowing a robot to learn based on a therapist's motions ("demonstrations") what the desired workplace activity ("task") is and how to recreate it for a worker with an injury ("patient"). Through Telerehabilitation and internet connectivity, these robotic assessment techniques can be used over a distance to reach rural and remote locations. Conclusions While the research is in the early stages, robotics with integrated machine learning algorithms have great potential for improving traditional FCE practice.

Computerized decision support and machine learning applications for the prevention and treatment of childhood obesity: A systematic review of the literature.

Digital health interventions based on tools for Computerized Decision Support (CDS) and Machine Learning (ML), which take advantage of new information, sensing and communication technologies, can play a key role in childhood obesity prevention and treatment. We present a systematic literature review of CDS and ML applications for the prevention and treatment of childhood obesity. The main characteristics and outcomes of studies using CDS and ML are demonstrated, to advance our understanding towards the development of smart and effective interventions for childhood obesity care. A search in the bibliographic databases of PubMed and Scopus was performed to identify childhood obesity studies incorporating either CDS interventions, or advanced data analytics through ML algorithms. Ongoing, case, and qualitative studies, along with those not providing specific quantitative outcomes were excluded. The studies incorporating CDS were synthesized according to the intervention's main technology (e.g., mobile app), design type (e.g., randomized controlled trial), number of enrolled participants, target age of children, participants' follow-up duration, primary outcome (e.g., Body Mass Index (BMI)), and main CDS feature(s) and their outcomes (e.g., alerts for caregivers when BMI is high). The studies incorporating ML were synthesized according to the number of subjects included and their age, the ML algorithm(s) used (e.g., logistic regression), as well as their main outcome (e.g., prediction of obesity). The literature search identified 8 studies incorporating CDS interventions and 9 studies utilizing ML algorithms, which met our eligibility criteria. All studies reported statistically significant interventional or ML model outcomes (e.g., in terms of accuracy). More than half of the interventional studies (n = 5, 63 %) were designed as randomized controlled trials. Half of the interventional studies (n = 4, 50 %) utilized Electronic Health Records (EHRs) and alerts for BMI as means of CDS. From the 9 studies using ML, the highest percentage targeted at the prognosis of obesity (n = 4, 44 %). In the studies incorporating more than one ML algorithms and reporting accuracy, it was shown that decision trees and artificial neural networks can accurately predict childhood obesity. This review has found that CDS tools can be useful for the self-management or remote medical management of childhood obesity, whereas ML algorithms such as decision trees and artificial neural networks can be helpful for prediction purposes. Further rigorous studies in the area of CDS and ML for childhood obesity care are needed, considering the low number of studies identified in this review, their methodological limitations, and the scarcity of interventional studies incorporating ML algorithms in CDS tools.