Introduction. Inadequate efficacy of medication for periodontal diseases leads to the search for new ways to treat this group of diseases, and, in particular, by using non-drug methods. Among the latter, the use of low-intensity radiation, in particular Polychromatic Incoherent Low Energy Radiation, PILER, seems very promising and becoming more widespread. The aim of this study is to evaluate the effect of PILER irradiation in the integrated treatment of patients with acute and chronic catarrhal gingivitis. Materials and methods. We examined 26 patients with inflammatory periodontal diseases aged from 17 to 28 years. We carried out clinical examination of all participants, performed Schiller-Pisarev tests, and determined Fedorov-Volodkina and Parma PMA indices. Orthopantomogram and laboratory investigation were also performed. Patients were divided into 4 groups: group 1 included patients with acute catarrhal gingivitis, and group 2 included patients with chronic catarrhal gingivitis, who took the courses of PILER irradiation of the gingival mucosa with red and purple filters in addition to standard therapy; group 3rd included patients with acute catarrhal gingivitis, and group 4 involved patients with chronic catarrhal gingivitis, who received the medication only without the PILER irradiation course. We used the Bioptron "MedAll" device. Results and discussion. After the course of integrated treatment, the patients of groups 1 and 2 demonstrated faster and more pronounced improvement of clinical signs compared with groups 3 and 4. The patients of group 1 were registered to experience improvement on day 3 of the treatment; on the 14th day of the treatment, Fedorov-Volodkina index and PMA were assessed as by 15.4 and 15.6% better compared to group 3. The patients of group 2 found to have the improvement on the 7th day of the treatment; on the 14th day of the treatment, the values of the FedorovVolodkina and PMA indexes were by 14.3 and 17.2% better compared with those in group 4. Conclusions. PILER irradiation in combination with medication accelerates and improves the treatment of acute and chronic catarrhal gingivitis, compared with the use of drug therapy alone, improves microcirculation and periodontal tissue trophism.